GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase)

Gene

• Entrez ID: 2618
• Gene name: Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
• Gene symbol: GART
• Synonyms: AIRS, GARS, GARTF, PAIS, PGFT, PRGS
• Chromosome: 21
• Chromosome location: 21q22.11
• Summary: The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis.

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044765	hsa-miR-320a	CLASH	23622248
MIRT043703	hsa-miR-342-3p	CLASH	23622248
MIRT042138	hsa-miR-484	CLASH	23622248
MIRT040950	hsa-miR-18a-3p	CLASH	23622248
MIRT039806	hsa-miR-615-3p	CLASH	23622248
MIRT039806	hsa-miR-615-3p	CLASH	23622248
MIRT039189	hsa-miR-769-5p	CLASH	23622248
MIRT037430	hsa-miR-744-5p	CLASH	23622248
MIRT1012184	hsa-miR-103b	CLIP-seq
MIRT1012185	hsa-miR-1225-3p	CLIP-seq
MIRT1012186	hsa-miR-1233	CLIP-seq
MIRT1012187	hsa-miR-186	CLIP-seq
MIRT1012188	hsa-miR-188-3p	CLIP-seq
MIRT1012189	hsa-miR-1972	CLIP-seq
MIRT1012190	hsa-miR-200b	CLIP-seq
MIRT1012191	hsa-miR-200c	CLIP-seq
MIRT1012192	hsa-miR-203	CLIP-seq
MIRT1012193	hsa-miR-296-3p	CLIP-seq
MIRT1012194	hsa-miR-3122	CLIP-seq
MIRT1012195	hsa-miR-3167	CLIP-seq
MIRT1012196	hsa-miR-330-3p	CLIP-seq
MIRT1012197	hsa-miR-338-3p	CLIP-seq
MIRT1012198	hsa-miR-34c-3p	CLIP-seq
MIRT1012199	hsa-miR-3613-3p	CLIP-seq
MIRT1012200	hsa-miR-3614-5p	CLIP-seq
MIRT1012201	hsa-miR-3689a-3p	CLIP-seq
MIRT1012202	hsa-miR-3689c	CLIP-seq
MIRT1012203	hsa-miR-376c	CLIP-seq
MIRT1012204	hsa-miR-3913-5p	CLIP-seq
MIRT1012205	hsa-miR-3926	CLIP-seq
MIRT1012206	hsa-miR-3942-3p	CLIP-seq
MIRT1012207	hsa-miR-3944-5p	CLIP-seq
MIRT1012208	hsa-miR-429	CLIP-seq
MIRT1012209	hsa-miR-4310	CLIP-seq
MIRT1012210	hsa-miR-4459	CLIP-seq
MIRT1012211	hsa-miR-4480	CLIP-seq
MIRT1012212	hsa-miR-4650-5p	CLIP-seq
MIRT1012213	hsa-miR-4722-5p	CLIP-seq
MIRT1012214	hsa-miR-4724-5p	CLIP-seq
MIRT1012215	hsa-miR-4728-5p	CLIP-seq
MIRT1012216	hsa-miR-483-3p	CLIP-seq
MIRT1012217	hsa-miR-519a	CLIP-seq
MIRT1012218	hsa-miR-519b-3p	CLIP-seq
MIRT1012219	hsa-miR-519c-3p	CLIP-seq
MIRT1012220	hsa-miR-532-3p	CLIP-seq
MIRT1012221	hsa-miR-569	CLIP-seq
MIRT1012222	hsa-miR-876-5p	CLIP-seq
MIRT1999884	hsa-miR-137	CLIP-seq
MIRT1012187	hsa-miR-186	CLIP-seq
MIRT1012188	hsa-miR-188-3p	CLIP-seq
MIRT1012190	hsa-miR-200b	CLIP-seq
MIRT1012191	hsa-miR-200c	CLIP-seq
MIRT1012192	hsa-miR-203	CLIP-seq
MIRT1012193	hsa-miR-296-3p	CLIP-seq
MIRT1012194	hsa-miR-3122	CLIP-seq
MIRT1999885	hsa-miR-3163	CLIP-seq
MIRT1012196	hsa-miR-330-3p	CLIP-seq
MIRT1012198	hsa-miR-34c-3p	CLIP-seq
MIRT1012199	hsa-miR-3613-3p	CLIP-seq
MIRT1012201	hsa-miR-3689a-3p	CLIP-seq
MIRT1012202	hsa-miR-3689c	CLIP-seq
MIRT1012204	hsa-miR-3913-5p	CLIP-seq
MIRT1012205	hsa-miR-3926	CLIP-seq
MIRT1999886	hsa-miR-421	CLIP-seq
MIRT1012208	hsa-miR-429	CLIP-seq
MIRT1999887	hsa-miR-4709-5p	CLIP-seq
MIRT1012214	hsa-miR-4724-5p	CLIP-seq
MIRT1012215	hsa-miR-4728-5p	CLIP-seq
MIRT1012216	hsa-miR-483-3p	CLIP-seq
MIRT1999888	hsa-miR-496	CLIP-seq
MIRT1999889	hsa-miR-505	CLIP-seq
MIRT1012220	hsa-miR-532-3p	CLIP-seq
MIRT1999890	hsa-miR-550a	CLIP-seq
MIRT1012221	hsa-miR-569	CLIP-seq
MIRT1999891	hsa-miR-587	CLIP-seq
MIRT1012194	hsa-miR-3122	CLIP-seq
MIRT1012196	hsa-miR-330-3p	CLIP-seq
MIRT1012201	hsa-miR-3689a-3p	CLIP-seq
MIRT1012202	hsa-miR-3689c	CLIP-seq
MIRT1012204	hsa-miR-3913-5p	CLIP-seq
MIRT1012205	hsa-miR-3926	CLIP-seq
MIRT1012207	hsa-miR-3944-5p	CLIP-seq
MIRT1012210	hsa-miR-4459	CLIP-seq
MIRT1012213	hsa-miR-4722-5p	CLIP-seq
MIRT1012215	hsa-miR-4728-5p	CLIP-seq
MIRT1012217	hsa-miR-519a	CLIP-seq
MIRT1012218	hsa-miR-519b-3p	CLIP-seq
MIRT1012219	hsa-miR-519c-3p	CLIP-seq
MIRT1999891	hsa-miR-587	CLIP-seq
