LSM1 (LSM1 homolog, mRNA degradation associated)

Gene

• Entrez ID: 27257
• Gene name: LSM1 homolog, mRNA degradation associated
• Gene symbol: LSM1
• Synonyms: CASM, FICUS, YJL124C
• Chromosome: 8
• Chromosome location: 8p11.23
• Summary: This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3`-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Inc

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028662	hsa-miR-30a-5p	Proteomics	18668040
MIRT030039	hsa-miR-26b-5p	Microarray	19088304
MIRT459086	hsa-miR-128-3p	PAR-CLIP	23592263
MIRT459085	hsa-miR-216a-3p	PAR-CLIP	23592263
MIRT459084	hsa-miR-3681-3p	PAR-CLIP	23592263
MIRT459083	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT459082	hsa-miR-4252	PAR-CLIP	23592263
MIRT459081	hsa-miR-4294	PAR-CLIP	23592263
MIRT459080	hsa-miR-1227-3p	PAR-CLIP	23592263
MIRT459079	hsa-miR-3064-3p	PAR-CLIP	23592263
MIRT459078	hsa-miR-3611	PAR-CLIP	23592263
MIRT459077	hsa-miR-6818-5p	PAR-CLIP	23592263
MIRT459086	hsa-miR-128-3p	PAR-CLIP	23592263
MIRT459085	hsa-miR-216a-3p	PAR-CLIP	23592263
MIRT459084	hsa-miR-3681-3p	PAR-CLIP	23592263
MIRT459083	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT459082	hsa-miR-4252	PAR-CLIP	23592263
MIRT459081	hsa-miR-4294	PAR-CLIP	23592263
MIRT459080	hsa-miR-1227-3p	PAR-CLIP	23592263
MIRT459079	hsa-miR-3064-3p	PAR-CLIP	23592263
MIRT459078	hsa-miR-3611	PAR-CLIP	23592263
MIRT459077	hsa-miR-6818-5p	PAR-CLIP	23592263
MIRT2034396	hsa-miR-1244	CLIP-seq
MIRT2034397	hsa-miR-1323	CLIP-seq
MIRT2034398	hsa-miR-139-5p	CLIP-seq
MIRT2034399	hsa-miR-142-5p	CLIP-seq
MIRT2034400	hsa-miR-186	CLIP-seq
MIRT2034401	hsa-miR-3122	CLIP-seq
MIRT2034402	hsa-miR-3133	CLIP-seq
MIRT2034403	hsa-miR-3185	CLIP-seq
MIRT2034404	hsa-miR-3201	CLIP-seq
MIRT2034405	hsa-miR-338-5p	CLIP-seq
MIRT2034406	hsa-miR-340	CLIP-seq
MIRT2034407	hsa-miR-3913-5p	CLIP-seq
MIRT2034408	hsa-miR-450b-3p	CLIP-seq
MIRT2034409	hsa-miR-4677-3p	CLIP-seq
MIRT2034410	hsa-miR-4679	CLIP-seq
MIRT2034411	hsa-miR-4703-3p	CLIP-seq
MIRT2034412	hsa-miR-4735-5p	CLIP-seq
MIRT2034413	hsa-miR-4791	CLIP-seq
MIRT2034414	hsa-miR-548o	CLIP-seq
MIRT2034415	hsa-miR-618	CLIP-seq
MIRT2034416	hsa-miR-622	CLIP-seq
MIRT2034417	hsa-miR-769-3p	CLIP-seq
MIRT2563896	hsa-miR-1208	CLIP-seq
MIRT2563897	hsa-miR-1227	CLIP-seq
MIRT2034396	hsa-miR-1244	CLIP-seq
MIRT2563898	hsa-miR-1252	CLIP-seq
MIRT2563899	hsa-miR-128	CLIP-seq
MIRT2563900	hsa-miR-138	CLIP-seq
MIRT2034399	hsa-miR-142-5p	CLIP-seq
MIRT2034400	hsa-miR-186	CLIP-seq
MIRT2563901	hsa-miR-30a	CLIP-seq
MIRT2563902	hsa-miR-30b	CLIP-seq
MIRT2563903	hsa-miR-30c	CLIP-seq
MIRT2563904	hsa-miR-30d	CLIP-seq
MIRT2563905	hsa-miR-30e	CLIP-seq
MIRT2034401	hsa-miR-3122	CLIP-seq
MIRT2034402	hsa-miR-3133	CLIP-seq
MIRT2034403	hsa-miR-3185	CLIP-seq
MIRT2034404	hsa-miR-3201	CLIP-seq
MIRT2034405	hsa-miR-338-5p	CLIP-seq
MIRT2563906	hsa-miR-339-5p	CLIP-seq
MIRT2034406	hsa-miR-340	CLIP-seq
MIRT2563907	hsa-miR-3607-3p	CLIP-seq
MIRT2034407	hsa-miR-3913-5p	CLIP-seq
MIRT2563908	hsa-miR-4477a	CLIP-seq
MIRT2034408	hsa-miR-450b-3p	CLIP-seq
MIRT2563909	hsa-miR-452	CLIP-seq
MIRT2563910	hsa-miR-4676-3p	CLIP-seq
MIRT2034411	hsa-miR-4703-3p	CLIP-seq
MIRT2034412	hsa-miR-4735-5p	CLIP-seq
MIRT2034413	hsa-miR-4791	CLIP-seq
MIRT2563911	hsa-miR-548ac	CLIP-seq
MIRT2563912	hsa-miR-548d-3p	CLIP-seq
MIRT2563913	hsa-miR-548q	CLIP-seq
