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PITPNC1 (phosphatidylinositol transfer protein cytoplasmic 1)

Gene

26207

Phosphatidylinositol transfer protein cytoplasmic 1

PITPNC1

M-RDGB-beta, MRDGBbeta, RDGB-BETA, RDGBB, RDGBB1

17q24.2

This gene encodes a member of the phosphatidylinositol transfer protein family. The encoded cytoplasmic protein plays a role in multiple processes including cell signaling and lipid metabolism by facilitating the transfer of phosphatidylinositol between m

Show/Hide all(140)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006544	hsa-miR-126-3p	ELISA, Flow, Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22170610
MIRT006544	hsa-miR-126-3p	ELISA, Flow, Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22170610
MIRT006544	hsa-miR-126-3p	ELISA, Flow, Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22170610
MIRT006544	hsa-miR-126-3p	ELISA, Flow, Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	22170610
MIRT018806	hsa-miR-335-5p	Microarray	18185580
MIRT021552	hsa-miR-142-3p	Microarray	17612493
MIRT025935	hsa-miR-7-5p	Microarray	17612493
MIRT026883	hsa-miR-192-5p	Microarray	19074876
MIRT030173	hsa-miR-26b-5p	Microarray	19088304
MIRT521889	hsa-miR-369-3p	HITS-CLIP	21572407
MIRT521888	hsa-miR-374a-5p	HITS-CLIP	21572407
MIRT521887	hsa-miR-374b-5p	HITS-CLIP	21572407
MIRT521886	hsa-miR-6768-5p	HITS-CLIP	21572407
MIRT521885	hsa-miR-5692b	HITS-CLIP	21572407
MIRT521884	hsa-miR-5692c	HITS-CLIP	21572407
MIRT521883	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT521882	hsa-miR-4672	HITS-CLIP	21572407
MIRT521881	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT521880	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT521878	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT521889	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT521888	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT521887	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT521886	hsa-miR-6768-5p	PAR-CLIP	21572407
MIRT521885	hsa-miR-5692b	PAR-CLIP	21572407
MIRT521884	hsa-miR-5692c	PAR-CLIP	21572407
MIRT521883	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT521882	hsa-miR-4672	PAR-CLIP	21572407
MIRT521881	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT521880	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT521878	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT540415	hsa-miR-548aa	PAR-CLIP	21572407
MIRT540414	hsa-miR-548ap-3p	PAR-CLIP	21572407
MIRT540413	hsa-miR-548t-3p	PAR-CLIP	21572407
MIRT540412	hsa-miR-497-3p	PAR-CLIP	21572407
MIRT540411	hsa-miR-140-3p	PAR-CLIP	21572407
MIRT540410	hsa-miR-5003-3p	PAR-CLIP	21572407
MIRT540408	hsa-miR-4678	PAR-CLIP	21572407
MIRT540409	hsa-miR-935	PAR-CLIP	21572407
MIRT540406	hsa-miR-4635	PAR-CLIP	21572407
MIRT540407	hsa-miR-3665	PAR-CLIP	21572407
MIRT540405	hsa-miR-657	PAR-CLIP	21572407
MIRT540404	hsa-miR-488-3p	PAR-CLIP	21572407
MIRT540403	hsa-miR-6511b-5p	PAR-CLIP	21572407
MIRT540402	hsa-miR-6811-5p	PAR-CLIP	21572407
MIRT540401	hsa-miR-6516-5p	PAR-CLIP	21572407
MIRT540400	hsa-miR-450b-5p	PAR-CLIP	21572407
MIRT540399	hsa-miR-507	PAR-CLIP	21572407
MIRT540398	hsa-miR-557	PAR-CLIP	21572407
MIRT540397	hsa-miR-3680-3p	PAR-CLIP	21572407
MIRT540396	hsa-miR-548au-3p	PAR-CLIP	21572407
MIRT540395	hsa-miR-548d-3p	PAR-CLIP	21572407
MIRT540394	hsa-miR-548v	PAR-CLIP	21572407
MIRT521889	hsa-miR-369-3p	PAR-CLIP	23446348
MIRT521888	hsa-miR-374a-5p	PAR-CLIP	23446348
MIRT521887	hsa-miR-374b-5p	PAR-CLIP	23446348
MIRT521886	hsa-miR-6768-5p	PAR-CLIP	23446348
MIRT521885	hsa-miR-5692b	PAR-CLIP	23446348
MIRT521884	hsa-miR-5692c	PAR-CLIP	23446348
MIRT521883	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT521882	hsa-miR-4672	PAR-CLIP	23446348
MIRT521881	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT521880	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT521879	hsa-miR-6083	PAR-CLIP	23446348
MIRT521878	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT521889	hsa-miR-369-3p	HITS-CLIP	21572407
MIRT521888	hsa-miR-374a-5p	HITS-CLIP	21572407
MIRT521887	hsa-miR-374b-5p	HITS-CLIP	21572407
MIRT521886	hsa-miR-6768-5p	HITS-CLIP	21572407
MIRT521885	hsa-miR-5692b	HITS-CLIP	21572407
MIRT521884	hsa-miR-5692c	HITS-CLIP	21572407
MIRT521883	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT521882	hsa-miR-4672	HITS-CLIP	21572407
MIRT521881	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT521880	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT521878	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT521889	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT521888	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT521887	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT521886	hsa-miR-6768-5p	PAR-CLIP	21572407
