Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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26084 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Rho guanine nucleotide exchange factor 26 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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ARHGEF26 |
SynonymsGene synonyms aliases
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CSGEF, HMFN1864, SGEF |
ChromosomeChromosome number
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3 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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3q25.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011] |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0001726 |
Component |
Ruffle |
IEA |
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GO:0001886 |
Process |
Endothelial cell morphogenesis |
IEA |
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GO:0005829 |
Component |
Cytosol |
TAS |
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GO:0007186 |
Process |
G protein-coupled receptor signaling pathway |
TAS |
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GO:0043065 |
Process |
Positive regulation of apoptotic process |
TAS |
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GO:0051056 |
Process |
Regulation of small GTPase mediated signal transduction |
TAS |
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GO:0090630 |
Process |
Activation of GTPase activity |
IBA |
21873635 |
GO:0097178 |
Process |
Ruffle assembly |
IEA |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
Q96DR7 |
Protein name |
Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor) |
Protein function |
Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. |
PDB |
6MYE
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Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00621 |
RhoGEF |
443 → 621 |
RhoGEF domain |
Domain |
PF00018 |
SH3_1 |
799 → 842 |
SH3 domain |
Domain |
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Sequence |
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Sequence length |
871 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs-1, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
26198764 |
Coronary artery disease |
Coronary Artery Disease |
rs137852988, rs121918313, rs-1, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537 |
28714974, 29212778, 28714975 |
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