MIRT2563914	hsa-miR-548z	CLIP-seq
MIRT2034415	hsa-miR-618	CLIP-seq
MIRT2034417	hsa-miR-769-3p	CLIP-seq
MIRT2563896	hsa-miR-1208	CLIP-seq
MIRT2563897	hsa-miR-1227	CLIP-seq
MIRT2034396	hsa-miR-1244	CLIP-seq
MIRT2563898	hsa-miR-1252	CLIP-seq
MIRT2563899	hsa-miR-128	CLIP-seq
MIRT2563900	hsa-miR-138	CLIP-seq
MIRT2034399	hsa-miR-142-5p	CLIP-seq
MIRT2034400	hsa-miR-186	CLIP-seq
MIRT2563901	hsa-miR-30a	CLIP-seq
MIRT2563902	hsa-miR-30b	CLIP-seq
MIRT2563903	hsa-miR-30c	CLIP-seq
MIRT2563904	hsa-miR-30d	CLIP-seq
MIRT2563905	hsa-miR-30e	CLIP-seq
MIRT2034401	hsa-miR-3122	CLIP-seq
MIRT2034402	hsa-miR-3133	CLIP-seq
MIRT2034403	hsa-miR-3185	CLIP-seq
MIRT2034404	hsa-miR-3201	CLIP-seq
MIRT2034405	hsa-miR-338-5p	CLIP-seq
MIRT2563906	hsa-miR-339-5p	CLIP-seq
MIRT2034406	hsa-miR-340	CLIP-seq
MIRT2563907	hsa-miR-3607-3p	CLIP-seq
MIRT2034407	hsa-miR-3913-5p	CLIP-seq
MIRT2563908	hsa-miR-4477a	CLIP-seq
MIRT2034408	hsa-miR-450b-3p	CLIP-seq
MIRT2563909	hsa-miR-452	CLIP-seq
MIRT2563910	hsa-miR-4676-3p	CLIP-seq
MIRT2034411	hsa-miR-4703-3p	CLIP-seq
MIRT2034412	hsa-miR-4735-5p	CLIP-seq
MIRT2034413	hsa-miR-4791	CLIP-seq
MIRT2563913	hsa-miR-548q	CLIP-seq
MIRT2034415	hsa-miR-618	CLIP-seq
MIRT2034417	hsa-miR-769-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000290	Process	Deadenylation-dependent decapping of nuclear-transcribed mRNA	IBA	21873635
GO:0000339	Function	RNA cap binding	IBA	21873635
GO:0000375	Process	RNA splicing, via transesterification reactions	TAS	10369684
GO:0000932	Component	P-body	IBA	21873635
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA	21873635
GO:0003729	Function	MRNA binding	IEA
GO:0005515	Function	Protein binding	IPI	14667819, 15231747, 18172165, 19628699, 20584987, 20852261, 25416956, 26871637, 28514442, 32296183, 32814053
GO:0005634	Component	Nucleus	IDA	18559850
GO:0005737	Component	Cytoplasm	IDA	18559850
GO:0005829	Component	Cytosol	TAS
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	TAS	10369684
GO:0016070	Process	RNA metabolic process	IBA	21873635
GO:0019827	Process	Stem cell population maintenance	IEA
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IEA
GO:0036002	Function	Pre-mRNA binding	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043928	Process	Exonucleolytic catabolism of deadenylated mRNA	TAS
GO:0045665	Process	Negative regulation of neuron differentiation	IEA
GO:0071044	Process	Histone mRNA catabolic process	IMP	18172165
GO:1990124	Component	Messenger ribonucleoprotein complex	IEA
GO:1990726	Component	Lsm1-7-Pat1 complex	IBA	21873635

Other IDs

• MIM: 607281
• HGNC: 20472
• e!Ensembl: ENSG00000175324

Protein

• UniProt ID: O15116
• Protein name: U6 snRNA-associated Sm-like protein LSm1 (Cancer-associated Sm-like) (Small nuclear ribonuclear CaSm)
• Protein function: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (PubMed:18172165). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarit
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01423	LSM	8 → 76	LSM domain	Domain

• Sequence:

  MNYMPGTASLIEDIDKKHLVLLRDGRTLIGFLRSIDQFANLVLHQTVERIHVGKKYGDIP
  RGIFVVRGENVVLLGEIDLEKESDTPLQQVSIEEILEEQRVEQQTKLEAEKLKVQALKDR
  GLSIPRADTLDEY

• Sequence length: 133

Pathways

KEGG:

RNA degradation

Reactome:

mRNA decay by 5' to 3' exoribonuclease

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	22037555, 28991256