SIPA1L1 (signal induced proliferation associated 1 like 1)

Gene

• Entrez ID: 26037
• Gene name: Signal induced proliferation associated 1 like 1
• Gene symbol: SIPA1L1
• Synonyms: E6TP1, SPAR1
• Chromosome: 14
• Chromosome location: 14q24.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049597	hsa-miR-92a-3p	CLASH	23622248
MIRT715899	hsa-miR-539-5p	HITS-CLIP	19536157
MIRT715898	hsa-miR-4434	HITS-CLIP	19536157
MIRT715897	hsa-miR-4516	HITS-CLIP	19536157
MIRT715896	hsa-miR-5703	HITS-CLIP	19536157
MIRT715895	hsa-miR-5581-3p	HITS-CLIP	19536157
MIRT715894	hsa-miR-4531	HITS-CLIP	19536157
MIRT726571	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT726570	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT726569	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT726568	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT734963	hsa-miR-204-5p	Luciferase reporter assay, Western blotting, Immunofluorescence, qRT-PCR, In situ hybridization, Flow cytometry	33138854
MIRT715899	hsa-miR-539-5p	HITS-CLIP	19536157
MIRT715898	hsa-miR-4434	HITS-CLIP	19536157
MIRT715897	hsa-miR-4516	HITS-CLIP	19536157
MIRT715896	hsa-miR-5703	HITS-CLIP	19536157
MIRT715895	hsa-miR-5581-3p	HITS-CLIP	19536157
MIRT715894	hsa-miR-4531	HITS-CLIP	19536157
MIRT1349692	hsa-miR-1185	CLIP-seq
MIRT1349693	hsa-miR-125a-3p	CLIP-seq
MIRT1349694	hsa-miR-1283	CLIP-seq
MIRT1349695	hsa-miR-18a	CLIP-seq
MIRT1349696	hsa-miR-18b	CLIP-seq
MIRT1349697	hsa-miR-219-5p	CLIP-seq
MIRT1349698	hsa-miR-2276	CLIP-seq
MIRT1349699	hsa-miR-3160-5p	CLIP-seq
MIRT1349700	hsa-miR-3194-3p	CLIP-seq
MIRT1349701	hsa-miR-3605-5p	CLIP-seq
MIRT1349702	hsa-miR-3665	CLIP-seq
MIRT1349703	hsa-miR-3679-5p	CLIP-seq
MIRT1349704	hsa-miR-3682-3p	CLIP-seq
MIRT1349705	hsa-miR-3714	CLIP-seq
MIRT1349706	hsa-miR-3907	CLIP-seq
MIRT1349707	hsa-miR-3921	CLIP-seq
MIRT1349708	hsa-miR-4445	CLIP-seq
MIRT1349709	hsa-miR-4476	CLIP-seq
MIRT1349710	hsa-miR-4649-3p	CLIP-seq
MIRT1349711	hsa-miR-4653-5p	CLIP-seq
MIRT1349712	hsa-miR-4735-3p	CLIP-seq
MIRT1349713	hsa-miR-4736	CLIP-seq
MIRT1349714	hsa-miR-4747-5p	CLIP-seq
MIRT1349715	hsa-miR-4772-3p	CLIP-seq
MIRT1349716	hsa-miR-4782-3p	CLIP-seq
MIRT1349717	hsa-miR-4786-3p	CLIP-seq
MIRT1349718	hsa-miR-486-3p	CLIP-seq
MIRT1349719	hsa-miR-508-3p	CLIP-seq
MIRT1349720	hsa-miR-548an	CLIP-seq
