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AGO2 (argonaute RISC catalytic component 2)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
27161
Gene nameGene Name - the full gene name approved by the HGNC.
Argonaute RISC catalytic component 2
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
AGO2
SynonymsGene synonyms aliases
CASC7, EIF2C2, LESKRES, LINC00980, PPD, Q10
ChromosomeChromosome number
8
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q24.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-me
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT007020 hsa-miR-376a-3p Luciferase reporter assay 21556037
MIRT007020 hsa-miR-376a-3p Luciferase reporter assay 21556037
MIRT007020 hsa-miR-376a-3p Luciferase reporter assay 21556037
MIRT024741 hsa-miR-215-5p Microarray 19074876
MIRT026680 hsa-miR-192-5p Microarray 19074876
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000340 Function RNA 7-methylguanosine cap binding IDA 17524464
GO:0000932 Component P-body IDA 20616046, 22915799, 23125361
GO:0000993 Function RNA polymerase II complex binding IDA 25336585
GO:0001046 Function Core promoter sequence-specific DNA binding IMP 25336585
GO:0003723 Function RNA binding HDA 22658674, 22681889
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9UKV8
Protein name Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)
Protein function Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs dire
PDB 3LUC , 3LUD , 3LUG , 3LUH , 3LUJ , 3LUK , 3QX8 , 3QX9 , 4F3T , 4OLA , 4OLB , 4W5N , 4W5O , 4W5Q , 4W5R , 4W5T , 4Z4C , 4Z4D , 4Z4E , 4Z4F , 4Z4G , 4Z4H , 4Z4I , 5JS1 , 5JS2 , 5KI6 , 5T7B , 5WEA , 6CBD , 6MDZ , 6MFN , 6MFR , 6N4O , 6NIT , 6RA4 , 7C6B , 7D7U , 7KI3 , 8D6J , 8D71 , 8THQ , 9BEZ , 9BF0 , 9BF2 , 9CMP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16486 ArgoN
36 166
N-terminal domain of argonaute
Domain
PF08699 ArgoL1
176 226
Argonaute linker 1 domain
Domain
PF02170 PAZ
231 365
PAZ domain
Domain
PF16488 ArgoL2
374 420
Argonaute linker 2 domain
Family
PF16487 ArgoMid
429 511
Mid domain of argonaute
Domain
PF02171 Piwi
517 818
Piwi domain
Family
Sequence
MYSGAGPALAPPAPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELD
IKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLP
GEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVM
RHLPSMRYTPVGRS
FFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYK
AQPVIEFVCEVLDF
KSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQES
GQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQ
TSTMI
RATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILY
GGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRD
AGMPIQGQPCFCKYAQGADSVEPMFRHLKNT
YAGLQLVVVILPGKTPVYAEVKRVGDTVL
GMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTH
PPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFK
PTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDK
NERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQ
ILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLV
DKEHDSAEGSHTSGQSNGRDHQ
ALAKAVQVHQDTLRTMYFA
Sequence length 859
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Pre-NOTCH Transcription and Translation
MicroRNA (miRNA) biogenesis
Ca2+ pathway
Small interfering RNA (siRNA) biogenesis
Post-transcriptional silencing by small RNAs
Transcriptional regulation by small RNAs
TP53 Regulates Metabolic Genes
MAPK6/MAPK4 signaling
Regulation of RUNX1 Expression and Activity
Regulation of PTEN mRNA translation
Competing endogenous RNAs (ceRNAs) regulate PTEN translation
Transcriptional Regulation by MECP2
Estrogen-dependent gene expression
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Hypothyroidism Hypothyroidism rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912, rs121917847, rs104893655, rs104893657, rs104893658, rs104893659, rs104893660, rs104893656, rs121917719, rs786204790, rs189261858, rs879255608, rs868197660, rs879255609, rs1586744173, rs1586182837, rs771222349, rs1587618417, rs1601844140, rs760832986, rs780982673, rs1603336347, rs1691155605 30595370
Unknown
Disease name Disease term dbSNP ID References
Malignant mesothelioma Malignant mesothelioma 25756049
Monocytic leukemia Leukemia, Monocytic, Chronic 21535412
Myeloid leukemia Myeloid Leukemia 21535412

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