Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
27131 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Sorting nexin 5 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
SNX5 |
SynonymsGene synonyms aliases
|
- |
ChromosomeChromosome number
|
20 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
20p11.23 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoi |
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0001726 |
Component |
Ruffle |
IEA |
|
GO:0001891 |
Component |
Phagocytic cup |
IEA |
|
GO:0005515 |
Function |
Protein binding |
IPI |
19619496, 23085988, 25416956, 25588945, 28514442 |
GO:0005768 |
Component |
Endosome |
IBA |
21873635 |
GO:0005829 |
Component |
Cytosol |
IDA |
|
GO:0005903 |
Component |
Brush border |
IEA |
|
GO:0006886 |
Process |
Intracellular protein transport |
IEA |
|
GO:0006907 |
Process |
Pinocytosis |
IBA |
21873635 |
GO:0006907 |
Process |
Pinocytosis |
IDA |
18854019 |
GO:0007174 |
Process |
Epidermal growth factor catabolic process |
IEA |
|
GO:0010314 |
Function |
Phosphatidylinositol-5-phosphate binding |
IEA |
|
GO:0016241 |
Process |
Regulation of macroautophagy |
NAS |
26172538 |
GO:0030659 |
Component |
Cytoplasmic vesicle membrane |
IEA |
|
GO:0030904 |
Component |
Retromer complex |
IDA |
19619496 |
GO:0030905 |
Component |
Retromer, tubulation complex |
NAS |
26220253 |
GO:0031234 |
Component |
Extrinsic component of cytoplasmic side of plasma membrane |
IDA |
15561769, 18854019 |
GO:0031313 |
Component |
Extrinsic component of endosome membrane |
IDA |
15561769 |
GO:0031748 |
Function |
D1 dopamine receptor binding |
IEA |
|
GO:0031901 |
Component |
Early endosome membrane |
IDA |
15561769 |
GO:0034452 |
Function |
Dynactin binding |
IBA |
21873635 |
GO:0034452 |
Function |
Dynactin binding |
IDA |
19619496 |
GO:0035091 |
Function |
Phosphatidylinositol binding |
IBA |
21873635 |
GO:0035091 |
Function |
Phosphatidylinositol binding |
IDA |
15561769 |
GO:0035091 |
Function |
Phosphatidylinositol binding |
ISS |
|
GO:0035815 |
Process |
Positive regulation of renal sodium excretion |
IEA |
|
GO:0042147 |
Process |
Retrograde transport, endosome to Golgi |
IBA |
21873635 |
GO:0042147 |
Process |
Retrograde transport, endosome to Golgi |
IMP |
17148574 |
GO:0042147 |
Process |
Retrograde transport, endosome to Golgi |
NAS |
26220253 |
GO:0043231 |
Component |
Intracellular membrane-bounded organelle |
IDA |
|
GO:0045296 |
Function |
Cadherin binding |
HDA |
25468996 |
GO:0045776 |
Process |
Negative regulation of blood pressure |
IEA |
|
GO:0045893 |
Process |
Positive regulation of transcription, DNA-templated |
IMP |
25825816 |
GO:0046628 |
Process |
Positive regulation of insulin receptor signaling pathway |
IMP |
25825816 |
GO:0048471 |
Component |
Perinuclear region of cytoplasm |
IDA |
25825816 |
GO:0070273 |
Function |
Phosphatidylinositol-4-phosphate binding |
IEA |
|
GO:0070685 |
Component |
Macropinocytic cup |
IDA |
18854019 |
GO:0080025 |
Function |
Phosphatidylinositol-3,5-bisphosphate binding |
IEA |
|
GO:0097422 |
Component |
Tubular endosome |
IDA |
19619496 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
Q9Y5X3 |
Protein name |
Sorting nexin-5 |
Protein function |
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of t |
PDB |
1SYS
,
5TGH
,
5TGI
,
5TGJ
,
5WY2
,
6N5X
,
6N5Y
,
6N5Z
,
8A1G
,
8ABQ
,
8AFZ
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00787 |
PX |
55 → 169 |
PX domain |
Domain |
PF09325 |
Vps5 |
179 → 398 |
Vps5 C terminal like |
Domain |
|
Sequence |
|
Sequence length |
404 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
|
|
Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Gastric cancer |
Hereditary Diffuse Gastric Cancer |
rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208 |
21364753 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Stomach neoplasms |
Malignant neoplasm of stomach, Stomach Neoplasms |
|
21364753 |
|
|
|