MIRT1349721	hsa-miR-653	CLIP-seq
MIRT1349722	hsa-miR-671-5p	CLIP-seq
MIRT1349723	hsa-miR-891b	CLIP-seq
MIRT1349724	hsa-miR-940	CLIP-seq
MIRT1349692	hsa-miR-1185	CLIP-seq
MIRT1349693	hsa-miR-125a-3p	CLIP-seq
MIRT1349694	hsa-miR-1283	CLIP-seq
MIRT1349695	hsa-miR-18a	CLIP-seq
MIRT1349696	hsa-miR-18b	CLIP-seq
MIRT1349697	hsa-miR-219-5p	CLIP-seq
MIRT1349698	hsa-miR-2276	CLIP-seq
MIRT1349699	hsa-miR-3160-5p	CLIP-seq
MIRT1349700	hsa-miR-3194-3p	CLIP-seq
MIRT1349701	hsa-miR-3605-5p	CLIP-seq
MIRT1349702	hsa-miR-3665	CLIP-seq
MIRT1349703	hsa-miR-3679-5p	CLIP-seq
MIRT1349704	hsa-miR-3682-3p	CLIP-seq
MIRT1349705	hsa-miR-3714	CLIP-seq
MIRT1349706	hsa-miR-3907	CLIP-seq
MIRT1349707	hsa-miR-3921	CLIP-seq
MIRT1349708	hsa-miR-4445	CLIP-seq
MIRT1349709	hsa-miR-4476	CLIP-seq
MIRT1349710	hsa-miR-4649-3p	CLIP-seq
MIRT1349711	hsa-miR-4653-5p	CLIP-seq
MIRT1349712	hsa-miR-4735-3p	CLIP-seq
MIRT1349713	hsa-miR-4736	CLIP-seq
MIRT1349714	hsa-miR-4747-5p	CLIP-seq
MIRT1349715	hsa-miR-4772-3p	CLIP-seq
MIRT1349716	hsa-miR-4782-3p	CLIP-seq
MIRT1349717	hsa-miR-4786-3p	CLIP-seq
MIRT1349718	hsa-miR-486-3p	CLIP-seq
MIRT1349719	hsa-miR-508-3p	CLIP-seq
MIRT1349720	hsa-miR-548an	CLIP-seq
MIRT1349721	hsa-miR-653	CLIP-seq
MIRT1349722	hsa-miR-671-5p	CLIP-seq
MIRT1349723	hsa-miR-891b	CLIP-seq
MIRT1349724	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005096	Function	GTPase activator activity	IBA	21873635
GO:0005575	Component	Cellular_component	ND
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0008150	Process	Biological_process	ND
GO:0014069	Component	Postsynaptic density	ISS
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0031532	Process	Actin cytoskeleton reorganization	ISS
GO:0043087	Process	Regulation of GTPase activity	ISS
GO:0043197	Component	Dendritic spine	ISS
GO:0046875	Function	Ephrin receptor binding	IEA
GO:0048013	Process	Ephrin receptor signaling pathway	ISS
GO:0048167	Process	Regulation of synaptic plasticity	ISS
GO:0048814	Process	Regulation of dendrite morphogenesis	IEA
GO:0050770	Process	Regulation of axonogenesis	ISS
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IEA
GO:0061001	Process	Regulation of dendritic spine morphogenesis	ISS
GO:0090630	Process	Activation of GTPase activity	IBA	21873635
GO:0090630	Process	Activation of GTPase activity	ISS

