TXN2 (thioredoxin 2)

Gene

• Entrez ID: 25828
• Gene name: Thioredoxin 2
• Gene symbol: TXN2
• Synonyms: COXPD29, MT-TRX, MTRX, TRX2, TXN
• Chromosome: 22
• Chromosome location: 22q12.3
• Summary: This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection ag

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs754022333	C>T	Pathogenic	Coding sequence variant, stop gained

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001402	hsa-miR-16-5p	pSILAC	18668040
MIRT001402	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT044903	hsa-miR-186-5p	CLASH	23622248
MIRT039307	hsa-miR-425-5p	CLASH	23622248
MIRT038474	hsa-miR-296-3p	CLASH	23622248
MIRT037320	hsa-miR-877-5p	CLASH	23622248
MIRT1464843	hsa-miR-128	CLIP-seq
MIRT1464844	hsa-miR-1321	CLIP-seq
MIRT1464845	hsa-miR-15a	CLIP-seq
MIRT1464846	hsa-miR-15b	CLIP-seq
MIRT1464847	hsa-miR-16	CLIP-seq
MIRT1464848	hsa-miR-1827	CLIP-seq
MIRT1464849	hsa-miR-195	CLIP-seq
MIRT1464850	hsa-miR-214	CLIP-seq
MIRT1464851	hsa-miR-27a	CLIP-seq
MIRT1464852	hsa-miR-27b	CLIP-seq
MIRT1464853	hsa-miR-29a	CLIP-seq
MIRT1464854	hsa-miR-29b	CLIP-seq
MIRT1464855	hsa-miR-29c	CLIP-seq
MIRT1464856	hsa-miR-3065-3p	CLIP-seq
MIRT1464857	hsa-miR-3157-5p	CLIP-seq
MIRT1464858	hsa-miR-3168	CLIP-seq
MIRT1464859	hsa-miR-3170	CLIP-seq
MIRT1464860	hsa-miR-3173-3p	CLIP-seq
MIRT1464861	hsa-miR-3186-3p	CLIP-seq
MIRT1464862	hsa-miR-3202	CLIP-seq
MIRT1464863	hsa-miR-3612	CLIP-seq
MIRT1464864	hsa-miR-3619-5p	CLIP-seq
MIRT1464865	hsa-miR-3943	CLIP-seq
MIRT1464866	hsa-miR-424	CLIP-seq
MIRT1464867	hsa-miR-4291	CLIP-seq
MIRT1464868	hsa-miR-4313	CLIP-seq
MIRT1464869	hsa-miR-4419a	CLIP-seq
MIRT1464870	hsa-miR-4428	CLIP-seq
MIRT1464871	hsa-miR-4446-3p	CLIP-seq
MIRT1464872	hsa-miR-4459	CLIP-seq
MIRT1464873	hsa-miR-4476	CLIP-seq
MIRT1464874	hsa-miR-4492	CLIP-seq
MIRT1464875	hsa-miR-4498	CLIP-seq
MIRT1464876	hsa-miR-4510	CLIP-seq
MIRT1464877	hsa-miR-4521	CLIP-seq
MIRT1464878	hsa-miR-4640-5p	CLIP-seq
MIRT1464879	hsa-miR-4690-3p	CLIP-seq
MIRT1464880	hsa-miR-4707-5p	CLIP-seq
MIRT1464881	hsa-miR-4726-5p	CLIP-seq
MIRT1464882	hsa-miR-4739	CLIP-seq
MIRT1464883	hsa-miR-4756-5p	CLIP-seq
MIRT1464884	hsa-miR-4779	CLIP-seq
MIRT1464885	hsa-miR-497	CLIP-seq
MIRT1464886	hsa-miR-513a-5p	CLIP-seq
MIRT1464887	hsa-miR-548aa	CLIP-seq
MIRT1464888	hsa-miR-615-5p	CLIP-seq
MIRT1464889	hsa-miR-650	CLIP-seq
MIRT1464890	hsa-miR-662	CLIP-seq
MIRT1464891	hsa-miR-761	CLIP-seq
MIRT1464892	hsa-miR-762	CLIP-seq
MIRT1464893	hsa-miR-767-3p	CLIP-seq
MIRT1464894	hsa-miR-922	CLIP-seq
MIRT2139860	hsa-miR-1266	CLIP-seq
MIRT2139861	hsa-miR-1587	CLIP-seq
