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GNA12 (G protein subunit alpha 12)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2768
Gene nameGene Name - the full gene name approved by the HGNC.
G protein subunit alpha 12
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
GNA12
SynonymsGene synonyms aliases
HG1M1, NNX3, RMP, gep
ChromosomeChromosome number
7
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p22.3-p22.2
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023075 hsa-miR-124-3p Microarray 18668037
MIRT027790 hsa-miR-98-5p Microarray 19088304
MIRT028098 hsa-miR-93-5p Sequencing 20371350
MIRT046311 hsa-miR-23b-3p CLASH 23622248
MIRT045616 hsa-miR-149-5p CLASH 23622248
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001664 Function G protein-coupled receptor binding IBA 21873635
GO:0003924 Function GTPase activity IBA 21873635
GO:0005515 Function Protein binding IPI 10026210, 18703424
GO:0005525 Function GTP binding IEA
GO:0005737 Component Cytoplasm IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q03113
Protein name Guanine nucleotide-binding protein subunit alpha-12 (G alpha-12) (G-protein subunit alpha-12)
Protein function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:12515866, PubMed:15240885, PubMed:15525651, PubMed:16705036, PubMed:16787920, PubMed:17565996, PubMed:2
PDB 7YDJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00503 G-alpha
37 370
G-protein alpha subunit
Domain
Sequence
Sequence length 381
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  MAPK signaling pathway
cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Hormone signaling
Vascular smooth muscle contraction
Long-term depression
Regulation of actin cytoskeleton
Parathyroid hormone synthesis, secretion and action
Pathogenic Escherichia coli infection
Human cytomegalovirus infection
Pathways in cancer
  G alpha (12/13) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Inflammatory bowel disease Inflammatory Bowel Diseases rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs139868987, rs750447828, rs368138379, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468 26192919, 28067908
Psoriasis Psoriasis rs281875215, rs587777763, rs281875213, rs281875212 26974007
Unknown
Disease name Disease term dbSNP ID References
Ankylosing spondylitis Ankylosing spondylitis 26974007
Cholangitis Cholangitis, Sclerosing 26974007
Crohn disease Crohn Disease rs2066847, rs2066844, rs886052047, rs5743265, rs111608429, rs104895438 26974007
Myocardial ischemia Myocardial Ischemia 16214533

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