MXRA5 (matrix remodeling associated 5)

Gene

• Entrez ID: 25878
• Gene name: Matrix remodeling associated 5
• Gene symbol: MXRA5
• Synonyms: -
• Chromosome: X
• Chromosome location: Xp22.33
• Summary: This gene encodes one of the matrix-remodelling associated proteins. This protein contains 7 leucine-rich repeats and 12 immunoglobulin-like C2-type domains related to perlecan. This gene has a pseudogene on chromosome Y. [provided by RefSeq, Mar 2010]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1551464	hsa-miR-4680-3p	CLIP-seq
MIRT2277187	hsa-miR-144	CLIP-seq
MIRT2277188	hsa-miR-2110	CLIP-seq
MIRT2277189	hsa-miR-3185	CLIP-seq
MIRT2277190	hsa-miR-345	CLIP-seq
MIRT2277191	hsa-miR-3652	CLIP-seq
MIRT2277192	hsa-miR-3684	CLIP-seq
MIRT2277193	hsa-miR-4271	CLIP-seq
MIRT2277194	hsa-miR-4430	CLIP-seq
MIRT2277195	hsa-miR-4505	CLIP-seq
MIRT2277196	hsa-miR-4667-5p	CLIP-seq
MIRT2277197	hsa-miR-4691-3p	CLIP-seq
MIRT2277198	hsa-miR-4700-5p	CLIP-seq
MIRT2277199	hsa-miR-4725-3p	CLIP-seq
MIRT2277200	hsa-miR-4731-5p	CLIP-seq
MIRT2576027	hsa-miR-1225-3p	CLIP-seq
MIRT2576028	hsa-miR-1233	CLIP-seq
MIRT2576029	hsa-miR-1237	CLIP-seq
MIRT2576030	hsa-miR-1248	CLIP-seq
MIRT2277188	hsa-miR-2110	CLIP-seq
MIRT2576031	hsa-miR-2355-5p	CLIP-seq
MIRT2576032	hsa-miR-30a	CLIP-seq
MIRT2576033	hsa-miR-30b	CLIP-seq
MIRT2576034	hsa-miR-30c	CLIP-seq
MIRT2576035	hsa-miR-30d	CLIP-seq
MIRT2576036	hsa-miR-30e	CLIP-seq
MIRT2576037	hsa-miR-3140-5p	CLIP-seq
MIRT2576038	hsa-miR-3171	CLIP-seq
MIRT2277189	hsa-miR-3185	CLIP-seq
MIRT2576039	hsa-miR-331-3p	CLIP-seq
MIRT2576040	hsa-miR-3620	CLIP-seq
MIRT2576041	hsa-miR-3622b-5p	CLIP-seq
MIRT2277191	hsa-miR-3652	CLIP-seq
MIRT2576042	hsa-miR-3658	CLIP-seq
MIRT2277192	hsa-miR-3684	CLIP-seq
MIRT2576043	hsa-miR-3929	CLIP-seq
MIRT2576044	hsa-miR-3938	CLIP-seq
MIRT2277193	hsa-miR-4271	CLIP-seq
MIRT2576045	hsa-miR-4290	CLIP-seq
MIRT2576046	hsa-miR-4419b	CLIP-seq
MIRT2277194	hsa-miR-4430	CLIP-seq
MIRT2576047	hsa-miR-4478	CLIP-seq
MIRT2576048	hsa-miR-4495	CLIP-seq
MIRT2277195	hsa-miR-4505	CLIP-seq
MIRT2576049	hsa-miR-4663	CLIP-seq
MIRT2576050	hsa-miR-4667-3p	CLIP-seq
MIRT2277196	hsa-miR-4667-5p	CLIP-seq
MIRT2576051	hsa-miR-4687-5p	CLIP-seq
MIRT2277197	hsa-miR-4691-3p	CLIP-seq
MIRT2277198	hsa-miR-4700-5p	CLIP-seq
MIRT2576052	hsa-miR-4708-3p	CLIP-seq
MIRT2576053	hsa-miR-4720-5p	CLIP-seq
MIRT2277199	hsa-miR-4725-3p	CLIP-seq
MIRT2277200	hsa-miR-4731-5p	CLIP-seq
MIRT2576054	hsa-miR-4786-3p	CLIP-seq
MIRT2576055	hsa-miR-4799-3p	CLIP-seq
MIRT2576056	hsa-miR-545	CLIP-seq
MIRT2576057	hsa-miR-642b	CLIP-seq
MIRT2685600	hsa-miR-1206	CLIP-seq
MIRT2685601	hsa-miR-1294	CLIP-seq
MIRT2685602	hsa-miR-204	CLIP-seq
MIRT2685603	hsa-miR-211	CLIP-seq
MIRT2277188	hsa-miR-2110	CLIP-seq
MIRT2576031	hsa-miR-2355-5p	CLIP-seq
MIRT2576032	hsa-miR-30a	CLIP-seq
MIRT2576033	hsa-miR-30b	CLIP-seq
MIRT2576034	hsa-miR-30c	CLIP-seq
MIRT2576035	hsa-miR-30d	CLIP-seq
MIRT2576036	hsa-miR-30e	CLIP-seq
MIRT2576037	hsa-miR-3140-5p	CLIP-seq
MIRT2576038	hsa-miR-3171	CLIP-seq
MIRT2685604	hsa-miR-3174	CLIP-seq
MIRT2277189	hsa-miR-3185	CLIP-seq
MIRT2576039	hsa-miR-331-3p	CLIP-seq
MIRT2576040	hsa-miR-3620	CLIP-seq
MIRT2576041	hsa-miR-3622b-5p	CLIP-seq
MIRT2277191	hsa-miR-3652	CLIP-seq
MIRT2576042	hsa-miR-3658	CLIP-seq
MIRT2277192	hsa-miR-3684	CLIP-seq
MIRT2277193	hsa-miR-4271	CLIP-seq
MIRT2277194	hsa-miR-4430	CLIP-seq
MIRT2576048	hsa-miR-4495	CLIP-seq
MIRT2277195	hsa-miR-4505	CLIP-seq
MIRT2277196	hsa-miR-4667-5p	CLIP-seq
MIRT2277197	hsa-miR-4691-3p	CLIP-seq
MIRT2277198	hsa-miR-4700-5p	CLIP-seq
MIRT2576053	hsa-miR-4720-5p	CLIP-seq
MIRT2277199	hsa-miR-4725-3p	CLIP-seq
MIRT2277200	hsa-miR-4731-5p	CLIP-seq
MIRT2685605	hsa-miR-4755-5p	CLIP-seq
MIRT2576054	hsa-miR-4786-3p	CLIP-seq
MIRT2685606	hsa-miR-4796-5p	CLIP-seq
MIRT2576055	hsa-miR-4799-3p	CLIP-seq
MIRT2685607	hsa-miR-490-3p	CLIP-seq
MIRT2685608	hsa-miR-520d-5p	CLIP-seq
MIRT2685609	hsa-miR-524-5p	CLIP-seq
MIRT2685610	hsa-miR-623	CLIP-seq
MIRT2576057	hsa-miR-642b	CLIP-seq
MIRT2685611	hsa-miR-921	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005201	Function	Extracellular matrix structural constituent	HDA	28344315
GO:0005201	Function	Extracellular matrix structural constituent	RCA	28327460
GO:0005576	Component	Extracellular region	IBA	21873635
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	28327460, 28344315
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0071559	Process	Response to transforming growth factor beta	IBA	21873635
GO:0071559	Process	Response to transforming growth factor beta	IMP	27599751

