LTN1 (listerin E3 ubiquitin protein ligase 1)

Gene

• Entrez ID: 26046
• Gene name: Listerin E3 ubiquitin protein ligase 1
• Gene symbol: LTN1
• Synonyms: C21orf10, C21orf98, RNF160, ZNF294
• Chromosome: 21
• Chromosome location: 21q21.3
• Summary: Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005158	hsa-miR-30a-5p	pSILAC	18668040
MIRT018915	hsa-miR-335-5p	Microarray	18185580
MIRT021041	hsa-miR-155-5p	Proteomics	18668040
MIRT027323	hsa-miR-101-3p	Sequencing	20371350
MIRT005158	hsa-miR-30a-5p	Proteomics	18668040
MIRT031239	hsa-miR-19b-3p	Sequencing	20371350
MIRT039228	hsa-miR-454-3p	CLASH	23622248
MIRT036814	hsa-miR-877-3p	CLASH	23622248
MIRT439763	ebv-miR-BART4-5p	HITS-CLIP	22473208
MIRT439763	ebv-miR-BART4-5p	HITS-CLIP	22473208
MIRT1122233	hsa-miR-1243	CLIP-seq
MIRT1122234	hsa-miR-1269	CLIP-seq
MIRT1122235	hsa-miR-1269b	CLIP-seq
MIRT1122236	hsa-miR-1279	CLIP-seq
MIRT1122237	hsa-miR-150	CLIP-seq
MIRT1122238	hsa-miR-188-3p	CLIP-seq
MIRT1122239	hsa-miR-191	CLIP-seq
MIRT1122240	hsa-miR-200b	CLIP-seq
MIRT1122241	hsa-miR-200c	CLIP-seq
MIRT1122242	hsa-miR-2467-5p	CLIP-seq
MIRT1122243	hsa-miR-2909	CLIP-seq
MIRT1122244	hsa-miR-300	CLIP-seq
MIRT1122245	hsa-miR-3065-5p	CLIP-seq
MIRT1122246	hsa-miR-3122	CLIP-seq
MIRT1122247	hsa-miR-3123	CLIP-seq
MIRT1122248	hsa-miR-3154	CLIP-seq
MIRT1122249	hsa-miR-323b-3p	CLIP-seq
MIRT1122250	hsa-miR-3653	CLIP-seq
MIRT1122251	hsa-miR-3654	CLIP-seq
MIRT1122252	hsa-miR-3658	CLIP-seq
MIRT1122253	hsa-miR-376c	CLIP-seq
MIRT1122254	hsa-miR-381	CLIP-seq
MIRT1122255	hsa-miR-3913-5p	CLIP-seq
MIRT1122256	hsa-miR-3922-5p	CLIP-seq
MIRT1122257	hsa-miR-3925-5p	CLIP-seq
MIRT1122258	hsa-miR-3942-3p	CLIP-seq
MIRT1122259	hsa-miR-3974	CLIP-seq
MIRT1122260	hsa-miR-3976	CLIP-seq
MIRT1122261	hsa-miR-3978	CLIP-seq
MIRT1122262	hsa-miR-4257	CLIP-seq
MIRT1122263	hsa-miR-4278	CLIP-seq
MIRT1122264	hsa-miR-429	CLIP-seq
MIRT1122265	hsa-miR-4310	CLIP-seq
MIRT1122266	hsa-miR-4311	CLIP-seq
MIRT1122267	hsa-miR-433	CLIP-seq
MIRT1122268	hsa-miR-448	CLIP-seq
MIRT1122269	hsa-miR-4506	CLIP-seq
MIRT1122270	hsa-miR-450b-3p	CLIP-seq
MIRT1122271	hsa-miR-4529-3p	CLIP-seq
MIRT1122272	hsa-miR-4659a-3p	CLIP-seq
MIRT1122273	hsa-miR-4659b-3p	CLIP-seq
MIRT1122274	hsa-miR-4662a-3p	CLIP-seq
MIRT1122275	hsa-miR-4666-3p	CLIP-seq
MIRT1122276	hsa-miR-4713-5p	CLIP-seq
MIRT1122277	hsa-miR-4725-5p	CLIP-seq
MIRT1122278	hsa-miR-4729	CLIP-seq