MIRT1012194	hsa-miR-3122	CLIP-seq
MIRT1012197	hsa-miR-338-3p	CLIP-seq
MIRT1012201	hsa-miR-3689a-3p	CLIP-seq
MIRT1012202	hsa-miR-3689c	CLIP-seq
MIRT1012204	hsa-miR-3913-5p	CLIP-seq
MIRT1012205	hsa-miR-3926	CLIP-seq
MIRT1012209	hsa-miR-4310	CLIP-seq
MIRT1012215	hsa-miR-4728-5p	CLIP-seq
MIRT2537099	hsa-miR-101	CLIP-seq
MIRT2537100	hsa-miR-144	CLIP-seq
MIRT2537101	hsa-miR-1827	CLIP-seq
MIRT2537102	hsa-miR-1914	CLIP-seq
MIRT2537103	hsa-miR-2114	CLIP-seq
MIRT1012194	hsa-miR-3122	CLIP-seq
MIRT1012196	hsa-miR-330-3p	CLIP-seq
MIRT1012197	hsa-miR-338-3p	CLIP-seq
MIRT1012199	hsa-miR-3613-3p	CLIP-seq
MIRT1012201	hsa-miR-3689a-3p	CLIP-seq
MIRT1012202	hsa-miR-3689c	CLIP-seq
MIRT1012204	hsa-miR-3913-5p	CLIP-seq
MIRT1012205	hsa-miR-3926	CLIP-seq
MIRT2537104	hsa-miR-3929	CLIP-seq
MIRT2537105	hsa-miR-3934	CLIP-seq
MIRT1012209	hsa-miR-4310	CLIP-seq
MIRT2537106	hsa-miR-4419b	CLIP-seq
MIRT2537107	hsa-miR-4478	CLIP-seq
MIRT2537108	hsa-miR-4649-3p	CLIP-seq
MIRT2537109	hsa-miR-4662a-5p	CLIP-seq
MIRT2537110	hsa-miR-4676-5p	CLIP-seq
MIRT1012215	hsa-miR-4728-5p	CLIP-seq
MIRT2537111	hsa-miR-4762-5p	CLIP-seq
MIRT2537112	hsa-miR-485-5p	CLIP-seq
MIRT2537113	hsa-miR-520d-5p	CLIP-seq
MIRT2537114	hsa-miR-524-5p	CLIP-seq
MIRT1999890	hsa-miR-550a	CLIP-seq
MIRT2537115	hsa-miR-575	CLIP-seq
MIRT2537116	hsa-miR-582-5p	CLIP-seq
MIRT2537099	hsa-miR-101	CLIP-seq
MIRT2537100	hsa-miR-144	CLIP-seq
MIRT2537101	hsa-miR-1827	CLIP-seq
MIRT2537102	hsa-miR-1914	CLIP-seq
MIRT2537103	hsa-miR-2114	CLIP-seq
MIRT1012194	hsa-miR-3122	CLIP-seq
MIRT2681463	hsa-miR-3161	CLIP-seq
MIRT1012197	hsa-miR-338-3p	CLIP-seq
MIRT1012199	hsa-miR-3613-3p	CLIP-seq
MIRT1012201	hsa-miR-3689a-3p	CLIP-seq
MIRT1012202	hsa-miR-3689c	CLIP-seq
MIRT1012204	hsa-miR-3913-5p	CLIP-seq
MIRT1012205	hsa-miR-3926	CLIP-seq
MIRT2537104	hsa-miR-3929	CLIP-seq
MIRT2537105	hsa-miR-3934	CLIP-seq
MIRT2681464	hsa-miR-4277	CLIP-seq
MIRT1012209	hsa-miR-4310	CLIP-seq
MIRT2537106	hsa-miR-4419b	CLIP-seq
MIRT2537107	hsa-miR-4478	CLIP-seq
MIRT2537108	hsa-miR-4649-3p	CLIP-seq
MIRT2537109	hsa-miR-4662a-5p	CLIP-seq
MIRT2537110	hsa-miR-4676-5p	CLIP-seq
MIRT1012215	hsa-miR-4728-5p	CLIP-seq
MIRT2537111	hsa-miR-4762-5p	CLIP-seq
MIRT2537112	hsa-miR-485-5p	CLIP-seq
MIRT2537113	hsa-miR-520d-5p	CLIP-seq
MIRT2537114	hsa-miR-524-5p	CLIP-seq
MIRT1999890	hsa-miR-550a	CLIP-seq
MIRT2537115	hsa-miR-575	CLIP-seq
MIRT2537116	hsa-miR-582-5p	CLIP-seq
MIRT2681465	hsa-miR-630	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003360	Process	Brainstem development	IEA
GO:0004637	Function	Phosphoribosylamine-glycine ligase activity	IBA	21873635
GO:0004637	Function	Phosphoribosylamine-glycine ligase activity	TAS
GO:0004641	Function	Phosphoribosylformylglycinamidine cyclo-ligase activity	IBA	21873635
GO:0004641	Function	Phosphoribosylformylglycinamidine cyclo-ligase activity	TAS
GO:0004644	Function	Phosphoribosylglycinamide formyltransferase activity	TAS
GO:0005524	Function	ATP binding	IEA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0006164	Process	Purine nucleotide biosynthetic process	IBA	21873635
GO:0006189	Process	'de novo' IMP biosynthetic process	IEA
GO:0006544	Process	Glycine metabolic process	IEA
GO:0009168	Process	Purine ribonucleoside monophosphate biosynthetic process	TAS
GO:0010033	Process	Response to organic substance	IEA
GO:0010035	Process	Response to inorganic substance	IEA
GO:0021549	Process	Cerebellum development	IEA
GO:0021987	Process	Cerebral cortex development	IEA
GO:0046084	Process	Adenine biosynthetic process	IBA	21873635
GO:0046654	Process	Tetrahydrofolate biosynthetic process	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337

