GeDiPNet: Comprehensive Gene Data - OMIM, HGNC, Ensembl, UniProt, GO, Transcription Factors & miRNA

Home
Browse
- Genes
- Diseases
- Pathways
  - Reactome
  - KEGG
Analysis
Help
Links
FAQ
Contact us

GLP1R (glucagon like peptide 1 receptor)

Gene

2740

Glucagon like peptide 1 receptor

GLP1R

GLP-1, GLP-1-R, GLP-1R

6p21.2

This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response

Show/Hide all(184)

miRTarBase ID	miRNA	Experiments	Reference
MIRT640779	hsa-miR-4308	HITS-CLIP	23824327
MIRT640778	hsa-miR-4292	HITS-CLIP	23824327
MIRT640777	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT628189	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT640776	hsa-miR-4780	HITS-CLIP	23824327
MIRT640775	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT628188	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT628187	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT628186	hsa-miR-3657	HITS-CLIP	23824327
MIRT628185	hsa-miR-4669	HITS-CLIP	23824327
MIRT628184	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT628183	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT640771	hsa-miR-4433b-5p	HITS-CLIP	23824327
MIRT640768	hsa-miR-4646-3p	HITS-CLIP	23824327
MIRT628182	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT640779	hsa-miR-4308	HITS-CLIP	23824327
MIRT640778	hsa-miR-4292	HITS-CLIP	23824327
MIRT640777	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT628189	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT640776	hsa-miR-4780	HITS-CLIP	23824327
MIRT640775	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT628188	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT628187	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT628186	hsa-miR-3657	HITS-CLIP	23824327
MIRT628185	hsa-miR-4669	HITS-CLIP	23824327
MIRT640774	hsa-miR-623	HITS-CLIP	23824327
MIRT640773	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT640772	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT628183	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT640771	hsa-miR-4433b-5p	HITS-CLIP	23824327
MIRT640770	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT640769	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT640768	hsa-miR-4646-3p	HITS-CLIP	23824327
MIRT628189	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT628188	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT628187	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT628186	hsa-miR-3657	HITS-CLIP	23824327
MIRT628185	hsa-miR-4669	HITS-CLIP	23824327
MIRT628184	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT628183	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT628182	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT628186	hsa-miR-3657	HITS-CLIP	27418678
MIRT628186	hsa-miR-3657	HITS-CLIP	27418678
MIRT628186	hsa-miR-3657	HITS-CLIP	27418678
MIRT628187	hsa-miR-3667-3p	HITS-CLIP	27418678
MIRT628187	hsa-miR-3667-3p	HITS-CLIP	27418678
MIRT628187	hsa-miR-3667-3p	HITS-CLIP	27418678
MIRT628185	hsa-miR-4669	HITS-CLIP	27418678
MIRT628185	hsa-miR-4669	HITS-CLIP	27418678
MIRT628185	hsa-miR-4669	HITS-CLIP	27418678
MIRT628189	hsa-miR-5088-3p	HITS-CLIP	27418678
MIRT628189	hsa-miR-5088-3p	HITS-CLIP	27418678
MIRT628189	hsa-miR-5088-3p	HITS-CLIP	27418678
MIRT628182	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT628182	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT628182	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT628184	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT628184	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT628184	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT628183	hsa-miR-6868-3p	HITS-CLIP	27418678
MIRT640779	hsa-miR-4308	HITS-CLIP	23824327
MIRT640778	hsa-miR-4292	HITS-CLIP	23824327
MIRT640777	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT628189	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT640776	hsa-miR-4780	HITS-CLIP	23824327
MIRT640775	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT628188	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT628187	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT628186	hsa-miR-3657	HITS-CLIP	23824327
MIRT628185	hsa-miR-4669	HITS-CLIP	23824327
MIRT628184	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT628183	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT640771	hsa-miR-4433b-5p	HITS-CLIP	23824327
MIRT640768	hsa-miR-4646-3p	HITS-CLIP	23824327
MIRT628182	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT640779	hsa-miR-4308	HITS-CLIP	23824327
MIRT640778	hsa-miR-4292	HITS-CLIP	23824327
MIRT640777	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT628189	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT640776	hsa-miR-4780	HITS-CLIP	23824327
MIRT640775	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT628188	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT628187	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT628186	hsa-miR-3657	HITS-CLIP	23824327
