PPP1R14B (protein phosphatase 1 regulatory inhibitor subunit 14B)

Gene

• Entrez ID: 26472
• Gene name: Protein phosphatase 1 regulatory inhibitor subunit 14B
• Gene symbol: PPP1R14B
• Synonyms: PHI-1, PLCB3N, PNG, SOM172
• Chromosome: 11
• Chromosome location: 11q13.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029319	hsa-miR-26b-5p	Microarray	19088304
MIRT040374	hsa-miR-615-3p	CLASH	23622248
MIRT1255918	hsa-miR-1275	CLIP-seq
MIRT1255919	hsa-miR-1914	CLIP-seq
MIRT1255920	hsa-miR-219-5p	CLIP-seq
MIRT1255921	hsa-miR-2355-3p	CLIP-seq
MIRT1255922	hsa-miR-3163	CLIP-seq
MIRT1255923	hsa-miR-4300	CLIP-seq
MIRT1255924	hsa-miR-4328	CLIP-seq
MIRT1255925	hsa-miR-4477a	CLIP-seq
MIRT1255926	hsa-miR-4648	CLIP-seq
MIRT1255927	hsa-miR-4654	CLIP-seq
MIRT1255928	hsa-miR-4665-5p	CLIP-seq
MIRT1255929	hsa-miR-4769-5p	CLIP-seq
MIRT1255930	hsa-miR-4782-3p	CLIP-seq
MIRT1255931	hsa-miR-486-3p	CLIP-seq
MIRT1255932	hsa-miR-548ac	CLIP-seq
MIRT1255933	hsa-miR-548ae	CLIP-seq
MIRT1255934	hsa-miR-548aj	CLIP-seq
MIRT1255935	hsa-miR-548am	CLIP-seq
MIRT1255936	hsa-miR-548d-3p	CLIP-seq
MIRT1255937	hsa-miR-548x	CLIP-seq
MIRT1255938	hsa-miR-548z	CLIP-seq
MIRT1255939	hsa-miR-676	CLIP-seq
MIRT1255940	hsa-miR-885-3p	CLIP-seq
MIRT1255941	hsa-miR-920	CLIP-seq
MIRT2075438	hsa-miR-3130-3p	CLIP-seq
MIRT1255922	hsa-miR-3163	CLIP-seq
MIRT1255925	hsa-miR-4477a	CLIP-seq
MIRT2075439	hsa-miR-4484	CLIP-seq
MIRT1255931	hsa-miR-486-3p	CLIP-seq
MIRT1255932	hsa-miR-548ac	CLIP-seq
MIRT1255933	hsa-miR-548ae	CLIP-seq
MIRT1255934	hsa-miR-548aj	CLIP-seq
MIRT1255935	hsa-miR-548am	CLIP-seq
MIRT1255936	hsa-miR-548d-3p	CLIP-seq
MIRT1255937	hsa-miR-548x	CLIP-seq
MIRT1255938	hsa-miR-548z	CLIP-seq
MIRT2075440	hsa-miR-767-5p	CLIP-seq
MIRT2302046	hsa-miR-1207-5p	CLIP-seq
MIRT2302047	hsa-miR-183	CLIP-seq
MIRT2302048	hsa-miR-1909	CLIP-seq
MIRT2302049	hsa-miR-3148	CLIP-seq
MIRT1255922	hsa-miR-3163	CLIP-seq
MIRT2302050	hsa-miR-3184	CLIP-seq
MIRT2302051	hsa-miR-331-3p	CLIP-seq
MIRT2302052	hsa-miR-423-5p	CLIP-seq
MIRT2302053	hsa-miR-4271	CLIP-seq
MIRT2302054	hsa-miR-4292	CLIP-seq
MIRT1255924	hsa-miR-4328	CLIP-seq
MIRT1255925	hsa-miR-4477a	CLIP-seq
MIRT2302055	hsa-miR-4640-5p	CLIP-seq
MIRT2302056	hsa-miR-4688	CLIP-seq
MIRT2302057	hsa-miR-4725-3p	CLIP-seq
MIRT2302058	hsa-miR-4726-5p	CLIP-seq
MIRT2302059	hsa-miR-4763-3p	CLIP-seq
MIRT2302060	hsa-miR-4796-3p	CLIP-seq
MIRT1255931	hsa-miR-486-3p	CLIP-seq
MIRT2302061	hsa-miR-548a-3p	CLIP-seq
MIRT1255932	hsa-miR-548ac	CLIP-seq
MIRT1255933	hsa-miR-548ae	CLIP-seq
MIRT1255934	hsa-miR-548aj	CLIP-seq
MIRT1255935	hsa-miR-548am	CLIP-seq
MIRT1255936	hsa-miR-548d-3p	CLIP-seq
MIRT2302062	hsa-miR-548e	CLIP-seq
MIRT2302063	hsa-miR-548f	CLIP-seq
MIRT2302064	hsa-miR-548t	CLIP-seq
MIRT1255937	hsa-miR-548x	CLIP-seq
MIRT1255938	hsa-miR-548z	CLIP-seq
MIRT1255918	hsa-miR-1275	CLIP-seq
MIRT1255928	hsa-miR-4665-5p	CLIP-seq
MIRT1255931	hsa-miR-486-3p	CLIP-seq
MIRT1255940	hsa-miR-885-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004865	Function	Protein serine/threonine phosphatase inhibitor activity	IBA	21873635
GO:0005737	Component	Cytoplasm	IEA
GO:0032515	Process	Negative regulation of phosphoprotein phosphatase activity	IEA
GO:0042325	Process	Regulation of phosphorylation	IEA
GO:0045087	Process	Innate immune response	IBA	21873635

Other IDs

• MIM: 601140
• HGNC: 9057
• e!Ensembl: ENSG00000173457

Protein

• UniProt ID: Q96C90
• Protein name: Protein phosphatase 1 regulatory subunit 14B (Phospholipase C-beta-3 neighbouring gene protein)
• Protein function: Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05361	PP1_inhibitor	38 → 147	PKC-activated protein phosphatase-1 inhibitor	Family

• Sequence:

  MADSGTAGGAALAAPAPGPGSGGPGPRVYFQSPPGAAGEGPGGADDEGPVRRQGKVTVKY
  DRKELRKRLNLEEWILEQLTRLYDCQEEEIPELEIDVDELLDMESDDARAARVKELLVDC
  YKPTEAFISGLLDKIRGMQKLSTPQKK

• Sequence length: 147

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	22535842