MIRT521885	hsa-miR-5692b	PAR-CLIP	21572407
MIRT521884	hsa-miR-5692c	PAR-CLIP	21572407
MIRT521883	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT521882	hsa-miR-4672	PAR-CLIP	21572407
MIRT521881	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT521880	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT521878	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT540415	hsa-miR-548aa	PAR-CLIP	21572407
MIRT540414	hsa-miR-548ap-3p	PAR-CLIP	21572407
MIRT540413	hsa-miR-548t-3p	PAR-CLIP	21572407
MIRT540412	hsa-miR-497-3p	PAR-CLIP	21572407
MIRT540411	hsa-miR-140-3p	PAR-CLIP	21572407
MIRT540410	hsa-miR-5003-3p	PAR-CLIP	21572407
MIRT540408	hsa-miR-4678	PAR-CLIP	21572407
MIRT540409	hsa-miR-935	PAR-CLIP	21572407
MIRT540406	hsa-miR-4635	PAR-CLIP	21572407
MIRT540407	hsa-miR-3665	PAR-CLIP	21572407
MIRT540405	hsa-miR-657	PAR-CLIP	21572407
MIRT540404	hsa-miR-488-3p	PAR-CLIP	21572407
MIRT540403	hsa-miR-6511b-5p	PAR-CLIP	21572407
MIRT540402	hsa-miR-6811-5p	PAR-CLIP	21572407
MIRT540401	hsa-miR-6516-5p	PAR-CLIP	21572407
MIRT540400	hsa-miR-450b-5p	PAR-CLIP	21572407
MIRT540399	hsa-miR-507	PAR-CLIP	21572407
MIRT540398	hsa-miR-557	PAR-CLIP	21572407
MIRT540397	hsa-miR-3680-3p	PAR-CLIP	21572407
MIRT540396	hsa-miR-548au-3p	PAR-CLIP	21572407
MIRT540395	hsa-miR-548d-3p	PAR-CLIP	21572407
MIRT540394	hsa-miR-548v	PAR-CLIP	21572407
MIRT521889	hsa-miR-369-3p	PAR-CLIP	23446348
MIRT521888	hsa-miR-374a-5p	PAR-CLIP	23446348
MIRT521887	hsa-miR-374b-5p	PAR-CLIP	23446348
MIRT521886	hsa-miR-6768-5p	PAR-CLIP	23446348
MIRT521885	hsa-miR-5692b	PAR-CLIP	23446348
MIRT521884	hsa-miR-5692c	PAR-CLIP	23446348
MIRT521883	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT521882	hsa-miR-4672	PAR-CLIP	23446348
MIRT521881	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT521880	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT521879	hsa-miR-6083	PAR-CLIP	23446348
MIRT521878	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT1236706	hsa-miR-1252	CLIP-seq
MIRT1236707	hsa-miR-330-3p	CLIP-seq
MIRT1236708	hsa-miR-361-5p	CLIP-seq
MIRT1236709	hsa-miR-4274	CLIP-seq
MIRT1236710	hsa-miR-4658	CLIP-seq
MIRT1236711	hsa-miR-4684-5p	CLIP-seq
MIRT1236712	hsa-miR-4699-5p	CLIP-seq
MIRT1236713	hsa-miR-4758-5p	CLIP-seq
MIRT1236714	hsa-miR-4765	CLIP-seq
MIRT1236715	hsa-miR-4768-5p	CLIP-seq
MIRT1236716	hsa-miR-4324	CLIP-seq
MIRT1236717	hsa-miR-4633-5p	CLIP-seq
MIRT1236718	hsa-miR-4693-3p	CLIP-seq
MIRT1236719	hsa-miR-496	CLIP-seq
MIRT1236720	hsa-miR-532-5p	CLIP-seq
MIRT1236721	hsa-miR-567	CLIP-seq
MIRT1236708	hsa-miR-361-5p	CLIP-seq
MIRT1236711	hsa-miR-4684-5p	CLIP-seq
MIRT1236715	hsa-miR-4768-5p	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 19060904, 25416956
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	10531358
GO:0005829	Component	Cytosol	IDA
GO:0007165	Process	Signal transduction	IMP	10531358
GO:0008525	Function	Phosphatidylcholine transporter activity	IDA	22822086
GO:0008526	Function	Phosphatidylinositol transfer activity	IBA	21873635
GO:0008526	Function	Phosphatidylinositol transfer activity	IDA	22822086
GO:0008526	Function	Phosphatidylinositol transfer activity	IMP	10531358
GO:0015914	Process	Phospholipid transport	IDA	22822086
GO:0035091	Function	Phosphatidylinositol binding	IBA	21873635
GO:0035091	Function	Phosphatidylinositol binding	IDA	22822086
GO:0070300	Function	Phosphatidic acid binding	IDA	22822086
GO:0120009	Process	Intermembrane lipid transfer	IEA
GO:1901611	Function	Phosphatidylglycerol binding	IDA	22822086
GO:1990050	Function	Phosphatidic acid transfer activity	IDA	22822086

MIM	HGNC	e!Ensembl
605134	21045	ENSG00000154217

Protein

UniProt ID

Q9UKF7

Protein name

Cytoplasmic phosphatidylinositol transfer protein 1 (Mammalian rdgB homolog beta) (M-rdgB beta) (MrdgBbeta) (Retinal degeneration B homolog beta) (RdgBbeta)

Protein function

[Isoform 1]: Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidic acid (PA) between membranes (PubMed:10531358, PubMed:22822086). Binds PA derived from the phospholipase D signaling pathway and among the cellular PA species, pref

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02121	IP_trans	1 → 243	Phosphatidylinositol transfer protein	Family

Sequence

MLLKEYRICMPLTVDEYKIGQLYMISKHSHEQSDRGEGVEVVQNEPFEDPHHGNGQFTEK
RVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSN
DTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPI
MCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWYDMTMDEVREFERA
TQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSA
PETLTLPDPEKKATLNLPGMHSSDKPCRPKSE

Sequence length

332

Interactions

View interactions

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	25918132

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