ACOT11 (acyl-CoA thioesterase 11)

Gene

• Entrez ID: 26027
• Gene name: Acyl-CoA thioesterase 11
• Gene symbol: ACOT11
• Synonyms: BFIT, STARD14, THEA, THEM1
• Chromosome: 1
• Chromosome location: 1p32.3
• Summary: This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low te

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022706	hsa-miR-124-3p	Microarray	18668037
MIRT762866	hsa-miR-1205	CLIP-seq
MIRT762867	hsa-miR-221	CLIP-seq
MIRT762868	hsa-miR-222	CLIP-seq
MIRT762869	hsa-miR-3922-5p	CLIP-seq
MIRT762870	hsa-miR-4708-3p	CLIP-seq
MIRT762871	hsa-miR-4742-5p	CLIP-seq
MIRT1924883	hsa-miR-4501	CLIP-seq
MIRT2166090	hsa-miR-3940-5p	CLIP-seq
MIRT2166091	hsa-miR-4507	CLIP-seq
MIRT2166092	hsa-miR-548a-3p	CLIP-seq
MIRT2166093	hsa-miR-548e	CLIP-seq
MIRT2166094	hsa-miR-548f	CLIP-seq
MIRT2166095	hsa-miR-563	CLIP-seq
MIRT2468624	hsa-miR-1260	CLIP-seq
MIRT2468625	hsa-miR-1260b	CLIP-seq
MIRT2468626	hsa-miR-1827	CLIP-seq
MIRT2468627	hsa-miR-188-3p	CLIP-seq
MIRT2468628	hsa-miR-3156-3p	CLIP-seq
MIRT2468629	hsa-miR-3612	CLIP-seq
MIRT2468630	hsa-miR-650	CLIP-seq
MIRT2468631	hsa-miR-662	CLIP-seq
MIRT2468632	hsa-miR-940	CLIP-seq
MIRT2468624	hsa-miR-1260	CLIP-seq
MIRT2468625	hsa-miR-1260b	CLIP-seq
MIRT2468626	hsa-miR-1827	CLIP-seq
MIRT2468627	hsa-miR-188-3p	CLIP-seq
MIRT2468628	hsa-miR-3156-3p	CLIP-seq
MIRT2468629	hsa-miR-3612	CLIP-seq
MIRT2468630	hsa-miR-650	CLIP-seq
MIRT2468631	hsa-miR-662	CLIP-seq
MIRT2468632	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006631	Process	Fatty acid metabolic process	IBA	21873635
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	NAS	11696000
GO:0006637	Process	Acyl-CoA metabolic process	IBA	21873635
GO:0006637	Process	Acyl-CoA metabolic process	TAS
GO:0008289	Function	Lipid binding	IEA
GO:0009266	Process	Response to temperature stimulus	ISS
GO:0009409	Process	Response to cold	ISS	11696000
GO:0016290	Function	Palmitoyl-CoA hydrolase activity	IEA
GO:0035556	Process	Intracellular signal transduction	NAS	11696000
GO:0036042	Function	Long-chain fatty acyl-CoA binding	IBA	21873635
GO:0047617	Function	Acyl-CoA hydrolase activity	IBA	21873635
GO:0047617	Function	Acyl-CoA hydrolase activity	TAS	11696000
GO:0052689	Function	Carboxylic ester hydrolase activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0102991	Function	Myristoyl-CoA hydrolase activity	IEA
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	ISS	27110486

Other IDs

• MIM: 606803
• HGNC: 18156
• e!Ensembl: ENSG00000162390

Protein

• UniProt ID: Q8WXI4
• Protein name: Acyl-coenzyme A thioesterase 11 (Acyl-CoA thioesterase 11) (EC 3.1.2.-) (Acyl-CoA thioester hydrolase 11) (Adipose-associated thioesterase) (Brown fat-inducible thioesterase) (BFIT) (Palmitoyl-coenzyme A thioesterase) (EC 3.1.2.2)
• Protein function: Has an acyl-CoA thioesterase activity with a preference for the long chain fatty acyl-CoA thioesters hexadecanoyl-CoA/palmitoyl-CoA and tetradecanoyl-CoA/myristoyl-CoA which are the main substrates in the mitochondrial beta-oxidation pathway. {E
• PDB: 3FO5, 6VVQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03061	4HBT	62 → 135	Thioesterase superfamily	Domain
  PF03061	4HBT	234 → 309	Thioesterase superfamily	Domain
  PF01852	START	384 → 590	START domain	Domain

• Sequence:

  MIQNVGNHLRRGLASVFSNRTSRKSALRAGNDSAMADGEGYRNPTEVQMSQLVLPCHTNQ
  RGELSVGQLLKWIDTTACLSAERHAGCPCVTASMDDIYFEHTISVGQVVNIKAKVNRAFN
  SSMEVGIQVASEDLCSEKQWNVCKALATFVARREITKVKLKQITPRTEEEKMEHSVAAER
  RRMRLVYADTIKDLLANCAIQGDLESRDCSRMVPAEKTRVESVELVLPPHANHQGNTFGG
  QIMAWMENVATIAASRLCRAHPTLKAIEMFHFRGPSQVGDRLVLKAIVNNAFKHSMEVGV
  CVEAYRQEAETHRRHINSAFMTFVVLDADDQPQLLPWIRPQPGDGERRYREASARKKIRL
  DRKYIVSCKQTEVPLSVPWDPSNQVYLSYNNVSSLKMLVAKDNWVLSSEISQVRLYTLED
  DKFLSFHMEMVVHVDAAQAFLLLSDLRQRPEWDKHYRSVELVQQVDEDDAIYHVTSPALG
  GHTKPQDFVILASRRKPCDNGDPYVIALRSVTLPTHRETPEYRRGETLCSGFCLWREGDQ
  LTKCCWVRVSLTELVSASGFYSWGLESRSKGRRSDGWNGKLAGGHLSTLKAIPVAKINSR
  FGYLQDT

• Sequence length: 607

Pathways

Reactome:

Mitochondrial Fatty Acid Beta-Oxidation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Glioma	Glioma	rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499, rs1060500122, rs781647403, rs1060500126, rs1554897889, rs1114167629, rs1114167656, rs587782603, rs1554893824, rs1554900615, rs1564568660, rs786204900, rs762518389, rs1339631701	19578366

Unknown
Disease name	Disease term	dbSNP ID	References
Central nervous system neoplasms	Central Nervous System Neoplasms		19578366