FILIP1 (filamin A interacting protein 1)

Gene

• Entrez ID: 27145
• Gene name: Filamin A interacting protein 1
• Gene symbol: FILIP1
• Synonyms: FILIP, NMDF
• Chromosome: 6
• Chromosome location: 6q14.1
• Summary: This gene encodes a filamin A binding protein. The encoded protein promotes the degradation of filamin A and may regulate cortical neuron migration and dendritic spine morphology. Mice lacking a functional copy of this gene exhibit reduced dendritic spine

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024001	hsa-miR-1-3p	Microarray	18668037
MIRT996894	hsa-miR-186	CLIP-seq
MIRT996895	hsa-miR-2054	CLIP-seq
MIRT996896	hsa-miR-3133	CLIP-seq
MIRT996897	hsa-miR-3180-5p	CLIP-seq
MIRT739795	hsa-miR-3190	CLIP-seq
MIRT739793	hsa-miR-323-3p	CLIP-seq
MIRT996898	hsa-miR-338-3p	CLIP-seq
MIRT996899	hsa-miR-4422	CLIP-seq
MIRT996900	hsa-miR-4495	CLIP-seq
MIRT996901	hsa-miR-4511	CLIP-seq
MIRT996902	hsa-miR-4530	CLIP-seq
MIRT996903	hsa-miR-4666-5p	CLIP-seq
MIRT996904	hsa-miR-4760-3p	CLIP-seq
MIRT739792	hsa-miR-513a-3p	CLIP-seq
MIRT996905	hsa-miR-548a-5p	CLIP-seq
MIRT996906	hsa-miR-548ab	CLIP-seq
MIRT996907	hsa-miR-548ak	CLIP-seq
MIRT996908	hsa-miR-548b-5p	CLIP-seq
MIRT996909	hsa-miR-548c-5p	CLIP-seq
MIRT996910	hsa-miR-548d-5p	CLIP-seq
MIRT996911	hsa-miR-548h	CLIP-seq
MIRT996912	hsa-miR-548i	CLIP-seq
MIRT996913	hsa-miR-548j	CLIP-seq
MIRT996914	hsa-miR-548k	CLIP-seq
MIRT996915	hsa-miR-548l	CLIP-seq
MIRT996916	hsa-miR-548w	CLIP-seq
MIRT996917	hsa-miR-548y	CLIP-seq
MIRT996918	hsa-miR-559	CLIP-seq
MIRT996919	hsa-miR-583	CLIP-seq
MIRT739794	hsa-miR-624	CLIP-seq
MIRT996920	hsa-miR-654-3p	CLIP-seq
MIRT996894	hsa-miR-186	CLIP-seq
MIRT996896	hsa-miR-3133	CLIP-seq
MIRT996900	hsa-miR-4495	CLIP-seq
MIRT996901	hsa-miR-4511	CLIP-seq
MIRT996903	hsa-miR-4666-5p	CLIP-seq
MIRT2533545	hsa-miR-340	CLIP-seq
MIRT2533546	hsa-miR-4259	CLIP-seq
MIRT2533547	hsa-miR-4715-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0015629	Component	Actin cytoskeleton	IBA	21873635
GO:0015629	Component	Actin cytoskeleton	IDA

Other IDs

• MIM: 607307
• HGNC: 21015
• e!Ensembl: ENSG00000118407

Protein

• UniProt ID: Q7Z7B0
• Protein name: Filamin-A-interacting protein 1 (FILIP)
• Protein function: By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09727	CortBP2	71 → 256	Cortactin-binding protein-2	Family

• Sequence:

  MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLK
  TSGECERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEP
  EKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTV
  YELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDEL
  VKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLE
  VDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQ
  ELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKE
  LRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKEL
  ECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKV
  MDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRL
  DGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEY
  DQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDL
  KAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSK
  RYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQ
  VGLKKPVERSSVLDRYPPAANELTMRKSWIPWMRKRENGPSITQEKGPRTNSSPGHPGEV
  VLSPKQGQPLHIRVTPDHENSTATLEITSPTSEEFFSSTTVIPTLGNQKPRITIIPSPNV
  MPQKQKSGDTTLGPERAMSPVTITTFSREKTPESGRGAFADRPTSPIQIMTVSTSAAPAE
  IAVSPESQEMPMGRTILKVTPEKQTVPTPVRKYNSNANIITTEDNKIHIHLGSQFKRSPG
  TSGEGVSPVITVRPVNVTAEKEVSTGTVLRSPRNHLSSRPGASKVTSTITITPVTTSSAR
  GTQSVSGQDGSSQRPTPTRIPMSKGMKAGKPVVAAPGAGNLTKFEPRAETQSMKIELKKS
  AASSTTSLGGGKG

• Sequence length: 1213

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	16367923
Leprosy	Leprosy	rs121917864, rs2239704	22019778

Unknown
Disease name	Disease term	dbSNP ID	References
Osteoarthritis of hip	Osteoarthritis of hip		30374069, 30664745
Stomach neoplasms	Malignant neoplasm of stomach, Stomach Neoplasms		16367923