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RGMB (repulsive guidance molecule BMP co-receptor b)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
285704
Gene nameGene Name - the full gene name approved by the HGNC.
Repulsive guidance molecule BMP co-receptor b
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
RGMB
SynonymsGene synonyms aliases
DRAGON
ChromosomeChromosome number
5
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q15
SummarySummary of gene provided in NCBI Entrez Gene.
RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016098 hsa-miR-769-5p Sequencing 20371350
MIRT016114 hsa-miR-421 Sequencing 20371350
MIRT023409 hsa-miR-30b-5p Sequencing 20371350
MIRT046176 hsa-miR-27b-3p CLASH 23622248
MIRT044170 hsa-miR-130b-3p CLASH 23622248
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25938661
GO:0005793 Component Endoplasmic reticulum-Golgi intermediate compartment ISS
GO:0005886 Component Plasma membrane IBA 21873635
GO:0007155 Process Cell adhesion ISS
GO:0007165 Process Signal transduction ISS
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q6NW40
Protein name Repulsive guidance molecule B (DRG11-responsive axonal guidance and outgrowth of neurite) (DRAGON)
Protein function Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Pro
PDB 4BQ6 , 4BQ7 , 4BQ8 , 4UHZ , 4UI0 , 4UI2 , 6Z3H , 6Z3J , 6Z3M
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06535 RGM_N
54 222
Repulsive guidance molecule (RGM) N-terminus
Family
PF06534 RGM_C
226 400
Repulsive guidance molecule (RGM) C-terminus
Family
Sequence
Sequence length 437
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
  TGF-beta signaling pathway  
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 29662167
Rheumatoid arthritis Rheumatoid Arthritis rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212 17568789
Unknown
Disease name Disease term dbSNP ID References
Prostatic neoplasms Prostatic Neoplasms 29662167

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