LRRC32 (leucine rich repeat containing 32)

Gene

• Entrez ID: 2615
• Gene name: Leucine rich repeat containing 32
• Gene symbol: LRRC32
• Synonyms: CPPRDD, D11S833E, GARP
• Chromosome: 11
• Chromosome location: 11q13.5
• Summary: This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017818	hsa-miR-335-5p	Microarray	18185580
MIRT438904	hsa-miR-142-3p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	23650616
MIRT438904	hsa-miR-142-3p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	23650616
MIRT438904	hsa-miR-142-3p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	23650616
MIRT438904	hsa-miR-142-3p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	23650616
MIRT438904	hsa-miR-142-3p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	23650616
MIRT438904	hsa-miR-142-3p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	23650616
MIRT438904	hsa-miR-142-3p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	23650616
MIRT438904	hsa-miR-142-3p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	23650616
MIRT1119473	hsa-miR-146b-3p	CLIP-seq
MIRT1119474	hsa-miR-19a	CLIP-seq
MIRT1119475	hsa-miR-19b	CLIP-seq
MIRT1119476	hsa-miR-2277-3p	CLIP-seq
MIRT1119477	hsa-miR-2355-5p	CLIP-seq
MIRT1119478	hsa-miR-3202	CLIP-seq
MIRT1119479	hsa-miR-3679-3p	CLIP-seq
MIRT1119480	hsa-miR-3942-3p	CLIP-seq
MIRT1119481	hsa-miR-4328	CLIP-seq
MIRT1119482	hsa-miR-4428	CLIP-seq
MIRT1119483	hsa-miR-4533	CLIP-seq
MIRT1119484	hsa-miR-4646-5p	CLIP-seq
MIRT1119485	hsa-miR-4747-5p	CLIP-seq
MIRT1119486	hsa-miR-542-3p	CLIP-seq
MIRT1119487	hsa-miR-1184	CLIP-seq
MIRT1119488	hsa-miR-1229	CLIP-seq
MIRT1119489	hsa-miR-1254	CLIP-seq
MIRT1119490	hsa-miR-1256	CLIP-seq
MIRT1119491	hsa-miR-1301	CLIP-seq
MIRT1119473	hsa-miR-146b-3p	CLIP-seq
MIRT1119492	hsa-miR-183	CLIP-seq
MIRT1119493	hsa-miR-185	CLIP-seq
MIRT1119494	hsa-miR-216a	CLIP-seq
MIRT1119495	hsa-miR-22	CLIP-seq
MIRT1119476	hsa-miR-2277-3p	CLIP-seq
MIRT1119496	hsa-miR-3116	CLIP-seq
MIRT1119497	hsa-miR-3192	CLIP-seq
MIRT1119498	hsa-miR-4306	CLIP-seq
MIRT1119499	hsa-miR-4464	CLIP-seq
MIRT1119500	hsa-miR-4644	CLIP-seq
MIRT1119484	hsa-miR-4646-5p	CLIP-seq
MIRT1119501	hsa-miR-4660	CLIP-seq
MIRT1119485	hsa-miR-4747-5p	CLIP-seq
MIRT1119502	hsa-miR-4748	CLIP-seq
MIRT1119503	hsa-miR-4763-5p	CLIP-seq
MIRT1119504	hsa-miR-5047	CLIP-seq
MIRT1119486	hsa-miR-542-3p	CLIP-seq
MIRT1119505	hsa-miR-661	CLIP-seq
MIRT1119490	hsa-miR-1256	CLIP-seq
MIRT1119493	hsa-miR-185	CLIP-seq
MIRT2033759	hsa-miR-198	CLIP-seq
MIRT2033760	hsa-miR-2278	CLIP-seq
MIRT2033761	hsa-miR-3616-3p	CLIP-seq
MIRT1119498	hsa-miR-4306	CLIP-seq
MIRT1119500	hsa-miR-4644	CLIP-seq
MIRT2033762	hsa-miR-4693-3p	CLIP-seq
