SULT4A1 (sulfotransferase family 4A member 1)

Gene

• Entrez ID: 25830
• Gene name: Sulfotransferase family 4A member 1
• Gene symbol: SULT4A1
• Synonyms: BR-STL-1, BRSTL1, DJ388M5.3, NST, SULTX3, hBR-STL-1
• Chromosome: 22
• Chromosome location: 22q13.31
• Summary: This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizop

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1402934	hsa-miR-146a	CLIP-seq
MIRT1402935	hsa-miR-146b-5p	CLIP-seq
MIRT1402936	hsa-miR-298	CLIP-seq
MIRT1402937	hsa-miR-3128	CLIP-seq
MIRT1402938	hsa-miR-326	CLIP-seq
MIRT1402939	hsa-miR-330-5p	CLIP-seq
MIRT1402940	hsa-miR-4330	CLIP-seq
MIRT1402941	hsa-miR-4632	CLIP-seq
MIRT1402942	hsa-miR-4720-5p	CLIP-seq
MIRT1402943	hsa-miR-4773	CLIP-seq
MIRT1402944	hsa-miR-4799-3p	CLIP-seq
MIRT1402945	hsa-miR-589	CLIP-seq
MIRT1402946	hsa-miR-593	CLIP-seq
MIRT1402937	hsa-miR-3128	CLIP-seq
MIRT1402938	hsa-miR-326	CLIP-seq
MIRT1402939	hsa-miR-330-5p	CLIP-seq
MIRT1402941	hsa-miR-4632	CLIP-seq
MIRT1402942	hsa-miR-4720-5p	CLIP-seq
MIRT1402944	hsa-miR-4799-3p	CLIP-seq
MIRT1402946	hsa-miR-593	CLIP-seq
MIRT2120791	hsa-miR-153	CLIP-seq
MIRT1402937	hsa-miR-3128	CLIP-seq
MIRT2120792	hsa-miR-3180-5p	CLIP-seq
MIRT1402938	hsa-miR-326	CLIP-seq
MIRT1402939	hsa-miR-330-5p	CLIP-seq
MIRT2120793	hsa-miR-448	CLIP-seq
MIRT1402941	hsa-miR-4632	CLIP-seq
MIRT1402942	hsa-miR-4720-5p	CLIP-seq
MIRT1402944	hsa-miR-4799-3p	CLIP-seq
MIRT1402946	hsa-miR-593	CLIP-seq
MIRT2120794	hsa-miR-656	CLIP-seq
MIRT2342814	hsa-miR-1229	CLIP-seq
MIRT2342815	hsa-miR-197	CLIP-seq
MIRT2342816	hsa-miR-2117	CLIP-seq
MIRT1402937	hsa-miR-3128	CLIP-seq
MIRT2120792	hsa-miR-3180-5p	CLIP-seq
MIRT1402938	hsa-miR-326	CLIP-seq
MIRT1402939	hsa-miR-330-5p	CLIP-seq
MIRT2342817	hsa-miR-4273	CLIP-seq
MIRT1402941	hsa-miR-4632	CLIP-seq
MIRT1402942	hsa-miR-4720-5p	CLIP-seq
MIRT1402944	hsa-miR-4799-3p	CLIP-seq
MIRT1402946	hsa-miR-593	CLIP-seq
MIRT1402937	hsa-miR-3128	CLIP-seq
MIRT1402938	hsa-miR-326	CLIP-seq
MIRT1402939	hsa-miR-330-5p	CLIP-seq
MIRT1402941	hsa-miR-4632	CLIP-seq
MIRT1402942	hsa-miR-4720-5p	CLIP-seq
MIRT1402944	hsa-miR-4799-3p	CLIP-seq
MIRT1402946	hsa-miR-593	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	19439498, 21044950, 32296183
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0008146	Function	Sulfotransferase activity	IBA	21873635
GO:0008146	Function	Sulfotransferase activity	NAS	10698717
GO:0008150	Process	Biological_process	ND
GO:0008202	Process	Steroid metabolic process	IEA
GO:0042802	Function	Identical protein binding	IPI	19439498, 32296183
GO:0050427	Process	3'-phosphoadenosine 5'-phosphosulfate metabolic process	TAS
GO:0051923	Process	Sulfation	IBA	21873635

Other IDs

• MIM: 608359
• HGNC: 14903
• e!Ensembl: ENSG00000130540

Protein

• UniProt ID: Q9BR01
• Protein name: Sulfotransferase 4A1 (ST4A1) (EC 2.8.2.-) (Brain sulfotransferase-like protein) (hBR-STL) (hBR-STL-1) (Nervous system sulfotransferase) (NST)
• Protein function: Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May hav
• PDB: 1ZD1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00685	Sulfotransfer_1	45 → 277	Sulfotransferase domain	Domain

• Sequence:

  MAESEAETPSTPGEFESKYFEFHGVRLPPFCRGKMEEIANFPVRPSDVWIVTYPKSGTSL
  LQEVVYLVSQGADPDEIGLMNIDEQLPVLEYPQPGLDIIKELTSPRLIKSHLPYRFLPSD
  LHNGDSKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQ
  EFWEHRMDSNVLFLKYEDMHRDLVTMVEQLARFLGVSCDKAQLEALTEHCHQLVDQCCNA
  EALPVGRGRVGLWKDIFTVSMNEKFDLVYKQKMGKCDLTFDFYL

• Sequence length: 284

Pathways

Reactome:

Cytosolic sulfonation of small molecules

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	19125109, 16152568, 18823757, 17728668

Unknown
Disease name	Disease term	dbSNP ID	References
Schizoaffective disorder	Schizoaffective Disorder		18823757