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NUDT7 (nudix hydrolase 7)

Gene

Nudix hydrolase 7

NUDT7

16q23.1

The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofacto

Show/Hide all(118)

miRTarBase ID	miRNA	Experiments	Reference
MIRT715817	hsa-miR-590-3p	HITS-CLIP	19536157
MIRT715816	hsa-miR-379-3p	HITS-CLIP	19536157
MIRT715815	hsa-miR-411-3p	HITS-CLIP	19536157
MIRT715813	hsa-miR-4502	HITS-CLIP	19536157
MIRT715814	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT715811	hsa-miR-3171	HITS-CLIP	19536157
MIRT715812	hsa-miR-194-5p	HITS-CLIP	19536157
MIRT715810	hsa-miR-3192-3p	HITS-CLIP	19536157
MIRT715809	hsa-miR-4762-3p	HITS-CLIP	19536157
MIRT712691	hsa-miR-4464	HITS-CLIP	19536157
MIRT712690	hsa-miR-4748	HITS-CLIP	19536157
MIRT712689	hsa-miR-3938	HITS-CLIP	19536157
MIRT712688	hsa-miR-4780	HITS-CLIP	19536157
MIRT712687	hsa-miR-6780b-3p	HITS-CLIP	19536157
MIRT712686	hsa-miR-623	HITS-CLIP	19536157
MIRT712685	hsa-miR-204-5p	HITS-CLIP	19536157
MIRT712684	hsa-miR-211-5p	HITS-CLIP	19536157
MIRT712683	hsa-miR-7641	HITS-CLIP	19536157
MIRT712682	hsa-miR-4755-5p	HITS-CLIP	19536157
MIRT712681	hsa-miR-5006-3p	HITS-CLIP	19536157
MIRT689595	hsa-miR-548ac	HITS-CLIP	23313552
MIRT689594	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT689593	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT689592	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT689591	hsa-miR-548z	HITS-CLIP	23313552
MIRT689590	hsa-miR-548as-3p	HITS-CLIP	23313552
MIRT689589	hsa-miR-1273d	HITS-CLIP	23313552
MIRT689588	hsa-miR-942-3p	HITS-CLIP	23313552
MIRT689587	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT689586	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT689585	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT689584	hsa-miR-4470	HITS-CLIP	23313552
MIRT689583	hsa-miR-3926	HITS-CLIP	23313552
MIRT689582	hsa-miR-548s	HITS-CLIP	23313552
MIRT689581	hsa-miR-214-5p	HITS-CLIP	23313552
MIRT689580	hsa-miR-6811-3p	HITS-CLIP	23313552
MIRT689579	hsa-miR-6847-3p	HITS-CLIP	23313552
MIRT689578	hsa-miR-4284	HITS-CLIP	23313552
MIRT689577	hsa-miR-24-3p	HITS-CLIP	23313552
MIRT689576	hsa-miR-6514-3p	HITS-CLIP	23313552
MIRT689575	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT689574	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT689573	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT689572	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT689571	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT689570	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT689569	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT689568	hsa-miR-3689c	HITS-CLIP	23313552
MIRT689567	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT689566	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT689565	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT689564	hsa-miR-3122	HITS-CLIP	23313552
MIRT689563	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT689562	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT689561	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT689589	hsa-miR-1273d	PAR-CLIP	27292025
MIRT715817	hsa-miR-590-3p	HITS-CLIP	19536157
MIRT715816	hsa-miR-379-3p	HITS-CLIP	19536157
MIRT715815	hsa-miR-411-3p	HITS-CLIP	19536157
MIRT715813	hsa-miR-4502	HITS-CLIP	19536157
MIRT715814	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT715811	hsa-miR-3171	HITS-CLIP	19536157
MIRT715812	hsa-miR-194-5p	HITS-CLIP	19536157
MIRT715810	hsa-miR-3192-3p	HITS-CLIP	19536157
MIRT715809	hsa-miR-4762-3p	HITS-CLIP	19536157
MIRT712691	hsa-miR-4464	HITS-CLIP	19536157
MIRT712690	hsa-miR-4748	HITS-CLIP	19536157
MIRT712689	hsa-miR-3938	HITS-CLIP	19536157
MIRT712688	hsa-miR-4780	HITS-CLIP	19536157
MIRT712687	hsa-miR-6780b-3p	HITS-CLIP	19536157
MIRT712686	hsa-miR-623	HITS-CLIP	19536157
MIRT712685	hsa-miR-204-5p	HITS-CLIP	19536157
MIRT712684	hsa-miR-211-5p	HITS-CLIP	19536157
MIRT712683	hsa-miR-7641	HITS-CLIP	19536157
MIRT712682	hsa-miR-4755-5p	HITS-CLIP	19536157
MIRT712681	hsa-miR-5006-3p	HITS-CLIP	19536157
MIRT689595	hsa-miR-548ac	HITS-CLIP	23313552
MIRT689594	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT689593	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT689592	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT689591	hsa-miR-548z	HITS-CLIP	23313552
MIRT689590	hsa-miR-548as-3p	HITS-CLIP	23313552
MIRT689589	hsa-miR-1273d	HITS-CLIP	23313552
MIRT689588	hsa-miR-942-3p	HITS-CLIP	23313552
MIRT689587	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT689586	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT689585	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT689584	hsa-miR-4470	HITS-CLIP	23313552
MIRT689583	hsa-miR-3926	HITS-CLIP	23313552
MIRT689582	hsa-miR-548s	HITS-CLIP	23313552
MIRT689581	hsa-miR-214-5p	HITS-CLIP	23313552
MIRT689580	hsa-miR-6811-3p	HITS-CLIP	23313552
MIRT689579	hsa-miR-6847-3p	HITS-CLIP	23313552
MIRT689578	hsa-miR-4284	HITS-CLIP	23313552
MIRT689577	hsa-miR-24-3p	HITS-CLIP	23313552
MIRT689576	hsa-miR-6514-3p	HITS-CLIP	23313552
MIRT689575	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT689574	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT689573	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT689572	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT689571	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT689570	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT689569	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT689568	hsa-miR-3689c	HITS-CLIP	23313552
MIRT689567	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT689566	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT689565	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT689564	hsa-miR-3122	HITS-CLIP	23313552
MIRT689563	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT689562	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT689561	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT2285869	hsa-miR-1256	CLIP-seq
MIRT2285870	hsa-miR-135a	CLIP-seq
MIRT2285871	hsa-miR-135b	CLIP-seq
MIRT2285872	hsa-miR-3119	CLIP-seq
MIRT2285873	hsa-miR-4720-5p	CLIP-seq
MIRT2285874	hsa-miR-4790-3p	CLIP-seq
MIRT2285875	hsa-miR-4799-3p	CLIP-seq

