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GCNT1 (glucosaminyl (N-acetyl) transferase 1)

Gene

2650

Glucosaminyl (N-acetyl) transferase 1

GCNT1

C2GNT, C2GNT-L, C2GNT1, C2GlcNAcT, G6NT, NACGT2, NAGCT2

9q21.13

This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch. The gene coding this enzyme was originally mapped to 9q21

Show/Hide all(183)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021750	hsa-miR-132-3p	Microarray	17612493
MIRT025075	hsa-miR-181a-5p	Microarray	17612493
MIRT625787	hsa-miR-586	HITS-CLIP	23824327
MIRT625786	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT625785	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT625784	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT625783	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT625782	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT625781	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT625780	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT625779	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT625778	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT625777	hsa-miR-491-3p	HITS-CLIP	23824327
MIRT625787	hsa-miR-586	HITS-CLIP	23824327
MIRT625786	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT625785	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT625784	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT625783	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT625782	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT625781	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT625780	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT625779	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT625778	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT625777	hsa-miR-491-3p	HITS-CLIP	23824327
MIRT625787	hsa-miR-586	HITS-CLIP	23824327
MIRT625786	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT625785	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT625784	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT625783	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT625782	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT625781	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT625780	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT625779	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT625778	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT625777	hsa-miR-491-3p	HITS-CLIP	23824327
MIRT625787	hsa-miR-586	HITS-CLIP	23824327
MIRT625786	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT625785	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT625784	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT625783	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT625782	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT625781	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT625780	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT625779	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT625778	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT625777	hsa-miR-491-3p	HITS-CLIP	23824327
MIRT1014894	hsa-miR-146a	CLIP-seq
MIRT1014895	hsa-miR-146b-5p	CLIP-seq
MIRT1014896	hsa-miR-421	CLIP-seq
MIRT1014897	hsa-miR-4272	CLIP-seq
MIRT1014898	hsa-miR-4307	CLIP-seq
MIRT1014899	hsa-miR-4477b	CLIP-seq
MIRT1014900	hsa-miR-4718	CLIP-seq
MIRT1014901	hsa-miR-485-3p	CLIP-seq
MIRT1014902	hsa-miR-548ag	CLIP-seq
MIRT1014903	hsa-miR-548ai	CLIP-seq
MIRT1014904	hsa-miR-556-5p	CLIP-seq
MIRT1014905	hsa-miR-589	CLIP-seq
MIRT1014906	hsa-miR-610	CLIP-seq
MIRT1014907	hsa-miR-664	CLIP-seq
MIRT1014908	hsa-miR-1	CLIP-seq
MIRT1014909	hsa-miR-101	CLIP-seq
MIRT1014910	hsa-miR-125a-5p	CLIP-seq
MIRT1014911	hsa-miR-125b	CLIP-seq
MIRT1014912	hsa-miR-1273f	CLIP-seq
MIRT1014913	hsa-miR-143	CLIP-seq
MIRT1014914	hsa-miR-144	CLIP-seq
MIRT1014915	hsa-miR-146b-3p	CLIP-seq
MIRT1014916	hsa-miR-18a	CLIP-seq
MIRT1014917	hsa-miR-18b	CLIP-seq
MIRT1014918	hsa-miR-206	CLIP-seq
MIRT1014919	hsa-miR-3173-5p	CLIP-seq
MIRT1014920	hsa-miR-3190	CLIP-seq
MIRT1014921	hsa-miR-3192	CLIP-seq
MIRT1014922	hsa-miR-339-5p	CLIP-seq
MIRT1014923	hsa-miR-3673	CLIP-seq
MIRT1014924	hsa-miR-3915	CLIP-seq
MIRT1014925	hsa-miR-3928	CLIP-seq
MIRT1014926	hsa-miR-4274	CLIP-seq
MIRT1014927	hsa-miR-4314	CLIP-seq
MIRT1014928	hsa-miR-4319	CLIP-seq
MIRT1014929	hsa-miR-4324	CLIP-seq
MIRT1014930	hsa-miR-4421	CLIP-seq
MIRT1014931	hsa-miR-4424	CLIP-seq
