PLEK2 (pleckstrin 2)

Gene

• Entrez ID: 26499
• Gene name: Pleckstrin 2
• Gene symbol: PLEK2
• Synonyms: -
• Chromosome: 14
• Chromosome location: 14q23.3-q24.1
• Summary: The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement compo

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016423	hsa-miR-193b-3p	Microarray	20304954
MIRT021685	hsa-miR-138-5p	qRT-PCR	21770894
MIRT1240690	hsa-miR-183	CLIP-seq
MIRT1240691	hsa-miR-199a-5p	CLIP-seq
MIRT1240692	hsa-miR-199b-5p	CLIP-seq
MIRT1240693	hsa-miR-2054	CLIP-seq
MIRT1240694	hsa-miR-3065-5p	CLIP-seq
MIRT1240695	hsa-miR-3200-5p	CLIP-seq
MIRT1240696	hsa-miR-3622b-5p	CLIP-seq
MIRT1240697	hsa-miR-3915	CLIP-seq
MIRT1240698	hsa-miR-3928	CLIP-seq
MIRT1240699	hsa-miR-421	CLIP-seq
MIRT1240700	hsa-miR-4272	CLIP-seq
MIRT1240701	hsa-miR-4435	CLIP-seq
MIRT1240702	hsa-miR-4649-3p	CLIP-seq
MIRT1240703	hsa-miR-4680-5p	CLIP-seq
MIRT2070760	hsa-miR-1252	CLIP-seq
MIRT1240690	hsa-miR-183	CLIP-seq
MIRT1240693	hsa-miR-2054	CLIP-seq
MIRT2070761	hsa-miR-2110	CLIP-seq
MIRT1240695	hsa-miR-3200-5p	CLIP-seq
MIRT2070762	hsa-miR-4271	CLIP-seq
MIRT2070763	hsa-miR-4426	CLIP-seq
MIRT2070764	hsa-miR-4533	CLIP-seq
MIRT2070765	hsa-miR-4647	CLIP-seq
MIRT2070766	hsa-miR-4662b	CLIP-seq
MIRT2070767	hsa-miR-4699-5p	CLIP-seq
MIRT2070768	hsa-miR-4725-3p	CLIP-seq
MIRT2070769	hsa-miR-4747-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0031258	Component	Lamellipodium membrane	IEA
GO:0031532	Process	Actin cytoskeleton reorganization	IBA	21873635
GO:0032266	Function	Phosphatidylinositol-3-phosphate binding	IEA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0043325	Function	Phosphatidylinositol-3,4-bisphosphate binding	IEA
GO:0080025	Function	Phosphatidylinositol-3,5-bisphosphate binding	IEA
GO:0120034	Process	Positive regulation of plasma membrane bounded cell projection assembly	IEA

Other IDs

• MIM: 608007
• HGNC: 19238
• e!Ensembl: ENSG00000100558

Protein

• UniProt ID: Q9NYT0
• Protein name: Pleckstrin-2
• Protein function: May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation.
• PDB: 1X1G
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00169	PH	5 → 104	PH domain	Domain
  PF00610	DEP	142 → 223	Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)	Domain
  PF00169	PH	248 → 353	PH domain	Domain

• Sequence:

  MEDGVLKEGFLVKRGHIVHNWKARWFILRQNTLVYYKLEGGRRVTPPKGRILLDGCTITC
  PCLEYENRPLLIKLKTQTSTEYFLEACSREERDAWAFEITGAIHAGQPGKVQQLHSLRNS
  FKLPPHISLHRIVDKMHDSNTGIRSSPNMEQGSTYKKTFLGSSLVDWLISNSFTASRLEA
  VTLASMLMEENFLRPVGVRSMGAIRSGDLAEQFLDDSTALYTFAESYKKKISPKEEISLS
  TVELSGTVVKQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKEENRPVGGFSLRGSL
  VSALEDNGVPTGVKGNVQGNLFKVITKDDTHYYIQASSKAERAEWIEAIKKLT

• Sequence length: 353

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Unknown
Disease name	Disease term	dbSNP ID	References
Mental depression	Major Depressive Disorder	rs587778876, rs587778877	30626913
Prostatic neoplasms	Prostatic Neoplasms		17013881