TTLL6 (tubulin tyrosine ligase like 6)

Gene

• Entrez ID: 284076
• Gene name: Tubulin tyrosine ligase like 6
• Gene symbol: TTLL6
• Synonyms: TTL.6
• Chromosome: 17
• Chromosome location: 17q21.32

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2359822	hsa-miR-141	CLIP-seq
MIRT2359823	hsa-miR-200a	CLIP-seq
MIRT2359824	hsa-miR-4677-3p	CLIP-seq
MIRT2359825	hsa-miR-4679	CLIP-seq
MIRT2359826	hsa-miR-4778-5p	CLIP-seq
MIRT2442778	hsa-miR-1226	CLIP-seq
MIRT2442779	hsa-miR-1321	CLIP-seq
MIRT2442780	hsa-miR-138	CLIP-seq
MIRT2442781	hsa-miR-1587	CLIP-seq
MIRT2442782	hsa-miR-3126-5p	CLIP-seq
MIRT2442783	hsa-miR-4299	CLIP-seq
MIRT2442784	hsa-miR-4419a	CLIP-seq
MIRT2442785	hsa-miR-4492	CLIP-seq
MIRT2442786	hsa-miR-4498	CLIP-seq
MIRT2442787	hsa-miR-4510	CLIP-seq
MIRT2442788	hsa-miR-4656	CLIP-seq
MIRT2442789	hsa-miR-4675	CLIP-seq
MIRT2442790	hsa-miR-4710	CLIP-seq
MIRT2442791	hsa-miR-4733-3p	CLIP-seq
MIRT2442792	hsa-miR-4739	CLIP-seq
MIRT2442793	hsa-miR-4741	CLIP-seq
MIRT2442794	hsa-miR-4756-5p	CLIP-seq
MIRT2442795	hsa-miR-4792	CLIP-seq
MIRT2442796	hsa-miR-762	CLIP-seq
MIRT2653108	hsa-miR-1207-5p	CLIP-seq
MIRT2653109	hsa-miR-1827	CLIP-seq
MIRT2653110	hsa-miR-3189-5p	CLIP-seq
MIRT2653111	hsa-miR-328	CLIP-seq
MIRT2653112	hsa-miR-4446-3p	CLIP-seq
MIRT2442789	hsa-miR-4675	CLIP-seq
MIRT2653113	hsa-miR-4687-3p	CLIP-seq
MIRT2442793	hsa-miR-4741	CLIP-seq
MIRT2653114	hsa-miR-4763-3p	CLIP-seq
MIRT2653115	hsa-miR-940	CLIP-seq
MIRT2653108	hsa-miR-1207-5p	CLIP-seq
MIRT2653109	hsa-miR-1827	CLIP-seq
MIRT2653110	hsa-miR-3189-5p	CLIP-seq
MIRT2653111	hsa-miR-328	CLIP-seq
MIRT2653112	hsa-miR-4446-3p	CLIP-seq
MIRT2442789	hsa-miR-4675	CLIP-seq
MIRT2653113	hsa-miR-4687-3p	CLIP-seq
MIRT2442793	hsa-miR-4741	CLIP-seq
MIRT2653114	hsa-miR-4763-3p	CLIP-seq
MIRT2653115	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000226	Process	Microtubule cytoskeleton organization	IBA	21873635
GO:0001578	Process	Microtubule bundle formation	IEA
GO:0003353	Process	Positive regulation of cilium movement	IEA
GO:0005515	Function	Protein binding	IPI	22246503
GO:0005524	Function	ATP binding	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005874	Component	Microtubule	IEA
GO:0005929	Component	Cilium	IBA	21873635
GO:0015631	Function	Tubulin binding	IBA	21873635
GO:0015631	Function	Tubulin binding	ISS
GO:0018095	Process	Protein polyglutamylation	IBA	21873635
GO:0018095	Process	Protein polyglutamylation	ISS
GO:0018095	Process	Protein polyglutamylation	TAS
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0036064	Component	Ciliary basal body	IDA	22246503
GO:0051013	Process	Microtubule severing	IEA
GO:0070739	Function	Protein-glutamic acid ligase activity	ISS
GO:0070740	Function	Tubulin-glutamic acid ligase activity	IBA	21873635
GO:0097731	Component	9+0 non-motile cilium	IEA

Other IDs

• MIM: 610849
• HGNC: 26664
• e!Ensembl: ENSG00000170703

Protein

• UniProt ID: Q8N841
• Protein name: Tubulin polyglutamylase TTLL6 (EC 6.3.2.-) (Protein polyglutamylase TTLL6) (Tubulin--tyrosine ligase-like protein 6)
• Protein function: Polyglutamylase which modifies both tubulin and non-tubulin proteins, generating alpha-linked polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues of target proteins. Preferentially mediates ATP-dependent long pol
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03133	TTL	104 → 398	Tubulin-tyrosine ligase family	Family

• Sequence:

  MPQCPTLESQEGENSEEKGDSSKEDPKETVALAFVRENPGAQNGLQNAQQQGKKKRKKKR
  LVINLSSCRYESVRRAAQQYGFREGGEDDDWTLYWTDYSVSLERVMEMKSYQKINHFPGM
  SEICRKDLLARNMSRMLKMFPKDFRFFPRTWCLPADWGDLQTYSRSRKNKTYICKPDSGC
  QGKGIFITRTVKEIKPGEDMICQLYISKPFIIDGFKFDLRIYVLVTSCDPLRIFVYNEGL
  ARFATTSYSRPCTDNLDDICMHLTNYSINKHSSNFSRDAHSGSKRKLSTFSAYLEDHSYN
  VEQIWRDIEDVIIKTLISAHPIIRHNYHTCFPNHTLNSACFEILGFDILLDHKLKPWLLE
  VNHSPSFSTDSRLDKEVKDGLLYDTLVLINLESCDKKKVLEEERQRGQFLQQCCSREMRI
  EEAKGFRAVQLKKTETYEKENCGGFRLIYPSLNSEKYEKFFQDNNSLFQNTVASRAREEY
  ARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQY
  IQPLTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNI
  NLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVHLTSVETTPESTTQLSISPKSPPTLAVT
  ASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMN
  KPHLISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVS
  SLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRSHASAMRDPCMQDQEAYSHCLISGQKGC
  ERS

• Sequence length: 843

Pathways

Reactome:

Carboxyterminal post-translational modifications of tubulin

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	29632382
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	24280982

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		24280982
Mental disorders	Mental disorders		24280982
Psychosis	Psychotic Disorders		24280982