ARFGAP3 (ARF GTPase activating protein 3)

Gene

• Entrez ID: 26286
• Gene name: ARF GTPase activating protein 3
• Gene symbol: ARFGAP3
• Synonyms: ARFGAP1
• Chromosome: 22
• Chromosome location: 22q13.2
• Summary: The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, wh

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT038823	hsa-miR-93-3p	CLASH	23622248
MIRT792880	hsa-miR-361-3p	CLIP-seq
MIRT792881	hsa-miR-3925-3p	CLIP-seq
MIRT792882	hsa-miR-4279	CLIP-seq
MIRT792883	hsa-miR-4643	CLIP-seq
MIRT792884	hsa-miR-466	CLIP-seq
MIRT792885	hsa-miR-4717-3p	CLIP-seq
MIRT792886	hsa-miR-4789-3p	CLIP-seq
MIRT792887	hsa-miR-4789-5p	CLIP-seq
MIRT792888	hsa-miR-4802-3p	CLIP-seq
MIRT792889	hsa-miR-592	CLIP-seq
MIRT792890	hsa-miR-597	CLIP-seq
MIRT792891	hsa-miR-617	CLIP-seq
MIRT792892	hsa-miR-626	CLIP-seq
MIRT792893	hsa-miR-665	CLIP-seq
MIRT792894	hsa-miR-766	CLIP-seq
MIRT792895	hsa-miR-769-5p	CLIP-seq
MIRT792896	hsa-miR-944	CLIP-seq
MIRT792897	hsa-miR-1184	CLIP-seq
MIRT792898	hsa-miR-1205	CLIP-seq
MIRT792899	hsa-miR-3158-5p	CLIP-seq
MIRT792900	hsa-miR-3659	CLIP-seq
MIRT792882	hsa-miR-4279	CLIP-seq
MIRT792901	hsa-miR-4658	CLIP-seq
MIRT792885	hsa-miR-4717-3p	CLIP-seq
MIRT792888	hsa-miR-4802-3p	CLIP-seq
MIRT792902	hsa-miR-544	CLIP-seq
MIRT792903	hsa-miR-574-5p	CLIP-seq
MIRT792889	hsa-miR-592	CLIP-seq
MIRT792890	hsa-miR-597	CLIP-seq
MIRT792895	hsa-miR-769-5p	CLIP-seq
MIRT792880	hsa-miR-361-3p	CLIP-seq
MIRT792882	hsa-miR-4279	CLIP-seq
MIRT792880	hsa-miR-361-3p	CLIP-seq
MIRT792882	hsa-miR-4279	CLIP-seq
MIRT792880	hsa-miR-361-3p	CLIP-seq
MIRT792882	hsa-miR-4279	CLIP-seq
MIRT792881	hsa-miR-3925-3p	CLIP-seq
MIRT792883	hsa-miR-4643	CLIP-seq
MIRT792884	hsa-miR-466	CLIP-seq
MIRT792886	hsa-miR-4789-3p	CLIP-seq
MIRT1933981	hsa-miR-515-5p	CLIP-seq
MIRT792893	hsa-miR-665	CLIP-seq
MIRT792894	hsa-miR-766	CLIP-seq
MIRT792897	hsa-miR-1184	CLIP-seq
MIRT792898	hsa-miR-1205	CLIP-seq
MIRT2173807	hsa-miR-3120-3p	CLIP-seq
MIRT792899	hsa-miR-3158-5p	CLIP-seq
MIRT2173808	hsa-miR-4420	CLIP-seq
MIRT2173809	hsa-miR-4457	CLIP-seq
MIRT2173810	hsa-miR-4795-3p	CLIP-seq
MIRT2173811	hsa-miR-494	CLIP-seq
MIRT2173812	hsa-miR-513b	CLIP-seq
MIRT2384359	hsa-miR-1252	CLIP-seq
MIRT2384360	hsa-miR-147	CLIP-seq
MIRT2384361	hsa-miR-3911	CLIP-seq
MIRT2384362	hsa-miR-595	CLIP-seq
MIRT2384363	hsa-miR-644	CLIP-seq
MIRT2443854	hsa-miR-4433	CLIP-seq
MIRT2443855	hsa-miR-4459	CLIP-seq
MIRT2443856	hsa-miR-4537	CLIP-seq
MIRT2443857	hsa-miR-4722-5p	CLIP-seq
MIRT2443858	hsa-miR-4768-3p	CLIP-seq
MIRT2443859	hsa-miR-765	CLIP-seq
MIRT2477507	hsa-miR-1245b-3p	CLIP-seq
MIRT2477508	hsa-miR-139-3p	CLIP-seq
MIRT2477509	hsa-miR-3163	CLIP-seq
MIRT2477510	hsa-miR-3173-3p	CLIP-seq
MIRT792880	hsa-miR-361-3p	CLIP-seq
MIRT2477511	hsa-miR-3671	CLIP-seq
MIRT792882	hsa-miR-4279	CLIP-seq
MIRT2477512	hsa-miR-4311	CLIP-seq
MIRT2477513	hsa-miR-4455	CLIP-seq
MIRT2477514	hsa-miR-4779	CLIP-seq
MIRT2173810	hsa-miR-4795-3p	CLIP-seq
MIRT2477515	hsa-miR-513a-3p	CLIP-seq
MIRT2477516	hsa-miR-520d-5p	CLIP-seq
MIRT2477517	hsa-miR-524-5p	CLIP-seq
MIRT2477518	hsa-miR-607	CLIP-seq
MIRT792891	hsa-miR-617	CLIP-seq
MIRT2477519	hsa-miR-656	CLIP-seq
MIRT2477509	hsa-miR-3163	CLIP-seq
MIRT2477512	hsa-miR-4311	CLIP-seq
MIRT2477515	hsa-miR-513a-3p	CLIP-seq
MIRT2477516	hsa-miR-520d-5p	CLIP-seq
MIRT2477517	hsa-miR-524-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005096	Function	GTPase activator activity	IBA	21873635
GO:0005096	Function	GTPase activator activity	IDA	11172815
GO:0005515	Function	Protein binding	IPI	23275563, 24705354, 32296183, 32814053
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IDA	11172815
GO:0005829	Component	Cytosol	TAS
GO:0006886	Process	Intracellular protein transport	NAS	11172815
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	TAS
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	TAS
GO:0009306	Process	Protein secretion	IEP	11172815
GO:0016020	Component	Membrane	HDA	19946888
GO:0016192	Process	Vesicle-mediated transport	NAS	11172815
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048205	Process	COPI coating of Golgi vesicle	IBA	21873635

