GPM6A (glycoprotein M6A)

Gene

• Entrez ID: 2823
• Gene name: Glycoprotein M6A
• Gene symbol: GPM6A
• Synonyms: GPM6, M6A
• Chromosome: 4
• Chromosome location: 4q34.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020434	hsa-miR-106b-5p	Microarray	17242205
MIRT024239	hsa-miR-218-5p	Sequencing	20371350
MIRT050918	hsa-miR-17-5p	CLASH	23622248
MIRT498419	hsa-miR-548e-5p	PAR-CLIP	22291592
MIRT498418	hsa-miR-548az-5p	PAR-CLIP	22291592
MIRT498417	hsa-miR-548t-5p	PAR-CLIP	22291592
MIRT498419	hsa-miR-548e-5p	PAR-CLIP	22291592
MIRT498418	hsa-miR-548az-5p	PAR-CLIP	22291592
MIRT498417	hsa-miR-548t-5p	PAR-CLIP	22291592
MIRT1029553	hsa-miR-186	CLIP-seq
MIRT1029554	hsa-miR-200b	CLIP-seq
MIRT1029555	hsa-miR-200c	CLIP-seq
MIRT1029556	hsa-miR-3133	CLIP-seq
MIRT1029557	hsa-miR-374c	CLIP-seq
MIRT1029558	hsa-miR-429	CLIP-seq
MIRT1029559	hsa-miR-4650-3p	CLIP-seq
MIRT1029560	hsa-miR-4773	CLIP-seq
MIRT1029561	hsa-miR-628-5p	CLIP-seq
MIRT1029562	hsa-miR-655	CLIP-seq
MIRT1029563	hsa-miR-1206	CLIP-seq
MIRT1029564	hsa-miR-1283	CLIP-seq
MIRT1029565	hsa-miR-2054	CLIP-seq
MIRT1029566	hsa-miR-221	CLIP-seq
MIRT1029567	hsa-miR-222	CLIP-seq
MIRT1029568	hsa-miR-302a	CLIP-seq
MIRT1029569	hsa-miR-302b	CLIP-seq
MIRT1029570	hsa-miR-302c	CLIP-seq
MIRT1029571	hsa-miR-302d	CLIP-seq
MIRT1029572	hsa-miR-302e	CLIP-seq
MIRT1029573	hsa-miR-3074-3p	CLIP-seq
MIRT1029574	hsa-miR-3153	CLIP-seq
MIRT1029575	hsa-miR-330-3p	CLIP-seq
MIRT1029576	hsa-miR-340	CLIP-seq
MIRT1029577	hsa-miR-361-5p	CLIP-seq
MIRT1029578	hsa-miR-3646	CLIP-seq
MIRT1029579	hsa-miR-365	CLIP-seq
MIRT1029580	hsa-miR-372	CLIP-seq
MIRT1029581	hsa-miR-373	CLIP-seq
MIRT1029582	hsa-miR-409-3p	CLIP-seq
MIRT1029583	hsa-miR-4281	CLIP-seq
MIRT1029584	hsa-miR-448	CLIP-seq
MIRT1029585	hsa-miR-4517	CLIP-seq
MIRT1029586	hsa-miR-4668-5p	CLIP-seq
MIRT1029587	hsa-miR-4763-5p	CLIP-seq
MIRT1029588	hsa-miR-519a	CLIP-seq
MIRT1029589	hsa-miR-519b-3p	CLIP-seq
MIRT1029590	hsa-miR-519c-3p	CLIP-seq
MIRT1029591	hsa-miR-520a-3p	CLIP-seq
MIRT1029592	hsa-miR-520b	CLIP-seq
MIRT1029593	hsa-miR-520c-3p	CLIP-seq
MIRT1029594	hsa-miR-520d-3p	CLIP-seq
MIRT1029595	hsa-miR-520d-5p	CLIP-seq
MIRT1029596	hsa-miR-520e	CLIP-seq
MIRT1029597	hsa-miR-524-5p	CLIP-seq
MIRT1029598	hsa-miR-548v	CLIP-seq
MIRT1029599	hsa-miR-653	CLIP-seq
MIRT2005478	hsa-miR-1178	CLIP-seq
MIRT2005479	hsa-miR-452	CLIP-seq
MIRT2005480	hsa-miR-4676-3p	CLIP-seq
MIRT2450554	hsa-miR-3973	CLIP-seq
MIRT2450555	hsa-miR-450b-5p	CLIP-seq
MIRT2450556	hsa-miR-4731-3p	CLIP-seq
MIRT2450557	hsa-miR-4801	CLIP-seq
MIRT2450558	hsa-miR-507	CLIP-seq
MIRT2450559	hsa-miR-548k	CLIP-seq
MIRT2450560	hsa-miR-556-3p	CLIP-seq
MIRT2450561	hsa-miR-557	CLIP-seq
MIRT2542053	hsa-miR-1305	CLIP-seq
MIRT1029573	hsa-miR-3074-3p	CLIP-seq
MIRT2542054	hsa-miR-3671	CLIP-seq
MIRT2542055	hsa-miR-4643	CLIP-seq
MIRT2542056	hsa-miR-466	CLIP-seq
MIRT2542057	hsa-miR-4789-3p	CLIP-seq
MIRT2542058	hsa-miR-485-3p	CLIP-seq
MIRT2542059	hsa-miR-487a	CLIP-seq
MIRT2542060	hsa-miR-607	CLIP-seq
MIRT2542053	hsa-miR-1305	CLIP-seq
MIRT1029573	hsa-miR-3074-3p	CLIP-seq
MIRT2542054	hsa-miR-3671	CLIP-seq
MIRT2542055	hsa-miR-4643	CLIP-seq
MIRT2542056	hsa-miR-466	CLIP-seq
MIRT2542057	hsa-miR-4789-3p	CLIP-seq
MIRT2542058	hsa-miR-485-3p	CLIP-seq
MIRT2542059	hsa-miR-487a	CLIP-seq
MIRT2542060	hsa-miR-607	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001764	Process	Neuron migration	IDA	19298174
GO:0003407	Process	Neural retina development	ISS
GO:0005262	Function	Calcium channel activity	IEA
GO:0005515	Function	Protein binding	IPI	17500595, 24705354, 31286866, 32814053
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	ISS
GO:0007416	Process	Synapse assembly	ISS
GO:0009617	Process	Response to bacterium	IEA
GO:0030175	Component	Filopodium	IBA	21873635
GO:0030175	Component	Filopodium	ISS
GO:0031175	Process	Neuron projection development	IBA	21873635
GO:0043005	Component	Neuron projection	ISS
GO:0043025	Component	Neuronal cell body	IBA	21873635
GO:0043025	Component	Neuronal cell body	ISS
GO:0043197	Component	Dendritic spine	IEA
GO:0044295	Component	Axonal growth cone	IBA	21873635
GO:0044295	Component	Axonal growth cone	ISS
GO:0048812	Process	Neuron projection morphogenesis	ISS
GO:0048863	Process	Stem cell differentiation	IDA	19298174
GO:0050807	Process	Regulation of synapse organization	IEA
GO:0051491	Process	Positive regulation of filopodium assembly	ISS
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099059	Component	Integral component of presynaptic active zone membrane	IEA
GO:1903561	Component	Extracellular vesicle	HDA	24769233

