GPC1 (glypican 1)

Gene

• Entrez ID: 2817
• Gene name: Glypican 1
• Gene symbol: GPC1
• Synonyms: glypican
• Chromosome: 2
• Chromosome location: 2q37.3
• Summary: Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protei

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022703	hsa-miR-124-3p	Microarray	18668037
MIRT023811	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT054857	hsa-miR-149-5p	Luciferase reporter assay, qRT-PCR, Western blot	24463821
MIRT054858	hsa-miR-149-3p	Luciferase reporter assay, qRT-PCR, Western blot	24463821
MIRT054858	hsa-miR-149-3p	qRT-PCR, Western blot, MTT	28233416
MIRT734395	hsa-miR-125b-5p	Luciferase reporter assay, Western blotting	32435510
MIRT1028528	hsa-miR-1226	CLIP-seq
MIRT1028529	hsa-miR-1271	CLIP-seq
MIRT1028530	hsa-miR-15a	CLIP-seq
MIRT1028531	hsa-miR-15b	CLIP-seq
MIRT1028532	hsa-miR-16	CLIP-seq
MIRT1028533	hsa-miR-182	CLIP-seq
MIRT1028534	hsa-miR-1910	CLIP-seq
MIRT1028535	hsa-miR-195	CLIP-seq
MIRT1028536	hsa-miR-223	CLIP-seq
MIRT1028537	hsa-miR-298	CLIP-seq
MIRT1028538	hsa-miR-3133	CLIP-seq
MIRT1028539	hsa-miR-330-3p	CLIP-seq
MIRT1028540	hsa-miR-338-3p	CLIP-seq
MIRT1028541	hsa-miR-3613-5p	CLIP-seq
MIRT1028542	hsa-miR-3689a-3p	CLIP-seq
MIRT1028543	hsa-miR-3689c	CLIP-seq
MIRT1028544	hsa-miR-371b-5p	CLIP-seq
MIRT1028545	hsa-miR-424	CLIP-seq
MIRT1028546	hsa-miR-4459	CLIP-seq
MIRT1028547	hsa-miR-4494	CLIP-seq
MIRT1028548	hsa-miR-4530	CLIP-seq
MIRT1028549	hsa-miR-4648	CLIP-seq
MIRT1028550	hsa-miR-4654	CLIP-seq
MIRT1028551	hsa-miR-4667-3p	CLIP-seq
MIRT1028552	hsa-miR-4691-5p	CLIP-seq
MIRT1028553	hsa-miR-4697-3p	CLIP-seq
MIRT1028554	hsa-miR-4728-5p	CLIP-seq
MIRT1028555	hsa-miR-4733-3p	CLIP-seq
MIRT1028556	hsa-miR-4765	CLIP-seq
MIRT1028557	hsa-miR-4769-5p	CLIP-seq
MIRT1028558	hsa-miR-497	CLIP-seq
MIRT1028559	hsa-miR-499a-5p	CLIP-seq
MIRT1028560	hsa-miR-542-3p	CLIP-seq
MIRT1028561	hsa-miR-766	CLIP-seq
MIRT1028562	hsa-miR-888	CLIP-seq
MIRT1028563	hsa-miR-922	CLIP-seq
MIRT1028564	hsa-miR-96	CLIP-seq
MIRT1921627	hsa-miR-1205	CLIP-seq
MIRT1921628	hsa-miR-1286	CLIP-seq
MIRT1921629	hsa-miR-3691-3p	CLIP-seq
MIRT1921630	hsa-miR-4722-5p	CLIP-seq
MIRT1921627	hsa-miR-1205	CLIP-seq
MIRT1921628	hsa-miR-1286	CLIP-seq
MIRT1921629	hsa-miR-3691-3p	CLIP-seq
MIRT1921630	hsa-miR-4722-5p	CLIP-seq
MIRT2005101	hsa-miR-1197	CLIP-seq
MIRT1921627	hsa-miR-1205	CLIP-seq
MIRT2005102	hsa-miR-1207-5p	CLIP-seq
MIRT2005103	hsa-miR-1266	CLIP-seq
MIRT1921628	hsa-miR-1286	CLIP-seq
MIRT2005104	hsa-miR-1291	CLIP-seq
MIRT2005105	hsa-miR-136	CLIP-seq
MIRT2005106	hsa-miR-146b-3p	CLIP-seq
MIRT2005107	hsa-miR-1470	CLIP-seq
MIRT1028534	hsa-miR-1910	CLIP-seq
MIRT2005108	hsa-miR-1913	CLIP-seq
MIRT2005109	hsa-miR-214	CLIP-seq
MIRT2005110	hsa-miR-22	CLIP-seq
MIRT2005111	hsa-miR-296-5p	CLIP-seq
MIRT1028537	hsa-miR-298	CLIP-seq
MIRT2005112	hsa-miR-3064-5p	CLIP-seq
MIRT2005113	hsa-miR-3115	CLIP-seq
MIRT2005114	hsa-miR-3117-5p	CLIP-seq