MIRT2139862	hsa-miR-2355-5p	CLIP-seq
MIRT1464851	hsa-miR-27a	CLIP-seq
MIRT1464852	hsa-miR-27b	CLIP-seq
MIRT2139863	hsa-miR-3127-5p	CLIP-seq
MIRT1464862	hsa-miR-3202	CLIP-seq
MIRT2139864	hsa-miR-3672	CLIP-seq
MIRT2139865	hsa-miR-3918	CLIP-seq
MIRT2139866	hsa-miR-3925-3p	CLIP-seq
MIRT1464871	hsa-miR-4446-3p	CLIP-seq
MIRT1464874	hsa-miR-4492	CLIP-seq
MIRT1464875	hsa-miR-4498	CLIP-seq
MIRT2139867	hsa-miR-4518	CLIP-seq
MIRT2139868	hsa-miR-4533	CLIP-seq
MIRT2139869	hsa-miR-4685-5p	CLIP-seq
MIRT1464879	hsa-miR-4690-3p	CLIP-seq
MIRT2139870	hsa-miR-4705	CLIP-seq
MIRT2139871	hsa-miR-510	CLIP-seq
MIRT2139872	hsa-miR-617	CLIP-seq
MIRT2139873	hsa-miR-661	CLIP-seq
MIRT1464892	hsa-miR-762	CLIP-seq
MIRT2139874	hsa-miR-766	CLIP-seq
MIRT2360412	hsa-miR-1207-3p	CLIP-seq
MIRT2360413	hsa-miR-1254	CLIP-seq
MIRT2360414	hsa-miR-1262	CLIP-seq
MIRT1464843	hsa-miR-128	CLIP-seq
MIRT1464848	hsa-miR-1827	CLIP-seq
MIRT1464851	hsa-miR-27a	CLIP-seq
MIRT1464852	hsa-miR-27b	CLIP-seq
MIRT2360415	hsa-miR-3116	CLIP-seq
MIRT2360416	hsa-miR-3130-3p	CLIP-seq
MIRT1464857	hsa-miR-3157-5p	CLIP-seq
MIRT1464860	hsa-miR-3173-3p	CLIP-seq
MIRT2360417	hsa-miR-3190	CLIP-seq
MIRT2360418	hsa-miR-3192	CLIP-seq
MIRT1464862	hsa-miR-3202	CLIP-seq
MIRT1464863	hsa-miR-3612	CLIP-seq
MIRT2360419	hsa-miR-3622a-5p	CLIP-seq
MIRT2360420	hsa-miR-3689a-3p	CLIP-seq
MIRT2360421	hsa-miR-3689c	CLIP-seq
MIRT2360422	hsa-miR-3689d	CLIP-seq
MIRT2360423	hsa-miR-3942-3p	CLIP-seq
MIRT1464865	hsa-miR-3943	CLIP-seq
MIRT2360424	hsa-miR-3978	CLIP-seq
MIRT2360425	hsa-miR-4266	CLIP-seq
MIRT2360426	hsa-miR-4269	CLIP-seq
MIRT2360427	hsa-miR-4292	CLIP-seq
MIRT2360428	hsa-miR-4308	CLIP-seq
MIRT2360429	hsa-miR-4311	CLIP-seq
MIRT1464868	hsa-miR-4313	CLIP-seq
MIRT2360430	hsa-miR-4475	CLIP-seq
MIRT2360431	hsa-miR-4506	CLIP-seq
MIRT2139868	hsa-miR-4533	CLIP-seq
MIRT2360432	hsa-miR-4640-3p	CLIP-seq
MIRT2360433	hsa-miR-4645-5p	CLIP-seq
MIRT2360434	hsa-miR-4651	CLIP-seq
MIRT2360435	hsa-miR-4660	CLIP-seq
MIRT2360436	hsa-miR-4673	CLIP-seq
MIRT1464879	hsa-miR-4690-3p	CLIP-seq
MIRT2360437	hsa-miR-4695-5p	CLIP-seq
MIRT2360438	hsa-miR-4701-3p	CLIP-seq
MIRT2360439	hsa-miR-4728-5p	CLIP-seq
MIRT2360440	hsa-miR-4755-3p	CLIP-seq
MIRT1464884	hsa-miR-4779	CLIP-seq
MIRT2360441	hsa-miR-4793-3p	CLIP-seq
MIRT1464886	hsa-miR-513a-5p	CLIP-seq
MIRT2360442	hsa-miR-539	CLIP-seq
MIRT2360443	hsa-miR-544	CLIP-seq
MIRT1464887	hsa-miR-548aa	CLIP-seq
MIRT2360444	hsa-miR-608	CLIP-seq
MIRT2360445	hsa-miR-637	CLIP-seq
MIRT2360446	hsa-miR-646	CLIP-seq
MIRT1464889	hsa-miR-650	CLIP-seq
MIRT2139873	hsa-miR-661	CLIP-seq
