GNAI1 (G protein subunit alpha i1)

Gene

• Entrez ID: 2770
• Gene name: G protein subunit alpha i1
• Gene symbol: GNAI1
• Synonyms: Gi, HG1B, NEDHISB
• Chromosome: 7
• Chromosome location: 7q21.11
• Summary: Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021108	hsa-miR-186-5p	Sequencing	20371350
MIRT023552	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT054488	hsa-miR-320a	Luciferase reporter assay, Western blot, Immunohistochemical (IHC) staining	23691483
MIRT054489	hsa-miR-320c	Luciferase reporter assay, Western blot, Immunohistochemical (IHC) staining	23691483
MIRT054490	hsa-miR-320d	Luciferase reporter assay, Western blot, Immunohistochemical (IHC) staining	23691483
MIRT054491	hsa-miR-9-3p	Luciferase reporter assay, Western blot, Immunohistochemical (IHC) staining	23691483
MIRT610892	hsa-miR-8485	HITS-CLIP	23313552
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT626104	hsa-miR-603	HITS-CLIP	23313552
MIRT610891	hsa-miR-4719	HITS-CLIP	23313552
MIRT619597	hsa-miR-676-5p	HITS-CLIP	23313552
MIRT671961	hsa-miR-409-5p	HITS-CLIP	23313552
MIRT626103	hsa-miR-3941	HITS-CLIP	23313552
MIRT626102	hsa-miR-4672	HITS-CLIP	23313552
MIRT626101	hsa-miR-466	HITS-CLIP	23313552
MIRT610892	hsa-miR-8485	HITS-CLIP	23313552
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT626104	hsa-miR-603	HITS-CLIP	23313552
MIRT610891	hsa-miR-4719	HITS-CLIP	23313552
MIRT671961	hsa-miR-409-5p	HITS-CLIP	23313552
MIRT626103	hsa-miR-3941	HITS-CLIP	23313552
MIRT626101	hsa-miR-466	HITS-CLIP	23313552
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT626104	hsa-miR-603	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT671961	hsa-miR-409-5p	HITS-CLIP	23824327
MIRT626103	hsa-miR-3941	HITS-CLIP	23824327
MIRT626102	hsa-miR-4672	HITS-CLIP	23824327
MIRT626101	hsa-miR-466	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT626104	hsa-miR-603	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT626103	hsa-miR-3941	HITS-CLIP	23824327
MIRT626102	hsa-miR-4672	HITS-CLIP	23824327
MIRT626101	hsa-miR-466	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT626104	hsa-miR-603	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT626103	hsa-miR-3941	HITS-CLIP	23824327
MIRT626102	hsa-miR-4672	HITS-CLIP	23824327
MIRT626101	hsa-miR-466	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT626104	hsa-miR-603	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT626103	hsa-miR-3941	HITS-CLIP	23824327
MIRT626102	hsa-miR-4672	HITS-CLIP	23824327
MIRT626101	hsa-miR-466	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT626104	hsa-miR-603	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT626103	hsa-miR-3941	HITS-CLIP	23824327
MIRT626102	hsa-miR-4672	HITS-CLIP	23824327
MIRT626101	hsa-miR-466	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT626104	hsa-miR-603	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT671961	hsa-miR-409-5p	HITS-CLIP	23824327
MIRT626103	hsa-miR-3941	HITS-CLIP	23824327
MIRT626102	hsa-miR-4672	HITS-CLIP	23824327
MIRT626101	hsa-miR-466	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT626104	hsa-miR-603	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT626103	hsa-miR-3941	HITS-CLIP	23824327
MIRT626102	hsa-miR-4672	HITS-CLIP	23824327
MIRT626101	hsa-miR-466	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT626104	hsa-miR-603	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT626103	hsa-miR-3941	HITS-CLIP	23824327