MIRT2005115	hsa-miR-3127-3p	CLIP-seq
MIRT2005116	hsa-miR-3144-5p	CLIP-seq
MIRT2005117	hsa-miR-3173-5p	CLIP-seq
MIRT2005118	hsa-miR-3187-3p	CLIP-seq
MIRT2005119	hsa-miR-324-3p	CLIP-seq
MIRT1028540	hsa-miR-338-3p	CLIP-seq
MIRT2005120	hsa-miR-3591-3p	CLIP-seq
MIRT2005121	hsa-miR-361-3p	CLIP-seq
MIRT2005122	hsa-miR-3619-5p	CLIP-seq
MIRT2005123	hsa-miR-3649	CLIP-seq
MIRT2005124	hsa-miR-3675-5p	CLIP-seq
MIRT1028542	hsa-miR-3689a-3p	CLIP-seq
MIRT1028543	hsa-miR-3689c	CLIP-seq
MIRT1921629	hsa-miR-3691-3p	CLIP-seq
MIRT2005125	hsa-miR-3918	CLIP-seq
MIRT2005126	hsa-miR-4252	CLIP-seq
MIRT2005127	hsa-miR-4290	CLIP-seq
MIRT2005128	hsa-miR-4313	CLIP-seq
MIRT2005129	hsa-miR-4435	CLIP-seq
MIRT2005130	hsa-miR-4436a	CLIP-seq
MIRT2005131	hsa-miR-4447	CLIP-seq
MIRT1028546	hsa-miR-4459	CLIP-seq
MIRT2005132	hsa-miR-4472	CLIP-seq
MIRT2005133	hsa-miR-4476	CLIP-seq
MIRT2005134	hsa-miR-4518	CLIP-seq
MIRT1028548	hsa-miR-4530	CLIP-seq
MIRT2005135	hsa-miR-4533	CLIP-seq
MIRT2005136	hsa-miR-4650-5p	CLIP-seq
MIRT2005137	hsa-miR-4651	CLIP-seq
MIRT1028551	hsa-miR-4667-3p	CLIP-seq
MIRT2005138	hsa-miR-4671-5p	CLIP-seq
MIRT2005139	hsa-miR-4690-5p	CLIP-seq
MIRT1028552	hsa-miR-4691-5p	CLIP-seq
MIRT2005140	hsa-miR-4701-5p	CLIP-seq
MIRT1921630	hsa-miR-4722-5p	CLIP-seq
MIRT1028554	hsa-miR-4728-5p	CLIP-seq
MIRT2005141	hsa-miR-4732-3p	CLIP-seq
MIRT2005142	hsa-miR-4736	CLIP-seq
MIRT2005143	hsa-miR-4752	CLIP-seq
MIRT2005144	hsa-miR-4763-3p	CLIP-seq
MIRT2005145	hsa-miR-4795-3p	CLIP-seq
MIRT2005146	hsa-miR-485-3p	CLIP-seq
MIRT2005147	hsa-miR-548s	CLIP-seq
MIRT2005148	hsa-miR-566	CLIP-seq
MIRT2005149	hsa-miR-588	CLIP-seq
MIRT2005150	hsa-miR-608	CLIP-seq
MIRT2005151	hsa-miR-626	CLIP-seq
MIRT2005152	hsa-miR-661	CLIP-seq
MIRT2005153	hsa-miR-761	CLIP-seq
MIRT2005154	hsa-miR-765	CLIP-seq
MIRT1028561	hsa-miR-766	CLIP-seq
MIRT2005155	hsa-miR-874	CLIP-seq
MIRT1028563	hsa-miR-922	CLIP-seq
MIRT2005101	hsa-miR-1197	CLIP-seq
MIRT2237785	hsa-miR-1207-3p	CLIP-seq
MIRT2005103	hsa-miR-1266	CLIP-seq
MIRT2237786	hsa-miR-1321	CLIP-seq
MIRT2005106	hsa-miR-146b-3p	CLIP-seq
MIRT1028534	hsa-miR-1910	CLIP-seq
MIRT2005109	hsa-miR-214	CLIP-seq
MIRT2005114	hsa-miR-3117-5p	CLIP-seq
MIRT2237787	hsa-miR-3127-5p	CLIP-seq
MIRT2005116	hsa-miR-3144-5p	CLIP-seq
MIRT2005117	hsa-miR-3173-5p	CLIP-seq
MIRT2005118	hsa-miR-3187-3p	CLIP-seq
MIRT2005122	hsa-miR-3619-5p	CLIP-seq
MIRT2005123	hsa-miR-3649	CLIP-seq
MIRT2237788	hsa-miR-3689d	CLIP-seq
MIRT2005125	hsa-miR-3918	CLIP-seq
MIRT2005126	hsa-miR-4252	CLIP-seq
MIRT2237789	hsa-miR-4270	CLIP-seq
MIRT2005129	hsa-miR-4435	CLIP-seq
MIRT2237790	hsa-miR-4441	CLIP-seq
MIRT2237791	hsa-miR-4446-3p	CLIP-seq
MIRT2005131	hsa-miR-4447	CLIP-seq
MIRT1028546	hsa-miR-4459	CLIP-seq
MIRT2005132	hsa-miR-4472	CLIP-seq
MIRT2005134	hsa-miR-4518	CLIP-seq
MIRT2005139	hsa-miR-4690-5p	CLIP-seq
MIRT2005140	hsa-miR-4701-5p	CLIP-seq
MIRT1028554	hsa-miR-4728-5p	CLIP-seq