MIRT2360447	hsa-miR-7	CLIP-seq
MIRT1464893	hsa-miR-767-3p	CLIP-seq
MIRT2360448	hsa-miR-875-3p	CLIP-seq
MIRT1464862	hsa-miR-3202	CLIP-seq
MIRT2139868	hsa-miR-4533	CLIP-seq
MIRT1464884	hsa-miR-4779	CLIP-seq
MIRT1464844	hsa-miR-1321	CLIP-seq
MIRT1464848	hsa-miR-1827	CLIP-seq
MIRT1464850	hsa-miR-214	CLIP-seq
MIRT1464862	hsa-miR-3202	CLIP-seq
MIRT1464863	hsa-miR-3612	CLIP-seq
MIRT1464864	hsa-miR-3619-5p	CLIP-seq
MIRT2441558	hsa-miR-3622b-5p	CLIP-seq
MIRT1464871	hsa-miR-4446-3p	CLIP-seq
MIRT1464873	hsa-miR-4476	CLIP-seq
MIRT1464874	hsa-miR-4492	CLIP-seq
MIRT1464875	hsa-miR-4498	CLIP-seq
MIRT2441559	hsa-miR-4720-5p	CLIP-seq
MIRT1464882	hsa-miR-4739	CLIP-seq
MIRT1464883	hsa-miR-4756-5p	CLIP-seq
MIRT2441560	hsa-miR-4799-3p	CLIP-seq
MIRT1464889	hsa-miR-650	CLIP-seq
MIRT1464891	hsa-miR-761	CLIP-seq
MIRT1464892	hsa-miR-762	CLIP-seq
MIRT2462688	hsa-miR-1285	CLIP-seq
MIRT2462689	hsa-miR-3187-5p	CLIP-seq
MIRT2462690	hsa-miR-331-3p	CLIP-seq
MIRT2360427	hsa-miR-4292	CLIP-seq
MIRT2462691	hsa-miR-4502	CLIP-seq
MIRT2462692	hsa-miR-612	CLIP-seq
MIRT2653902	hsa-miR-1203	CLIP-seq
MIRT2360412	hsa-miR-1207-3p	CLIP-seq
MIRT2360413	hsa-miR-1254	CLIP-seq
MIRT2139860	hsa-miR-1266	CLIP-seq
MIRT2653903	hsa-miR-1283	CLIP-seq
MIRT2462688	hsa-miR-1285	CLIP-seq
MIRT2653904	hsa-miR-1343	CLIP-seq
MIRT2653905	hsa-miR-146a	CLIP-seq
MIRT2653906	hsa-miR-146b-5p	CLIP-seq
MIRT2139861	hsa-miR-1587	CLIP-seq
MIRT1464845	hsa-miR-15a	CLIP-seq
MIRT1464846	hsa-miR-15b	CLIP-seq
MIRT1464847	hsa-miR-16	CLIP-seq
MIRT1464848	hsa-miR-1827	CLIP-seq
MIRT1464849	hsa-miR-195	CLIP-seq
MIRT1464850	hsa-miR-214	CLIP-seq
MIRT2653907	hsa-miR-2277-3p	CLIP-seq
MIRT2139862	hsa-miR-2355-5p	CLIP-seq
MIRT2653908	hsa-miR-2467-5p	CLIP-seq
MIRT2653909	hsa-miR-296-5p	CLIP-seq
MIRT1464853	hsa-miR-29a	CLIP-seq
MIRT1464854	hsa-miR-29b	CLIP-seq
MIRT1464855	hsa-miR-29c	CLIP-seq
MIRT1464856	hsa-miR-3065-3p	CLIP-seq
MIRT2360415	hsa-miR-3116	CLIP-seq
MIRT2139863	hsa-miR-3127-5p	CLIP-seq
MIRT2360416	hsa-miR-3130-3p	CLIP-seq
MIRT2653910	hsa-miR-3135b	CLIP-seq
MIRT2653911	hsa-miR-3154	CLIP-seq
MIRT1464860	hsa-miR-3173-3p	CLIP-seq
MIRT2462689	hsa-miR-3187-5p	CLIP-seq
MIRT2360418	hsa-miR-3192	CLIP-seq
MIRT2462690	hsa-miR-331-3p	CLIP-seq
MIRT1464863	hsa-miR-3612	CLIP-seq
MIRT2653912	hsa-miR-3613-3p	CLIP-seq
MIRT1464864	hsa-miR-3619-5p	CLIP-seq
MIRT2653913	hsa-miR-3652	CLIP-seq
MIRT2653914	hsa-miR-3662	CLIP-seq
MIRT2139864	hsa-miR-3672	CLIP-seq
MIRT2360420	hsa-miR-3689a-3p	CLIP-seq
MIRT2360421	hsa-miR-3689c	CLIP-seq
MIRT2653915	hsa-miR-378g	CLIP-seq
MIRT2139865	hsa-miR-3918	CLIP-seq
