GBP2 (guanylate binding protein 2)

Gene

• Entrez ID: 2634
• Gene name: Guanylate binding protein 2
• Gene symbol: GBP2
• Synonyms: -
• Chromosome: 1
• Chromosome location: 1p22.2
• Summary: This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017798	hsa-miR-335-5p	Microarray	18185580
MIRT029407	hsa-miR-26b-5p	Microarray	19088304
MIRT573882	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT573881	hsa-miR-4709-5p	PAR-CLIP	20371350
MIRT573880	hsa-miR-6806-5p	PAR-CLIP	20371350
MIRT573882	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT573881	hsa-miR-4709-5p	PAR-CLIP	20371350
MIRT573880	hsa-miR-6806-5p	PAR-CLIP	20371350
MIRT756350	hsa-miR-221-3p	Luciferase reporter assay, Western blotting, qRT-PCR	38450521
MIRT2537618	hsa-miR-1178	CLIP-seq
MIRT2537619	hsa-miR-1269	CLIP-seq
MIRT2537620	hsa-miR-1269b	CLIP-seq
MIRT2537621	hsa-miR-2110	CLIP-seq
MIRT2537622	hsa-miR-3117-5p	CLIP-seq
MIRT2537623	hsa-miR-3150a-3p	CLIP-seq
MIRT2537624	hsa-miR-3175	CLIP-seq
MIRT2537625	hsa-miR-3189-3p	CLIP-seq
MIRT2537626	hsa-miR-4268	CLIP-seq
MIRT2537627	hsa-miR-4300	CLIP-seq
MIRT2537628	hsa-miR-4419a	CLIP-seq
MIRT2537629	hsa-miR-4448	CLIP-seq
MIRT2537630	hsa-miR-4487	CLIP-seq
MIRT2537631	hsa-miR-4510	CLIP-seq
MIRT2537632	hsa-miR-4520a-3p	CLIP-seq
MIRT2537633	hsa-miR-4529-3p	CLIP-seq
MIRT2537634	hsa-miR-4638-3p	CLIP-seq
MIRT2537635	hsa-miR-4670-3p	CLIP-seq
MIRT2537636	hsa-miR-4714-5p	CLIP-seq
MIRT2537637	hsa-miR-4742-5p	CLIP-seq
MIRT2537638	hsa-miR-514	CLIP-seq
MIRT2537639	hsa-miR-514b-3p	CLIP-seq
MIRT2537640	hsa-miR-578	CLIP-seq
MIRT2537641	hsa-miR-635	CLIP-seq
MIRT2537642	hsa-miR-920	CLIP-seq
MIRT2537643	hsa-miR-939	CLIP-seq
MIRT2537618	hsa-miR-1178	CLIP-seq
MIRT2537619	hsa-miR-1269	CLIP-seq
MIRT2537620	hsa-miR-1269b	CLIP-seq
MIRT2537621	hsa-miR-2110	CLIP-seq
MIRT2537622	hsa-miR-3117-5p	CLIP-seq
MIRT2537623	hsa-miR-3150a-3p	CLIP-seq
MIRT2537624	hsa-miR-3175	CLIP-seq
MIRT2537625	hsa-miR-3189-3p	CLIP-seq
MIRT2537626	hsa-miR-4268	CLIP-seq
MIRT2537627	hsa-miR-4300	CLIP-seq
MIRT2537628	hsa-miR-4419a	CLIP-seq
MIRT2537629	hsa-miR-4448	CLIP-seq
MIRT2537630	hsa-miR-4487	CLIP-seq
MIRT2537631	hsa-miR-4510	CLIP-seq
MIRT2537632	hsa-miR-4520a-3p	CLIP-seq
MIRT2537633	hsa-miR-4529-3p	CLIP-seq
MIRT2537634	hsa-miR-4638-3p	CLIP-seq
MIRT2537635	hsa-miR-4670-3p	CLIP-seq
MIRT2537636	hsa-miR-4714-5p	CLIP-seq
MIRT2537637	hsa-miR-4742-5p	CLIP-seq
MIRT2537638	hsa-miR-514	CLIP-seq
MIRT2537639	hsa-miR-514b-3p	CLIP-seq
MIRT2537640	hsa-miR-578	CLIP-seq
MIRT2537641	hsa-miR-635	CLIP-seq
MIRT2537642	hsa-miR-920	CLIP-seq
MIRT2537643	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0003924	Function	GTPase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	18985028, 21151871
GO:0005525	Function	GTP binding	IBA	21873635
GO:0005634	Component	Nucleus	IDA	17266443, 21151871
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	21151871
GO:0005794	Component	Golgi apparatus	IDA	17266443
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006955	Process	Immune response	TAS	1715024
GO:0031410	Component	Cytoplasmic vesicle	IBA	21873635
GO:0034504	Process	Protein localization to nucleus	IDA	21151871
GO:0042803	Function	Protein homodimerization activity	IDA	21151871
GO:0042832	Process	Defense response to protozoan	IBA	21873635
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	17266443
GO:0050830	Process	Defense response to Gram-positive bacterium	IBA	21873635
GO:0060333	Process	Interferon-gamma-mediated signaling pathway	TAS
GO:0060337	Process	Type I interferon signaling pathway	TAS
GO:0071346	Process	Cellular response to interferon-gamma	IBA	21873635
GO:0071346	Process	Cellular response to interferon-gamma	IDA	17266443
GO:0071347	Process	Cellular response to interleukin-1	IEP	17266443
GO:0071356	Process	Cellular response to tumor necrosis factor	IEP	17266443

Other IDs

• MIM: 600412
• HGNC: 4183
• e!Ensembl: ENSG00000162645

Protein

• UniProt ID: P32456
• Protein name: Guanylate-binding protein 2 (EC 3.6.5.-) (GTP-binding protein 2) (GBP-2) (HuGBP-2) (Guanine nucleotide-binding protein 2) (Interferon-induced guanylate-binding protein 2)
• Protein function: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:31091448). Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major react
• PDB: 6VKJ, 7E58, 7M1S
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02263	GBP	18 → 280	Guanylate-binding protein, N-terminal domain	Domain
  PF02841	GBP_C	282 → 578	Guanylate-binding protein, C-terminal domain	Domain

• Sequence:

  MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
  KKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAI
  LLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTL
  RDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPA
  PKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVN
  AISSGDLPCMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSER
  EAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEEDV
  KQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQSL
  SEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQL
  MAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKSLEPICNIL

• Sequence length: 591

Pathways

KEGG:

NOD-like receptor signaling pathway

Reactome:

Interferon gamma signaling
Interferon alpha/beta signaling

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Myocardial ischemia	Myocardial Ischemia		16214533