Other IDs

• MIM: 138440
• HGNC: 4163
• e!Ensembl: ENSG00000159131

Protein

• UniProt ID: P22102
• Protein name: Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.
• Protein function: Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway. {ECO:0000305|PubMed:12450384, ECO:0000305|PubMed:12755606, ECO:0000305|PubMed:20631005, ECO:0000305|PubMed:2183217}
• PDB: 1MEJ, 1MEN, 1MEO, 1NJS, 1RBM, 1RBQ, 1RBY, 1RBZ, 1RC0, 1RC1, 1ZLX, 1ZLY, 2QK4, 2V9Y, 4EW1, 4EW2, 4EW3, 4ZYT, 4ZYU, 4ZYV, 4ZYW, 4ZYX, 4ZYY, 4ZYZ, 4ZZ0, 4ZZ1, 4ZZ2, 4ZZ3, 5J9F, 7JG0, 7JG3, 7JG4, 8FDX, 8FDY, 8FE0, 8FJV, 8FJW, 8FJX, 8FJY, 9NX6
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02844	GARS_N	3 → 104	Phosphoribosylglycinamide synthetase, N domain	Domain
  PF01071	GARS_A	105 → 298	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain	Domain
  PF02843	GARS_C	334 → 424	Phosphoribosylglycinamide synthetase, C domain	Domain
  PF00586	AIRS	474 → 593	AIR synthase related protein, N-terminal domain	Domain
  PF02769	AIRS_C	606 → 777	AIR synthase related protein, C-terminal domain	Domain
  PF00551	Formyl_trans_N	808 → 988	Formyl transferase	Domain