MIRT2139866	hsa-miR-3925-3p	CLIP-seq
MIRT2360424	hsa-miR-3978	CLIP-seq
MIRT1464866	hsa-miR-424	CLIP-seq
MIRT2653916	hsa-miR-4267	CLIP-seq
MIRT1464867	hsa-miR-4291	CLIP-seq
MIRT2360427	hsa-miR-4292	CLIP-seq
MIRT2360428	hsa-miR-4308	CLIP-seq
MIRT2360429	hsa-miR-4311	CLIP-seq
MIRT2653917	hsa-miR-4430	CLIP-seq
MIRT2653918	hsa-miR-4437	CLIP-seq
MIRT1464871	hsa-miR-4446-3p	CLIP-seq
MIRT2653919	hsa-miR-4484	CLIP-seq
MIRT1464874	hsa-miR-4492	CLIP-seq
MIRT1464875	hsa-miR-4498	CLIP-seq
MIRT2462691	hsa-miR-4502	CLIP-seq
MIRT2360431	hsa-miR-4506	CLIP-seq
MIRT2139867	hsa-miR-4518	CLIP-seq
MIRT2360432	hsa-miR-4640-3p	CLIP-seq
MIRT2360434	hsa-miR-4651	CLIP-seq
MIRT2360435	hsa-miR-4660	CLIP-seq
MIRT2653920	hsa-miR-4674	CLIP-seq
MIRT2139869	hsa-miR-4685-5p	CLIP-seq
MIRT1464879	hsa-miR-4690-3p	CLIP-seq
MIRT2139870	hsa-miR-4705	CLIP-seq
MIRT1464880	hsa-miR-4707-5p	CLIP-seq
MIRT2360439	hsa-miR-4728-5p	CLIP-seq
MIRT2653921	hsa-miR-4746-5p	CLIP-seq
MIRT2653922	hsa-miR-4747-3p	CLIP-seq
MIRT2653923	hsa-miR-4769-3p	CLIP-seq
MIRT1464884	hsa-miR-4779	CLIP-seq
MIRT2360441	hsa-miR-4793-3p	CLIP-seq
MIRT2653924	hsa-miR-4793-5p	CLIP-seq
MIRT2653925	hsa-miR-488	CLIP-seq
MIRT1464885	hsa-miR-497	CLIP-seq
MIRT2139871	hsa-miR-510	CLIP-seq
MIRT2653926	hsa-miR-520d-5p	CLIP-seq
MIRT2653927	hsa-miR-524-5p	CLIP-seq
MIRT2360442	hsa-miR-539	CLIP-seq
MIRT2360443	hsa-miR-544	CLIP-seq
MIRT2360444	hsa-miR-608	CLIP-seq
MIRT2462692	hsa-miR-612	CLIP-seq
MIRT2139872	hsa-miR-617	CLIP-seq
MIRT2360445	hsa-miR-637	CLIP-seq
MIRT2360446	hsa-miR-646	CLIP-seq
MIRT1464889	hsa-miR-650	CLIP-seq
MIRT2139873	hsa-miR-661	CLIP-seq
MIRT2360447	hsa-miR-7	CLIP-seq
MIRT1464891	hsa-miR-761	CLIP-seq
MIRT1464892	hsa-miR-762	CLIP-seq
MIRT2139874	hsa-miR-766	CLIP-seq
MIRT2360448	hsa-miR-875-3p	CLIP-seq
MIRT1464894	hsa-miR-922	CLIP-seq
MIRT2653902	hsa-miR-1203	CLIP-seq
MIRT2360412	hsa-miR-1207-3p	CLIP-seq
MIRT2360413	hsa-miR-1254	CLIP-seq
MIRT2139860	hsa-miR-1266	CLIP-seq
MIRT2653903	hsa-miR-1283	CLIP-seq
MIRT2462688	hsa-miR-1285	CLIP-seq
MIRT2653904	hsa-miR-1343	CLIP-seq
MIRT2653905	hsa-miR-146a	CLIP-seq
MIRT2653906	hsa-miR-146b-5p	CLIP-seq
MIRT2139861	hsa-miR-1587	CLIP-seq
MIRT1464845	hsa-miR-15a	CLIP-seq
MIRT1464846	hsa-miR-15b	CLIP-seq
MIRT1464847	hsa-miR-16	CLIP-seq
MIRT1464848	hsa-miR-1827	CLIP-seq
MIRT1464849	hsa-miR-195	CLIP-seq
MIRT1464850	hsa-miR-214	CLIP-seq
MIRT2653907	hsa-miR-2277-3p	CLIP-seq
MIRT2139862	hsa-miR-2355-5p	CLIP-seq
MIRT2653908	hsa-miR-2467-5p	CLIP-seq
MIRT1464853	hsa-miR-29a	CLIP-seq
MIRT1464854	hsa-miR-29b	CLIP-seq
MIRT1464855	hsa-miR-29c	CLIP-seq