MIRT628185	hsa-miR-4669	HITS-CLIP	23824327
MIRT640774	hsa-miR-623	HITS-CLIP	23824327
MIRT640773	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT640772	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT628183	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT640771	hsa-miR-4433b-5p	HITS-CLIP	23824327
MIRT640770	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT640769	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT640768	hsa-miR-4646-3p	HITS-CLIP	23824327
MIRT628189	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT628188	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT628187	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT628186	hsa-miR-3657	HITS-CLIP	23824327
MIRT628185	hsa-miR-4669	HITS-CLIP	23824327
MIRT628184	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT628183	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT628182	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT1021366	hsa-miR-122	CLIP-seq
MIRT1021367	hsa-miR-150	CLIP-seq
MIRT1021368	hsa-miR-2110	CLIP-seq
MIRT1021369	hsa-miR-3150a-3p	CLIP-seq
MIRT1021370	hsa-miR-3153	CLIP-seq
MIRT1021371	hsa-miR-3175	CLIP-seq
MIRT1021372	hsa-miR-3192	CLIP-seq
MIRT1021373	hsa-miR-4260	CLIP-seq
MIRT1021374	hsa-miR-4271	CLIP-seq
MIRT1021375	hsa-miR-4428	CLIP-seq
MIRT1021376	hsa-miR-4667-5p	CLIP-seq
MIRT1021377	hsa-miR-4700-5p	CLIP-seq
MIRT1021378	hsa-miR-4713-5p	CLIP-seq
MIRT1021379	hsa-miR-4725-3p	CLIP-seq
MIRT1021380	hsa-miR-4728-5p	CLIP-seq
MIRT1021381	hsa-miR-532-3p	CLIP-seq
MIRT1021382	hsa-miR-548a-5p	CLIP-seq
MIRT1021383	hsa-miR-548ab	CLIP-seq
MIRT1021384	hsa-miR-548ak	CLIP-seq
MIRT1021385	hsa-miR-548b-5p	CLIP-seq
MIRT1021386	hsa-miR-548c-5p	CLIP-seq
MIRT1021387	hsa-miR-548d-5p	CLIP-seq
MIRT1021388	hsa-miR-548h	CLIP-seq
MIRT1021389	hsa-miR-548i	CLIP-seq
MIRT1021390	hsa-miR-548j	CLIP-seq
MIRT1021391	hsa-miR-548k	CLIP-seq
MIRT1021392	hsa-miR-548l	CLIP-seq
MIRT1021393	hsa-miR-548w	CLIP-seq
MIRT1021394	hsa-miR-548y	CLIP-seq
MIRT1021395	hsa-miR-559	CLIP-seq
MIRT1021396	hsa-miR-593	CLIP-seq
MIRT1021397	hsa-miR-637	CLIP-seq
MIRT1021398	hsa-miR-647	CLIP-seq
MIRT1021399	hsa-miR-939	CLIP-seq
MIRT2235612	hsa-miR-1301	CLIP-seq
MIRT2235613	hsa-miR-1915	CLIP-seq
MIRT2235614	hsa-miR-3120-5p	CLIP-seq
MIRT2235615	hsa-miR-34a	CLIP-seq
MIRT2235616	hsa-miR-34c-5p	CLIP-seq
MIRT2235617	hsa-miR-3612	CLIP-seq
MIRT2235618	hsa-miR-4459	CLIP-seq
MIRT2235619	hsa-miR-449a	CLIP-seq
MIRT2235620	hsa-miR-449b	CLIP-seq
MIRT2235621	hsa-miR-4641	CLIP-seq
MIRT2235622	hsa-miR-4691-3p	CLIP-seq
MIRT2235623	hsa-miR-4695-5p	CLIP-seq
MIRT2235624	hsa-miR-4726-3p	CLIP-seq
MIRT2235625	hsa-miR-502-5p	CLIP-seq
MIRT2235626	hsa-miR-5047	CLIP-seq
MIRT2235627	hsa-miR-650	CLIP-seq
MIRT2235628	hsa-miR-665	CLIP-seq
MIRT2450361	hsa-miR-3150b-3p	CLIP-seq
MIRT2450362	hsa-miR-3663-3p	CLIP-seq
MIRT2450363	hsa-miR-4254	CLIP-seq
MIRT2450364	hsa-miR-4434	CLIP-seq
MIRT2450365	hsa-miR-4516	CLIP-seq
MIRT2450366	hsa-miR-4784	CLIP-seq
MIRT2450367	hsa-miR-619	CLIP-seq
MIRT2450368	hsa-miR-765	CLIP-seq
MIRT2450361	hsa-miR-3150b-3p	CLIP-seq
MIRT2450362	hsa-miR-3663-3p	CLIP-seq
MIRT2450363	hsa-miR-4254	CLIP-seq
MIRT2450364	hsa-miR-4434	CLIP-seq
MIRT2450365	hsa-miR-4516	CLIP-seq
MIRT2450366	hsa-miR-4784	CLIP-seq
MIRT2450367	hsa-miR-619	CLIP-seq
MIRT2450368	hsa-miR-765	CLIP-seq
MIRT2450361	hsa-miR-3150b-3p	CLIP-seq
MIRT2450362	hsa-miR-3663-3p	CLIP-seq
MIRT2450363	hsa-miR-4254	CLIP-seq
MIRT2450364	hsa-miR-4434	CLIP-seq
MIRT2450365	hsa-miR-4516	CLIP-seq
MIRT2450366	hsa-miR-4784	CLIP-seq
MIRT2450367	hsa-miR-619	CLIP-seq
MIRT2450368	hsa-miR-765	CLIP-seq
MIRT2450361	hsa-miR-3150b-3p	CLIP-seq
MIRT2450362	hsa-miR-3663-3p	CLIP-seq
MIRT2450363	hsa-miR-4254	CLIP-seq
MIRT2450364	hsa-miR-4434	CLIP-seq
MIRT2450365	hsa-miR-4516	CLIP-seq
MIRT2450366	hsa-miR-4784	CLIP-seq
MIRT2450367	hsa-miR-619	CLIP-seq
MIRT2450368	hsa-miR-765	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	TAS	8405712
GO:0004967	Function	Glucagon receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IDA	28514449
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	28514449
GO:0007190	Process	Activation of adenylate cyclase activity	TAS	8405712
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IDA	7589461
GO:0008528	Function	G protein-coupled peptide receptor activity	IBA	21873635
GO:0016021	Component	Integral component of membrane	TAS	8405712
GO:0017046	Function	Peptide hormone binding	IBA	21873635
GO:0019933	Process	CAMP-mediated signaling	IDA	7589461
GO:0044508	Function	Glucagon-like peptide 1 receptor activity	IBA	21873635
GO:0044508	Function	Glucagon-like peptide 1 receptor activity	IDA	28514449
GO:0045777	Process	Positive regulation of blood pressure	IBA	21873635
GO:0050796	Process	Regulation of insulin secretion	TAS
GO:0071377	Process	Cellular response to glucagon stimulus	IEA

