OPN1MW (opsin 1, medium wave sensitive)

Gene

• Entrez ID: 2652
• Gene name: Opsin 1, medium wave sensitive
• Gene symbol: OPN1MW
• Synonyms: CBBM, CBD, COD5, GCP, GOP, OPN1MW1
• Chromosome: X
• Chromosome location: Xq28
• Summary: This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-term

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017886	hsa-miR-335-5p	Microarray	18185580
MIRT1204408	hsa-miR-4434	CLIP-seq
MIRT1204409	hsa-miR-4516	CLIP-seq
MIRT1204410	hsa-miR-4531	CLIP-seq
MIRT1204411	hsa-miR-4534	CLIP-seq
MIRT1204412	hsa-miR-4729	CLIP-seq
MIRT1204413	hsa-miR-5095	CLIP-seq
MIRT2058977	hsa-miR-1200	CLIP-seq
MIRT2058978	hsa-miR-1297	CLIP-seq
MIRT2058979	hsa-miR-26a	CLIP-seq
MIRT2058980	hsa-miR-26b	CLIP-seq
MIRT2058981	hsa-miR-4324	CLIP-seq
MIRT2058982	hsa-miR-4465	CLIP-seq
MIRT2058983	hsa-miR-544b	CLIP-seq
MIRT2058984	hsa-miR-937	CLIP-seq
MIRT2287071	hsa-miR-3064-3p	CLIP-seq
MIRT2287072	hsa-miR-3182	CLIP-seq
MIRT2287073	hsa-miR-4494	CLIP-seq
MIRT2287074	hsa-miR-4634	CLIP-seq
MIRT2287075	hsa-miR-4652-3p	CLIP-seq
MIRT2287076	hsa-miR-4722-3p	CLIP-seq
MIRT2287077	hsa-miR-4783-5p	CLIP-seq
MIRT2391912	hsa-miR-1224-3p	CLIP-seq
MIRT2287072	hsa-miR-3182	CLIP-seq
MIRT2391913	hsa-miR-342-3p	CLIP-seq
MIRT2287075	hsa-miR-4652-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001523	Process	Retinoid metabolic process	TAS
GO:0001750	Component	Photoreceptor outer segment	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	20579627
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007601	Process	Visual perception	IEA
GO:0007602	Process	Phototransduction	IBA	21873635
GO:0008020	Function	G protein-coupled photoreceptor activity	IBA	21873635
GO:0009584	Process	Detection of visible light	IEA
GO:0009881	Function	Photoreceptor activity	IMP	8185948
GO:0018298	Process	Protein-chromophore linkage	IEA
GO:0032467	Process	Positive regulation of cytokinesis	IMP	22888021
GO:0042802	Function	Identical protein binding	IDA	28402104
GO:0071482	Process	Cellular response to light stimulus	IBA	21873635
GO:0097381	Component	Photoreceptor disc membrane	TAS

Other IDs

• MIM: 300821
• HGNC: 4206
• e!Ensembl: ENSG00000268221

Pathways

Reactome:

The retinoid cycle in cones (daylight vision)
Retinoid cycle disease events
G alpha (i) signalling events
Opsins