MIRT1464856	hsa-miR-3065-3p	CLIP-seq
MIRT2360415	hsa-miR-3116	CLIP-seq
MIRT2139863	hsa-miR-3127-5p	CLIP-seq
MIRT2360416	hsa-miR-3130-3p	CLIP-seq
MIRT2653910	hsa-miR-3135b	CLIP-seq
MIRT2653911	hsa-miR-3154	CLIP-seq
MIRT1464860	hsa-miR-3173-3p	CLIP-seq
MIRT2462689	hsa-miR-3187-5p	CLIP-seq
MIRT2360418	hsa-miR-3192	CLIP-seq
MIRT2462690	hsa-miR-331-3p	CLIP-seq
MIRT1464863	hsa-miR-3612	CLIP-seq
MIRT2653912	hsa-miR-3613-3p	CLIP-seq
MIRT1464864	hsa-miR-3619-5p	CLIP-seq
MIRT2653913	hsa-miR-3652	CLIP-seq
MIRT2653914	hsa-miR-3662	CLIP-seq
MIRT2139864	hsa-miR-3672	CLIP-seq
MIRT2360420	hsa-miR-3689a-3p	CLIP-seq
MIRT2360421	hsa-miR-3689c	CLIP-seq
MIRT2653915	hsa-miR-378g	CLIP-seq
MIRT2139865	hsa-miR-3918	CLIP-seq
MIRT2139866	hsa-miR-3925-3p	CLIP-seq
MIRT2360424	hsa-miR-3978	CLIP-seq
MIRT1464866	hsa-miR-424	CLIP-seq
MIRT2653916	hsa-miR-4267	CLIP-seq
MIRT1464867	hsa-miR-4291	CLIP-seq
MIRT2360427	hsa-miR-4292	CLIP-seq
MIRT2360428	hsa-miR-4308	CLIP-seq
MIRT2360429	hsa-miR-4311	CLIP-seq
MIRT2653917	hsa-miR-4430	CLIP-seq
MIRT2653918	hsa-miR-4437	CLIP-seq
MIRT1464871	hsa-miR-4446-3p	CLIP-seq
MIRT2653919	hsa-miR-4484	CLIP-seq
MIRT1464874	hsa-miR-4492	CLIP-seq
MIRT1464875	hsa-miR-4498	CLIP-seq
MIRT2462691	hsa-miR-4502	CLIP-seq
MIRT2139867	hsa-miR-4518	CLIP-seq
MIRT2360432	hsa-miR-4640-3p	CLIP-seq
MIRT2360434	hsa-miR-4651	CLIP-seq
MIRT2360435	hsa-miR-4660	CLIP-seq
MIRT2653920	hsa-miR-4674	CLIP-seq
MIRT2139869	hsa-miR-4685-5p	CLIP-seq
MIRT1464879	hsa-miR-4690-3p	CLIP-seq
MIRT2139870	hsa-miR-4705	CLIP-seq
MIRT1464880	hsa-miR-4707-5p	CLIP-seq
MIRT2360439	hsa-miR-4728-5p	CLIP-seq
MIRT2653921	hsa-miR-4746-5p	CLIP-seq
MIRT2653922	hsa-miR-4747-3p	CLIP-seq
MIRT2653923	hsa-miR-4769-3p	CLIP-seq
MIRT1464884	hsa-miR-4779	CLIP-seq
MIRT2360441	hsa-miR-4793-3p	CLIP-seq
MIRT2653924	hsa-miR-4793-5p	CLIP-seq
MIRT2653925	hsa-miR-488	CLIP-seq
MIRT1464885	hsa-miR-497	CLIP-seq
MIRT2139871	hsa-miR-510	CLIP-seq
MIRT2653926	hsa-miR-520d-5p	CLIP-seq
MIRT2653927	hsa-miR-524-5p	CLIP-seq
MIRT2360442	hsa-miR-539	CLIP-seq
MIRT2360443	hsa-miR-544	CLIP-seq
MIRT2360444	hsa-miR-608	CLIP-seq
MIRT2462692	hsa-miR-612	CLIP-seq
MIRT2139872	hsa-miR-617	CLIP-seq
MIRT2360445	hsa-miR-637	CLIP-seq
MIRT2360446	hsa-miR-646	CLIP-seq
MIRT1464889	hsa-miR-650	CLIP-seq
MIRT2139873	hsa-miR-661	CLIP-seq
MIRT2360447	hsa-miR-7	CLIP-seq
MIRT1464891	hsa-miR-761	CLIP-seq
MIRT1464892	hsa-miR-762	CLIP-seq
MIRT2139874	hsa-miR-766	CLIP-seq
MIRT2360448	hsa-miR-875-3p	CLIP-seq
MIRT1464894	hsa-miR-922	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
RUNX3	Repression	17956589