Other IDs

• MIM: 617504
• HGNC: 20284
• e!Ensembl: ENSG00000197555

Protein

• UniProt ID: O43166
• Protein name: Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1)
• Protein function: Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02145	Rap_GAP	628 → 810	Rap/ran-GAP	Family
  PF11881	SPAR_C	1504 → 1749	C-terminal domain of SPAR protein	Family

• Sequence:

  MTSLKRSQTERPLATDRASVVGTDGTPKVHTDDFYMRRFRSQNGSLGSSVMAPVGPPRSE
  GSHHITSTPGVPKMGVRARIADWPPRKENIKESSRSSQEIETSSCLDSLSSKSSPVSQGS
  SVSLNSNDSAMLKSIQNTLKNKTRPSENMDSRFLMPEAYPSSPRKALRRIRQRSNSDITI
  SELDVDSFDECISPTYKTGPSLHREYGSTSSIDKQGTSGESFFDLLKGYKDDKSDRGPTP
  TKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFKEREKPLKRRSKSETGDSSIFRKLR
  NAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHYDVQSILFDLNEAIMNRHNVIKRRNTT
  TGASAAAVASLVSGPLSHSASFSSPMGSTEDLNSKGSLSMDQGDDKSNELVMSCPYFRNE
  IGGEGERKISLSKSNSGSFSGCESASFESTLSSHCTNAGVAVLEVPKENLVLHLDRVKRY
  IVEHVDLGAYYYRKFFYQKEHWNYFGADENLGPVAVSIRREKPDEMKENGSPYNYRIIFR
  TSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVVPELNVQCLRLAFNTPKVTEQLM
  KLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQ
  LDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGA
  QPFSPKNIRSHFQHVFVIVRVHNPCSDSVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVF
  RDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASK
  KKEKSKPYPGAELSSMGAIVWAVRAEDYNKAMELDCLLGISNEFIVLIEQETKSVVFNCS
  CRDVIGWTSTDTSLKIFYERGECVSVGSFINIEEIKEIVKRLQFVSKGCESVEMTLRRNG
  LGQLGFHVNYEGIVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTV
  KVVIIPPHDDCTPRRSCSETYRMPVMEYKMNEGVSYEFKFPFRNNNKWQRNASKGPHSPQ
  VPSQVQSPMTSRLNAGKGDGKMPPPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMA
  LARSQCRNSPSNLSSSSDTGSVGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDIGGSGKS
  TPSWQRSEDSIADQMAYSYRGPQDFNSFVLEQHEYTEPTCHLPAVSKVLPAFRESPSGRL
  MRQDPVVHLSPNKQGHSDSHYSSHSSSNTLSSNASSAHSDEKWYDGDRTESELNSYNYLQ
  GTSADSGIDTTSYGPSHGSTASLGAATSSPRSGPGKEKVAPLWHSSSEVISMADRTLETE
  SHGLDRKTESSLSLDIHSKSQAGSTPLTRENSTFSINDAASHTSTMSSRHSASPVVFTSA
  RSSPKEELHPAAPSQLAPSFSSSSSSSSGPRSFYPRQGATSKYLIGWKKPEGTINSVGFM
  DTRKRHQSDGNEIAHTRLRASTRDLRASPKPTSKSTIEEDLKKLIDLESPTPESQKSFKF
  HALSSPQSPFPSTPTSRRALHRTLSDESIYNSQREHFFTSRASLLDQALPNDVLFSSTYP
  SLPKSLPLRRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPMPDPGLMPLPDTAADLDWS
  NLVDAAKAYEVQRASFFAASDENHRPLSAASNSDQLEDQALAQMKPYSSSKDSSPTLASK
  VDQLEGMLKMLREDLKKEKEDKAHLQAEVQHLREDNLRLQEESQNASDKLKKFTEWVFNT
  IDMS

• Sequence length: 1804

Pathways

KEGG:

Rap1 signaling pathway

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Arthritis	Juvenile arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	19565504
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243

Unknown
Disease name	Disease term	dbSNP ID	References
Heart failure	Heart Failure, Diastolic	rs121918074, rs142027794, rs148791216, rs72648927, rs71578935, rs142416150, rs199830512, rs755445214, rs150102469, rs779568205, rs907992794, rs1202130741	29556499
Juvenile arthritis	Juvenile psoriatic arthritis		19565504
Seronegative polyarthritis	Polyarthritis, Juvenile, Rheumatoid Factor Negative		19565504
Polyarthritis, rheumatoid factor positive	Polyarthritis, Juvenile, Rheumatoid Factor Positive		19565504
Still disease	Juvenile-Onset Still Disease		19565504