RPL36 (ribosomal protein L36)

Gene

• Entrez ID: 25873
• Gene name: Ribosomal protein L36
• Gene symbol: RPL36
• Synonyms: L36, eL36
• Chromosome: 19
• Chromosome location: 19p13.3
• Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044992	hsa-miR-186-5p	CLASH	23622248
MIRT044707	hsa-miR-320a	CLASH	23622248
MIRT042307	hsa-miR-484	CLASH	23622248
MIRT039808	hsa-miR-615-3p	CLASH	23622248
MIRT457418	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT457417	hsa-miR-205-3p	PAR-CLIP	23592263
MIRT457416	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT457415	hsa-miR-4270	PAR-CLIP	23592263
MIRT457414	hsa-miR-4441	PAR-CLIP	23592263
MIRT457413	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT457412	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT457411	hsa-miR-8085	PAR-CLIP	23592263
MIRT457410	hsa-miR-3127-5p	PAR-CLIP	23592263
MIRT726685	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT726683	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT726684	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT726682	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT457418	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT457417	hsa-miR-205-3p	PAR-CLIP	23592263
MIRT457416	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT457415	hsa-miR-4270	PAR-CLIP	23592263
MIRT457414	hsa-miR-4441	PAR-CLIP	23592263
MIRT457413	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT457412	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT457411	hsa-miR-8085	PAR-CLIP	23592263
MIRT457410	hsa-miR-3127-5p	PAR-CLIP	23592263
MIRT1316763	hsa-miR-2116	CLIP-seq
MIRT1316764	hsa-miR-4677-5p	CLIP-seq
MIRT1316765	hsa-miR-1207-5p	CLIP-seq
MIRT1316766	hsa-miR-1909	CLIP-seq
MIRT1316763	hsa-miR-2116	CLIP-seq
MIRT1316767	hsa-miR-3184	CLIP-seq
MIRT1316768	hsa-miR-3616-3p	CLIP-seq
MIRT1316769	hsa-miR-423-5p	CLIP-seq
MIRT1316770	hsa-miR-4436b-3p	CLIP-seq
MIRT1316764	hsa-miR-4677-5p	CLIP-seq
MIRT1316771	hsa-miR-4728-5p	CLIP-seq
MIRT1316772	hsa-miR-4763-3p	CLIP-seq
MIRT1316765	hsa-miR-1207-5p	CLIP-seq
MIRT1316766	hsa-miR-1909	CLIP-seq
MIRT1316768	hsa-miR-3616-3p	CLIP-seq
MIRT1316770	hsa-miR-4436b-3p	CLIP-seq
MIRT1316772	hsa-miR-4763-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0002181	Process	Cytoplasmic translation	IBA	21873635
GO:0002181	Process	Cytoplasmic translation	IDA	25957688
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003735	Function	Structural constituent of ribosome	IBA	21873635
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0005730	Component	Nucleolus	HDA	16791210
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	HDA	16791210
GO:0005829	Component	Cytosol	TAS
GO:0006412	Process	Translation	NAS	12962325
GO:0006413	Process	Translational initiation	TAS
GO:0006614	Process	SRP-dependent cotranslational protein targeting to membrane	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0019083	Process	Viral transcription	TAS
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA	21873635
GO:0022625	Component	Cytosolic large ribosomal subunit	IDA	25957688
GO:0042788	Component	Polysomal ribosome	IDA	25957688

Other IDs

• MIM: 617893
• HGNC: 13631
• e!Ensembl: ENSG00000130255

Protein

• UniProt ID: Q9Y3U8
• Protein name: Large ribosomal subunit protein eL36 (60S ribosomal protein L36)
• Protein function: Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25901680, PubMed:25957688, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962
• PDB: 4UG0, 4V6X, 5AJ0, 5LKS, 5T2C, 6IP5, 6IP6, 6IP8, 6LQM, 6LSR, 6LSS, 6LU8, 6OLE, 6OLF, 6OLG, 6OLI, 6OLZ, 6OM0, 6OM7, 6QZP, 6W6L, 6XA1, 6Y0G, 6Y2L, 6Y57, 6Y6X, 6Z6L, 6Z6M, 6Z6N, 6ZM7, 6ZME, 6ZMI, 6ZMO, 7BHP, 7F5S, 7OW7, 7QGG, 7QVP, 7XNX, 7XNY, 8A3D, 8FKP, 8FKQ, 8FKR, 8FKS, 8FKT, 8FKU, 8FKV, 8FKW, 8FKX, 8FKY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01158	Ribosomal_L36e	4 → 99	Ribosomal protein L36e	Family

• Sequence:

  MALRYPMAVGLNKGHKVTKNVSKPRHSRRRGRLTKHTKFVRDMIREVCGFAPYERRAMEL
  LKVSKDKRALKFIKKRVGTHIRAKRKREELSNVLAAMRKAAAKKD

• Sequence length: 105

Pathways

KEGG:

Ribosome
Coronavirus disease - COVID-19

Reactome:

L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Anemia	Anemia, Diamond-Blackfan	rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966, rs137853122, rs137853123, rs786205060, rs267607121, rs121908584, rs80338697, rs80338699, rs120074166, rs120074167, rs1050828, rs74575103, rs137852314, rs5030868, rs137852316, rs137852317, rs137852318, rs137852319, rs137852320, rs137852321, rs137852322, rs137852323, rs137852324, rs72554665, rs387906468, rs5030872, rs137852326, rs137852333, rs137852327, rs137852328, rs137852329, rs137852330, rs137852331, rs137852332, rs137852334, rs137852335, rs137852336, rs137852339, rs76645461, rs137852340, rs137852341, rs78478128, rs137852343, rs137852344, rs137852345, rs587776730, rs137852346, rs137852347, rs137852349, rs2070404412, rs2070350038, rs2070350009, rs137852303, rs137852304, rs33946267, rs34378160, rs33933298, rs11549407, rs35724775, rs34598529, rs41469945, rs267607201, rs80338694, rs80338696, rs387907018, rs398123546, rs78365220, rs587777100, rs587777101, rs483352840, rs869312752, rs765487627, rs1557229599, rs1557230040, rs1555524842, rs782090947, rs1358275550, rs1557229736, rs1557230573, rs1556323334, rs1233124208, rs1293528130, rs146864395, rs1595503440, rs1603411214, rs137852325, rs1575247302, rs1603411177, rs1336651679, rs782322505	28297620