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000098	Process	Sulfur amino acid catabolic process	TAS
GO:0001666	Process	Response to hypoxia	IEA
GO:0005515	Function	Protein binding	IPI	21988832, 25416956, 31515488, 32296183, 32814053
GO:0005730	Component	Nucleolus	IDA
GO:0005739	Component	Mitochondrion	IDA	12032145
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006662	Process	Glycerol ether metabolic process	IEA
GO:0006979	Process	Response to oxidative stress	IEA
GO:0008113	Function	Peptide-methionine (S)-S-oxide reductase activity	IEA
GO:0009725	Process	Response to hormone	IEA
GO:0009749	Process	Response to glucose	IEA
GO:0014070	Process	Response to organic cyclic compound	IEA
GO:0015035	Function	Protein disulfide oxidoreductase activity	IEA
GO:0030425	Component	Dendrite	IEA
GO:0031669	Process	Cellular response to nutrient levels	IEA
GO:0033743	Function	Peptide-methionine (R)-S-oxide reductase activity	IEA
GO:0042493	Process	Response to drug	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045454	Process	Cell redox homeostasis	IEA
GO:0048678	Process	Response to axon injury	IEA

Other IDs

• MIM: 609063
• HGNC: 17772
• e!Ensembl: ENSG00000100348

Protein

• UniProt ID: Q99757
• Protein name: Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2)
• Protein function: Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability (PubMed:12032145, PubMed:12080052, PubMed:26626369) Is involved in various redox reactions including the reduction of protein
• PDB: 1UVZ, 1W4V, 1W89
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00085	Thioredoxin	61 → 163	Thioredoxin	Domain

• Sequence:

  MAQRLLLRRFLASVISRKPSQGQWPPLTSRALQTPQCSPGGLTVTPNPARTIYTTRISLT
  TFNIQDGPDFQDRVVNSETPVVVDFHAQWCGPCKILGPRLEKMVAKQHGKVVMAKVDIDD
  HTDLAIEYEVSAVPTVLAMKNGDVVDKFVGIKDEDQLEAFLKKLIG

• Sequence length: 166

Pathways

KEGG:

NOD-like receptor signaling pathway
Parkinson disease
Salmonella infection
Fluid shear stress and atherosclerosis

Reactome:

Degradation of cysteine and homocysteine
Detoxification of Reactive Oxygen Species