Other IDs

• MIM: 601275
• HGNC: 4460
• e!Ensembl: ENSG00000150625

Protein

• UniProt ID: P51674
• Protein name: Neuronal membrane glycoprotein M6-a (M6a)
• Protein function: Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01275	Myelin_PLP	14 → 247	Myelin proteolipid protein (PLP or lipophilin)	Family

• Sequence:

  MEENMEEGQTQKGCFECCIKCLGGIPYASLIATILLYAGVALFCGCGHEALSGTVNILQT
  YFEMARTAGDTLDVFTMIDIFKYVIYGIAAAFFVYGILLMVEGFFTTGAIKDLYGDFKIT
  TCGRCVSAWFIMLTYLFMLAWLGVTAFTSLPVYMYFNLWTICRNTTLVEGANLCLDLRQF
  GIVTIGEEKKICTVSENFLRMCESTELNMTFHLFIVALAGAGAAVIAMVHYLMVLSANWA
  YVKDACRMQKYEDIKSKEEQELHDIHSTRSKERLNAYT

• Sequence length: 278

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	30285260, 25056061, 26198764, 18163405, 28991256, 31268507, 31374203, 29483656

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560
Mental depression	Major Depressive Disorder	rs587778876, rs587778877	29942085
Mood disorder	Mood Disorders		29942085