MCHR1 (melanin concentrating hormone receptor 1)

Gene

• Entrez ID: 2847
• Gene name: Melanin concentrating hormone receptor 1
• Gene symbol: MCHR1
• Synonyms: GPR24, MCH-1R, MCH1R, SLC-1, SLC1
• Chromosome: 22
• Chromosome location: 22q13.2
• Summary: The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1137137	hsa-miR-1207-5p	CLIP-seq
MIRT1137138	hsa-miR-1270	CLIP-seq
MIRT1137139	hsa-miR-1293	CLIP-seq
MIRT1137140	hsa-miR-146b-3p	CLIP-seq
MIRT1137141	hsa-miR-1909	CLIP-seq
MIRT1137142	hsa-miR-3173-5p	CLIP-seq
MIRT1137143	hsa-miR-3689d	CLIP-seq
MIRT1137144	hsa-miR-3944-5p	CLIP-seq
MIRT1137145	hsa-miR-432	CLIP-seq
MIRT1137146	hsa-miR-4443	CLIP-seq
MIRT1137147	hsa-miR-4483	CLIP-seq
MIRT1137148	hsa-miR-4683	CLIP-seq
MIRT1137149	hsa-miR-4732-3p	CLIP-seq
MIRT1137150	hsa-miR-4736	CLIP-seq
MIRT1137151	hsa-miR-4763-3p	CLIP-seq
MIRT1137152	hsa-miR-620	CLIP-seq
MIRT1137153	hsa-miR-874	CLIP-seq
MIRT1137154	hsa-miR-890	CLIP-seq
MIRT2039034	hsa-miR-3182	CLIP-seq
MIRT2039035	hsa-miR-4652-3p	CLIP-seq
MIRT2269056	hsa-miR-1178	CLIP-seq
MIRT1137140	hsa-miR-146b-3p	CLIP-seq
MIRT1137142	hsa-miR-3173-5p	CLIP-seq
MIRT1137143	hsa-miR-3689d	CLIP-seq
MIRT1137145	hsa-miR-432	CLIP-seq
MIRT1137146	hsa-miR-4443	CLIP-seq
MIRT1137149	hsa-miR-4732-3p	CLIP-seq
MIRT2269057	hsa-miR-483-3p	CLIP-seq
MIRT2269058	hsa-miR-508-5p	CLIP-seq
MIRT2269059	hsa-miR-766	CLIP-seq
MIRT1137153	hsa-miR-874	CLIP-seq
MIRT1137154	hsa-miR-890	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA	21873635
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005929	Component	Cilium	IDA	28154160
GO:0006091	Process	Generation of precursor metabolites and energy	TAS	10421367
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	TAS	10421367
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IEA
GO:0007218	Process	Neuropeptide signaling pathway	IBA	21873635
GO:0007631	Process	Feeding behavior	TAS	10421367
GO:0008022	Function	Protein C-terminus binding	IEA
GO:0008188	Function	Neuropeptide receptor activity	TAS	10860944
GO:0030273	Function	Melanin-concentrating hormone receptor activity	IEA
GO:0042277	Function	Peptide binding	IBA	21873635
GO:0042562	Function	Hormone binding	IEA
GO:0042923	Function	Neuropeptide binding	IBA	21873635
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0051928	Process	Positive regulation of calcium ion transport	IEA
GO:0060170	Component	Ciliary membrane	IEA
GO:0097730	Component	Non-motile cilium	ISS

Other IDs

• MIM: 601751
• HGNC: 4479
• e!Ensembl: ENSG00000128285

Protein

• UniProt ID: Q99705
• Protein name: Melanin-concentrating hormone receptor 1 (MCH receptor 1) (MCH-R1) (MCHR-1) (G-protein coupled receptor 24) (MCH-1R) (MCH1R) (MCHR) (SLC-1) (Somatostatin receptor-like protein)
• Protein function: Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.
• PDB: 8WSS, 8WWH, 8WWI, 8WWJ, 8WWK, 8WWL, 8WWM, 8WWN, 8YNT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	126 → 380	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
  WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
  LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
  GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
  FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
  LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
  LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
  GT

• Sequence length: 422

Pathways

KEGG:

Neuroactive ligand-receptor interaction
Hormone signaling

Reactome:

Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
BBSome-mediated cargo-targeting to cilium

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	22081064, 19502010, 16741940

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		16741940, 19502010
Mental depression	Mental Depression, Depressive disorder	rs587778876, rs587778877	16934771, 22209364, 16230605, 19182070, 17655875, 16934771, 19182070, 17655875, 16230605, 22209364
Mood disorder	Mood Disorders		16934771, 19418262