TENM4 (teneurin transmembrane protein 4)

Gene

• Entrez ID: 26011
• Gene name: Teneurin transmembrane protein 4
• Gene symbol: TENM4
• Synonyms: Doc4, ETM5, ODZ4, TEN4, TNM4, Ten-M4, ten-4
• Chromosome: 11
• Chromosome location: 11q14.1
• Summary: The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs199687168	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs375681722	C>T	Pathogenic	Missense variant, coding sequence variant
rs538881762	C>A,T	Pathogenic	Missense variant, coding sequence variant
rs763485258	G>A,T	Pathogenic	Missense variant, coding sequence variant
rs1555080708	G>-	Likely-pathogenic	Coding sequence variant, frameshift variant, genic upstream transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018799	hsa-miR-335-5p	Microarray	18185580
MIRT041218	hsa-miR-193b-3p	CLASH	23622248
MIRT724252	hsa-miR-532-5p	HITS-CLIP	19536157
MIRT724251	hsa-miR-622	HITS-CLIP	19536157
MIRT724250	hsa-miR-3127-3p	HITS-CLIP	19536157
MIRT724249	hsa-miR-6756-3p	HITS-CLIP	19536157
MIRT724248	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT724247	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT724246	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT724245	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT724244	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT724243	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT652765	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT652764	hsa-miR-1470	HITS-CLIP	23824327
MIRT652763	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT652762	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT652761	hsa-miR-4290	HITS-CLIP	23824327
MIRT652760	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT652759	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT652758	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT652757	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT450387	hsa-miR-3121-3p	PAR-CLIP	22100165
MIRT450386	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT450385	hsa-miR-8063	PAR-CLIP	22100165
MIRT450384	hsa-miR-4698	PAR-CLIP	22100165
MIRT724252	hsa-miR-532-5p	HITS-CLIP	19536157
MIRT724251	hsa-miR-622	HITS-CLIP	19536157
MIRT724250	hsa-miR-3127-3p	HITS-CLIP	19536157
MIRT724249	hsa-miR-6756-3p	HITS-CLIP	19536157
MIRT724248	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT724247	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT724246	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT724245	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT724244	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT724243	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT652765	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT652764	hsa-miR-1470	HITS-CLIP	23824327
MIRT652763	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT652762	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT652761	hsa-miR-4290	HITS-CLIP	23824327
MIRT652760	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT652759	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT652758	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT652757	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT450387	hsa-miR-3121-3p	PAR-CLIP	22100165
MIRT450386	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT450385	hsa-miR-8063	PAR-CLIP	22100165
MIRT450384	hsa-miR-4698	PAR-CLIP	22100165

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001702	Process	Gastrulation with mouth forming second	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	ISS
GO:0005886	Component	Plasma membrane	IDA	26188006
GO:0005887	Component	Integral component of plasma membrane	IEA
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA	21873635
GO:0007165	Process	Signal transduction	IEA
GO:0031641	Process	Regulation of myelination	IMP	26188006
GO:0031643	Process	Positive regulation of myelination	ISS
GO:0032289	Process	Central nervous system myelin formation	IMP	26188006
GO:0032289	Process	Central nervous system myelin formation	ISS
GO:0042803	Function	Protein homodimerization activity	IBA	21873635
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0043005	Component	Neuron projection	ISS
GO:0046982	Function	Protein heterodimerization activity	IBA	21873635
GO:0048666	Process	Neuron development	IBA	21873635
GO:0048666	Process	Neuron development	IMP	26188006
GO:0048714	Process	Positive regulation of oligodendrocyte differentiation	ISS
GO:0050839	Function	Cell adhesion molecule binding	IBA	21873635
GO:0060038	Process	Cardiac muscle cell proliferation	IEA
GO:0060912	Process	Cardiac cell fate specification	IEA
GO:2000543	Process	Positive regulation of gastrulation	ISS