MIRT626102	hsa-miR-4672	HITS-CLIP	23824327
MIRT626101	hsa-miR-466	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT619597	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT626104	hsa-miR-603	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT626103	hsa-miR-3941	HITS-CLIP	23824327
MIRT626102	hsa-miR-4672	HITS-CLIP	23824327
MIRT626101	hsa-miR-466	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT619597	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT626106	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT626106	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT626105	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT626105	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT626103	hsa-miR-3941	HITS-CLIP	27418678
MIRT626103	hsa-miR-3941	HITS-CLIP	27418678
MIRT671961	hsa-miR-409-5p	HITS-CLIP	27418678
MIRT626101	hsa-miR-466	HITS-CLIP	27418678
MIRT626101	hsa-miR-466	HITS-CLIP	27418678
MIRT626102	hsa-miR-4672	HITS-CLIP	27418678
MIRT626102	hsa-miR-4672	HITS-CLIP	27418678
MIRT610891	hsa-miR-4719	HITS-CLIP	27418678
MIRT610891	hsa-miR-4719	HITS-CLIP	27418678
MIRT626104	hsa-miR-603	HITS-CLIP	27418678
MIRT626104	hsa-miR-603	HITS-CLIP	27418678
MIRT610892	hsa-miR-8485	HITS-CLIP	27418678
MIRT610892	hsa-miR-8485	HITS-CLIP	27418678
MIRT610892	hsa-miR-8485	HITS-CLIP	23313552
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT626104	hsa-miR-603	HITS-CLIP	23313552
MIRT610891	hsa-miR-4719	HITS-CLIP	23313552
MIRT619597	hsa-miR-676-5p	HITS-CLIP	23313552
MIRT671961	hsa-miR-409-5p	HITS-CLIP	23313552
MIRT626103	hsa-miR-3941	HITS-CLIP	23313552
MIRT626102	hsa-miR-4672	HITS-CLIP	23313552
MIRT626101	hsa-miR-466	HITS-CLIP	23313552
MIRT610892	hsa-miR-8485	HITS-CLIP	23313552
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT626104	hsa-miR-603	HITS-CLIP	23313552
MIRT610891	hsa-miR-4719	HITS-CLIP	23313552
MIRT671961	hsa-miR-409-5p	HITS-CLIP	23313552
MIRT626103	hsa-miR-3941	HITS-CLIP	23313552
MIRT626101	hsa-miR-466	HITS-CLIP	23313552
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT626104	hsa-miR-603	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT671961	hsa-miR-409-5p	HITS-CLIP	23824327
MIRT626103	hsa-miR-3941	HITS-CLIP	23824327
MIRT626102	hsa-miR-4672	HITS-CLIP	23824327
MIRT626101	hsa-miR-466	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT626104	hsa-miR-603	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT626103	hsa-miR-3941	HITS-CLIP	23824327
MIRT626102	hsa-miR-4672	HITS-CLIP	23824327
MIRT626101	hsa-miR-466	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT626104	hsa-miR-603	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT626103	hsa-miR-3941	HITS-CLIP	23824327
MIRT626102	hsa-miR-4672	HITS-CLIP	23824327
MIRT626101	hsa-miR-466	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT626104	hsa-miR-603	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT626103	hsa-miR-3941	HITS-CLIP	23824327
MIRT626102	hsa-miR-4672	HITS-CLIP	23824327
MIRT626101	hsa-miR-466	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT626104	hsa-miR-603	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT626103	hsa-miR-3941	HITS-CLIP	23824327
MIRT626102	hsa-miR-4672	HITS-CLIP	23824327
MIRT626101	hsa-miR-466	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT626104	hsa-miR-603	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT671961	hsa-miR-409-5p	HITS-CLIP	23824327
