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GMDS (GDP-mannose 4,6-dehydratase)

Gene

2762

GDP-mannose 4,6-dehydratase

GMDS

GMD, SDR3E1

6p25.3

GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are c

Show/Hide all(116)

miRTarBase ID	miRNA	Experiments	Reference
MIRT712759	hsa-miR-3150a-5p	HITS-CLIP	19536157
MIRT712758	hsa-miR-3150b-5p	HITS-CLIP	19536157
MIRT712756	hsa-miR-6812-3p	HITS-CLIP	19536157
MIRT712757	hsa-miR-1307-3p	HITS-CLIP	19536157
MIRT712755	hsa-miR-744-5p	HITS-CLIP	19536157
MIRT712754	hsa-miR-1908-5p	HITS-CLIP	19536157
MIRT712753	hsa-miR-663a	HITS-CLIP	19536157
MIRT712751	hsa-miR-6787-5p	HITS-CLIP	19536157
MIRT712752	hsa-miR-3180	HITS-CLIP	19536157
MIRT712750	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT712748	hsa-miR-3196	HITS-CLIP	19536157
MIRT712749	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT712759	hsa-miR-3150a-5p	HITS-CLIP	19536157
MIRT712758	hsa-miR-3150b-5p	HITS-CLIP	19536157
MIRT712756	hsa-miR-6812-3p	HITS-CLIP	19536157
MIRT712757	hsa-miR-1307-3p	HITS-CLIP	19536157
MIRT712755	hsa-miR-744-5p	HITS-CLIP	19536157
MIRT712754	hsa-miR-1908-5p	HITS-CLIP	19536157
MIRT712753	hsa-miR-663a	HITS-CLIP	19536157
MIRT712751	hsa-miR-6787-5p	HITS-CLIP	19536157
MIRT712752	hsa-miR-3180	HITS-CLIP	19536157
MIRT712750	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT712748	hsa-miR-3196	HITS-CLIP	19536157
MIRT712749	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT712759	hsa-miR-3150a-5p	HITS-CLIP	19536157
MIRT712758	hsa-miR-3150b-5p	HITS-CLIP	19536157
MIRT712756	hsa-miR-6812-3p	HITS-CLIP	19536157
MIRT712757	hsa-miR-1307-3p	HITS-CLIP	19536157
MIRT712755	hsa-miR-744-5p	HITS-CLIP	19536157
MIRT712754	hsa-miR-1908-5p	HITS-CLIP	19536157
MIRT712753	hsa-miR-663a	HITS-CLIP	19536157
MIRT712751	hsa-miR-6787-5p	HITS-CLIP	19536157
MIRT712752	hsa-miR-3180	HITS-CLIP	19536157
MIRT712750	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT712748	hsa-miR-3196	HITS-CLIP	19536157
MIRT712749	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT526051	hsa-miR-4803	PAR-CLIP	22012620
MIRT526050	hsa-miR-5582-5p	PAR-CLIP	22012620
MIRT526049	hsa-miR-3622a-5p	PAR-CLIP	22012620
MIRT526048	hsa-miR-654-3p	PAR-CLIP	22012620
MIRT526047	hsa-miR-3128	PAR-CLIP	22012620
MIRT526046	hsa-miR-6868-5p	PAR-CLIP	22012620
MIRT526045	hsa-miR-4720-5p	PAR-CLIP	22012620
MIRT526044	hsa-miR-4799-3p	PAR-CLIP	22012620
MIRT526043	hsa-miR-5588-5p	PAR-CLIP	22012620
MIRT526042	hsa-miR-3622b-5p	PAR-CLIP	22012620
MIRT526041	hsa-miR-496	PAR-CLIP	22012620
MIRT526040	hsa-miR-3143	PAR-CLIP	22012620
MIRT526039	hsa-miR-4423-3p	PAR-CLIP	22012620
MIRT526038	hsa-miR-1231	PAR-CLIP	22012620
MIRT526037	hsa-miR-302c-5p	PAR-CLIP	22012620
MIRT440560	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440560	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT712759	hsa-miR-3150a-5p	HITS-CLIP	19536157
MIRT712758	hsa-miR-3150b-5p	HITS-CLIP	19536157
MIRT712756	hsa-miR-6812-3p	HITS-CLIP	19536157
MIRT712757	hsa-miR-1307-3p	HITS-CLIP	19536157
MIRT712755	hsa-miR-744-5p	HITS-CLIP	19536157
MIRT712754	hsa-miR-1908-5p	HITS-CLIP	19536157
MIRT712753	hsa-miR-663a	HITS-CLIP	19536157
MIRT712751	hsa-miR-6787-5p	HITS-CLIP	19536157
MIRT712752	hsa-miR-3180	HITS-CLIP	19536157
MIRT712750	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT712748	hsa-miR-3196	HITS-CLIP	19536157
MIRT712749	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT712759	hsa-miR-3150a-5p	HITS-CLIP	19536157
MIRT712758	hsa-miR-3150b-5p	HITS-CLIP	19536157
MIRT712756	hsa-miR-6812-3p	HITS-CLIP	19536157
MIRT712757	hsa-miR-1307-3p	HITS-CLIP	19536157
MIRT712755	hsa-miR-744-5p	HITS-CLIP	19536157
MIRT712754	hsa-miR-1908-5p	HITS-CLIP	19536157
MIRT712753	hsa-miR-663a	HITS-CLIP	19536157
MIRT712751	hsa-miR-6787-5p	HITS-CLIP	19536157
MIRT712752	hsa-miR-3180	HITS-CLIP	19536157
MIRT712750	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT712748	hsa-miR-3196	HITS-CLIP	19536157
MIRT712749	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT712759	hsa-miR-3150a-5p	HITS-CLIP	19536157
MIRT712758	hsa-miR-3150b-5p	HITS-CLIP	19536157
MIRT712756	hsa-miR-6812-3p	HITS-CLIP	19536157
MIRT712757	hsa-miR-1307-3p	HITS-CLIP	19536157
MIRT712755	hsa-miR-744-5p	HITS-CLIP	19536157
MIRT712754	hsa-miR-1908-5p	HITS-CLIP	19536157
MIRT712753	hsa-miR-663a	HITS-CLIP	19536157
MIRT712751	hsa-miR-6787-5p	HITS-CLIP	19536157
MIRT712752	hsa-miR-3180	HITS-CLIP	19536157
MIRT712750	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT712748	hsa-miR-3196	HITS-CLIP	19536157
MIRT712749	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT526051	hsa-miR-4803	PAR-CLIP	22012620
MIRT526050	hsa-miR-5582-5p	PAR-CLIP	22012620
MIRT526049	hsa-miR-3622a-5p	PAR-CLIP	22012620
MIRT526048	hsa-miR-654-3p	PAR-CLIP	22012620
MIRT526047	hsa-miR-3128	PAR-CLIP	22012620
MIRT526046	hsa-miR-6868-5p	PAR-CLIP	22012620
MIRT526045	hsa-miR-4720-5p	PAR-CLIP	22012620
MIRT526044	hsa-miR-4799-3p	PAR-CLIP	22012620
MIRT526043	hsa-miR-5588-5p	PAR-CLIP	22012620
MIRT526042	hsa-miR-3622b-5p	PAR-CLIP	22012620
MIRT526041	hsa-miR-496	PAR-CLIP	22012620
MIRT526040	hsa-miR-3143	PAR-CLIP	22012620
MIRT526039	hsa-miR-4423-3p	PAR-CLIP	22012620
MIRT526038	hsa-miR-1231	PAR-CLIP	22012620
MIRT526037	hsa-miR-302c-5p	PAR-CLIP	22012620
MIRT1022450	hsa-miR-1909	CLIP-seq
MIRT1022451	hsa-miR-214	CLIP-seq
MIRT1022452	hsa-miR-3197	CLIP-seq
MIRT1022453	hsa-miR-3619-5p	CLIP-seq
MIRT1022454	hsa-miR-761	CLIP-seq
MIRT1022450	hsa-miR-1909	CLIP-seq
MIRT1022452	hsa-miR-3197	CLIP-seq
MIRT2236037	hsa-miR-4493	CLIP-seq
MIRT2236038	hsa-miR-4719	CLIP-seq
MIRT2236039	hsa-miR-4758-3p	CLIP-seq
MIRT2236040	hsa-miR-513b	CLIP-seq
MIRT2236041	hsa-miR-744	CLIP-seq