Other IDs

• MIM: 610084
• HGNC: 29945
• e!Ensembl: ENSG00000149256

Protein

• UniProt ID: Q6N022
• Protein name: Teneurin-4 (Ten-4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4)
• Protein function: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular proce
• PDB: 7BAM, 7BAN, 7BAO, 7PLP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06484	Ten_N	11 → 171	Teneurin Intracellular Region	Family
  PF06484	Ten_N	164 → 340	Teneurin Intracellular Region	Family
  PF07974	EGF_2	626 → 657	EGF-like domain	Domain
  PF07974	EGF_2	729 → 755	EGF-like domain	Domain
  PF15636	Tox-GHH	2685 → 2762	GHH signature containing HNH/Endo VII superfamily nuclease toxin	Family

• Sequence:

  MDVKERKPYRSLTRRRDAERRYTSSSADSEEGKAPQKSYSSSETLKAYDQDARLAYGSRV
  KDIVPQEAEEFCRTGANFTLRELGLEEVTPPHGTLYRTDIGLPHCGYSMGAGSDADMEAD
  TVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENTETDHPGGLQNHARLRTPP
  PPLSHAHTPNQHHAASINSLNRGNFTPRSNPSPAPTDHSLSGEPPAGGAQEPAHAQENWL
  LNSNIPLETRNLGKQPFLGTLQDNLIEMDILGASRHDGAYSDGHFLFKPGGTSPLFCTTS
  PGYPLTSSTVYSPPPRPLPRSTFARPAFNLKKPSKYCNWKCAALSAIVISATLVILLAYF
  VAMHLFGLNWHLQPMEGQMYEITEDTASSWPVPTDVSLYPSGGTGLETPDRKGKGTTEGK
  PSSFFPEDSFIDSGEIDVGRRASQKIPPGTFWRSQVFIDHPVHLKFNVSLGKAALVGIYG
  RKGLPPSHTQFDFVELLDGRRLLTQEARSLEGTPRQSRGTVPPSSHETGFIQYLDSGIWH
  LAFYNDGKESEVVSFLTTAIESVDNCPSNCYGNGDCISGTCHCFLGFLGPDCGRASCPVL
  CSGNGQYMKGRCLCHSGWKGAECDVPTNQCIDVACSNHGTCITGTCICNPGYKGESCEEV
  DCMDPTCSGRGVCVRGECHCSVGWGGTNCETPRATCLDQCSGHGTFLPDTGLCSCDPSWT
  GHDCSIEICAADCGGHGVCVGGTCRCEDGWMGAACDQRACHPRCAEHGTCRDGKCECSPG
  WNGEHCTIAHYLDRVVKEGCPGLCNGNGRCTLDLNGWHCVCQLGWRGAGCDTSMETACGD
  SKDNDGDGLVDCMDPDCCLQPLCHINPLCLGSPNPLDIIQETQVPVSQQNLHSFYDRIKF
  LVGRDSTHIIPGENPFDGGHACVIRGQVMTSDGTPLVGVNISFVNNPLFGYTISRQDGSF
  DLVTNGGISIILRFERAPFITQEHTLWLPWDRFFVMETIIMRHEENEIPSCDLSNFARPN
  PVVSPSPLTSFASSCAEKGPIVPEIQALQEEISISGCKMRLSYLSSRTPGYKSVLRISLT
  HPTIPFNLMKVHLMVAVEGRLFRKWFAAAPDLSYYFIWDKTDVYNQKVFGLSEAFVSVGY
  EYESCPDLILWEKRTTVLQGYEIDASKLGGWSLDKHHALNIQSGILHKGNGENQFVSQQP
  PVIGSIMGNGRRRSISCPSCNGLADGNKLLAPVALTCGSDGSLYVGDFNYIRRIFPSGNV
  TNILELRNKDFRHSHSPAHKYYLATDPMSGAVFLSDSNSRRVFKIKSTVVVKDLVKNSEV
  VAGTGDQCLPFDDTRCGDGGKATEATLTNPRGITVDKFGLIYFVDGTMIRRIDQNGIIST
  LLGSNDLTSARPLSCDSVMDISQVHLEWPTDLAINPMDNSLYVLDNNVVLQISENHQVRI
  VAGRPMHCQVPGIDHFLLSKVAIHATLESATALAVSHNGVLYIAETDEKKINRIRQVTTS
  GEISLVAGAPSGCDCKNDANCDCFSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRI
  RFIRKNKPFLNTQNMYELSSPIDQELYLFDTTGKHLYTQSLPTGDYLYNFTYTGDGDITL
