Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
25898 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Ring finger and CHY zinc finger domain containing 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
RCHY1 |
SynonymsGene synonyms aliases
|
ARNIP, CHIMP, PIRH2, PRO1996, RNF199, ZCHY, ZNF363 |
ChromosomeChromosome number
|
4 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
4q21.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regul |
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000151 |
Component |
Ubiquitin ligase complex |
IDA |
19043414 |
GO:0002039 |
Function |
P53 binding |
IPI |
19043414 |
GO:0004842 |
Function |
Ubiquitin-protein transferase activity |
TAS |
|
GO:0005515 |
Function |
Protein binding |
IPI |
15781263, 17568776, 19043414, 19483087, 20452352, 21988832, 25416956, 27519799, 31515488, 32296183, 32814053 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005634 |
Component |
Nucleus |
IDA |
19483087, 25848801 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
|
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005737 |
Component |
Cytoplasm |
IDA |
15781263 |
GO:0005829 |
Component |
Cytosol |
IDA |
|
GO:0006511 |
Process |
Ubiquitin-dependent protein catabolic process |
IBA |
21873635 |
GO:0006511 |
Process |
Ubiquitin-dependent protein catabolic process |
IDA |
19483087 |
GO:0008270 |
Function |
Zinc ion binding |
IDA |
19043414 |
GO:0016567 |
Process |
Protein ubiquitination |
IBA |
21873635 |
GO:0016567 |
Process |
Protein ubiquitination |
IDA |
19043414, 19483087 |
GO:0016567 |
Process |
Protein ubiquitination |
IEA |
|
GO:0016607 |
Component |
Nuclear speck |
IEA |
|
GO:0031398 |
Process |
Positive regulation of protein ubiquitination |
IDA |
19483087 |
GO:0032436 |
Process |
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
IDA |
19483087 |
GO:0042803 |
Function |
Protein homodimerization activity |
IPI |
19483087 |
GO:0043231 |
Component |
Intracellular membrane-bounded organelle |
IDA |
|
GO:0061630 |
Function |
Ubiquitin protein ligase activity |
IBA |
21873635 |
GO:0061630 |
Function |
Ubiquitin protein ligase activity |
IDA |
19483087 |
GO:0070987 |
Process |
Error-free translesion synthesis |
TAS |
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
Q96PM5 |
Protein name |
RING finger and CHY zinc finger domain-containing protein 1 (EC 2.3.2.27) (Androgen receptor N-terminal-interacting protein) (CH-rich-interacting match with PLAG1) (E3 ubiquitin-protein ligase Pirh2) (RING finger protein 199) (RING-type E3 ubiquitin trans |
Protein function |
E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B (PubMed:16914734, PubMed:17721809, PubMed:18006823, PubMed:19043414, PubMed:19483087, PubMed:21994467). Mediates ubiquitinati |
PDB |
2JRJ
,
2K2C
,
2K2D
,
7YNX
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF05495 |
zf-CHY |
20 → 93 |
CHY zinc finger |
Domain |
PF13639 |
zf-RING_2 |
143 → 187 |
Ring finger domain |
Domain |
PF14599 |
zinc_ribbon_6 |
191 → 249 |
Zinc-ribbon |
Domain |
|
Sequence |
|
Sequence length |
261 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
|
|
Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Lung cancer |
Malignant neoplasm of lung |
rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 |
28191284 |
Rheumatoid arthritis |
Rheumatoid Arthritis |
rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212 |
22491018 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Lung neoplasms |
Lung Neoplasms |
|
28191284 |
|