MIRT2033763	hsa-miR-4722-5p	CLIP-seq
MIRT2033764	hsa-miR-4768-3p	CLIP-seq
MIRT2033765	hsa-miR-520a-5p	CLIP-seq
MIRT2033766	hsa-miR-525-5p	CLIP-seq
MIRT2033759	hsa-miR-198	CLIP-seq
MIRT2033760	hsa-miR-2278	CLIP-seq
MIRT2033763	hsa-miR-4722-5p	CLIP-seq
MIRT2033764	hsa-miR-4768-3p	CLIP-seq
MIRT2264201	hsa-miR-4790-3p	CLIP-seq
MIRT2033765	hsa-miR-520a-5p	CLIP-seq
MIRT2033766	hsa-miR-525-5p	CLIP-seq
MIRT2264202	hsa-miR-615-5p	CLIP-seq
MIRT1119487	hsa-miR-1184	CLIP-seq
MIRT2563256	hsa-miR-122	CLIP-seq
MIRT2563257	hsa-miR-1225-3p	CLIP-seq
MIRT2563258	hsa-miR-1228	CLIP-seq
MIRT2563259	hsa-miR-1233	CLIP-seq
MIRT1119489	hsa-miR-1254	CLIP-seq
MIRT2563260	hsa-miR-1262	CLIP-seq
MIRT2563261	hsa-miR-1272	CLIP-seq
MIRT2563262	hsa-miR-1285	CLIP-seq
MIRT1119491	hsa-miR-1301	CLIP-seq
MIRT2563263	hsa-miR-133a	CLIP-seq
MIRT2563264	hsa-miR-133b	CLIP-seq
MIRT1119493	hsa-miR-185	CLIP-seq
MIRT2563265	hsa-miR-219-1-3p	CLIP-seq
MIRT1119495	hsa-miR-22	CLIP-seq
MIRT2563266	hsa-miR-2467-5p	CLIP-seq
MIRT2563267	hsa-miR-2861	CLIP-seq
MIRT2563268	hsa-miR-29a	CLIP-seq
MIRT2563269	hsa-miR-29b	CLIP-seq
MIRT2563270	hsa-miR-29c	CLIP-seq
MIRT1119496	hsa-miR-3116	CLIP-seq
MIRT2563271	hsa-miR-3119	CLIP-seq
MIRT2563272	hsa-miR-3120-3p	CLIP-seq
MIRT2563273	hsa-miR-3126-5p	CLIP-seq
MIRT2563274	hsa-miR-3148	CLIP-seq
MIRT2563275	hsa-miR-3173-3p	CLIP-seq
MIRT2563276	hsa-miR-3187-5p	CLIP-seq
MIRT2563277	hsa-miR-3188	CLIP-seq
MIRT1119497	hsa-miR-3192	CLIP-seq
MIRT2563278	hsa-miR-326	CLIP-seq
MIRT2563279	hsa-miR-330-5p	CLIP-seq
MIRT2563280	hsa-miR-3659	CLIP-seq
MIRT2563281	hsa-miR-3975	CLIP-seq
MIRT2563282	hsa-miR-4265	CLIP-seq
MIRT2563283	hsa-miR-4281	CLIP-seq
MIRT2563284	hsa-miR-4287	CLIP-seq
MIRT2563285	hsa-miR-4296	CLIP-seq
MIRT1119498	hsa-miR-4306	CLIP-seq
MIRT2563286	hsa-miR-4316	CLIP-seq
MIRT2563287	hsa-miR-4318	CLIP-seq
MIRT2563288	hsa-miR-4322	CLIP-seq
MIRT2563289	hsa-miR-4417	CLIP-seq
MIRT2563290	hsa-miR-4419a	CLIP-seq
MIRT2563291	hsa-miR-4426	CLIP-seq
MIRT1119482	hsa-miR-4428	CLIP-seq
MIRT2563292	hsa-miR-4455	CLIP-seq
MIRT2563293	hsa-miR-4469	CLIP-seq
MIRT2563294	hsa-miR-4486	CLIP-seq
MIRT2563295	hsa-miR-4494	CLIP-seq
MIRT2563296	hsa-miR-4510	CLIP-seq
MIRT2563297	hsa-miR-4521	CLIP-seq
MIRT2563298	hsa-miR-4522	CLIP-seq
MIRT2563299	hsa-miR-4640-5p	CLIP-seq
MIRT1119500	hsa-miR-4644	CLIP-seq
MIRT2563300	hsa-miR-4645-5p	CLIP-seq
MIRT2563301	hsa-miR-4647	CLIP-seq
MIRT1119501	hsa-miR-4660	CLIP-seq
MIRT2563302	hsa-miR-4662b	CLIP-seq
MIRT2563303	hsa-miR-4668-5p	CLIP-seq
MIRT2563304	hsa-miR-4673	CLIP-seq
MIRT2563305	hsa-miR-4685-3p	CLIP-seq
MIRT2563306	hsa-miR-4701-3p	CLIP-seq
MIRT2563307	hsa-miR-4710	CLIP-seq
