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DKK3 (dickkopf Wnt signaling pathway inhibitor 3)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
27122
Gene nameGene Name - the full gene name approved by the HGNC.
Dickkopf Wnt signaling pathway inhibitor 3
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
DKK3
SynonymsGene synonyms aliases
CRRL, REIC, RIG
ChromosomeChromosome number
11
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p15.3
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is d
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT053048 hsa-miR-183-5p Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot 23538390
MIRT438225 hsa-miR-92b-3p Luciferase reporter assay, Western blot 24325785
MIRT438225 hsa-miR-92b-3p Luciferase reporter assay, Western blot 24325785
MIRT438225 hsa-miR-92b-3p Luciferase reporter assay, Western blot 24325785
MIRT438225 hsa-miR-92b-3p Luciferase reporter assay, Western blot 24325785
Transcription factors
Transcription factor Regulation Reference
MYCN Repression 18059033;21796614
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183, 32814053
GO:0005615 Component Extracellular space IBA 21873635
GO:0009653 Process Anatomical structure morphogenesis TAS 10570958
GO:0016055 Process Wnt signaling pathway IEA
GO:0017015 Process Regulation of transforming growth factor beta receptor signaling pathway NAS 24431302
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9UBP4
Protein name Dickkopf-related protein 3 (Dickkopf-3) (Dkk-3) (hDkk-3)
Protein function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development,
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04706 Dickkopf_N
146 196
Dickkopf N-terminal cysteine-rich region
Family
Sequence
MQRLGATLLCLLLAAAVPTAPAPAPTATSAPVKPGPALSYPQEEATLNEMFREVEELMED
TQHKLRSAVEEMEAEEAAAKASSEVNLANLPPSYHNETNTDTKVGNNTIHVHREIHKITN
NQTGQMVFSETVITSVGDEEGRRSHECIIDEDCGPSMYCQFASFQYTCQPCRGQRMLCTR
DSECCGDQLCVWGHCT
KMATRGSNGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGEL
CHDPASRLLDLITWELEPDGALDRCPCASGLLCQPHSHSLVYVCKPTFVGSRDQDGEILL
PREVPDEYEVGSFMEEVRQELEDLERSLTEEMALREPAAAAAALLGGEEI
Sequence length 350
Interactions View interactions
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Rheumatoid arthritis Rheumatoid Arthritis rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212 22491018
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 15998302

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