MIRT2237792	hsa-miR-4731-5p	CLIP-seq
MIRT2005141	hsa-miR-4732-3p	CLIP-seq
MIRT2237793	hsa-miR-4739	CLIP-seq
MIRT2005143	hsa-miR-4752	CLIP-seq
MIRT2237794	hsa-miR-4756-5p	CLIP-seq
MIRT2237795	hsa-miR-4779	CLIP-seq
MIRT2237796	hsa-miR-486-3p	CLIP-seq
MIRT2237797	hsa-miR-510	CLIP-seq
MIRT2005147	hsa-miR-548s	CLIP-seq
MIRT2005149	hsa-miR-588	CLIP-seq
MIRT2005153	hsa-miR-761	CLIP-seq
MIRT2005154	hsa-miR-765	CLIP-seq
MIRT2005155	hsa-miR-874	CLIP-seq
MIRT2237798	hsa-miR-885-3p	CLIP-seq
MIRT2005104	hsa-miR-1291	CLIP-seq
MIRT2541829	hsa-miR-1915	CLIP-seq
MIRT2541830	hsa-miR-2355-5p	CLIP-seq
MIRT2005120	hsa-miR-3591-3p	CLIP-seq
MIRT2005125	hsa-miR-3918	CLIP-seq
MIRT2541831	hsa-miR-4685-5p	CLIP-seq
MIRT2005103	hsa-miR-1266	CLIP-seq
MIRT2005109	hsa-miR-214	CLIP-seq
MIRT2005122	hsa-miR-3619-5p	CLIP-seq
MIRT2681895	hsa-miR-3664-3p	CLIP-seq
MIRT2681896	hsa-miR-3907	CLIP-seq
MIRT2681897	hsa-miR-4291	CLIP-seq
MIRT2005134	hsa-miR-4518	CLIP-seq
MIRT2681898	hsa-miR-4519	CLIP-seq
MIRT2005151	hsa-miR-626	CLIP-seq
MIRT2005153	hsa-miR-761	CLIP-seq
MIRT1028563	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	TAS
GO:0005507	Function	Copper ion binding	IDA	12732622
GO:0005576	Component	Extracellular region	HDA	27068509
GO:0005615	Component	Extracellular space	TAS	2148568
GO:0005654	Component	Nucleoplasm	IDA
GO:0005768	Component	Endosome	IEA
GO:0005796	Component	Golgi lumen	TAS
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0006024	Process	Glycosaminoglycan biosynthetic process	TAS
GO:0006027	Process	Glycosaminoglycan catabolic process	TAS
GO:0007411	Process	Axon guidance	TAS
GO:0009986	Component	Cell surface	IBA	21873635
GO:0014037	Process	Schwann cell differentiation	ISS
GO:0016477	Process	Cell migration	IBA	21873635
GO:0017134	Function	Fibroblast growth factor binding	IBA	21873635
GO:0017134	Function	Fibroblast growth factor binding	ISS
GO:0030200	Process	Heparan sulfate proteoglycan catabolic process	IDA	12732622
GO:0031012	Component	Extracellular matrix	ISS
GO:0031226	Component	Intrinsic component of plasma membrane	TAS	2148568
GO:0032288	Process	Myelin assembly	ISS
GO:0040037	Process	Negative regulation of fibroblast growth factor receptor signaling pathway	IBA	21873635
GO:0040037	Process	Negative regulation of fibroblast growth factor receptor signaling pathway	ISS
GO:0043202	Component	Lysosomal lumen	TAS
GO:0043236	Function	Laminin binding	ISS
GO:0045121	Component	Membrane raft	IDA	12732622
GO:0045121	Component	Membrane raft	ISS
GO:0045202	Component	Synapse	IBA	21873635
GO:0046658	Component	Anchored component of plasma membrane	IEA
GO:0050900	Process	Leukocyte migration	TAS
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	27559042
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:1905475	Process	Regulation of protein localization to membrane	IBA	21873635
GO:2001016	Process	Positive regulation of skeletal muscle cell differentiation	ISS

