GRK5 (G protein-coupled receptor kinase 5)

Gene

• Entrez ID: 2869
• Gene name: G protein-coupled receptor kinase 5
• Gene symbol: GRK5
• Synonyms: FP2025, GPRK5
• Chromosome: 10
• Chromosome location: 10q26.11
• Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their de

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT036566	hsa-miR-941	CLASH	23622248
MIRT487507	hsa-miR-570-3p	PAR-CLIP	23592263
MIRT487505	hsa-miR-4481	PAR-CLIP	23592263
MIRT487506	hsa-miR-4745-5p	PAR-CLIP	23592263
MIRT487504	hsa-miR-1238-5p	PAR-CLIP	23592263
MIRT487503	hsa-miR-4758-5p	PAR-CLIP	23592263
MIRT487507	hsa-miR-570-3p	PAR-CLIP	23592263
MIRT487505	hsa-miR-4481	PAR-CLIP	23592263
MIRT487506	hsa-miR-4745-5p	PAR-CLIP	23592263
MIRT487504	hsa-miR-1238-5p	PAR-CLIP	23592263
MIRT487503	hsa-miR-4758-5p	PAR-CLIP	23592263
MIRT1034929	hsa-miR-129-5p	CLIP-seq
MIRT1034930	hsa-miR-23a	CLIP-seq
MIRT1034931	hsa-miR-23b	CLIP-seq
MIRT1034932	hsa-miR-23c	CLIP-seq
MIRT1034933	hsa-miR-3161	CLIP-seq
MIRT1034934	hsa-miR-627	CLIP-seq
MIRT2239367	hsa-miR-1285	CLIP-seq
MIRT2239368	hsa-miR-132	CLIP-seq
MIRT2239369	hsa-miR-135a	CLIP-seq
MIRT2239370	hsa-miR-135b	CLIP-seq
MIRT2239371	hsa-miR-1587	CLIP-seq
MIRT2239372	hsa-miR-1909	CLIP-seq
MIRT2239373	hsa-miR-212	CLIP-seq
MIRT2239374	hsa-miR-2278	CLIP-seq
MIRT2239375	hsa-miR-3187-5p	CLIP-seq
MIRT2239376	hsa-miR-378g	CLIP-seq
MIRT2239377	hsa-miR-4283	CLIP-seq
MIRT2239378	hsa-miR-4486	CLIP-seq
MIRT2239379	hsa-miR-4492	CLIP-seq
MIRT2239380	hsa-miR-4498	CLIP-seq
MIRT2239381	hsa-miR-4656	CLIP-seq
MIRT2239382	hsa-miR-4675	CLIP-seq
MIRT2239383	hsa-miR-4741	CLIP-seq
MIRT2239384	hsa-miR-4804-3p	CLIP-seq
MIRT2239385	hsa-miR-604	CLIP-seq
MIRT2239386	hsa-miR-612	CLIP-seq
MIRT2239387	hsa-miR-647	CLIP-seq
MIRT2239388	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	20124405
GO:0004703	Function	G protein-coupled receptor kinase activity	IEA
GO:0005080	Function	Protein kinase C binding	TAS	9813065
GO:0005515	Function	Protein binding	IPI	17986524, 19008357, 19661922, 20124405
GO:0005524	Function	ATP binding	IEA
GO:0005543	Function	Phospholipid binding	TAS	9813065
GO:0005737	Component	Cytoplasm	TAS	7685906
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA	14976207, 17986524
GO:0005886	Component	Plasma membrane	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS	8626574
GO:0007217	Process	Tachykinin receptor signaling pathway	IDA	17986524
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	TAS	8288567
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	22099983
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0031965	Component	Nuclear membrane	IDA
GO:0043066	Process	Negative regulation of apoptotic process	IDA	20124405
GO:0046777	Process	Protein autophosphorylation	IDA	14976207
GO:0047696	Function	Beta-adrenergic receptor kinase activity	IMP	20038610
GO:0047696	Function	Beta-adrenergic receptor kinase activity	TAS
GO:0051726	Process	Regulation of cell cycle	IMP	22099983

Other IDs

• MIM: 600870
• HGNC: 4544
• e!Ensembl: ENSG00000198873

Protein

• UniProt ID: P34947
• Protein name: G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5)
• Protein function: Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and sig
• PDB: 4TNB, 4TND, 6PJX, 8UAP, 8UAQ, 9BRE, 9BRG, 9BRH, 9BRI, 9BRJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00615	RGS	52 → 170	Regulator of G protein signaling domain	Domain
  PF00069	Pkinase	186 → 448	Protein kinase domain	Domain

• Sequence:

  MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ
  PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ
  VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP
  VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK
  VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE
  DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ
  RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC
  KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI
  EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRN
  HPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS

• Sequence length: 590

Pathways

KEGG:

Chemokine signaling pathway
Endocytosis
Morphine addiction

Reactome:

G alpha (s) signalling events

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	22961080
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959

Unknown
Disease name	Disease term	dbSNP ID	References
Cardiovascular diseases	Cardiovascular Diseases		26032411
Crohn disease	Crohn Disease	rs2066847, rs2066844, rs886052047, rs5743265, rs111608429, rs104895438	17804789