PCDH17 (protocadherin 17)

Gene

• Entrez ID: 27253
• Gene name: Protocadherin 17
• Gene symbol: PCDH17
• Synonyms: PCDH68, PCH68
• Chromosome: 13
• Chromosome location: 13q21.1
• Summary: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. T

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT709689	hsa-miR-548m	HITS-CLIP	19536157
MIRT709688	hsa-miR-548ag	HITS-CLIP	19536157
MIRT709687	hsa-miR-548ai	HITS-CLIP	19536157
MIRT709686	hsa-miR-548ba	HITS-CLIP	19536157
MIRT709685	hsa-miR-570-5p	HITS-CLIP	19536157
MIRT709684	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT709683	hsa-miR-4793-5p	HITS-CLIP	19536157
MIRT709682	hsa-miR-6072	HITS-CLIP	19536157
MIRT709681	hsa-miR-6891-3p	HITS-CLIP	19536157
MIRT709680	hsa-miR-5193	HITS-CLIP	19536157
MIRT709679	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT709678	hsa-miR-6870-3p	HITS-CLIP	19536157
MIRT709677	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT709676	hsa-miR-4279	HITS-CLIP	19536157
MIRT709675	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT709674	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT622911	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT622910	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT622909	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT622908	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT622907	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT622906	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT622905	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT709689	hsa-miR-548m	HITS-CLIP	19536157
MIRT709688	hsa-miR-548ag	HITS-CLIP	19536157
MIRT709687	hsa-miR-548ai	HITS-CLIP	19536157
MIRT709686	hsa-miR-548ba	HITS-CLIP	19536157
MIRT709685	hsa-miR-570-5p	HITS-CLIP	19536157
MIRT709684	hsa-miR-5196-3p	HITS-CLIP	19536157
MIRT709683	hsa-miR-4793-5p	HITS-CLIP	19536157
MIRT709682	hsa-miR-6072	HITS-CLIP	19536157
MIRT709681	hsa-miR-6891-3p	HITS-CLIP	19536157
MIRT709680	hsa-miR-5193	HITS-CLIP	19536157
MIRT709679	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT709678	hsa-miR-6870-3p	HITS-CLIP	19536157
MIRT709677	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT709676	hsa-miR-4279	HITS-CLIP	19536157
MIRT709675	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT709674	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT622911	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT622910	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT622909	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT622908	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT622907	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT622906	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT622905	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT1216791	hsa-miR-1200	CLIP-seq
MIRT1216792	hsa-miR-127-5p	CLIP-seq
MIRT1216793	hsa-miR-224	CLIP-seq
MIRT1216794	hsa-miR-30a	CLIP-seq
MIRT1216795	hsa-miR-30b	CLIP-seq
MIRT1216796	hsa-miR-30c	CLIP-seq
MIRT1216797	hsa-miR-30d	CLIP-seq
MIRT1216798	hsa-miR-30e	CLIP-seq
MIRT1216799	hsa-miR-3140-5p	CLIP-seq
MIRT1216800	hsa-miR-3607-3p	CLIP-seq
MIRT1216801	hsa-miR-3662	CLIP-seq
MIRT1216802	hsa-miR-4282	CLIP-seq
MIRT1216803	hsa-miR-4310	CLIP-seq
MIRT1216804	hsa-miR-4446-5p	CLIP-seq
MIRT1216805	hsa-miR-4729	CLIP-seq
MIRT1216806	hsa-miR-4760-5p	CLIP-seq
MIRT1216807	hsa-miR-579	CLIP-seq
MIRT1216808	hsa-miR-590-3p	CLIP-seq
MIRT1921689	hsa-miR-4422	CLIP-seq
MIRT1216791	hsa-miR-1200	CLIP-seq
MIRT1216799	hsa-miR-3140-5p	CLIP-seq
MIRT2062563	hsa-miR-409-3p	CLIP-seq
MIRT1216804	hsa-miR-4446-5p	CLIP-seq
MIRT2291007	hsa-miR-140-3p	CLIP-seq
MIRT2291008	hsa-miR-217	CLIP-seq
MIRT2291009	hsa-miR-2276	CLIP-seq
MIRT2291010	hsa-miR-4789-5p	CLIP-seq
MIRT2588632	hsa-miR-1179	CLIP-seq
MIRT2588633	hsa-miR-3163	CLIP-seq
MIRT2588634	hsa-miR-340	CLIP-seq
MIRT2588635	hsa-miR-3653	CLIP-seq
MIRT2588636	hsa-miR-3658	CLIP-seq
MIRT2588637	hsa-miR-532-5p	CLIP-seq
MIRT2588632	hsa-miR-1179	CLIP-seq
MIRT2588633	hsa-miR-3163	CLIP-seq
MIRT2588634	hsa-miR-340	CLIP-seq
MIRT2588635	hsa-miR-3653	CLIP-seq
MIRT2588636	hsa-miR-3658	CLIP-seq
MIRT2588637	hsa-miR-532-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	19945174, 32296183
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0007155	Process	Cell adhesion	IBA	21873635
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0030534	Process	Adult behavior	IEA
GO:0050805	Process	Negative regulation of synaptic transmission	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0098982	Component	GABA-ergic synapse	IEA
GO:0099055	Component	Integral component of postsynaptic membrane	IEA
GO:0099056	Component	Integral component of presynaptic membrane	IEA
GO:0099560	Process	Synaptic membrane adhesion	IEA
GO:1904071	Process	Presynaptic active zone assembly	IEA
GO:2000807	Process	Regulation of synaptic vesicle clustering	IEA