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Combined oxidative phosphorylation deficiency	COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 29, Combined oxidative phosphorylation defect type 29	rs587776508, rs576462794, rs118203917, rs387906327, rs139430866, rs387906962, rs138119149, rs387907061, rs1562800908, rs397515421, rs397514598, rs397514610, rs397514611, rs397514612, rs201431517, rs397514613, rs397514614, rs200286768, rs397515463, rs397515464, rs397515465, rs397515466, rs587777218, rs587777244, rs587777417, rs587777418, rs587777419, rs587777583, rs587777584, rs587777585, rs587777589, rs587777591, rs587777593, rs587777594, rs115079861, rs587777788, rs144972972, rs606231472, rs869320746, rs886037734, rs730880255, rs886037735, rs886037736, rs730882154, rs730882155, rs794726869, rs114638163, rs143712760, rs780383722, rs200105202, rs1554169353, rs751459058, rs775690041, rs863224897, rs863225449, rs869025313, rs869025314, rs869025315, rs781798317, rs754022333, rs869320703, rs869320704, rs771894262, rs764427452, rs879255657, rs778100619, rs759477396, rs1057518742, rs1057518743, rs1057517685, rs1057519299, rs1057523346, rs1057524183, rs1060502161, rs184469579, rs1064794140, rs755122704, rs1064797230, rs202183509, rs1131691396, rs1131692037, rs1161932777, rs144042123, rs777725264, rs563189672, rs763672163, rs746538436, rs1554042187, rs767427194, rs1555532483, rs1394499137, rs1555532484, rs763658299, rs763770476, rs199863563, rs148620369, rs1554147776, rs761385155, rs1555575927, rs1555576642, rs1554169280, rs1407198979, rs1274363168, rs1555726849, rs770871640, rs1555404423, rs924099073, rs775439829, rs1554268077, rs1308121771, rs1047420796, rs1322974029, rs751069628, rs368934219, rs761709212, rs1555342802, rs761334309, rs1554116357, rs536000212, rs565910322, rs376766195, rs1562168768, rs763443331, rs1370579526, rs755068980, rs1567773277, rs761097220, rs780533096, rs746356243, rs1559114055, rs752550279, rs1559094461, rs146988468, rs1561990552, rs1298860043, rs746746116, rs1568293849, rs1559359546, rs1561938413, rs565224393, rs1565216037, rs1035101172, rs1565235204, rs763770414, rs764714439, rs777185638, rs1169927428, rs1229314240, rs1429774361, rs374954001, rs1599560256, rs1582724664, rs1574663066, rs778120270, rs1574675683, rs1365308037, rs1582970514, rs777028011, rs1582957532, rs1170907347, rs773688171, rs1777047446, rs947204455, rs1049082567, rs754537066, rs758094541, rs1689552727, rs2077262520, rs748779965, rs1785349774	26626369
Developmental delay	Global developmental delay	rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291, rs886041382, rs1057518991, rs1057518699, rs753254213, rs748294403, rs762552974, rs1135401795, rs1553121073, rs1553122926, rs1364690005, rs1554086554, rs1554210415, rs1554168326, rs1554776342, rs1553873247, rs1567860112, rs779009256, rs1557447255, rs1564568350, rs780011005, rs1597464953, rs1200336864, rs1569513017, rs1587459606, rs1570332505, rs748888652, rs1575155995, rs2087029320, rs1589669105, rs1601769604, rs1184981709, rs749201074
Dysautonomia	Dysautonomia	rs111033171, rs137853022, rs28939712, rs754348901, rs749052963, rs1057517169, rs1057516865, rs763445509, rs767527819, rs781333644, rs1239081703, rs1554696574, rs539544212, rs1201626345, rs774890086, rs1554703061, rs1554703613, rs1319053366, rs1554703851, rs868073099, rs926177767, rs376078668, rs1554695299, rs1554696648, rs1554696934, rs1554699327, rs1554691572, rs1554695846, rs1554697001, rs770668926, rs1554698037, rs759412460, rs1554702142, rs765572951, rs1554702880, rs1554703831, rs760774999, rs1554696650, rs757972943, rs1554703874, rs1554703907, rs571348995