Other IDs

• MIM: 300938
• HGNC: 7539
• e!Ensembl: ENSG00000101825

Protein

• UniProt ID: Q9NR99
• Protein name: Matrix-remodeling-associated protein 5 (Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan) (Adlican)
• Protein function: In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	55 → 115	Leucine rich repeat	Repeat
  PF13855	LRR_8	80 → 130	Leucine rich repeat	Repeat
  PF13855	LRR_8	103 → 163	Leucine rich repeat	Repeat
  PF13855	LRR_8	127 → 184	Leucine rich repeat	Repeat
  PF13927	Ig_3	480 → 558		Domain
  PF13927	Ig_3	575 → 655		Domain
  PF13927	Ig_3	1852 → 1932		Domain
  PF07679	I-set	1950 → 2042	Immunoglobulin I-set domain	Domain
  PF07679	I-set	2047 → 2139	Immunoglobulin I-set domain	Domain
  PF13927	Ig_3	2147 → 2225		Domain
  PF07679	I-set	2244 → 2341	Immunoglobulin I-set domain	Domain
  PF07679	I-set	2348 → 2435	Immunoglobulin I-set domain	Domain
  PF13927	Ig_3	2439 → 2522		Domain
  PF07679	I-set	2542 → 2633	Immunoglobulin I-set domain	Domain
  PF13927	Ig_3	2732 → 2814		Domain

• Sequence:

  MPKRAHWGALSVVLILLWGHPRVALACPHPCACYVPSEVHCTFRSLASVPAGIAKHVERI
  NLGFNSIQALSETSFAGLTKLELLMIHGNEIPSIPDGALRDLSSLQVFKFSYNKLRVITG
  QTLQGLSNLMRLHIDHNKIEFIHPQAFNGLTSLRLLHLEGNLLHQLHPSTFSTFTFLDYF
  RLSTIRHLYLAENMVRTLPASMLRNMPLLENLYLQGNPWTCDCEMRWFLEWDAKSRGILK
  CKKDKAYEGGQLCAMCFSPKKLYKHEIHKLKDMTCLKPSIESPLRQNRSRSIEEEQEQEE
  DGGSQLILEKFQLPQWSISLNMTDEHGNMVNLVCDIKKPMDVYKIHLNQTDPPDIDINAT
  VALDFECPMTRENYEKLWKLIAYYSEVPVKLHRELMLSKDPRVSYQYRQDADEEALYYTG
  VRAQILAEPEWVMQPSIDIQLNRRQSTAKKVLLSYYTQYSQTISTKDTRQARGRSWVMIE
  PSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWL
  RIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCN
  ALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGAD
  HFTVGITVTKKGSGLPSKRGRRPGAKALSRVREDIVEDEGGSGMGDEENTSRRLLHPKDQ
  EVFLKTKDDAINGDKKAKKGRRKLKLWKHSEKEPETNVAEGRRVFESRRRINMANKQINP
  ERWADILAKVRGKNLPKGTEVPPLIKTTSPPSLSLEVTPPFPAISPPSASPVQTVTSAEE
  SSADVPLLGEEEHVLGTISSASMGLEHNHNGVILVEPEVTSTPLEEVVDDLSEKTEEITS
  TEGDLKGTAAPTLISEPYEPSPTLHTLDTVYEKPTHEETATEGWSAADVGSSPEPTSSEY
  EPPLDAVSLAESEPMQYFDPDLETKSQPDEDKMKEDTFAHLTPTPTIWVNDSSTSQLFED
  STIGEPGVPGQSHLQGLTDNIHLVKSSLSTQDTLLIKKGMKEMSQTLQGGNMLEGDPTHS
  RSSESEGQESKSITLPDSTLGIMSSMSPVKKPAETTVGTLLDKDTTTATTTPRQKVAPSS
  TMSTHPSRRRPNGRRRLRPNKFRHRHKQTPPTTFAPSETFSTQPTQAPDIKISSQVESSL
  VPTAWVDNTVNTPKQLEMEKNAEPTSKGTPRRKHGKRPNKHRYTPSTVSSRASGSKPSPS
  PENKHRNIVTPSSETILLPRTVSLKTEGPYDSLDYMTTTRKIYSSYPKVQETLPVTYKPT
  SDGKEIKDDVATNVDKHKSDILVTGESITNAIPTSRSLVSTMGEFKEESSPVGFPGTPTW
  NPSRTAQPGRLQTGIPVTTSGENLTDPPLLKELEDVDFTSEFLSSLTVSTPFHQEEAGSS
  TTLSSIKVEVASSQAETTTLDQDHLETTVAILLSETRPQNHTPTAARMKEPASSSPSTIL
  MSLGQTTTTKPALPSPRISQASRDSKENVFLNYVGNPETEATPVNNEGTQHMSGPNELST
  PSSDQDAFNLSTKLELEKQVFGSRSLPRGPDSQRQDGRVHASHQLTRVPAKPILPTATVR
  LPEMSTQSASRYFVTSQSPRHWTNKPEITTYPSGALPENKQFTTPRLSSTTIPLPLHMSK
  PSIPSKFTDRRTDQFNGYSKVFGNNNIPEARNPVGKPPSPRIPHYSNGRLPFFTNKTLSF
  PQLGVTRRPQIPTSPAPVMRERKVIPGSYNRIHSHSTFHLDFGPPAPPLLHTPQTTGSPS
  TNLQNIPMVSSTQSSISFITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQILTKSP
  QTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQV
  QDRGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAP
  QISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRL
  HVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLF
  VFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRY
  GGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYL
  CVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLP
  DGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVK
  VVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQD
  GTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNPITTVREIAAGGS
  RKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMA
  RNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSAAGTPTPSLVWVLPN
  GTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEAN
  KQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVRE
  ASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGI
  PKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDS
  KTTYIHVF

• Sequence length: 2828

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Lung carcinoma	Non-Small Cell Lung Carcinoma, Carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	22696596