Show/Hide all(18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IC	9525924
GO:0005829	Component	Cytosol	TAS
GO:0007219	Process	Notch signaling pathway	ISS
GO:0008446	Function	GDP-mannose 4,6-dehydratase activity	IBA	21873635
GO:0008446	Function	GDP-mannose 4,6-dehydratase activity	IDA	9525924
GO:0008446	Function	GDP-mannose 4,6-dehydratase activity	IGI	9603974
GO:0008446	Function	GDP-mannose 4,6-dehydratase activity	TAS
GO:0019673	Process	GDP-mannose metabolic process	IBA	21873635
GO:0019673	Process	GDP-mannose metabolic process	IDA	9525924
GO:0019673	Process	GDP-mannose metabolic process	IGI	9603974
GO:0042351	Process	'de novo' GDP-L-fucose biosynthetic process	IBA	21873635
GO:0042351	Process	'de novo' GDP-L-fucose biosynthetic process	IDA	9525924
GO:0042351	Process	'de novo' GDP-L-fucose biosynthetic process	IEA
GO:0042802	Function	Identical protein binding	IPI	16189514, 25416956, 31515488, 32296183
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:0070401	Function	NADP+ binding	IDA	9525924

MIM	HGNC	e!Ensembl
602884	4369	ENSG00000112699

Protein

UniProt ID

O60547

Protein name

GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD)

Protein function

Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.

PDB

1T2A , 5IN4 , 5IN5 , 6GPJ , 6GPK , 6GPL , 6Q94

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16363	GDP_Man_Dehyd	27 → 358	GDP-mannose 4,6 dehydratase	Domain

Sequence

MAHAPARCPSARGSGDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSF
NTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDL
AEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYG
AAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSL
GNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEG
KNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVH
ADVELMRTNPNA

Sequence length

372

Interactions

View interactions

	KEGG		Reactome
	Fructose and mannose metabolism Biosynthesis of various nucleotide sugars Metabolic pathways Biosynthesis of nucleotide sugars		GDP-fucose biosynthesis

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Glaucoma	Glaucoma, Open-Angle	rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328, rs121909193, rs74315330, rs74315329, rs74315332, rs74315334, rs74315336, rs74315338, rs74315341, rs121909194, rs74315331, rs1558603396, rs387907175, rs587778873, rs587778875, rs104894979, rs137854895, rs766425037, rs72549380, rs148542782, rs541217363, rs753021890, rs771076928, rs56010818, rs777678299, rs1446110883, rs1573274915, rs1587545234, rs751768343, rs944452644	25173105, 29891935

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