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NPTN (neuroplastin)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
27020
Gene nameGene Name - the full gene name approved by the HGNC.
Neuroplastin
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
NPTN
SynonymsGene synonyms aliases
GP55, GP65, SDFR1, SDR1, np55, np65
ChromosomeChromosome number
15
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q24.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. [provided by R
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023641 hsa-miR-1-3p Proteomics 18668040
MIRT029137 hsa-miR-26b-5p Microarray 19088304
MIRT051931 hsa-let-7b-5p CLASH 23622248
MIRT046088 hsa-miR-125b-5p CLASH 23622248
MIRT037907 hsa-miR-455-3p CLASH 23622248
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001772 Component Immunological synapse ISS
GO:0001818 Process Negative regulation of cytokine production ISS
GO:0001934 Process Positive regulation of protein phosphorylation ISS
GO:0005105 Function Type 1 fibroblast growth factor receptor binding ISS
GO:0005515 Function Protein binding IPI 30190470
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9Y639
Protein name Neuroplastin (Stromal cell-derived receptor 1) (SDR-1)
Protein function Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May p
PDB 6A69
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13927 Ig_3
33 120
Domain
PF13927 Ig_3
147 221
Domain
PF13927 Ig_3
237 320
Domain
Sequence
Sequence length 398
Interactions View interactions
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Hypertension Hypertensive disease rs13306026, rs13333226 22228705
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 17123723
Unknown
Disease name Disease term dbSNP ID References
Myocardial ischemia Myocardial Ischemia 16214533

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