• Sequence:

  MAARVLIIGSGGREHTLAWKLAQSHHVKQVLVAPGNAGTACSEKISNTAISISDHTALAQ
  FCKEKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGPTAEAAQLESSKRFAKEFMDRHGIP
  TAQWKAFTKPEEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAF
  GAAGETIVIEELLDGEEVSCLCFTDGKTVAPMPPAQDHKRLLEGDGGPNTGGMGAYCPAP
  QVSNDLLLKIKDTVLQRTVDGMQQEGTPYTGILYAGIMLTKNGPKVLEFNCRFGDPECQV
  ILPLLKSDLYEVIQSTLDGLLCTSLPVWLENHTALTVVMASKGYPGDYTKGVEITGFPEA
  QALGLEVFHAGTALKNGKVVTHGGRVLAVTAIRENLISALEEAKKGLAAIKFEGAIYRKD
  VGFRAIAFLQQPRSLTYKESGVDIAAGNMLVKKIQPLAKATSRSGCKVDLGGFAGLFDLK
  AAGFKDPLLASGTDGVGTKLKIAQLCNKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
  GKLDLSVTEAVVAGIAKACGKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
  HLERITEGDVVVGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTR
  IYSHSLLPVLRSGHVKAFAHITGGGLLENIPRVLPEKLGVDLDAQTWRIPRVFSWLQQEG
  HLSEEEMARTFNCGVGAVLVVSKEQTEQILRDIQQHKEEAWVIGSVVARAEGSPRVKVKN
  LIESMQINGSVLKNGSLTNHFSFEKKKARVAVLISGTGSNLQALIDSTREPNSSAQIDIV
  ISNKAAVAGLDKAERAGIPTRVINHKLYKNRVEFDSAIDLVLEEFSIDIVCLAGFMRILS
  GPFVQKWNGKMLNIHPSLLPSFKGSNAHEQALETGVTVTGCTVHFVAEDVDAGQIILQEA
  VPVKRGDTVATLSERVKLAEHKIFPAALQLVASGTVQLGENGKICWVKEE

• Sequence length: 1010

Pathways

KEGG:

Purine metabolism
One carbon pool by folate
Metabolic pathways
Antifolate resistance

Reactome:

Purine ribonucleoside monophosphate biosynthesis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Charcot-marie-tooth disease	Autosomal dominant Charcot-Marie-Tooth disease type 2D	rs137852739, rs137852737, rs118203972, rs118203974, rs267607183, rs267606878, rs121908287, rs1562648373, rs121908288, rs1368013631, rs28940291, rs28940292, rs28940293, rs28940294, rs28940295, rs28940296, rs119103261, rs119103262, rs119103263, rs119103265, rs119103266, rs119103267, rs119103268, rs80338924, rs80338932, rs80338933, rs80338934, rs104894351, rs104894345, rs120074137, rs120074138, rs120074139, rs104894075, rs104894076, rs104894077, rs28937906, rs104894078, rs104894079, rs104894080, rs121908114, rs587777608, rs758843908, rs137852972, rs137852973, rs137852975, rs121908160, rs104894714, rs104894715, rs104894706, rs104894707, rs104894708, rs119482081, rs119482083, rs119482082, rs121912632, rs121912633, rs77975504, rs121912637, rs267607143, rs267607144, rs267607145, rs267607146, rs119483085, rs113994102, rs606231157, rs606231158, rs104894519, rs104894520, rs104894521, rs104894522, rs111033171, rs137853022, rs28939712, rs121908833, rs121908834, rs786200893, rs121434402, rs121434403, rs121434404, rs121909089, rs121909090, rs121909091, rs121909092, rs121909095, rs267606772, rs121909078, rs121909079, rs28939680, rs29001571, rs28937568, rs28937569, rs28939681, rs104894020, rs121909112, rs267607194, rs587776688, rs104894617, rs104894618, rs104894620, rs104894621, rs104894622, rs104894623, rs80338763, rs104894626, rs104894627, rs28936682, rs104894625, rs267606621, rs137852665, rs137852666, rs786205089, rs137852669, rs137852643, rs137852644, rs137852646, rs199476138, rs80338732, rs104894810, rs104894811, rs104894812, rs104894814, rs104894818, rs104894819, rs104894821, rs104894822, rs104894824, rs267606672, rs28933979, rs121918070, rs121918071, rs76992529, rs59443585, rs28928910, rs60261494, rs62636505, rs121913663, rs121913583, rs121913584, rs121913585, rs121913586, rs2102257349, rs121913587, rs121913588, rs121913589, rs121913590, rs121913594, rs121913595, rs121913596, rs121913597, rs121913598, rs121913599, rs121913601, rs121913602, rs121913603, rs1558154193, rs58932704, rs57520892, rs28933091, rs28933092, rs60864230, rs57920071, rs61282106, rs61672878, rs58596362, rs28933093, rs58048078, rs121912496, rs60458016, rs121909721, rs121909723, rs121909724, rs104894159, rs104894161, rs121434563, rs267607148, rs267607149, rs387906324, rs116840818, rs116840819, rs116840815, rs116840822, rs116840821, rs137852736, rs137852738, rs80338922, rs80338925, rs80338926, rs80338929, rs80338931, rs80338936, rs80338937, rs80338921, rs267607243, rs199473690, rs199422214, rs387906738, rs606231229, rs387906902, rs387906904, rs387906905, rs1555365597, rs387906990, rs387906991, rs387907032, rs786200930, rs387907035, rs387907036, rs387907037, rs387907038, rs387907242, rs386134243, rs267607578, rs147952488, rs267607261, rs267607263, rs267607257, rs267607258, rs281865060, rs63749871, rs397514494, rs397514534, rs606231237, rs397515432, rs281865136, rs281865137, rs281865121, rs281865123, rs281865124, rs281865125, rs281865128, rs267607247, rs281865134, rs281865135, rs58982919, rs1564287793, rs387907340, rs387907341, rs397517888, rs397517889, rs57508089, rs58013325, rs56984562, rs267607646, rs58917027, rs397517904, rs61195471, rs60682848, rs267607573, rs397517908, rs58978449, rs397517909, rs267607593, rs397517911, rs56816490, rs397517915, rs267607554, rs397515441, rs397515442, rs786200937, rs587776986, rs397509411, rs397509412, rs397515454, rs397515455, rs61295588, rs62636503, rs61491953, rs58332872, rs267607555, rs267607644, rs267607617, rs267607567, rs267607634, rs267607575, rs267607590, rs267607545, rs57983345, rs267607620, rs267607618, rs267607577, rs58541611, rs267607637, rs267607598, rs267607638, rs267607597, rs267607599, rs267607550, rs267607552, rs58100028, rs57629361, rs267607592, rs267607581, rs61444459, rs56793579, rs59270054, rs59040894, rs267607569, rs60652225, rs61661343, rs267607570, rs267607542, rs59026483, rs267607571, rs80356807, rs267607584, rs267607609, rs57207746, rs267607587, rs58327533, rs59332535, rs61578124, rs267607632, rs59914820, rs267607591, rs59684