Other IDs

• MIM: 600395
• HGNC: 4449
• e!Ensembl: ENSG00000063660

Protein

• UniProt ID: P35052
• Protein name: Glypican-1 [Cleaved into: Secreted glypican-1]
• Protein function: Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of pr
• PDB: 4ACR, 4AD7, 4BWE, 4YWT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01153	Glypican	11 → 555	Glypican	Family

• Sequence:

  MELRARGWWLLCAAAALVACARGDPASKSRSCGEVRQIYGAKGFSLSDVPQAEISGEHLR
  ICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSER
  TLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHP
  QLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQV
  PLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLI
  TDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNPQGPGPEEKRR
  RGKLAPRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMALSTASDDRCWNGMA
  RGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGNDVDFQD
  ASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTPLTHALPGLSEQEGQKTSAASCPQPPTF
  LLPLLLFLALTVARPRWR

• Sequence length: 558

Pathways

KEGG:

Proteoglycans in cancer
Fluid shear stress and atherosclerosis

Reactome:

A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
Cell surface interactions at the vascular wall
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective EXT2 causes exostoses 2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Signaling by ROBO receptors
Defective B3GALT6 causes EDSP2 and SEMDJL1
Retinoid metabolism and transport

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Hypothyroidism	Hypothyroidism	rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912, rs121917847, rs104893655, rs104893657, rs104893658, rs104893659, rs104893660, rs104893656, rs121917719, rs786204790, rs189261858, rs879255608, rs868197660, rs879255609, rs1586744173, rs1586182837, rs771222349, rs1587618417, rs1601844140, rs760832986, rs780982673, rs1603336347, rs1691155605

Unknown
Disease name	Disease term	dbSNP ID	References
Biliary atresia	Biliary Atresia		23336978
Cirrhosis	Cirrhosis	rs119465999, rs144369314, rs8056684, rs112053857, rs75998507
Conjugated hyperbilirubinemia	Conjugated hyperbilirubinemia
Eyelid xanthoma	Eyelid Xanthoma
Hypopituitarism	Hypopituitarism
Xanthoma	Xanthoma