  ITDNNGNMVNVRRDSTGMPLWLVVPDGQVYWVTMGTNSALKSVTTQGHELAMMTYHGNSG
  LLATKSNENGWTTFYEYDSFGRLTNVTFPTGQVSSFRSDTDSSVHVQVETSSKDDVTITT
  NLSASGAFYTLLQDQVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVNPTVGKRNV
  TLPIDNGLNLVEWRQRKEQARGQVTVFGRRLRVHNRNLLSLDFDRVTRTEKIYDDHRKFT
  LRILYDQAGRPSLWSPSSRLNGVNVTYSPGGYIAGIQRGIMSERMEYDQAGRITSRIFAD
  GKTWSYTYLEKSMVLLLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQ
  PPEGNASVIQDFTEDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGM
  LKTINLQNEGFTCTIRYRQIGPLIDRQIFRFTEEGMVNARFDYNYDNSFRVTSMQAVINE
  TPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYGRMKEVQYEIFR
  SLMYWMTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLN
  GNLHLLSPGNSARLTPLRYDIRDRITRLGDVQYKMDEDGFLRQRGGDIFEYNSAGLLIKA
  YNRAGSWSVRYRYDGLGRRVSSKSSHSHHLQFFYADLTNPTKVTHLYNHSSSEITSLYYD
  LQGHLFAMELSSGDEFYIACDNIGTPLAVFSGTGLMIKQILYTAYGEIYMDTNPNFQIII
  GYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDHELWKHLSSSNVMPFNLYMFKNNNPISN
  SQDIKCFMTDVNSWLLTFGFQLHNVIPGYPKPDMDAMEPSYELIHTQMKTQEWDNSKSIL
  GVQCEVQKQLKAFVTLERFDQLYGSTITSCQQAPKTKKFASSGSVFGKGVKFALKDGRVT
  TDIISVANEDGRRVAAILNHAHYLENLHFTIDGVDTHYFVKPGPSEGDLAILGLSGGRRT
  LENGVNVTVSQINTVLNGRTRRYTDIQLQYGALCLNTRYGTTLDEEKARVLELARQRAVR
  QAWAREQQRLREGEEGLRAWTEGEKQQVLSTGRVQGYDGFFVISVEQYPELSDSANNIHF
  MRQSEMGRR

• Sequence length: 2769

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Attention deficit hyperactivity disorder	Attention deficit hyperactivity disorder	rs120074176, rs786205019	23453885
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959
Lung carcinoma	Carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	28604730
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	25124521, 23453885
Tremor	TREMOR, HEREDITARY ESSENTIAL, 5	rs387907274, rs763485258, rs551348450	26188006

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder, Depression, Bipolar		21926972, 23453885, 24618891, 28115744, 23070075, 22182935, 21926972
Development disorder	Child Development Disorders, Pervasive		23453885
Hereditary essential tremor	NON RARE IN EUROPE: Hereditary essential tremor	rs886057789, rs200825904, rs199852439, rs75091114, rs886057790, rs201561838, rs886057788, rs200206712, rs201872343, rs886057791
Manic disorder	Manic, Manic Disorder		21926972
Mental depression	Major Depressive Disorder	rs587778876, rs587778877	23453885
Nonorganic psychosis	Nonorganic psychosis		25124521
Psychosis	Psychotic Disorders		25124521