335, rs267607645, rs60872029, rs267607614, rs59301204, rs587777063, rs587777838, rs515726153, rs515726154, rs515726162, rs587780564, rs587777606, rs587777877, rs587777878, rs587777876, rs587777875, rs587777880, rs587777715, rs199927590, rs587781250, rs587783595, rs587783596, rs587783597, rs587783598, rs713993043, rs372000714, rs724159994, rs724159959, rs111569862, rs730882139, rs730882140, rs781140315, rs786204003, rs786204215, rs786204119, rs786204095, rs786204123, rs786205157, rs786205207, rs191346286, rs794727035, rs756928158, rs797044758, rs794728598, rs794728604, rs794728589, rs794728597, rs794728606, rs794728593, rs794728610, rs267607623, rs1553265865, rs794728613, rs794729198, rs756880678, rs797044802, rs797044803, rs796052862, rs797044845, rs797045102, rs797044941, rs797044913, rs797044901, rs797044918, rs797045177, rs797045039, rs863224069, rs863224074, rs777604559, rs782490558, rs782190413, rs863224842, rs863224449, rs863224520, rs863224454, rs863224781, rs776221160, rs863224516, rs863224472, rs863224613, rs779696968, rs863224471, rs863224969, rs863224970, rs863224967, rs863224968, rs863225025, rs371856018, rs770546306, rs377357931, rs863225022, rs863225023, rs745663149, rs863225029, rs863225028, rs863225027, rs754521978, rs863224971, rs863224974, rs863224972, rs863224973, rs139643362, rs746581714, rs780594709, rs143473232, rs863225122, rs863225123, rs863225124, rs756614404, rs782726390, rs864309500, rs864309501, rs864309502, rs864309503, rs864309504, rs864309526, rs864309525, rs864309709, rs864309705, rs864622480, rs864622732, rs864622664, rs370115218, rs864622663, rs770272088, rs864622501, rs864622273, rs864622678, rs864622180, rs864622215, rs876657411, rs876657412, rs749850181, rs876661208, rs145226920, rs775019409, rs876661252, rs876661269, rs28933090, rs878855234, rs878855092, rs138226428, rs757563721, rs1057519023, rs879253751, rs879253752, rs1057519024, rs765591205, rs879253755, rs879253777, rs879253861, rs763492075, rs879253863, rs879253859, rs879253869, rs879253858, rs879253957, rs879254011, rs879253939, rs879253932, rs879254081, rs879254054, rs879254109, rs760730366, rs879253926, rs747768373, rs879254290, rs879253927, rs770501034, rs201060167, rs368775789, rs879254085, rs879253881, rs757725348, rs879253954, rs121909093, rs879254086, rs773009397, rs879253919, rs879254047, rs879254012, rs879253935, rs879254096, rs756000896, rs879253946, rs879254098, rs879253909, rs879254099, rs886037934, rs764717219, rs886039361, rs886039755, rs886041051, rs886041386, rs886041200, rs886043109, rs886043774, rs766160589, rs772320287, rs753207473, rs876661155, rs762730861, rs749890533, rs1057517987, rs1057518021, rs774799167, rs267607087, rs1057517942, rs1057518083, rs773690764, rs1057518961, rs80338930, rs375401970, rs104894624, rs1057520778, rs1060501918, rs879254210, rs1060501925, rs1060501920, rs1060501915, rs1060502215, rs1060502210, rs1060502214, rs1060502211, rs1060503423, rs1060503418, rs1060503420, rs1553259651, rs1060502838, rs538412810, rs1060500979, rs1060502839, rs1060503021, rs1060500978, rs1060503092, rs759312530, rs756461496, rs749558026, rs1060499999, rs1555057316, rs1060500001, rs778377449, rs1060501904, rs781347519, rs906563423, rs1060501002, rs1060500998, rs1555937150, rs1060501004, rs1060501000, rs1064794316, rs1064795818, rs886044113, rs749361266, rs750529207, rs776005417, rs770043095, rs1064796370, rs1064795077, rs1064793771, rs747912710, rs1064795696, rs751035912, rs1064796765, rs1064795664, rs1064793101, rs1064796495, rs1064794244, rs60290646, rs1064797314, rs1085307888, rs749320057, rs772823083, rs1131691980, rs1131691852, rs1131691657, rs1131691322, rs200435950, rs1395068713, rs1553765316, rs1555938796, rs1553265433, rs780302064, rs515726215, rs1247055716, rs1554614680, rs1553259697, rs1429859627, rs764928653, rs1555937009, rs1556300610, rs1556300621, rs572010627, rs759785462, rs1554122541, rs745790694, rs1422978230, rs771606350, rs1555800610, rs1555937020, rs1555937122, rs1555937197, rs1555937233, rs1555937270, rs759844257, rs1458700065, rs1553259663, rs765231758, rs1554122847, rs1323153568, rs773598203, rs1555937180, rs1553141686, rs1553142436, rs1553146559, rs778937659, rs1553261891, rs1553265