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Cone dystrophy, x-linked	CONE DYSTROPHY 5, X-LINKED	rs267606927
Cone monochromatism	Cone monochromatism	rs104894912, rs121434621, rs104894914	20579627, 8666378, 15069569
Cone-rod dystrophy	Cone-Rod Dystrophy 2, Cone rod dystrophy	rs200691042, rs121908281, rs28940314, rs121434337, rs80338903, rs121909398, rs28937883, rs397515360, rs137853006, rs786205085, rs137853040, rs137853041, rs786205086, rs104894671, rs1568626209, rs104894672, rs61748436, rs2123743692, rs61751408, rs61751374, rs61750200, rs62642560, rs61752410, rs121909206, rs387906388, rs61753033, rs61750172, rs61750173, rs267606857, rs606231180, rs606231181, rs137852551, rs863223294, rs61755792, rs61755786, rs62625014, rs781781440, rs137853932, rs1064792853, rs387907136, rs397517974, rs397517994, rs786200944, rs398123044, rs398122960, rs61752435, rs1800728, rs398124354, rs61749679, rs61750184, rs61755781, rs281865373, rs62653029, rs62635009, rs281865297, rs61748558, rs61749409, rs61750202, rs61750065, rs61751398, rs61750146, rs281865377, rs61751388, rs62646861, rs61750158, rs61751403, rs62646872, rs61750575, rs61751407, rs61750645, rs281865516, rs61751266, rs137853907, rs483353055, rs587777469, rs587777470, rs587777471, rs199882533, rs76216585, rs587777693, rs587777694, rs786205151, rs150115958, rs2723341, rs201422368, rs786205664, rs746559651, rs786205665, rs786205661, rs794727197, rs192003551, rs886041039, rs863224913, rs771214648, rs863225090, rs751163782, rs875989778, rs886044750, rs768278935, rs886044735, rs201471607, rs61752398, rs878853400, rs886037880, rs886037881, rs886039559, rs748706582, rs886039882, rs886041900, rs886042153, rs749526785, rs1057516195, rs1057516199, rs543698823, rs199840367, rs752175052, rs1085307121, rs104893793, rs1064797182, rs1131691378, rs778234759, rs1553193813, rs373331232, rs756678484, rs780667159, rs1557110499, rs1553901823, rs201587670, rs1439202144, rs1555635778, rs1429786931, rs1553187160, rs1553188916, rs1555345387, rs61749412, rs951379922, rs1554186472, rs767528365, rs1210104601, rs776289402, rs750740765, rs544616523, rs75459701, rs759940113, rs1557787559, rs782581701, rs771116776, rs1006935198, rs755733328, rs1560141393, rs121918567, rs752263228, rs775957498, rs1030149008, rs530749007, rs141823837, rs1570393848, rs1571250020, rs1570382663, rs78484040, rs766357803, rs1437021651, rs1601982595, rs1597331616, rs748798324, rs759408031, rs747512450, rs373680665, rs1355802816, rs374017889, rs1589307705, rs376500610, rs1598146173, rs1598149154, rs752619497, rs1571257937, rs1572829866, rs1426009756, rs1464167194, rs1588391640, rs1588865728, rs1589306127, rs1420750126, rs1598150539, rs1598150793, rs1601972449, rs782740998, rs767366723, rs1602653110, rs778456901, rs1662213462, rs1662507319, rs751644763, rs1689012192, rs1667508280, rs1719285721, rs1734066547, rs1800111659, rs1827340429, rs1196886096, rs1882924778, rs2046020472, rs2046113301, rs1594280740, rs1590681805, rs1570373408, rs369973540, rs1005271380, rs368213921, rs535922252, rs745741473, rs138370992, rs772656461, rs749738655, rs1968173024, rs746128841, rs1887576038, rs909373397, rs750116711, rs1659840790, rs1768016995, rs1186795749	20579627
Corneal dystrophy	Corneal dystrophy	rs121909212, rs121909214, rs760714959, rs766305306, rs1554579819, rs1554579832, rs1554579878
Deuteranomaly	Deuteranomaly	rs104894914, rs104894916, rs724159983, rs104894915	12051694, 1302020
Myopia	Myopia	rs387907109, rs146936371, rs587776903, rs786205127, rs398122836, rs199624584, rs587777625, rs786205216, rs758872875, rs764211125, rs1135402746, rs765658563, rs1555941129, rs1555941116, rs199923805, rs782555528, rs1554862601, rs1586620121, rs1387950081, rs2051026773, rs1422332023
Nystagmus	Nystagmus	rs137852207, rs137852208, rs1928435502, rs137852209, rs137852210, rs1929191668, rs137852211, rs137852212, rs2124209414, rs387906720, rs387906721, rs1602791884, rs786205896

Unknown
Disease name	Disease term	dbSNP ID	References
Achromatopsia incomplete, x-linked	Achromatopsia incomplete, X-linked		15069569
Blue cone monochromacy	Blue cone monochromatism
Bornholm eye disease	BORNHOLM EYE DISEASE		23322568
Color blindness	Color Blindness, Red-Green
Cone dysfunction syndrome with myopia, x-linked	X-linked cone dysfunction syndrome with myopia
Nyctalopia	Nyctalopia
Partial color blindness	NON RARE IN EUROPE: Partial color blindness, deutan type
Pendular nystagmus	Pendular Nystagmus