MIRT1014932	hsa-miR-4491	CLIP-seq
MIRT1014933	hsa-miR-4499	CLIP-seq
MIRT1014934	hsa-miR-4503	CLIP-seq
MIRT1014935	hsa-miR-4519	CLIP-seq
MIRT1014936	hsa-miR-4646-5p	CLIP-seq
MIRT1014937	hsa-miR-4657	CLIP-seq
MIRT1014938	hsa-miR-4672	CLIP-seq
MIRT1014939	hsa-miR-4708-5p	CLIP-seq
MIRT1014940	hsa-miR-4732-3p	CLIP-seq
MIRT1014941	hsa-miR-4735-3p	CLIP-seq
MIRT1014942	hsa-miR-4747-5p	CLIP-seq
MIRT1014943	hsa-miR-4770	CLIP-seq
MIRT1014944	hsa-miR-603	CLIP-seq
MIRT1014945	hsa-miR-613	CLIP-seq
MIRT1014946	hsa-miR-622	CLIP-seq
MIRT1014947	hsa-miR-670	CLIP-seq
MIRT1014948	hsa-miR-7	CLIP-seq
MIRT1014949	hsa-miR-874	CLIP-seq
MIRT1014950	hsa-miR-23a	CLIP-seq
MIRT1014951	hsa-miR-23b	CLIP-seq
MIRT1014952	hsa-miR-23c	CLIP-seq
MIRT1014898	hsa-miR-4307	CLIP-seq
MIRT1014899	hsa-miR-4477b	CLIP-seq
MIRT2000506	hsa-miR-1236	CLIP-seq
MIRT1014914	hsa-miR-144	CLIP-seq
MIRT2000507	hsa-miR-1915	CLIP-seq
MIRT1014950	hsa-miR-23a	CLIP-seq
MIRT1014951	hsa-miR-23b	CLIP-seq
MIRT1014952	hsa-miR-23c	CLIP-seq
MIRT1014920	hsa-miR-3190	CLIP-seq
MIRT1014898	hsa-miR-4307	CLIP-seq
MIRT1014938	hsa-miR-4672	CLIP-seq
MIRT2000508	hsa-miR-4681	CLIP-seq
MIRT2000509	hsa-miR-4709-5p	CLIP-seq
MIRT2000510	hsa-miR-4736	CLIP-seq
MIRT1014901	hsa-miR-485-3p	CLIP-seq
MIRT2000511	hsa-miR-486-3p	CLIP-seq
MIRT2000512	hsa-miR-513b	CLIP-seq
MIRT2000513	hsa-miR-942	CLIP-seq
MIRT1014909	hsa-miR-101	CLIP-seq
MIRT2234023	hsa-miR-1184	CLIP-seq
MIRT2234024	hsa-miR-1205	CLIP-seq
MIRT1014910	hsa-miR-125a-5p	CLIP-seq
MIRT1014911	hsa-miR-125b	CLIP-seq
MIRT1014912	hsa-miR-1273f	CLIP-seq
MIRT2234025	hsa-miR-1276	CLIP-seq
MIRT2234026	hsa-miR-1301	CLIP-seq
MIRT1014913	hsa-miR-143	CLIP-seq
MIRT1014914	hsa-miR-144	CLIP-seq
MIRT2234027	hsa-miR-2114	CLIP-seq
MIRT2234028	hsa-miR-217	CLIP-seq
MIRT2234029	hsa-miR-298	CLIP-seq
MIRT2234030	hsa-miR-3124-3p	CLIP-seq
MIRT2234031	hsa-miR-3156-3p	CLIP-seq
MIRT2234032	hsa-miR-3158-5p	CLIP-seq
MIRT2234033	hsa-miR-3194-3p	CLIP-seq
MIRT2234034	hsa-miR-3620	CLIP-seq
MIRT2234035	hsa-miR-3660	CLIP-seq
MIRT2234036	hsa-miR-3663-3p	CLIP-seq
MIRT2234037	hsa-miR-3692	CLIP-seq
MIRT2234038	hsa-miR-371-5p	CLIP-seq
MIRT2234039	hsa-miR-3921	CLIP-seq
MIRT2234040	hsa-miR-3925-5p	CLIP-seq
MIRT2234041	hsa-miR-3929	CLIP-seq
MIRT2234042	hsa-miR-4281	CLIP-seq
MIRT2234043	hsa-miR-4301	CLIP-seq
MIRT2234044	hsa-miR-4311	CLIP-seq
MIRT1014928	hsa-miR-4319	CLIP-seq
MIRT1014929	hsa-miR-4324	CLIP-seq
MIRT2234045	hsa-miR-4419b	CLIP-seq
MIRT2234046	hsa-miR-4420	CLIP-seq
MIRT2234047	hsa-miR-4438	CLIP-seq
MIRT1014899	hsa-miR-4477b	CLIP-seq
MIRT2234048	hsa-miR-4478	CLIP-seq
MIRT1014934	hsa-miR-4503	CLIP-seq
MIRT2234049	hsa-miR-4526	CLIP-seq
MIRT2234050	hsa-miR-4639-5p	CLIP-seq
MIRT2234051	hsa-miR-4653-5p	CLIP-seq
MIRT2234052	hsa-miR-4660	CLIP-seq
MIRT1014938	hsa-miR-4672	CLIP-seq
MIRT2234053	hsa-miR-4691-3p	CLIP-seq
MIRT1014939	hsa-miR-4708-5p	CLIP-seq
MIRT2234054	hsa-miR-4713-5p	CLIP-seq
MIRT1014940	hsa-miR-4732-3p	CLIP-seq
MIRT1014943	hsa-miR-4770	CLIP-seq
MIRT1014901	hsa-miR-485-3p	CLIP-seq
MIRT2234055	hsa-miR-496	CLIP-seq
MIRT2234056	hsa-miR-5047	CLIP-seq
MIRT2234057	hsa-miR-522	CLIP-seq
MIRT2234058	hsa-miR-532-3p	CLIP-seq
MIRT2234059	hsa-miR-548g	CLIP-seq
MIRT2234060	hsa-miR-583	CLIP-seq
MIRT1014944	hsa-miR-603	CLIP-seq
MIRT2234061	hsa-miR-668	CLIP-seq
MIRT1014947	hsa-miR-670	CLIP-seq
MIRT2000513	hsa-miR-942	CLIP-seq
MIRT2000509	hsa-miR-4709-5p	CLIP-seq
MIRT2437393	hsa-miR-3120-3p	CLIP-seq
MIRT2234037	hsa-miR-3692	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0003829	Function	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity	IBA	21873635
GO:0003829	Function	Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity	IEA
GO:0005515	Function	Protein binding	IPI	23027862
GO:0005615	Component	Extracellular space	IEA
GO:0005802	Component	Trans-Golgi network	IDA	23027862
GO:0008375	Function	Acetylglucosaminyltransferase activity	IBA	21873635
GO:0009101	Process	Glycoprotein biosynthetic process	IMP	23027862
GO:0016021	Component	Integral component of membrane	IEA
GO:0016266	Process	O-glycan processing	TAS
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0031985	Component	Golgi cisterna	IDA	23027862
GO:0032868	Process	Response to insulin	IEA
GO:0048729	Process	Tissue morphogenesis	IEA
GO:0050901	Process	Leukocyte tethering or rolling	IMP	23027862
GO:0060352	Process	Cell adhesion molecule production	IMP	23027862
GO:0060993	Process	Kidney morphogenesis	IEA