MIM	HGNC	e!Ensembl
138032	4324	ENSG00000112164

Protein

UniProt ID

P43220

Protein name

Glucagon-like peptide 1 receptor (GLP-1 receptor) (GLP-1-R) (GLP-1R)

Protein function

G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449, PubMed:7517895, PubMed:8216285, PubMed:8405712). Ligand binding triggers activation of a signaling cascade that l

PDB

3C59 , 3C5T , 3IOL , 4ZGM , 5E94 , 5NX2 , 5OTT , 5OTU , 5OTV , 5OTW , 5OTX , 5VEW , 5VEX , 6B3J , 6GB1 , 6ORV , 6VCB , 6X18 , 6X19 , 6X1A , 6XOX , 7C2E , 7DUQ , 7DUR , 7E14 , 7EVM , 7FIM , 7KI0 , 7KI1 , 7LCI , 7LCJ , 7LCK , 7LLL , 7LLY , 7RG9 , 7RGP , 7RTB , 7S15 , 7S1M , 7S3I , 7VBH , 7VBI , 7X8R , 7X8S , 8JIP , 8JIR , 8JIS , 8WG7 , 8YW3 , 9IVG , 9IVM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02793	HRM	59 → 129	Hormone receptor domain	Family
PF00002	7tm_2	141 → 398	7 transmembrane receptor (Secretin family)	Family

Sequence

MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDL
FCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPW
RDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIH
LNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAAN
YYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRN
SNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLL
GTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERW
RLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS

Sequence length

463

Interactions

View interactions

	KEGG		Reactome
	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Insulin secretion		Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	30718926
Hypertension	Hypertensive disease	rs13306026, rs13333226	22228705

Show/Hide Unknown Diseases (3)

Unknown
Disease name	Disease term	dbSNP ID	References
Benign neoplasm	Benign Neoplasm		23471186
Malignant neoplasm	Malignant Neoplasms		23471186
Neoplasms	Neoplasms		23471186

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412