MIRT2563308	hsa-miR-4726-5p	CLIP-seq
MIRT2563309	hsa-miR-4733-5p	CLIP-seq
MIRT2563310	hsa-miR-4757-5p	CLIP-seq
MIRT1119503	hsa-miR-4763-5p	CLIP-seq
MIRT2563311	hsa-miR-485-5p	CLIP-seq
MIRT1119504	hsa-miR-5047	CLIP-seq
MIRT2563312	hsa-miR-526b	CLIP-seq
MIRT2563313	hsa-miR-545	CLIP-seq
MIRT2563314	hsa-miR-548p	CLIP-seq
MIRT2563315	hsa-miR-571	CLIP-seq
MIRT2563316	hsa-miR-609	CLIP-seq
MIRT2563317	hsa-miR-612	CLIP-seq
MIRT2563318	hsa-miR-624	CLIP-seq
MIRT1119505	hsa-miR-661	CLIP-seq
MIRT2563319	hsa-miR-765	CLIP-seq
MIRT1119487	hsa-miR-1184	CLIP-seq
MIRT2563256	hsa-miR-122	CLIP-seq
MIRT2563257	hsa-miR-1225-3p	CLIP-seq
MIRT2563258	hsa-miR-1228	CLIP-seq
MIRT2563259	hsa-miR-1233	CLIP-seq
MIRT1119489	hsa-miR-1254	CLIP-seq
MIRT2563260	hsa-miR-1262	CLIP-seq
MIRT2563261	hsa-miR-1272	CLIP-seq
MIRT2563262	hsa-miR-1285	CLIP-seq
MIRT2684187	hsa-miR-129-3p	CLIP-seq
MIRT1119491	hsa-miR-1301	CLIP-seq
MIRT2563263	hsa-miR-133a	CLIP-seq
MIRT2563264	hsa-miR-133b	CLIP-seq
MIRT1119493	hsa-miR-185	CLIP-seq
MIRT2684188	hsa-miR-193a-5p	CLIP-seq
MIRT1119474	hsa-miR-19a	CLIP-seq
MIRT1119475	hsa-miR-19b	CLIP-seq
MIRT2684189	hsa-miR-2117	CLIP-seq
MIRT2563265	hsa-miR-219-1-3p	CLIP-seq
MIRT1119495	hsa-miR-22	CLIP-seq
MIRT2563266	hsa-miR-2467-5p	CLIP-seq
MIRT2563267	hsa-miR-2861	CLIP-seq
MIRT2563268	hsa-miR-29a	CLIP-seq
MIRT2563269	hsa-miR-29b	CLIP-seq
MIRT2563270	hsa-miR-29c	CLIP-seq
MIRT1119496	hsa-miR-3116	CLIP-seq
MIRT2563271	hsa-miR-3119	CLIP-seq
MIRT2563272	hsa-miR-3120-3p	CLIP-seq
MIRT2563273	hsa-miR-3126-5p	CLIP-seq
MIRT2684190	hsa-miR-3169	CLIP-seq
MIRT2563275	hsa-miR-3173-3p	CLIP-seq
MIRT2563276	hsa-miR-3187-5p	CLIP-seq
MIRT2563277	hsa-miR-3188	CLIP-seq
MIRT1119497	hsa-miR-3192	CLIP-seq
MIRT2684191	hsa-miR-320e	CLIP-seq
MIRT2563278	hsa-miR-326	CLIP-seq
MIRT2684192	hsa-miR-329	CLIP-seq
MIRT2563279	hsa-miR-330-5p	CLIP-seq
MIRT2684193	hsa-miR-346	CLIP-seq
MIRT2684194	hsa-miR-3607-3p	CLIP-seq
MIRT2684195	hsa-miR-362-3p	CLIP-seq
MIRT2563280	hsa-miR-3659	CLIP-seq
MIRT2684196	hsa-miR-3671	CLIP-seq
MIRT2684197	hsa-miR-3686	CLIP-seq
MIRT2684198	hsa-miR-3907	CLIP-seq
MIRT2684199	hsa-miR-3918	CLIP-seq
MIRT2563281	hsa-miR-3975	CLIP-seq
MIRT2563282	hsa-miR-4265	CLIP-seq
MIRT2684200	hsa-miR-4273	CLIP-seq
MIRT2684201	hsa-miR-4279	CLIP-seq
MIRT2563283	hsa-miR-4281	CLIP-seq
MIRT2563284	hsa-miR-4287	CLIP-seq
MIRT2563285	hsa-miR-4296	CLIP-seq
MIRT1119498	hsa-miR-4306	CLIP-seq
MIRT2563286	hsa-miR-4316	CLIP-seq
MIRT2563287	hsa-miR-4318	CLIP-seq
MIRT2684202	hsa-miR-4320	CLIP-seq
MIRT2563288	hsa-miR-4322	CLIP-seq
MIRT2563289	hsa-miR-4417	CLIP-seq
MIRT2563290	hsa-miR-4419a	CLIP-seq
MIRT2563291	hsa-miR-4426	CLIP-seq
MIRT1119482	hsa-miR-4428	CLIP-seq
