Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
27020 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Neuroplastin |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
NPTN |
SynonymsGene synonyms aliases
|
GP55, GP65, SDFR1, SDR1, np55, np65 |
ChromosomeChromosome number
|
15 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
15q24.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. [provided by R |
miRNAmiRNA information provided by mirtarbase database.
|
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0001772 |
Component |
Immunological synapse |
ISS |
|
GO:0001818 |
Process |
Negative regulation of cytokine production |
ISS |
|
GO:0001934 |
Process |
Positive regulation of protein phosphorylation |
ISS |
|
GO:0005105 |
Function |
Type 1 fibroblast growth factor receptor binding |
ISS |
|
GO:0005515 |
Function |
Protein binding |
IPI |
30190470 |
GO:0005886 |
Component |
Plasma membrane |
IBA |
21873635 |
GO:0006874 |
Process |
Cellular calcium ion homeostasis |
ISS |
|
GO:0007156 |
Process |
Homophilic cell adhesion via plasma membrane adhesion molecules |
IBA |
21873635 |
GO:0007156 |
Process |
Homophilic cell adhesion via plasma membrane adhesion molecules |
ISS |
|
GO:0007204 |
Process |
Positive regulation of cytosolic calcium ion concentration |
ISS |
|
GO:0007411 |
Process |
Axon guidance |
IBA |
21873635 |
GO:0008542 |
Process |
Visual learning |
IEA |
|
GO:0009986 |
Component |
Cell surface |
HDA |
19581412 |
GO:0010976 |
Process |
Positive regulation of neuron projection development |
ISS |
|
GO:0030424 |
Component |
Axon |
IBA |
21873635 |
GO:0030425 |
Component |
Dendrite |
IEA |
|
GO:0042734 |
Component |
Presynaptic membrane |
ISS |
|
GO:0044325 |
Function |
Ion channel binding |
IEA |
|
GO:0045743 |
Process |
Positive regulation of fibroblast growth factor receptor signaling pathway |
ISS |
|
GO:0048170 |
Process |
Positive regulation of long-term neuronal synaptic plasticity |
ISS |
|
GO:0050839 |
Function |
Cell adhesion molecule binding |
ISS |
|
GO:0060077 |
Component |
Inhibitory synapse |
IEA |
|
GO:0060291 |
Process |
Long-term synaptic potentiation |
ISS |
|
GO:0070374 |
Process |
Positive regulation of ERK1 and ERK2 cascade |
IEA |
|
GO:0070593 |
Process |
Dendrite self-avoidance |
IBA |
21873635 |
GO:0098632 |
Function |
Cell-cell adhesion mediator activity |
IBA |
21873635 |
GO:0098685 |
Component |
Schaffer collateral - CA1 synapse |
IEA |
|
GO:0098978 |
Component |
Glutamatergic synapse |
IEA |
|
GO:0098982 |
Component |
GABA-ergic synapse |
IEA |
|
GO:0099059 |
Component |
Integral component of presynaptic active zone membrane |
IEA |
|
GO:0099061 |
Component |
Integral component of postsynaptic density membrane |
IEA |
|
GO:0099557 |
Process |
Trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission |
IEA |
|
GO:1900273 |
Process |
Positive regulation of long-term synaptic potentiation |
IEA |
|
GO:1902683 |
Process |
Regulation of receptor localization to synapse |
IEA |
|
GO:1903829 |
Process |
Positive regulation of cellular protein localization |
IEA |
|
GO:1904861 |
Process |
Excitatory synapse assembly |
IEA |
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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|
Protein
|
UniProt ID |
Q9Y639 |
Protein name |
Neuroplastin (Stromal cell-derived receptor 1) (SDR-1) |
Protein function |
Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May p |
PDB |
6A69
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF13927 |
Ig_3 |
33 → 120 |
|
Domain |
PF13927 |
Ig_3 |
147 → 221 |
|
Domain |
PF13927 |
Ig_3 |
237 → 320 |
|
Domain |
|
Sequence |
|
Sequence length |
398 |
Interactions |
View interactions |
Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Hypertension |
Hypertensive disease |
rs13306026, rs13333226 |
22228705 |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
17123723 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Myocardial ischemia |
Myocardial Ischemia |
|
16214533 |
|