ASF1A (anti-silencing function 1A histone chaperone)

Gene

• Entrez ID: 25842
• Gene name: Anti-silencing function 1A histone chaperone
• Gene symbol: ASF1A
• Synonyms: CGI-98, CIA, HSPC146
• Chromosome: 6
• Chromosome location: 6q22.31
• Summary: This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019628	hsa-miR-340-5p	Sequencing	20371350
MIRT020266	hsa-miR-130b-3p	Sequencing	20371350
MIRT028099	hsa-miR-93-5p	Sequencing	20371350
MIRT217679	hsa-miR-132-3p	PAR-CLIP	21572407
MIRT217678	hsa-miR-212-3p	PAR-CLIP	21572407
MIRT559425	hsa-miR-5003-3p	PAR-CLIP	21572407
MIRT244053	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT559424	hsa-miR-302c-5p	PAR-CLIP	21572407
MIRT217676	hsa-miR-6083	PAR-CLIP	21572407
MIRT559423	hsa-miR-552-5p	PAR-CLIP	21572407
MIRT217679	hsa-miR-132-3p	PAR-CLIP	21572407
MIRT217678	hsa-miR-212-3p	PAR-CLIP	21572407
MIRT559425	hsa-miR-5003-3p	PAR-CLIP	21572407
MIRT244053	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT559424	hsa-miR-302c-5p	PAR-CLIP	21572407
MIRT217676	hsa-miR-6083	PAR-CLIP	21572407
MIRT559423	hsa-miR-552-5p	PAR-CLIP	21572407
MIRT802707	hsa-miR-105	CLIP-seq
MIRT802708	hsa-miR-1231	CLIP-seq
MIRT802709	hsa-miR-1265	CLIP-seq
MIRT802710	hsa-miR-132	CLIP-seq
MIRT802711	hsa-miR-139-5p	CLIP-seq
MIRT802712	hsa-miR-2052	CLIP-seq
MIRT802713	hsa-miR-212	CLIP-seq
MIRT802714	hsa-miR-23a	CLIP-seq
MIRT802715	hsa-miR-23b	CLIP-seq
MIRT802716	hsa-miR-23c	CLIP-seq
MIRT802717	hsa-miR-27a	CLIP-seq
MIRT802718	hsa-miR-27b	CLIP-seq
MIRT802719	hsa-miR-3120-5p	CLIP-seq
MIRT802720	hsa-miR-3127-5p	CLIP-seq
MIRT802721	hsa-miR-3148	CLIP-seq
MIRT802722	hsa-miR-3168	CLIP-seq
MIRT802723	hsa-miR-3188	CLIP-seq
MIRT802724	hsa-miR-3192	CLIP-seq
MIRT802725	hsa-miR-3617	CLIP-seq
MIRT802726	hsa-miR-3647-3p	CLIP-seq
MIRT802727	hsa-miR-3689a-3p	CLIP-seq
MIRT802728	hsa-miR-3689c	CLIP-seq
MIRT802729	hsa-miR-369-3p	CLIP-seq
MIRT802730	hsa-miR-374a	CLIP-seq
MIRT802731	hsa-miR-374b	CLIP-seq
MIRT802732	hsa-miR-3978	CLIP-seq
MIRT802733	hsa-miR-412	CLIP-seq
MIRT802734	hsa-miR-4270	CLIP-seq
MIRT802735	hsa-miR-4289	CLIP-seq
MIRT802736	hsa-miR-4307	CLIP-seq
MIRT802737	hsa-miR-4314	CLIP-seq
MIRT802738	hsa-miR-4441	CLIP-seq
MIRT802739	hsa-miR-4646-5p	CLIP-seq
MIRT802740	hsa-miR-4668-3p	CLIP-seq
MIRT802741	hsa-miR-4700-3p	CLIP-seq
MIRT802742	hsa-miR-4728-5p	CLIP-seq
MIRT802743	hsa-miR-4788	CLIP-seq
MIRT802744	hsa-miR-494	CLIP-seq
MIRT802745	hsa-miR-513a-5p	CLIP-seq
MIRT802746	hsa-miR-548u	CLIP-seq
MIRT802747	hsa-miR-569	CLIP-seq
MIRT802748	hsa-miR-626	CLIP-seq
MIRT802749	hsa-miR-633	CLIP-seq
MIRT802750	hsa-miR-641	CLIP-seq
MIRT802751	hsa-miR-654-3p	CLIP-seq
MIRT802708	hsa-miR-1231	CLIP-seq
MIRT802719	hsa-miR-3120-5p	CLIP-seq
MIRT802724	hsa-miR-3192	CLIP-seq
MIRT802725	hsa-miR-3617	CLIP-seq