165, rs1553265660, rs267607557, rs1553259648, rs1553265455, rs1553266024, rs267607588, rs1553259649, rs1553259703, rs1553259511, rs1553259662, rs1463859150, rs1198337036, rs1554121691, rs1064795123, rs1554338260, rs150110356, rs1554337974, rs747659617, rs1554548334, rs1554763017, rs1221804567, rs556827873, rs1554762671, rs760386662, rs1554982914, rs1327664377, rs1555373599, rs1555715869, rs1555936999, rs1555937084, rs1555937135, rs1555937194, rs1555937218, rs1555937015, rs1555937223, rs1553851490, rs753287764, rs774294963, rs991227431, rs1553174566, rs1553265755, rs763937206, rs1555937143, rs1553264668, rs57730570, rs1555381416, rs1555937168, rs113055360, rs1202430946, rs1266361856, rs530391015, rs1553143890, rs1553146551, rs1553142428, rs1064793170, rs1553144086, rs1553261855, rs1553261982, rs1553264593, rs747711259, rs1553143165, rs1553265328, rs1553265342, rs1553265647, rs1553265760, rs1553259566, rs1553259643, rs1407955132, rs1553259683, rs1553259691, rs1553265606, rs1553265924, rs1553259790, rs1222150652, rs773554464, rs1554121665, rs1554122560, rs1554120331, rs1554300952, rs1554303800, rs557327165, rs1554338262, rs1554338641, rs757417962, rs1554754342, rs1554547986, rs1345228128, rs1554753670, rs1554763035, rs779654686, rs1289139464, rs1555060614, rs1555061026, rs1358449243, rs1555223595, rs1555540896, rs1426969421, rs1555568475, rs1301129751, rs1555936989, rs1555937082, rs1241595912, rs1554120215, rs1553190285, rs1553192091, rs1553192086, rs1554107200, rs1553259707, rs1555060024, rs1555542415, rs1385904344, rs104894598, rs1553265736, rs1565929090, rs1000091588, rs1557537223, rs1557522794, rs1557524703, rs1340894696, rs1558133157, rs1017715903, rs1558115754, rs1558115970, rs267607561, rs1558154644, rs1557522849, rs1557525153, rs1557539119, rs1228406418, rs1558133435, rs1558153994, rs1558154754, rs376054085, rs1557525005, rs1557537346, rs1558154010, rs761972717, rs1561764735, rs1561765311, rs763949764, rs766728475, rs1561764925, rs1561770798, rs375431837, rs751448371, rs1270869520, rs770111639, rs751292488, rs1565115957, rs761035569, rs1183978180, rs750712213, rs1554309093, rs746455518, rs1564872328, rs752649372, rs1393673267, rs1565351898, rs749012928, rs866662905, rs1567704791, rs752192677, rs774667470, rs1564923441, rs746903992, rs1569215025, rs1569215351, rs771022595, rs1567019064, rs574861276, rs1569215061, rs1567604571, rs1569215346, rs1568710514, rs1569214985, rs1555937166, rs1564287871, rs1557525000, rs1558154149, rs1567698872, rs757937208, rs1568704829, rs138199394, rs1565869918, rs1565942358, rs1566778676, rs1563518388, rs1563518390, rs1564557037, rs1559961997, rs1559963660, rs1561764569, rs762729182, rs199615251, rs1476856429, rs1567704621, rs763758904, rs1569215443, rs1565342506, rs1571818248, rs140992482, rs1566439723, rs1182353109, rs1561770179, rs1569512576, rs869125101, rs1568708792, rs912928648, rs267607629, rs1572364243, rs1569816285, rs863224068, rs1569829894, rs1569830013, rs1569842143, rs1440006845, rs1569842714, rs1569843694, rs755065651, rs1553143852, rs1569854012, rs1569854342, rs1569868729, rs1569871830, rs375937289, rs1569889919, rs1485714154, rs1571695851, rs764992664, rs756981419, rs764816792, rs1571817146, rs1571817154, rs1571817911, rs1571817966, rs1571818312, rs1571818632, rs1456458087, rs1571818800, rs1571818819, rs1468741050, rs1571819182, rs573007540, rs1571819890, rs1571819906, rs201720099, rs1571819946, rs1571819964, rs1571819975, rs1571820143, rs1180998665, rs1571820186, rs1427063795, rs121909080, rs1580682390, rs1028404937, rs1580889866, rs147895061, rs1174949678, rs757797985, rs1580900758, rs1580901350, rs775740308, rs776090013, rs1197741113, rs1191997383, rs1554337369, rs1301948344, rs1583964560, rs1240900244, rs1583966508, rs778547659, rs1586795216, rs1586803063, rs1586803273, rs1443963090, rs1586804849, rs770658701, rs1586807387, rs1588143215, rs1589080524, rs1303837541, rs199839840, rs1590968942, rs1032796987, rs1595599240, rs1595600898, rs1555408333, rs1595163736, rs1595163851, rs1595164091, rs1594986869, rs1595430425, rs1597597534, rs1555564040, rs1597597678, rs1597597900, rs1597607532, rs11545341, rs1597608057, rs1597608086, rs1597608203, rs1597635540, rs1269225724, rs1599