Other IDs

• MIM: 612439
• HGNC: 661
• e!Ensembl: ENSG00000242247

Protein

• UniProt ID: Q9NP61
• Protein name: ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3)
• Protein function: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes.
• PDB: 2CRW
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01412	ArfGap	10 → 124	Putative GTPase activating protein for Arf	Domain

• Sequence:

  MGDPSKQDILTIFKRLRSVPTNKVCFDCGAKNPSWASITYGVFLCIDCSGSHRSLGVHLS
  FIRSTELDSNWSWFQLRCMQVGGNASASSFFHQHGCSTNDTNAKYNSRAAQLYREKIKSL
  ASQATRKHGTDLWLDSCVVPPLSPPPKEEDFFASHVSPEVSDTAWASAIAEPSSLTSRPV
  ETTLENNEGGQEQGPSVEGLNVPTKATLEVSSIIKKKPNQAKKGLGAKKGSLGAQKLANT
  CFNEIEKQAQAADKMKEQEDLAKVVSKEESIVSSLRLAYKDLEIQMKKDEKMNISGKKNV
  DSDRLGMGFGNCRSVISHSVTSDMQTIEQESPIMAKPRKKYNDDSDDSYFTSSSSYFDEP
  VELRSSSFSSWDDSSDSYWKKETSKDTETVLKTTGYSDRPTARRKPDYEPVENTDEAQKK
  FGNVKAISSDMYFGRQSQADYETRARLERLSASSSISSADLFEEPRKQPAGNYSLSSVLP
  NAPDMAQFKQGVRSVAGKLSVFANGVVTSIQDRYGS

• Sequence length: 516

Pathways

KEGG:

Endocytosis

Reactome:

COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243