MIRT626103	hsa-miR-3941	HITS-CLIP	23824327
MIRT626102	hsa-miR-4672	HITS-CLIP	23824327
MIRT626101	hsa-miR-466	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT626104	hsa-miR-603	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT626103	hsa-miR-3941	HITS-CLIP	23824327
MIRT626102	hsa-miR-4672	HITS-CLIP	23824327
MIRT626101	hsa-miR-466	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT626104	hsa-miR-603	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT626103	hsa-miR-3941	HITS-CLIP	23824327
MIRT626102	hsa-miR-4672	HITS-CLIP	23824327
MIRT626101	hsa-miR-466	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT619597	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT626106	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT626105	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT626104	hsa-miR-603	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT626103	hsa-miR-3941	HITS-CLIP	23824327
MIRT626102	hsa-miR-4672	HITS-CLIP	23824327
MIRT626101	hsa-miR-466	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT619597	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT610892	hsa-miR-8485	HITS-CLIP	23824327
MIRT610891	hsa-miR-4719	HITS-CLIP	23824327
MIRT1023158	hsa-miR-141	CLIP-seq
MIRT1023159	hsa-miR-200a	CLIP-seq
MIRT1023160	hsa-miR-205	CLIP-seq
MIRT1023161	hsa-miR-3201	CLIP-seq
MIRT1023162	hsa-miR-329	CLIP-seq
MIRT1023163	hsa-miR-3691-5p	CLIP-seq
MIRT1023164	hsa-miR-4491	CLIP-seq
MIRT1023165	hsa-miR-4657	CLIP-seq
MIRT1023166	hsa-miR-4752	CLIP-seq
MIRT1023167	hsa-miR-4791	CLIP-seq
MIRT1023168	hsa-miR-5095	CLIP-seq
MIRT1023169	hsa-miR-513b	CLIP-seq
MIRT1023170	hsa-miR-584	CLIP-seq
MIRT1023162	hsa-miR-329	CLIP-seq
MIRT2236288	hsa-miR-133a	CLIP-seq
MIRT2236289	hsa-miR-133b	CLIP-seq
MIRT1023162	hsa-miR-329	CLIP-seq
MIRT2236290	hsa-miR-4282	CLIP-seq
MIRT2236291	hsa-miR-4766-5p	CLIP-seq
MIRT1023170	hsa-miR-584	CLIP-seq
MIRT2236292	hsa-miR-624	CLIP-seq
MIRT2236293	hsa-miR-9	CLIP-seq
MIRT2429375	hsa-miR-3143	CLIP-seq
MIRT2429376	hsa-miR-3689a-5p	CLIP-seq
MIRT2429377	hsa-miR-3689b	CLIP-seq
MIRT2429378	hsa-miR-3689e	CLIP-seq
MIRT2429379	hsa-miR-3689f	CLIP-seq
MIRT2429380	hsa-miR-4775	CLIP-seq
MIRT2429381	hsa-miR-4803	CLIP-seq
MIRT2429382	hsa-miR-548a-5p	CLIP-seq
MIRT2429383	hsa-miR-548ab	CLIP-seq
MIRT2429384	hsa-miR-548ak	CLIP-seq
MIRT2429385	hsa-miR-548b-5p	CLIP-seq
MIRT2429386	hsa-miR-548c-5p	CLIP-seq
MIRT2429387	hsa-miR-548d-5p	CLIP-seq
MIRT2429388	hsa-miR-548h	CLIP-seq
MIRT2429389	hsa-miR-548i	CLIP-seq
MIRT2429390	hsa-miR-548j	CLIP-seq
MIRT2429391	hsa-miR-548w	CLIP-seq
MIRT2429392	hsa-miR-548y	CLIP-seq
MIRT2429393	hsa-miR-559	CLIP-seq
MIRT2429394	hsa-miR-590-3p	CLIP-seq
MIRT2429395	hsa-miR-648	CLIP-seq
MIRT1023158	hsa-miR-141	CLIP-seq
MIRT1023159	hsa-miR-200a	CLIP-seq
MIRT2429375	hsa-miR-3143	CLIP-seq
MIRT2437445	hsa-miR-3663-3p	CLIP-seq
MIRT2429376	hsa-miR-3689a-5p	CLIP-seq
MIRT2429377	hsa-miR-3689b	CLIP-seq
MIRT2429378	hsa-miR-3689e	CLIP-seq
MIRT2429379	hsa-miR-3689f	CLIP-seq
MIRT2429380	hsa-miR-4775	CLIP-seq
MIRT2437446	hsa-miR-4789-3p	CLIP-seq
MIRT2429381	hsa-miR-4803	CLIP-seq
MIRT2429382	hsa-miR-548a-5p	CLIP-seq
MIRT2429383	hsa-miR-548ab	CLIP-seq
MIRT2429384	hsa-miR-548ak	CLIP-seq
MIRT2429385	hsa-miR-548b-5p	CLIP-seq
MIRT2429386	hsa-miR-548c-5p	CLIP-seq
MIRT2429387	hsa-miR-548d-5p	CLIP-seq
