P2RY8 (P2Y receptor family member 8)

Gene

• Entrez ID: 286530
• Gene name: P2Y receptor family member 8
• Gene symbol: P2RY8
• Synonyms: P2Y8
• Chromosome: X|Y
• Chromosome location: X;Y
• Summary: The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromos

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1603452612	G>C	Likely-pathogenic	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1209103	hsa-miR-103a	CLIP-seq
MIRT1209104	hsa-miR-107	CLIP-seq
MIRT1209105	hsa-miR-3150b-3p	CLIP-seq
MIRT1209106	hsa-miR-324-5p	CLIP-seq
MIRT1209107	hsa-miR-331-3p	CLIP-seq
MIRT1209108	hsa-miR-378g	CLIP-seq
MIRT1209109	hsa-miR-4254	CLIP-seq
MIRT1209110	hsa-miR-4260	CLIP-seq
MIRT1209111	hsa-miR-4292	CLIP-seq
MIRT1209112	hsa-miR-4308	CLIP-seq
MIRT1209113	hsa-miR-4434	CLIP-seq
MIRT1209114	hsa-miR-4480	CLIP-seq
MIRT1209115	hsa-miR-4493	CLIP-seq
MIRT1209116	hsa-miR-4516	CLIP-seq
MIRT1209117	hsa-miR-4531	CLIP-seq
MIRT1209118	hsa-miR-4716-5p	CLIP-seq
MIRT1209119	hsa-miR-4722-3p	CLIP-seq
MIRT1209120	hsa-miR-4753-5p	CLIP-seq
MIRT1209121	hsa-miR-4773	CLIP-seq
MIRT1209122	hsa-miR-4784	CLIP-seq
MIRT1209123	hsa-miR-486-3p	CLIP-seq
MIRT1209124	hsa-miR-765	CLIP-seq
MIRT2060061	hsa-miR-1253	CLIP-seq
MIRT2060062	hsa-miR-214	CLIP-seq
MIRT2060063	hsa-miR-3619-5p	CLIP-seq
MIRT2060064	hsa-miR-3675-5p	CLIP-seq
MIRT2060065	hsa-miR-3925-3p	CLIP-seq
MIRT1209109	hsa-miR-4254	CLIP-seq
MIRT2060066	hsa-miR-4270	CLIP-seq
MIRT2060067	hsa-miR-4283	CLIP-seq
MIRT1209113	hsa-miR-4434	CLIP-seq
MIRT2060068	hsa-miR-4441	CLIP-seq
MIRT2060069	hsa-miR-4487	CLIP-seq
MIRT2060070	hsa-miR-4489	CLIP-seq
MIRT1209116	hsa-miR-4516	CLIP-seq
MIRT2060071	hsa-miR-4646-5p	CLIP-seq
MIRT2060072	hsa-miR-548c-3p	CLIP-seq
MIRT2060073	hsa-miR-761	CLIP-seq
MIRT2060061	hsa-miR-1253	CLIP-seq
MIRT2060064	hsa-miR-3675-5p	CLIP-seq
MIRT2288417	hsa-miR-3922-5p	CLIP-seq
MIRT2060067	hsa-miR-4283	CLIP-seq
MIRT1209113	hsa-miR-4434	CLIP-seq
MIRT2060069	hsa-miR-4487	CLIP-seq
MIRT2060070	hsa-miR-4489	CLIP-seq
MIRT1209116	hsa-miR-4516	CLIP-seq
MIRT2060071	hsa-miR-4646-5p	CLIP-seq
MIRT2288418	hsa-miR-4667-5p	CLIP-seq
MIRT2288419	hsa-miR-4700-5p	CLIP-seq
MIRT2288420	hsa-miR-508-5p	CLIP-seq
MIRT2288421	hsa-miR-574-3p	CLIP-seq
MIRT2392034	hsa-miR-3182	CLIP-seq
MIRT2060069	hsa-miR-4487	CLIP-seq
MIRT1209105	hsa-miR-3150b-3p	CLIP-seq
MIRT1209107	hsa-miR-331-3p	CLIP-seq
MIRT1209109	hsa-miR-4254	CLIP-seq
MIRT1209112	hsa-miR-4308	CLIP-seq
MIRT1209113	hsa-miR-4434	CLIP-seq
MIRT1209115	hsa-miR-4493	CLIP-seq
MIRT1209116	hsa-miR-4516	CLIP-seq
MIRT1209117	hsa-miR-4531	CLIP-seq
MIRT1209120	hsa-miR-4753-5p	CLIP-seq
MIRT1209122	hsa-miR-4784	CLIP-seq
MIRT1209124	hsa-miR-765	CLIP-seq
MIRT1209105	hsa-miR-3150b-3p	CLIP-seq
MIRT1209107	hsa-miR-331-3p	CLIP-seq
MIRT1209109	hsa-miR-4254	CLIP-seq
MIRT1209112	hsa-miR-4308	CLIP-seq
MIRT1209113	hsa-miR-4434	CLIP-seq
MIRT1209115	hsa-miR-4493	CLIP-seq
MIRT1209116	hsa-miR-4516	CLIP-seq
MIRT1209117	hsa-miR-4531	CLIP-seq
MIRT1209120	hsa-miR-4753-5p	CLIP-seq
MIRT1209122	hsa-miR-4784	CLIP-seq
MIRT1209124	hsa-miR-765	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0035025	Process	Positive regulation of Rho protein signal transduction	IBA	21873635
GO:0035589	Process	G protein-coupled purinergic nucleotide receptor signaling pathway	IEA
GO:0045028	Function	G protein-coupled purinergic nucleotide receptor activity	IEA
GO:0051482	Process	Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	IBA	21873635

Other IDs

• MIM: 300525
• HGNC: 15524
• e!Ensembl: ENSG00000182162

Protein

• UniProt ID: Q86VZ1
• Protein name: S-geranylgeranyl-glutathione receptor P2RY8 (P2Y purinoceptor 8) (P2Y8)
• Protein function: G protein-coupled receptor for S-geranylgeranyl-glutathione (GGG), an endogenous metabolite present in lymphoid tissues. Couples the binding of GGG to the activation of GNA13 and downstream repression of AKT activation in lymphocytes defining th
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	40 → 293	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MQVPNSTGPDNATLQMLRNPAIAVALPVVYSLVAAVSIPGNLFSLWVLCRRMGPRSPSVI
  FMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVAFYANMYSSILTMTCISVE
  RFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLARTDLTYPVHALGIITCFDVLK
  WTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATILKLLRTEEAHGREQRRRAVGLAA
  VVLLAFVTCFAPNNFVLLAHIVSRLFYGKSYYHVYKLTLCLSCLNNCLDPFVYYFASREF
  QLRLREYLGCRRVPRDTLDTRRESLFSARTTSVRSEAGAHPEGMEGATRPGLQRQESVF

• Sequence length: 359

Pathways

KEGG:

Neuroactive ligand-receptor interaction

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Lymphoblastic leukemia	Childhood Acute Lymphoblastic Leukemia, L2 Acute Lymphoblastic Leukemia, Precursor Cell Lymphoblastic Leukemia Lymphoma	rs387906351, rs104894562, rs398122513, rs398122840, rs398123063, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699, rs1597567692, rs1597567985, rs1438890364, rs1288977950, rs1597552140, rs1597566356, rs1597566726, rs1597568117, rs2069719445, rs2069729948, rs2070018439, rs745708044, rs1169577591	19838194