Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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27436 |
Gene nameGene Name - the full gene name approved by the HGNC.
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EMAP like 4 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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EML4 |
SynonymsGene synonyms aliases
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C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120 |
ChromosomeChromosome number
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2 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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2p21 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine ki |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
Q9HC35 |
Protein name |
Echinoderm microtubule-associated protein-like 4 (EMAP-4) (Restrictedly overexpressed proliferation-associated protein) (Ropp 120) |
Protein function |
Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruit |
PDB |
4CGC
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Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF03451 |
HELP |
225 → 297 |
HELP motif |
Family |
PF00400 |
WD40 |
299 → 347 |
WD domain, G-beta repeat |
Repeat |
PF00400 |
WD40 |
499 → 537 |
WD domain, G-beta repeat |
Repeat |
PF00400 |
WD40 |
583 → 620 |
WD domain, G-beta repeat |
Repeat |
PF00400 |
WD40 |
711 → 749 |
WD domain, G-beta repeat |
Repeat |
PF00400 |
WD40 |
824 → 863 |
WD domain, G-beta repeat |
Repeat |
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Sequence |
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Sequence length |
981 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Chronic obstructive pulmonary disease |
Chronic Obstructive Airway Disease |
rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928 |
30804561 |
Lung carcinoma |
Non-Small Cell Lung Carcinoma |
rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193 |
21757253, 22617245, 22986231, 21767331, 22568572, 17625570 |
Lung adenocarcinoma |
Adenocarcinoma of lung (disorder) |
rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382 |
22980554, 22999080 |
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Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Brain neoplasms |
Brain Neoplasms, Malignant neoplasm of brain, Benign neoplasm of brain, unspecified, Brain Tumor, Primary, Recurrent Brain Neoplasm, Primary malignant neoplasm of brain |
rs1800720, rs587781720 |
22986231 |
Intracranial neoplasm |
Neoplasms, Intracranial |
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22986231 |
Congenital hypertrophic pyloric stenosis |
Pyloric Stenosis, Hypertrophic |
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30281099 |
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