MIRT1122279	hsa-miR-4786-3p	CLIP-seq
MIRT1122280	hsa-miR-4795-3p	CLIP-seq
MIRT1122281	hsa-miR-4799-5p	CLIP-seq
MIRT1122282	hsa-miR-495	CLIP-seq
MIRT1122283	hsa-miR-504	CLIP-seq
MIRT1122284	hsa-miR-520d-5p	CLIP-seq
MIRT1122285	hsa-miR-524-5p	CLIP-seq
MIRT1122286	hsa-miR-532-3p	CLIP-seq
MIRT1122287	hsa-miR-544	CLIP-seq
MIRT1122288	hsa-miR-548p	CLIP-seq
MIRT1122289	hsa-miR-606	CLIP-seq
MIRT1122290	hsa-miR-629	CLIP-seq
MIRT1122291	hsa-miR-642a	CLIP-seq
MIRT1122292	hsa-miR-656	CLIP-seq
MIRT1122293	hsa-miR-769-3p	CLIP-seq
MIRT1122294	hsa-miR-875-3p	CLIP-seq
MIRT1122234	hsa-miR-1269	CLIP-seq
MIRT1122235	hsa-miR-1269b	CLIP-seq
MIRT1122239	hsa-miR-191	CLIP-seq
MIRT1122240	hsa-miR-200b	CLIP-seq
MIRT1122241	hsa-miR-200c	CLIP-seq
MIRT2034545	hsa-miR-2115	CLIP-seq
MIRT1122242	hsa-miR-2467-5p	CLIP-seq
MIRT1122245	hsa-miR-3065-5p	CLIP-seq
MIRT2034546	hsa-miR-3607-5p	CLIP-seq
MIRT2034547	hsa-miR-3614-5p	CLIP-seq
MIRT2034548	hsa-miR-3620	CLIP-seq
MIRT1122256	hsa-miR-3922-5p	CLIP-seq
MIRT2034549	hsa-miR-3924	CLIP-seq
MIRT2034550	hsa-miR-3977	CLIP-seq
MIRT1122262	hsa-miR-4257	CLIP-seq
MIRT1122264	hsa-miR-429	CLIP-seq
MIRT2034551	hsa-miR-4328	CLIP-seq
MIRT1122269	hsa-miR-4506	CLIP-seq
MIRT1122271	hsa-miR-4529-3p	CLIP-seq
MIRT1122277	hsa-miR-4725-5p	CLIP-seq
MIRT1122280	hsa-miR-4795-3p	CLIP-seq
MIRT1122281	hsa-miR-4799-5p	CLIP-seq
MIRT2034552	hsa-miR-488	CLIP-seq
MIRT1122282	hsa-miR-495	CLIP-seq
MIRT1122283	hsa-miR-504	CLIP-seq
MIRT2034553	hsa-miR-516a-3p	CLIP-seq
MIRT1122287	hsa-miR-544	CLIP-seq
MIRT2034554	hsa-miR-590-3p	CLIP-seq
MIRT1122290	hsa-miR-629	CLIP-seq
MIRT2034555	hsa-miR-890	CLIP-seq
MIRT1122234	hsa-miR-1269	CLIP-seq
MIRT1122235	hsa-miR-1269b	CLIP-seq
MIRT2264993	hsa-miR-188-5p	CLIP-seq
MIRT2264994	hsa-miR-1912	CLIP-seq
MIRT2264995	hsa-miR-19a	CLIP-seq
MIRT2264996	hsa-miR-19b	CLIP-seq
MIRT1122240	hsa-miR-200b	CLIP-seq
MIRT1122241	hsa-miR-200c	CLIP-seq
MIRT2264997	hsa-miR-3121-5p	CLIP-seq
MIRT1122246	hsa-miR-3122	CLIP-seq
MIRT2264998	hsa-miR-3130-5p	CLIP-seq
MIRT2264999	hsa-miR-3157-3p	CLIP-seq
MIRT2265000	hsa-miR-361-3p	CLIP-seq
MIRT2034547	hsa-miR-3614-5p	CLIP-seq
MIRT2265001	hsa-miR-3688-3p	CLIP-seq
MIRT2265002	hsa-miR-3691-3p	CLIP-seq
MIRT1122255	hsa-miR-3913-5p	CLIP-seq
MIRT2034549	hsa-miR-3924	CLIP-seq
MIRT2034550	hsa-miR-3977	CLIP-seq
MIRT1122261	hsa-miR-3978	CLIP-seq
MIRT2265003	hsa-miR-4264	CLIP-seq
MIRT2265004	hsa-miR-4277	CLIP-seq