MIRT2563292	hsa-miR-4455	CLIP-seq
MIRT2684203	hsa-miR-4457	CLIP-seq
MIRT2563293	hsa-miR-4469	CLIP-seq
MIRT2684204	hsa-miR-4480	CLIP-seq
MIRT2563294	hsa-miR-4486	CLIP-seq
MIRT2563295	hsa-miR-4494	CLIP-seq
MIRT2563296	hsa-miR-4510	CLIP-seq
MIRT2684205	hsa-miR-4512	CLIP-seq
MIRT2684206	hsa-miR-4515	CLIP-seq
MIRT2563297	hsa-miR-4521	CLIP-seq
MIRT2563298	hsa-miR-4522	CLIP-seq
MIRT2684207	hsa-miR-4527	CLIP-seq
MIRT2563299	hsa-miR-4640-5p	CLIP-seq
MIRT1119500	hsa-miR-4644	CLIP-seq
MIRT2563300	hsa-miR-4645-5p	CLIP-seq
MIRT2563301	hsa-miR-4647	CLIP-seq
MIRT1119501	hsa-miR-4660	CLIP-seq
MIRT2563302	hsa-miR-4662b	CLIP-seq
MIRT2563304	hsa-miR-4673	CLIP-seq
MIRT2563305	hsa-miR-4685-3p	CLIP-seq
MIRT2684208	hsa-miR-4685-5p	CLIP-seq
MIRT2684209	hsa-miR-4687-5p	CLIP-seq
MIRT2684210	hsa-miR-4694-5p	CLIP-seq
MIRT2563306	hsa-miR-4701-3p	CLIP-seq
MIRT2563307	hsa-miR-4710	CLIP-seq
MIRT2563308	hsa-miR-4726-5p	CLIP-seq
MIRT2684211	hsa-miR-4727-5p	CLIP-seq
MIRT2684212	hsa-miR-4731-3p	CLIP-seq
MIRT2684213	hsa-miR-4733-3p	CLIP-seq
MIRT2563309	hsa-miR-4733-5p	CLIP-seq
MIRT2563310	hsa-miR-4757-5p	CLIP-seq
MIRT2684214	hsa-miR-4762-5p	CLIP-seq
MIRT1119503	hsa-miR-4763-5p	CLIP-seq
MIRT2684215	hsa-miR-4769-3p	CLIP-seq
MIRT2684216	hsa-miR-4801	CLIP-seq
MIRT2563311	hsa-miR-485-5p	CLIP-seq
MIRT1119504	hsa-miR-5047	CLIP-seq
MIRT2563312	hsa-miR-526b	CLIP-seq
MIRT2563313	hsa-miR-545	CLIP-seq
MIRT2563314	hsa-miR-548p	CLIP-seq
MIRT2563315	hsa-miR-571	CLIP-seq
MIRT2684217	hsa-miR-607	CLIP-seq
MIRT2563316	hsa-miR-609	CLIP-seq
MIRT2563317	hsa-miR-612	CLIP-seq
MIRT2563318	hsa-miR-624	CLIP-seq
MIRT1119505	hsa-miR-661	CLIP-seq
MIRT2563319	hsa-miR-765	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001818	Process	Negative regulation of cytokine production	IEA
GO:0005515	Function	Protein binding	IPI	19651619, 26126825, 28514442
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005887	Component	Integral component of plasma membrane	TAS	8180135
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IDA	19750484
GO:0009986	Component	Cell surface	IDA	19651619, 19750484
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0031012	Component	Extracellular matrix	IBA	21873635
GO:0046007	Process	Negative regulation of activated T cell proliferation	IEA
GO:0050431	Function	Transforming growth factor beta binding	IDA	22278742
GO:0050431	Function	Transforming growth factor beta binding	IPI	19651619
GO:0062009	Process	Secondary palate development	ISS
GO:1901388	Process	Regulation of transforming growth factor beta activation	IDA	19651619, 19750484, 22278742
GO:1901398	Process	Regulation of transforming growth factor beta3 activation	IEA