MIRT2429388	hsa-miR-548h	CLIP-seq
MIRT2429389	hsa-miR-548i	CLIP-seq
MIRT2429390	hsa-miR-548j	CLIP-seq
MIRT2429391	hsa-miR-548w	CLIP-seq
MIRT2429392	hsa-miR-548y	CLIP-seq
MIRT2429393	hsa-miR-559	CLIP-seq
MIRT2429394	hsa-miR-590-3p	CLIP-seq
MIRT2429395	hsa-miR-648	CLIP-seq
MIRT2539999	hsa-miR-1237	CLIP-seq
MIRT2540000	hsa-miR-1248	CLIP-seq
MIRT2540001	hsa-miR-1298	CLIP-seq
MIRT2236288	hsa-miR-133a	CLIP-seq
MIRT2236289	hsa-miR-133b	CLIP-seq
MIRT1023158	hsa-miR-141	CLIP-seq
MIRT1023159	hsa-miR-200a	CLIP-seq
MIRT2540002	hsa-miR-23a	CLIP-seq
MIRT2540003	hsa-miR-23b	CLIP-seq
MIRT2540004	hsa-miR-23c	CLIP-seq
MIRT2540005	hsa-miR-3152-5p	CLIP-seq
MIRT2540006	hsa-miR-3182	CLIP-seq
MIRT2540007	hsa-miR-330-3p	CLIP-seq
MIRT2540008	hsa-miR-34b	CLIP-seq
MIRT2540009	hsa-miR-3647-3p	CLIP-seq
MIRT2540010	hsa-miR-3653	CLIP-seq
MIRT2540011	hsa-miR-3658	CLIP-seq
MIRT2437445	hsa-miR-3663-3p	CLIP-seq
MIRT2540012	hsa-miR-4263	CLIP-seq
MIRT2540013	hsa-miR-4420	CLIP-seq
MIRT2540014	hsa-miR-4477a	CLIP-seq
MIRT2540015	hsa-miR-4652-3p	CLIP-seq
MIRT2540016	hsa-miR-4774-3p	CLIP-seq
MIRT2437446	hsa-miR-4789-3p	CLIP-seq
MIRT2540017	hsa-miR-4797-3p	CLIP-seq
MIRT2540018	hsa-miR-576-5p	CLIP-seq
MIRT2540019	hsa-miR-586	CLIP-seq
MIRT2540020	hsa-miR-595	CLIP-seq
MIRT2540021	hsa-miR-616	CLIP-seq
MIRT2540022	hsa-miR-633	CLIP-seq
MIRT2540023	hsa-miR-642b	CLIP-seq
MIRT2236293	hsa-miR-9	CLIP-seq
MIRT2540024	hsa-miR-935	CLIP-seq
MIRT2540025	hsa-miR-944	CLIP-seq
MIRT2540023	hsa-miR-642b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	ISS
GO:0001664	Function	G protein-coupled receptor binding	IBA	21873635
GO:0001664	Function	G protein-coupled receptor binding	ISS
GO:0003924	Function	GTPase activity	IBA	21873635
GO:0003924	Function	GTPase activity	ISS
GO:0003924	Function	GTPase activity	TAS
GO:0005515	Function	Protein binding	IPI	15537540, 18434541, 22952234, 25416956, 28734930, 32296183
GO:0005525	Function	GTP binding	ISS
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	17635935
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005813	Component	Centrosome	IDA	17635935
GO:0005834	Component	Heterotrimeric G-protein complex	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	17635935, 23027904, 26766442
GO:0005886	Component	Plasma membrane	TAS
GO:0006457	Process	Protein folding	TAS
GO:0007049	Process	Cell cycle	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	ISS
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	TAS
GO:0019003	Function	GDP binding	ISS
GO:0030496	Component	Midbody	IDA	17635935
GO:0031683	Function	G-protein beta/gamma-subunit complex binding	IBA	21873635
GO:0031821	Function	G protein-coupled serotonin receptor binding	IBA	21873635
GO:0032794	Function	GTPase activating protein binding	IEA
GO:0043434	Process	Response to peptide hormone	ISS
GO:0043949	Process	Regulation of cAMP-mediated signaling	ISS
GO:0045121	Component	Membrane raft	IEA
GO:0050805	Process	Negative regulation of synaptic transmission	IEA
GO:0051301	Process	Cell division	IMP	17635935
GO:0060236	Process	Regulation of mitotic spindle organization	IMP	23027904
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0099738	Component	Cell cortex region	IDA	22327364, 23870127
GO:1904322	Process	Cellular response to forskolin	ISS
GO:1904778	Process	Positive regulation of protein localization to cell cortex	IMP	22327364, 23027904, 26766442