MIRT1122264	hsa-miR-429	CLIP-seq
MIRT2265005	hsa-miR-4482	CLIP-seq
MIRT2265006	hsa-miR-4502	CLIP-seq
MIRT2265007	hsa-miR-4503	CLIP-seq
MIRT1122270	hsa-miR-450b-3p	CLIP-seq
MIRT1122271	hsa-miR-4529-3p	CLIP-seq
MIRT2265008	hsa-miR-4775	CLIP-seq
MIRT2265009	hsa-miR-4797-3p	CLIP-seq
MIRT2265010	hsa-miR-500a	CLIP-seq
MIRT2265011	hsa-miR-501-5p	CLIP-seq
MIRT2265012	hsa-miR-576-3p	CLIP-seq
MIRT2034554	hsa-miR-590-3p	CLIP-seq
MIRT2265013	hsa-miR-622	CLIP-seq
MIRT1122293	hsa-miR-769-3p	CLIP-seq
MIRT2265014	hsa-miR-802	CLIP-seq
MIRT2034555	hsa-miR-890	CLIP-seq
MIRT2265015	hsa-miR-936	CLIP-seq
MIRT1122242	hsa-miR-2467-5p	CLIP-seq
MIRT2390397	hsa-miR-3159	CLIP-seq
MIRT1122256	hsa-miR-3922-5p	CLIP-seq
MIRT1122262	hsa-miR-4257	CLIP-seq
MIRT1122277	hsa-miR-4725-5p	CLIP-seq
MIRT1122280	hsa-miR-4795-3p	CLIP-seq
MIRT1122283	hsa-miR-504	CLIP-seq
MIRT1122242	hsa-miR-2467-5p	CLIP-seq
MIRT1122256	hsa-miR-3922-5p	CLIP-seq
MIRT2034549	hsa-miR-3924	CLIP-seq
MIRT1122262	hsa-miR-4257	CLIP-seq
MIRT1122277	hsa-miR-4725-5p	CLIP-seq
MIRT1122283	hsa-miR-504	CLIP-seq
MIRT1122242	hsa-miR-2467-5p	CLIP-seq
MIRT1122256	hsa-miR-3922-5p	CLIP-seq
MIRT1122262	hsa-miR-4257	CLIP-seq
MIRT1122277	hsa-miR-4725-5p	CLIP-seq
MIRT1122283	hsa-miR-504	CLIP-seq
MIRT2453503	hsa-miR-1197	CLIP-seq
MIRT2453504	hsa-miR-1285	CLIP-seq
MIRT2453505	hsa-miR-1286	CLIP-seq
MIRT2453506	hsa-miR-1323	CLIP-seq
MIRT2453507	hsa-miR-3187-5p	CLIP-seq
MIRT2453508	hsa-miR-4436a	CLIP-seq
MIRT2453509	hsa-miR-548a-3p	CLIP-seq
MIRT2453510	hsa-miR-548e	CLIP-seq
MIRT2453511	hsa-miR-548f	CLIP-seq
MIRT2453512	hsa-miR-548o	CLIP-seq
MIRT2453513	hsa-miR-612	CLIP-seq
MIRT2564073	hsa-miR-101	CLIP-seq
MIRT2453503	hsa-miR-1197	CLIP-seq
MIRT2564074	hsa-miR-1278	CLIP-seq
MIRT2453504	hsa-miR-1285	CLIP-seq
MIRT2453505	hsa-miR-1286	CLIP-seq
MIRT2453506	hsa-miR-1323	CLIP-seq
MIRT2564075	hsa-miR-144	CLIP-seq
MIRT2564076	hsa-miR-181a	CLIP-seq
MIRT2564077	hsa-miR-181b	CLIP-seq
MIRT2564078	hsa-miR-181c	CLIP-seq
MIRT2564079	hsa-miR-181d	CLIP-seq
MIRT2264994	hsa-miR-1912	CLIP-seq
MIRT1122242	hsa-miR-2467-5p	CLIP-seq
MIRT2264998	hsa-miR-3130-5p	CLIP-seq
MIRT2564080	hsa-miR-3145-5p	CLIP-seq
MIRT2564081	hsa-miR-3157-5p	CLIP-seq
MIRT2564082	hsa-miR-3170	CLIP-seq
MIRT2453507	hsa-miR-3187-5p	CLIP-seq
MIRT2034546	hsa-miR-3607-5p	CLIP-seq
MIRT2564083	hsa-miR-3612	CLIP-seq
MIRT2564084	hsa-miR-3613-3p	CLIP-seq
