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RCHY1 (ring finger and CHY zinc finger domain containing 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
25898
Gene nameGene Name - the full gene name approved by the HGNC.
Ring finger and CHY zinc finger domain containing 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
RCHY1
SynonymsGene synonyms aliases
ARNIP, CHIMP, PIRH2, PRO1996, RNF199, ZCHY, ZNF363
ChromosomeChromosome number
4
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q21.1
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regul
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT439795 hsa-miR-218-5p HITS-CLIP 23212916
MIRT439795 hsa-miR-218-5p HITS-CLIP 23212916
MIRT1298229 hsa-miR-1246 CLIP-seq
MIRT1298230 hsa-miR-1255a CLIP-seq
MIRT1298231 hsa-miR-1255b CLIP-seq
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000151 Component Ubiquitin ligase complex IDA 19043414
GO:0002039 Function P53 binding IPI 19043414
GO:0004842 Function Ubiquitin-protein transferase activity TAS
GO:0005515 Function Protein binding IPI 15781263, 17568776, 19043414, 19483087, 20452352, 21988832, 25416956, 27519799, 31515488, 32296183, 32814053
GO:0005634 Component Nucleus IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q96PM5
Protein name RING finger and CHY zinc finger domain-containing protein 1 (EC 2.3.2.27) (Androgen receptor N-terminal-interacting protein) (CH-rich-interacting match with PLAG1) (E3 ubiquitin-protein ligase Pirh2) (RING finger protein 199) (RING-type E3 ubiquitin trans
Protein function E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B (PubMed:16914734, PubMed:17721809, PubMed:18006823, PubMed:19043414, PubMed:19483087, PubMed:21994467). Mediates ubiquitinati
PDB 2JRJ , 2K2C , 2K2D , 7YNX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05495 zf-CHY
20 93
CHY zinc finger
Domain
PF13639 zf-RING_2
143 187
Ring finger domain
Domain
PF14599 zinc_ribbon_6
191 249
Zinc-ribbon
Domain
Sequence
Sequence length 261
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  p53 signaling pathway
Ubiquitin mediated proteolysis
Measles
  Translesion Synthesis by POLH
Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Lung cancer Malignant neoplasm of lung rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135 28191284
Rheumatoid arthritis Rheumatoid Arthritis rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212 22491018
Unknown
Disease name Disease term dbSNP ID References
Lung neoplasms Lung Neoplasms 28191284

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