Show/Hide all(22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IEA
GO:0003674	Function	Molecular_function	ND
GO:0003986	Function	Acetyl-CoA hydrolase activity	IBA	21873635
GO:0005777	Component	Peroxisome	ISS
GO:0005782	Component	Peroxisomal matrix	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006625	Process	Protein targeting to peroxisome	TAS
GO:0008150	Process	Biological_process	ND
GO:0009062	Process	Fatty acid catabolic process	TAS
GO:0009132	Process	Nucleoside diphosphate metabolic process	IEA
GO:0010945	Function	CoA pyrophosphatase activity	ISS
GO:0015938	Process	Coenzyme A catabolic process	IBA	21873635
GO:0015938	Process	Coenzyme A catabolic process	ISS
GO:0016289	Function	CoA hydrolase activity	TAS
GO:0030145	Function	Manganese ion binding	IEA
GO:0030515	Function	SnoRNA binding	ISS
GO:0036114	Process	Medium-chain fatty-acyl-CoA catabolic process	ISS
GO:0044580	Process	Butyryl-CoA catabolic process	ISS
GO:0046356	Process	Acetyl-CoA catabolic process	ISS
GO:0050072	Function	M7G(5')pppN diphosphatase activity	ISS
GO:0050873	Process	Brown fat cell differentiation	IEA
GO:1902859	Process	Propionyl-CoA catabolic process	ISS

MIM	HGNC	e!Ensembl
609231	8054	ENSG00000140876

Protein

UniProt ID

P0C024

Protein name

Peroxisomal coenzyme A diphosphatase NUDT7 (EC 3.6.1.-) (EC 3.6.1.77) (Nucleoside diphosphate-linked moiety X motif 7) (Nudix motif 7)

Protein function

Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies (By similarity). Pr

PDB

5QGG , 5QGH , 5QGI , 5QGJ , 5QGK , 5QGL , 5QGM , 5QGN , 5QGO , 5QGP , 5QGQ , 5QGR , 5QGS , 5QGT , 5QGU , 5QGV , 5QGW , 5QGX , 5QGY , 5QGZ , 5QH0 , 5QH1 , 5QH2 , 5QH3 , 5QH4 , 5QH5 , 5QH6 , 5QH7 , 5QH8 , 5QH9 , 5QHA , 5QHB , 5QHC , 5QHE , 5QHF , 5QHG , 5QHH , 5T3P

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00293	NUDIX	38 → 166	NUDIX domain	Domain

Sequence

MSRLGLPEEPVRNSLLDDAKARLRKYDIGGKYSHLPYNKYSVLLPLVAKEGKLHLLFTVR
SEKLRRAPGEVCFPGGKRDPTDMDDAATALREAQEEVGLRPHQVEVVCCLVPCLIDTDTL
ITPFVGLIDHNFQAQPNPAEVKDVFLVPLAYFLHPQVHDQHYVTRLGHRFINHIFEYTNP
EDGVTYQIKGMTANLAVLVAFIILEKKPTFEVQFNLNDVLASSEELFLKVHKKATSRL

Sequence length

238

Interactions

View interactions

	KEGG		Reactome
	Peroxisome		Peroxisomal lipid metabolism Peroxisomal protein import

Associated diseases

Show/Hide Unknown Diseases (2)

Unknown
Disease name	Disease term	dbSNP ID	References
Liver neoplasms	Liver neoplasms		25058030
Liver cancer	Malignant neoplasm of liver		25058030

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