651549, rs1210729449, rs757771239, rs144183238, rs1599656136, rs768074428, rs753857146, rs1599662837, rs1602348530, rs1602348610, rs1602348650, rs1602348658, rs104894817, rs863224612, rs1602348786, rs1602348794, rs1602348801, rs1602348804, rs1602348820, rs1602348897, rs1602348907, rs1602348917, rs1602348981, rs876661143, rs1602349017, rs1602349021, rs1602349066, rs1602349087, rs1602349095, rs1602349112, rs1602349131, rs1602349137, rs1602349248, rs1602349264, rs1602349293, rs1602349302, rs1602349369, rs1602349383, rs1602349451, rs1602349535, rs1602349572, rs1602349603, rs1602349628, rs1602349655, rs1555937259, rs1602349716, rs1602349730, rs1064795540, rs1602349940, rs1590970875, rs1569834500, rs1569861708, rs1571685736, rs748672380, rs1232901259, rs1571818339, rs1571820401, rs143956557, rs1370011538, rs1597607514, rs1597608225, rs1597633171, rs1580917130, rs1569816194, rs1569834720, rs1569842458, rs1569842483, rs764374251, rs1569865516, rs1569882539, rs1572331707, rs1572332235, rs1572358860, rs1572359991, rs59564495, rs1572362885, rs1572363397, rs1448275854, rs1572366412, rs1572366593, rs1572367812, rs1571820100, rs1279417718, rs1580901363, rs1488999396, rs1584034430, rs1174933176, rs1586803187, rs1417699318, rs1588132672, rs775965001, rs1315010600, rs1588144707, rs1590881633, rs1590974596, rs1590997023, rs1592387932, rs1597435337, rs1597435790, rs1597446183, rs1597448762, rs1597597527, rs756689732, rs1599656507, rs1599662669, rs1555938741, rs1602496057, rs1602348726, rs1602349029, rs1602349341, rs1602350012, rs1572359505, rs113610699, rs1365042239, rs1580891465, rs1586446057, rs1580900150, rs1595597572, rs1590971080, rs776757548, rs1171462240, rs1590974546, rs1572359848, rs267607622, rs1580917136, rs1588143112, rs1599656851, rs1602485728, rs145670786, rs1602499659, rs1586807529, rs1599651726, rs2047850664, rs1588216753, rs1569842296, rs1580900473, rs1580907885, rs1583695322, rs936681187, rs1589439508, rs1590076969, rs1595597963, rs1595608413, rs373682811, rs964195568, rs1602510200, rs1602510214, rs863225270, rs1602961831, rs769429967, rs1586128143, rs1562648414, rs1228223508, rs758183257, rs1009209509, rs146342432, rs1580900970, rs1572366216, rs1190163112, rs1599652316, rs1580889913, rs1639043704, rs1639045345, rs1060501921, rs866604005, rs1639197832, rs201165591, rs1649726768, rs1651352665, rs61235244, rs1651736894, rs1670264356, rs1670288801, rs1670288858, rs121909081, rs201692212, rs1714805406, rs1714910248, rs1754097044, rs1319576439, rs1754425732, rs769986219, rs1778167481, rs1855957969, rs766951637, rs150989205, rs747130246, rs1836370529, rs1863944217, rs1413469900, rs201676628, rs1948089932, rs2047931446, rs1906290133, rs1909248652, rs2073510805, rs2079456028, rs1262031967, rs2092542190, rs2092543211, rs1602349045, rs757808220, rs2092546039, rs1639048523, rs267607640, rs1651598289, rs866895236, rs1950619177, rs1586407193, rs1011200048, rs758718584, rs145183196, rs1960348987, rs2079511684, rs1670263519, rs139052887
Distal hereditary motor neuronopathy	Distal hereditary motor neuropathy type 5	rs104894345, rs104894351, rs137852970, rs137852972, rs267607143, rs267607145, rs28939680, rs29001571, rs28937568, rs28937569, rs104894020, rs121909112, rs121909113, rs121909342, rs786205090, rs137852644, rs137852646, rs121913595, rs387906904, rs387907242, rs398123028, rs398122838, rs730880031, rs730882139, rs730882140, rs267607623, rs797044802, rs746581714, rs756614404, rs770272088, rs876661124, rs879253868, rs879254085, rs764813110, rs1060502838, rs1064796370, rs1554338260, rs137852973, rs1347223331, rs377626365, rs772217003, rs1553174566, rs1324667543, rs557327165, rs1441260635, rs1565929080, rs770593694, rs1584026191, rs372181708, rs758322672, rs1587668798, rs1587671674, rs972425138, rs1594427564, rs1594445698, rs1594453111, rs1337346956, rs1240319744, rs199839840, rs754422011, rs1595599240, rs1595600898, rs1555408333, rs774079947, rs1584034430, rs562669797, rs749383814, rs762573767, rs767263669, rs746212067, rs1182614290, rs1018405924
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382	27602772
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	25854761
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	23897011