MIRT802727	hsa-miR-3689a-3p	CLIP-seq
MIRT802728	hsa-miR-3689c	CLIP-seq
MIRT802737	hsa-miR-4314	CLIP-seq
MIRT802739	hsa-miR-4646-5p	CLIP-seq
MIRT1937036	hsa-miR-4719	CLIP-seq
MIRT802742	hsa-miR-4728-5p	CLIP-seq
MIRT1937037	hsa-miR-561	CLIP-seq
MIRT802750	hsa-miR-641	CLIP-seq
MIRT802709	hsa-miR-1265	CLIP-seq
MIRT802711	hsa-miR-139-5p	CLIP-seq
MIRT2176826	hsa-miR-200b	CLIP-seq
MIRT2176827	hsa-miR-200c	CLIP-seq
MIRT802712	hsa-miR-2052	CLIP-seq
MIRT2176828	hsa-miR-21	CLIP-seq
MIRT802714	hsa-miR-23a	CLIP-seq
MIRT802715	hsa-miR-23b	CLIP-seq
MIRT802716	hsa-miR-23c	CLIP-seq
MIRT802720	hsa-miR-3127-5p	CLIP-seq
MIRT802722	hsa-miR-3168	CLIP-seq
MIRT2176829	hsa-miR-340	CLIP-seq
MIRT802733	hsa-miR-412	CLIP-seq
MIRT802734	hsa-miR-4270	CLIP-seq
MIRT802735	hsa-miR-4289	CLIP-seq
MIRT2176830	hsa-miR-429	CLIP-seq
MIRT802736	hsa-miR-4307	CLIP-seq
MIRT802738	hsa-miR-4441	CLIP-seq
MIRT802741	hsa-miR-4700-3p	CLIP-seq
MIRT2176831	hsa-miR-4775	CLIP-seq
MIRT802743	hsa-miR-4788	CLIP-seq
MIRT2176832	hsa-miR-590-5p	CLIP-seq
MIRT802749	hsa-miR-633	CLIP-seq
MIRT802708	hsa-miR-1231	CLIP-seq
MIRT2480157	hsa-miR-140-5p	CLIP-seq
MIRT2480158	hsa-miR-2116	CLIP-seq
MIRT802717	hsa-miR-27a	CLIP-seq
MIRT802718	hsa-miR-27b	CLIP-seq
MIRT802719	hsa-miR-3120-5p	CLIP-seq
MIRT2480159	hsa-miR-3145-3p	CLIP-seq
MIRT802724	hsa-miR-3192	CLIP-seq
MIRT2480160	hsa-miR-3194-3p	CLIP-seq
MIRT2480161	hsa-miR-3545-5p	CLIP-seq
MIRT2480162	hsa-miR-3616-5p	CLIP-seq
MIRT802725	hsa-miR-3617	CLIP-seq
MIRT2480163	hsa-miR-3647-5p	CLIP-seq
MIRT2480164	hsa-miR-3663-5p	CLIP-seq
MIRT802727	hsa-miR-3689a-3p	CLIP-seq
MIRT802728	hsa-miR-3689c	CLIP-seq
MIRT2480165	hsa-miR-375	CLIP-seq
MIRT802733	hsa-miR-412	CLIP-seq
MIRT2480166	hsa-miR-4273	CLIP-seq
MIRT802737	hsa-miR-4314	CLIP-seq
MIRT2480167	hsa-miR-4460	CLIP-seq
MIRT802739	hsa-miR-4646-5p	CLIP-seq
MIRT2480168	hsa-miR-4677-5p	CLIP-seq
MIRT802742	hsa-miR-4728-5p	CLIP-seq
MIRT2480169	hsa-miR-4753-5p	CLIP-seq
MIRT2480170	hsa-miR-4799-5p	CLIP-seq
MIRT2480171	hsa-miR-490-3p	CLIP-seq
MIRT802744	hsa-miR-494	CLIP-seq
MIRT802745	hsa-miR-513a-5p	CLIP-seq
MIRT802746	hsa-miR-548u	CLIP-seq
MIRT2480172	hsa-miR-573	CLIP-seq
MIRT2480173	hsa-miR-601	CLIP-seq
MIRT2480174	hsa-miR-607	CLIP-seq
MIRT802750	hsa-miR-641	CLIP-seq
MIRT802751	hsa-miR-654-3p	CLIP-seq
MIRT802708	hsa-miR-1231	CLIP-seq
MIRT2480157	hsa-miR-140-5p	CLIP-seq
MIRT2480158	hsa-miR-2116	CLIP-seq
MIRT802717	hsa-miR-27a	CLIP-seq
MIRT802718	hsa-miR-27b	CLIP-seq
MIRT802719	hsa-miR-3120-5p	CLIP-seq
MIRT2480159	hsa-miR-3145-3p	CLIP-seq
MIRT802724	hsa-miR-3192	CLIP-seq
MIRT2480160	hsa-miR-3194-3p	CLIP-seq
MIRT2480161	hsa-miR-3545-5p	CLIP-seq
MIRT2480162	hsa-miR-3616-5p	CLIP-seq
MIRT802725	hsa-miR-3617	CLIP-seq
MIRT2480163	hsa-miR-3647-5p	CLIP-seq