Other IDs

• MIM: 611760
• HGNC: 14267
• e!Ensembl: ENSG00000118946

Protein

• UniProt ID: O14917
• Protein name: Protocadherin-17 (Protocadherin-68)
• Protein function: Potential calcium-dependent cell-adhesion protein.
• PDB: 6VFT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08266	Cadherin_2	20 → 112	Cadherin-like	Domain
  PF00028	Cadherin	137 → 234	Cadherin domain	Domain
  PF00028	Cadherin	248 → 342	Cadherin domain	Domain
  PF00028	Cadherin	357 → 463	Cadherin domain	Domain
  PF00028	Cadherin	477 → 574	Cadherin domain	Domain
  PF00028	Cadherin	593 → 682	Cadherin domain	Domain

• Sequence:

  MYLSICCCFLLWAPALTLKNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSK
  SGSYRVLENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEICMIKV
  EIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRDDHGLFG
  LDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNS
  PVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKT
  GLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGA
  LSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGGSVPFKLEENYDN
  FYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDENDNPPRFTKGLYVLQ
  VHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYVSVNPTNGAIYALRSF
  NFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRN
  AGLGYLVSTVRALDSDFGESGRLTYEIVDGNDDHLFEIDPSSGEIRTLHPFWEDVTPVVE
  LVVKVTDHGKPTLSAVAKLIIRSVSGSLPEGVPRVNGEQHHWDMSLPLIVTLSTISIILL
  AAMITIAVKCKRENKEIRTYNCRIAEYSHPQLGGGKGKKKKINKNDIMLVQSEVEERNAM
  NVMNVVSSPSLATSPMYFDYQTRLPLSSPRSEVMYLKPASNNLTVPQGHAGCHTSFTGQG
  TNASETPATRMSIIQTDNFPAEPNYMGSRQQFVQSSSTFKDPERASLRDSGHGDSDQADS
  DQDTNKGSCCDMSVREALKMKTTSTKSQPLEQEPEECVNCTDECRVLGHSDRCWMPQFPA
  ANQAENADYRTNLFVPTVEANVETETYETVNPTGKKTFCTFGKDKREHTILIANVKPYLK
  AKRALSPLLQEVPSASSSPTKACIEPCTSTKGSLDGCEAKPGALAEASSQYLPTDSQYLS
  PSKQPRDPPFMASDQMARVFADVHSRASRDSSEMGAVLEQLDHPNRDLGRESVDAEEVVR
  EIDKLLQDCRGNDPVAVRK

• Sequence length: 1159

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	17464717, 31374203