MIRT2564085	hsa-miR-3662	CLIP-seq
MIRT2564086	hsa-miR-3671	CLIP-seq
MIRT2265001	hsa-miR-3688-3p	CLIP-seq
MIRT2564087	hsa-miR-3689a-5p	CLIP-seq
MIRT2564088	hsa-miR-3689b	CLIP-seq
MIRT2564089	hsa-miR-3689e	CLIP-seq
MIRT2564090	hsa-miR-3689f	CLIP-seq
MIRT2564091	hsa-miR-377	CLIP-seq
MIRT1122256	hsa-miR-3922-5p	CLIP-seq
MIRT2034549	hsa-miR-3924	CLIP-seq
MIRT2564092	hsa-miR-3929	CLIP-seq
MIRT1122261	hsa-miR-3978	CLIP-seq
MIRT2564093	hsa-miR-4256	CLIP-seq
MIRT1122262	hsa-miR-4257	CLIP-seq
MIRT2564094	hsa-miR-4260	CLIP-seq
MIRT2564095	hsa-miR-4262	CLIP-seq
MIRT2564096	hsa-miR-4266	CLIP-seq
MIRT2564097	hsa-miR-4282	CLIP-seq
MIRT2564098	hsa-miR-4419b	CLIP-seq
MIRT2453508	hsa-miR-4436a	CLIP-seq
MIRT2564099	hsa-miR-4436b-5p	CLIP-seq
MIRT2564100	hsa-miR-4470	CLIP-seq
MIRT2564101	hsa-miR-4473	CLIP-seq
MIRT2564102	hsa-miR-4478	CLIP-seq
MIRT2265005	hsa-miR-4482	CLIP-seq
MIRT2564103	hsa-miR-4493	CLIP-seq
MIRT2564104	hsa-miR-450b-5p	CLIP-seq
MIRT2564105	hsa-miR-4639-3p	CLIP-seq
MIRT2564106	hsa-miR-4668-3p	CLIP-seq
MIRT2564107	hsa-miR-4680-3p	CLIP-seq
MIRT2564108	hsa-miR-4695-5p	CLIP-seq
MIRT2564109	hsa-miR-4699-3p	CLIP-seq
MIRT2564110	hsa-miR-4724-5p	CLIP-seq
MIRT1122277	hsa-miR-4725-5p	CLIP-seq
MIRT2564111	hsa-miR-4762-3p	CLIP-seq
MIRT2564112	hsa-miR-4779	CLIP-seq
MIRT2564113	hsa-miR-4789-3p	CLIP-seq
MIRT2564114	hsa-miR-485-3p	CLIP-seq
MIRT2265010	hsa-miR-500a	CLIP-seq
MIRT1122283	hsa-miR-504	CLIP-seq
MIRT2564115	hsa-miR-508-5p	CLIP-seq
MIRT2564116	hsa-miR-512-3p	CLIP-seq
MIRT2564117	hsa-miR-513a-3p	CLIP-seq
MIRT2564118	hsa-miR-520f	CLIP-seq
MIRT2453509	hsa-miR-548a-3p	CLIP-seq
MIRT2453510	hsa-miR-548e	CLIP-seq
MIRT2453511	hsa-miR-548f	CLIP-seq
MIRT2453512	hsa-miR-548o	CLIP-seq
MIRT2564119	hsa-miR-579	CLIP-seq
MIRT2564120	hsa-miR-582-5p	CLIP-seq
MIRT2034554	hsa-miR-590-3p	CLIP-seq
MIRT2564121	hsa-miR-607	CLIP-seq
MIRT2453513	hsa-miR-612	CLIP-seq
MIRT2564122	hsa-miR-650	CLIP-seq
MIRT2265015	hsa-miR-936	CLIP-seq
MIRT2564073	hsa-miR-101	CLIP-seq
MIRT2564074	hsa-miR-1278	CLIP-seq
MIRT2453504	hsa-miR-1285	CLIP-seq
MIRT2453506	hsa-miR-1323	CLIP-seq
MIRT2564075	hsa-miR-144	CLIP-seq
MIRT1122242	hsa-miR-2467-5p	CLIP-seq
MIRT2264997	hsa-miR-3121-5p	CLIP-seq
MIRT1122246	hsa-miR-3122	CLIP-seq
MIRT2564080	hsa-miR-3145-5p	CLIP-seq
MIRT2564081	hsa-miR-3157-5p	CLIP-seq
MIRT2453507	hsa-miR-3187-5p	CLIP-seq
MIRT2034546	hsa-miR-3607-5p	CLIP-seq
MIRT2564083	hsa-miR-3612	CLIP-seq