MIRT802727	hsa-miR-3689a-3p	CLIP-seq
MIRT802728	hsa-miR-3689c	CLIP-seq
MIRT2480165	hsa-miR-375	CLIP-seq
MIRT802733	hsa-miR-412	CLIP-seq
MIRT2480166	hsa-miR-4273	CLIP-seq
MIRT802737	hsa-miR-4314	CLIP-seq
MIRT2480167	hsa-miR-4460	CLIP-seq
MIRT802739	hsa-miR-4646-5p	CLIP-seq
MIRT2480168	hsa-miR-4677-5p	CLIP-seq
MIRT802742	hsa-miR-4728-5p	CLIP-seq
MIRT2480169	hsa-miR-4753-5p	CLIP-seq
MIRT2480170	hsa-miR-4799-5p	CLIP-seq
MIRT802744	hsa-miR-494	CLIP-seq
MIRT802745	hsa-miR-513a-5p	CLIP-seq
MIRT802746	hsa-miR-548u	CLIP-seq
MIRT2480172	hsa-miR-573	CLIP-seq
MIRT2480174	hsa-miR-607	CLIP-seq
MIRT802750	hsa-miR-641	CLIP-seq
MIRT802751	hsa-miR-654-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IDA	14718166
GO:0001649	Process	Osteoblast differentiation	IEA
GO:0003682	Function	Chromatin binding	NAS	10759893
GO:0005515	Function	Protein binding	IPI	16980972, 19029251, 19862764, 21217774, 22407294, 23075851, 24981860, 25416956, 26167883, 26496610, 28514442, 31527615, 32296183
GO:0005634	Component	Nucleus	IDA
GO:0005634	Component	Nucleus	NAS	10759893
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006281	Process	DNA repair	IDA	11897662
GO:0006334	Process	Nucleosome assembly	IDA	11897662
GO:0006335	Process	DNA replication-dependent nucleosome assembly	IBA	21873635
GO:0006335	Process	DNA replication-dependent nucleosome assembly	IDA	14718166
GO:0006336	Process	DNA replication-independent nucleosome assembly	IBA	21873635
GO:0006336	Process	DNA replication-independent nucleosome assembly	IDA	14718166
GO:0031936	Process	Negative regulation of chromatin silencing	NAS	10759893
GO:0032991	Component	Protein-containing complex	IDA	14718166
GO:0042393	Function	Histone binding	IBA	21873635
GO:0042393	Function	Histone binding	IDA	10759893
GO:0042692	Process	Muscle cell differentiation	IEA

Other IDs

• MIM: 609189
• HGNC: 20995
• e!Ensembl: ENSG00000111875

Protein

• UniProt ID: Q9Y294
• Protein name: Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA)
• Protein function: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:10759893, PubMed:11897662, PubMed:12842904, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454
• PDB: 1TEY, 2I32, 2IIJ, 2IO5, 3AAD, 5C3I, 6F0F, 6F0G, 6F0H, 6ZUF, 7LNY, 7LO0, 7V6Q, 8BV1, 8CJ1, 8CJ2, 8CJ3, 8Z50
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04729	ASF1_hist_chap	1 → 154	ASF1 like histone chaperone	Family

• Sequence:

  MAKVQVNNVVVLDNPSPFYNPFQFEITFECIEDLSEDLEWKIIYVGSAESEEYDQVLDSV
  LVGPVPAGRHMFVFQADAPNPGLIPDADAVGVTVVLITCTYRGQEFIRVGYYVNNEYTET
  ELRENPPVKPDFSKLQRNILASNPRVTRFHINWEDNTEKLEDAESSNPNLQSLLSTDALP
  SASKGWSTSENSLNVMLESHMDCM

• Sequence length: 204

Pathways

Reactome:

Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	22535842