MIM	HGNC	e!Ensembl
600391	4203	ENSG00000187210

Protein

UniProt ID

Q02742

Protein name

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (Core 2 beta-1,6-N-acetylglucosaminyltransferase) (C2GlcNAcT) (Core 2-branching enzyme) (Core2-GlcNAc-transferase) (C2GNT) (Core 2 GNT) (Leukocyte type cor

Protein function

Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine (GlcNAc) moiety in beta1-6 linkage from UDP-GlcNAc onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan (PubMed:1329093, PubMed:23027862). The c

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02485	Branch	123 → 392	Core-2/I-Branching enzyme	Family

Sequence

MLRTLLRRRLFSYPTKYYFMVLVLSLITFSVLRIHQKPEFVSVRHLELAGENPSSDINCT
KVLQGDVNEIQKVKLEILTVKFKKRPRWTPDDYINMTSDCSSFIKRRKYIVEPLSKEEAE
FPIAYSIVVHHKIEMLDRLLRAIYMPQNFYCIHVDTKSEDSYLAAVMGIASCFSNVFVAS
RLESVVYASWSRVQADLNCMKDLYAMSANWKYLINLCGMDFPIKTNLEIVRKLKLLMGEN
NLETERMPSHKEERWKKRYEVVNGKLTNTGTVKMLPPLETPLFSGSAYFVVSREYVGYVL
QNEKIQKLMEWAQDTYSPDEYLWATIQRIPEVPGSLPASHKYDLSDMQAVARFVKWQYFE
GDVSKGAPYPPCDGVHVRSVCIFGAGDLNWMLRKHHLFANKFDVDVDLFAIQCLDEHLRH
KALETLKH

Sequence length

428

Interactions

View interactions

	KEGG		Reactome
	Mucin type O-glycan biosynthesis Metabolic pathways		O-linked glycosylation of mucins

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	15882971

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		15882971

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