MIRT2564084	hsa-miR-3613-3p	CLIP-seq
MIRT2265000	hsa-miR-361-3p	CLIP-seq
MIRT2564085	hsa-miR-3662	CLIP-seq
MIRT2564086	hsa-miR-3671	CLIP-seq
MIRT2564087	hsa-miR-3689a-5p	CLIP-seq
MIRT2564088	hsa-miR-3689b	CLIP-seq
MIRT2564089	hsa-miR-3689e	CLIP-seq
MIRT2564090	hsa-miR-3689f	CLIP-seq
MIRT2564091	hsa-miR-377	CLIP-seq
MIRT1122255	hsa-miR-3913-5p	CLIP-seq
MIRT1122256	hsa-miR-3922-5p	CLIP-seq
MIRT2034549	hsa-miR-3924	CLIP-seq
MIRT2564092	hsa-miR-3929	CLIP-seq
MIRT2564093	hsa-miR-4256	CLIP-seq
MIRT1122262	hsa-miR-4257	CLIP-seq
MIRT2564096	hsa-miR-4266	CLIP-seq
MIRT2564097	hsa-miR-4282	CLIP-seq
MIRT2564098	hsa-miR-4419b	CLIP-seq
MIRT2564099	hsa-miR-4436b-5p	CLIP-seq
MIRT2564100	hsa-miR-4470	CLIP-seq
MIRT2564101	hsa-miR-4473	CLIP-seq
MIRT2564102	hsa-miR-4478	CLIP-seq
MIRT2564103	hsa-miR-4493	CLIP-seq
MIRT1122270	hsa-miR-450b-3p	CLIP-seq
MIRT2564104	hsa-miR-450b-5p	CLIP-seq
MIRT2564105	hsa-miR-4639-3p	CLIP-seq
MIRT2564106	hsa-miR-4668-3p	CLIP-seq
MIRT2564107	hsa-miR-4680-3p	CLIP-seq
MIRT2564108	hsa-miR-4695-5p	CLIP-seq
MIRT2564110	hsa-miR-4724-5p	CLIP-seq
MIRT1122277	hsa-miR-4725-5p	CLIP-seq
MIRT2564111	hsa-miR-4762-3p	CLIP-seq
MIRT2564112	hsa-miR-4779	CLIP-seq
MIRT2564113	hsa-miR-4789-3p	CLIP-seq
MIRT2265010	hsa-miR-500a	CLIP-seq
MIRT2265011	hsa-miR-501-5p	CLIP-seq
MIRT1122283	hsa-miR-504	CLIP-seq
MIRT2564115	hsa-miR-508-5p	CLIP-seq
MIRT2564116	hsa-miR-512-3p	CLIP-seq
MIRT2564117	hsa-miR-513a-3p	CLIP-seq
MIRT2564118	hsa-miR-520f	CLIP-seq
MIRT2453509	hsa-miR-548a-3p	CLIP-seq
MIRT2453510	hsa-miR-548e	CLIP-seq
MIRT2453511	hsa-miR-548f	CLIP-seq
MIRT2453512	hsa-miR-548o	CLIP-seq
MIRT2564119	hsa-miR-579	CLIP-seq
MIRT2564120	hsa-miR-582-5p	CLIP-seq
MIRT2034554	hsa-miR-590-3p	CLIP-seq
MIRT2564121	hsa-miR-607	CLIP-seq
MIRT2453513	hsa-miR-612	CLIP-seq
MIRT2564122	hsa-miR-650	CLIP-seq
MIRT1122293	hsa-miR-769-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21903422
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0008270	Function	Zinc ion binding	IEA
GO:0043023	Function	Ribosomal large subunit binding	IBA	21873635
GO:0051865	Process	Protein autoubiquitination	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA	21873635
GO:0072344	Process	Rescue of stalled ribosome	IBA	21873635
GO:1990112	Component	RQC complex	IBA	21873635
GO:1990116	Process	Ribosome-associated ubiquitin-dependent protein catabolic process	IBA	21873635

