GediPNet logo

TES (testin LIM domain protein)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
26136
Gene nameGene Name - the full gene name approved by the HGNC.
Testin LIM domain protein
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
TES
SynonymsGene synonyms aliases
TESS, TESS-2
ChromosomeChromosome number
7
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q31.2
SummarySummary of gene provided in NCBI Entrez Gene.
Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli ce
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019575 hsa-miR-340-5p Sequencing 20371350
MIRT020280 hsa-miR-130b-3p Sequencing 20371350
MIRT021189 hsa-miR-186-5p Sequencing 20371350
MIRT025480 hsa-miR-34a-5p Proteomics 21566225
MIRT027620 hsa-miR-98-5p Microarray 19088304
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0005515 Function Protein binding IPI 21278383, 32814053
GO:0005634 Component Nucleus HDA 21630459
GO:0005829 Component Cytosol IDA
GO:0005886 Component Plasma membrane IDA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9UGI8
Protein name Testin (TESS)
Protein function Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. {ECO:000
PDB 2IYB , 2XQN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06297 PET
109 193
PET Domain
Domain
PF00412 LIM
236 297
LIM domain
Domain
PF00412 LIM
301 357
LIM domain
Domain
Sequence
MDLENKVKKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEED
RKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQ
ALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVK
KYKSEALGVGDVK
LPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCK
LSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSE
KPR
CAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVV
CQGCHNAIDPEVQRVTYNNFSWHASTECFLCSCCSKCLIGQKFMPVEGMVFCSVECKKRM
S
Sequence length 421
Interactions View interactions
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Glioblastoma Glioblastoma, Glioblastoma Multiforme rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888 16909125
Unknown
Disease name Disease term dbSNP ID References
Giant cell glioblastoma Giant Cell Glioblastoma 16909125

| © 2021, Biomedical Informatics Centre, NIRRH |
ICMR-National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Tel: +91-22-24192104, Fax No: +91-22-24139412