Other IDs

• MIM: 139310
• HGNC: 4384
• e!Ensembl: ENSG00000127955

Protein

• UniProt ID: P63096
• Protein name: Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein)
• Protein function: Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:18434541, PubMed:33762731, PubMed:34239069, PubMed:35610220, PubMed:37935376, PubMe
• PDB: 1KJY, 1Y3A, 2G83, 2GTP, 2IK8, 2OM2, 2XNS, 3ONW, 3QE0, 3QI2, 3UMR, 3UMS, 4G5Q, 5JS7, 5JS8, 5TDH, 6CMO, 6CRK, 6DDE, 6DDF, 6KPF, 6KPG, 6LFM, 6LFO, 6LML, 6N4B, 6OMM, 6OS9, 6OSA, 6OT0, 6PB0, 6PB1, 6PT0, 6QNO, 6VU8, 6XBJ, 6XBK, 6XBL, 6XBM, 7CMU, 7CMV, 7DB6, 7DW9, 7E2X, 7E2Y, 7E2Z, 7E32, 7E33, 7E9G, 7EB2, 7EJX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00503	G-alpha	13 → 343	G-protein alpha subunit	Domain

• Sequence:

  MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAG
  YSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMT
  AELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVK
  TTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM
  NRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAA
  AYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF

• Sequence length: 354

Pathways

KEGG:

Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
Sphingolipid signaling pathway
Hormone signaling
Adrenergic signaling in cardiomyocytes
Axon guidance
Apelin signaling pathway
Gap junction
Platelet activation
Leukocyte transendothelial migration
Circadian entrainment
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Long-term depression
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Oxytocin signaling pathway
Regulation of lipolysis in adipocytes
Renin secretion
Relaxin signaling pathway
Parathyroid hormone synthesis, secretion and action
Cushing syndrome
Growth hormone synthesis, secretion and action
Gastric acid secretion
Parkinson disease
Cocaine addiction
Morphine addiction
Alcoholism
Pertussis
Chagas disease
Toxoplasmosis
Human cytomegalovirus infection
Human immunodeficiency virus 1 infection
Pathways in cancer
Chemical carcinogenesis - receptor activation

Reactome:

PLC beta mediated events
Adenylate cyclase inhibitory pathway
G-protein activation
ADP signalling through P2Y purinoceptor 12
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Extra-nuclear estrogen signaling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	25918132

Unknown
Disease name	Disease term	dbSNP ID	References
Amnesia	Amnesia		11350863