Other IDs

• MIM: 613083
• HGNC: 13082
• e!Ensembl: ENSG00000198862

Protein

• UniProt ID: O94822
• Protein name: E3 ubiquitin-protein ligase listerin (EC 2.3.2.27) (RING finger protein 160) (RING-type E3 ubiquitin transferase listerin) (Zinc finger protein 294)
• Protein function: E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:2368507
• PDB: 3J92
• Sequence:

  MGGKNKQRTKGNLRPSNSGRAAELLAKEQGTVPGFIGFGTSQSDLGYVPAIQGAEEIDSL
  VDSDFRMVLRKLSKKDVTTKLKAMQEFGTMCTERDTETVKGVLPYWPRIFCKISLDHDRR
  VREATQQAFEKLILKVKKQLAPYLKSLMGYWLMAQCDTYTPAAFAAKDAFEAAFPPSKQP
  EAIAFCKDEITSVLQDHLIKETPDTLSDPQTVPEEEREAKFYRVVTCSLLALKRLLCLLP
  DNELDSLEEKFKSLLSQNKFWKYGKHSVPQIRSAYFELVSALCQRIPQLMKEEASKVSPS
  VLLSIDDSDPIVCPALWEAVLYTLTTIEDCWLHVNAKKSVFPKLSTVIREGGRGLATVIY
  PYLLPFISKLPQSITNPKLDFFKNFLTSLVAGLSTERTKTSSLESSAVISAFFECLRFIM
  QQNLGEEEIEQMLVNDQLIPFIDAVLKDPGLQHGQLFNHLAETLSSWEAKADTEKDEKTA
  HNLENVLIHFWERLSEICVAKISEPEADVESVLGVSNLLQVLQKPKSSLKSSKKKNGKVR
  FADEILESNKENEKCVSSEGEKIEGWELTTEPSLTHNSSGLLSPLRKKPLEDLVCKLADI
  SINYVNERKSEQHLRFLSTLLDSFSSSRVFKMLLGDEKQSIVQAKPLEIAKLVQKNPAVQ
  FLYQKLIGWLNEDQRKDFGFLVDILYSALRCCDNDMERKKVLDDLTKVDLKWNSLLKIIE
  KACPSSDKHALVTPWLKGDILGEKLVNLADCLCNEDLESRVSSESHFSERWTLLSLVLSQ
  HVKNDYLIGDVYVERIIVRLHETLFKTKKLSEAESSDSSVSFICDVAYNYFSSAKGCLLM
  PSSEDLLLTLFQLCAQSKEKTHLPDFLICKLKNTWLSGVNLLVHQTDSSYKESTFLHLSA
  LWLKNQVQASSLDINSLQVLLSAVDDLLNTLLESEDSYLMGVYIGSVMPNDSEWEKMRQS
  LPMQWLHRPLLEGRLSLNYECFKTDFKEQDIKTLPSHLCTSALLSKMVLIALRKETVLEN
  NELEKIIAELLYSLQWCEELDNPPIFLIGFCEILQKMNITYDNLRVLGNTSGLLQLLFNR
  SREHGTLWSLIIAKLILSRSISSDEVKPHYKRKESFFPLTEGNLHTIQSLCPFLSKEEKK
  EFSAQCIPALLGWTKKDLCSTNGGFGHLAIFNSCLQTKSIDDGELLHGILKIIISWKKEH
  EDIFLFSCNLSEASPEVLGVNIEIIRFLSLFLKYCSSPLAESEWDFIMCSMLAWLETTSE
  NQALYSIPLVQLFACVSCDLACDLSAFFDSTTLDTIGNLPVNLISEWKEFFSQGIHSLLL
  PILVTVTGENKDVSETSFQNAMLKPMCETLTYISKEQLLSHKLPARLVADQKTNLPEYLQ
  TLLNTLAPLLLFRARPVQIAVYHMLYKLMPELPQYDQDNLKSYGDEEEEPALSPPAALMS
  LLSIQEDLLENVLGCIPVGQIVTIKPLSEDFCYVLGYLLTWKLILTFFKAASSQLRALYS
  MYLRKTKSLNKLLYHLFRLMPENPTYAETAVEVPNKDPKTFFTEELQLSIRETTMLPYHI
  PHLACSVYHMTLKDLPAMVRLWWNSSEKRVFNIVDRFTSKYVSSVLSFQEISSVQTSTQL
  FNGMTVKARATTREVMATYTIEDIVIELIIQLPSNYPLGSIIVESGKRVGVAVQQWRNWM
  LQLSTYLTHQNGSIMEGLALWKNNVDKRFEGVEDCMICFSVIHGFNYSLPKKACRTCKKK
  FHSACLYKWFTSSNKSTCPLCRETFF

• Sequence length: 1766

Pathways

Reactome:

Antigen processing: Ubiquitination & Proteasome degradation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	29064472

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		29064472
Schizoaffective disorder	Schizoaffective Disorder		29064472