Other IDs

• MIM: 137207
• HGNC: 4161
• e!Ensembl: ENSG00000137507

Protein

• UniProt ID: Q14392
• Protein name: Transforming growth factor beta activator LRRC32 (Garpin) (Glycoprotein A repetitions predominant) (GARP) (Leucine-rich repeat-containing protein 32)
• Protein function: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19651619, PubMed:19750484, PubMed:22278742). Associates
• PDB: 6GFF, 8C7H, 8VSB, 8VSC, 8VSD
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01462	LRRNT	21 → 48	Leucine rich repeat N-terminal domain	Family
  PF13855	LRR_8	49 → 109	Leucine rich repeat	Repeat
  PF13855	LRR_8	149 → 209	Leucine rich repeat	Repeat
  PF13855	LRR_8	514 → 573	Leucine rich repeat	Repeat

• Sequence:

  MRPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQ
  LRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGL
  GPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDL
  HSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQ
  AEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSAL
  PLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLG
  SLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGN
  RVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPGLE
  VATGALGGLEASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEV
  LDLRNNSFSLLPGSAMGGLETSLRRLYLQGNPLSCCGNGWLAAQLHQGRVDVDATQDLIC
  RFSSQEEVSLSHVRPEDCEKGGLKNINLIIILTFILVSAILLTTLAACCCVRRQKFNQQY
  KA

• Sequence length: 662

Pathways

KEGG:

TGF-beta signaling pathway

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Developmental delay	Global developmental delay	rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291, rs886041382, rs1057518991, rs1057518699, rs753254213, rs748294403, rs762552974, rs1135401795, rs1553121073, rs1553122926, rs1364690005, rs1554086554, rs1554210415, rs1554168326, rs1554776342, rs1553873247, rs1567860112, rs779009256, rs1557447255, rs1564568350, rs780011005, rs1597464953, rs1200336864, rs1569513017, rs1587459606, rs1570332505, rs748888652, rs1575155995, rs2087029320, rs1589669105, rs1601769604, rs1184981709, rs749201074

Unknown
Disease name	Disease term	dbSNP ID	References
Uranostaphyloschisis	Uranostaphyloschisis
Vitreoretinal degeneration	Vitreoretinal degeneration