Microcephaly	Microcephaly	rs397704721, rs267607176, rs267607177, rs397704725, rs267606717, rs267606718, rs199422202, rs121434311, rs199422203, rs199422126, rs387906274, rs121434305, rs199422125, rs199422135, rs189678019, rs199422184, rs137852994, rs137852995, rs137852996, rs137852997, rs145489194, rs80338860, rs137852494, rs121918609, rs199422207, rs199422206, rs29001566, rs864321658, rs199422138, rs199422139, rs199422141, rs199422144, rs199422147, rs199422151, rs199422152, rs199422153, rs199422157, rs199422159, rs199422160, rs199422161, rs140602858, rs199422164, rs199422165, rs148294838, rs199422134, rs199422168, rs199422172, rs199422173, rs199422131, rs199422177, rs199422180, rs199422185, rs199422186, rs199422187, rs143931757, rs199422189, rs199422192, rs199422194, rs199422195, rs199422196, rs199422197, rs199422199, rs753597039, rs1488084787, rs387906961, rs755862917, rs387907082, rs587776899, rs387907083, rs587776900, rs587776901, rs387907084, rs863223322, rs764201220, rs202247811, rs763915472, rs587776986, rs587777036, rs398122971, rs374351172, rs373278668, rs398122976, rs121909123, rs587783393, rs730882076, rs587783211, rs144716013, rs606231255, rs587783215, rs587783216, rs587783220, rs587783221, rs587783225, rs587783227, rs587783228, rs587783230, rs587783238, rs587783239, rs587783240, rs587783245, rs587783247, rs587783248, rs587783258, rs587783259, rs587783263, rs587783265, rs587783268, rs587783269, rs587783272, rs587783275, rs587783277, rs587783278, rs587783280, rs587783282, rs587783283, rs587783285, rs587783287, rs587783288, rs587783289, rs587783292, rs587783295, rs587784452, rs587783741, rs587783735, rs587783392, rs587783390, rs587783387, rs587783410, rs202058504, rs587783423, rs587783421, rs587783414, rs587784553, rs587784558, rs587784546, rs587784549, rs587784554, rs587784412, rs876661307, rs869025200, rs747831095, rs748529285, rs797045316, rs797045315, rs797045314, rs759632528, rs797045313, rs797045311, rs754282058, rs797045441, rs797045454, rs797045430, rs869312853, rs797046109, rs767399782, rs863225127, rs863225464, rs863225465, rs780270096, rs864321621, rs864321620, rs775277800, rs879253817, rs869312824, rs761447719, rs753406334, rs147622433, rs199422137, rs879255522, rs879255524, rs879255523, rs886037892, rs886037893, rs886037894, rs886037895, rs199422169, rs886041709, rs886041282, rs138228629, rs759188041, rs769688376, rs1057517688, rs1057519087, rs1057518268, rs933106143, rs201362977, rs754909135, rs1057520873, rs1060499758, rs1060499757, rs199422146, rs748016594, rs1085307120, rs763715733, rs1064795945, rs763800571, rs1554728351, rs1553227021, rs555866170, rs1553895368, rs1334947797, rs769818500, rs1321892596, rs1553227645, rs1404276011, rs1553228275, rs1554471681, rs1554496609, rs1555420891, rs1555418825, rs587784548, rs1555723585, rs199736219, rs745997770, rs765275884, rs1553924800, rs1554730137, rs1229568621, rs1482100822, rs979186313, rs758157294, rs1555294652, rs1555299107, rs1553264033, rs1553259539, rs1553254322, rs1553259528, rs981349334, rs1553264036, rs1553253022, rs754267846, rs776034810, rs1342429887, rs752140135, rs1006898944, rs571640983, rs1477524771, rs763909256, rs199910503, rs1553223496, rs759663956, rs1553446603, rs1555139372, rs1555143325, rs1350194762, rs1555141158, rs1553225179, rs769481947, rs769364943, rs748011724, rs1334301723, rs746341112, rs149225624, rs765113367, rs1567024512, rs142865061, rs772050241, rs201721894, rs1557966012, rs1379578836, rs1568334868, rs1185537869, rs1602333390, rs1163303148, rs774338373, rs770540184, rs1571600045, rs1571601267, rs1571602991, rs1588472215, rs1599841026, rs1558328287, rs1571600860, rs1571596976, rs1309880692, rs1435239428, rs1588634016, rs1751797979, rs1810830776, rs1815354949, rs1949984655, rs886039658, rs1943461045, rs777711720, rs2031759596, rs1555710223, rs1221031683, rs774069989, rs2058919680, rs1170413397, rs1213710245, rs1599851667, rs1599760058, rs1971033478, rs746967357
Optic atrophy	Optic Atrophy	rs121434508, rs267607017, rs80356524, rs80356525, rs879255560, rs104893753, rs80356529, rs397515360, rs104893620, rs199476104, rs199476112, rs199476118, rs398124298, rs770066665, rs398124299, rs61750185, rs672601379, rs727504060, rs786204830, rs794727804, rs199946797, rs863224127, rs863224131, rs863224134, rs863224906, rs372054380, rs886037828, rs764791523, rs145639028, rs1057519312, rs1064794257, rs1064794656, rs1064797303, rs774265764, rs760337383, rs1553784985, rs72653786, rs1555229948, rs1555119216, rs761743852, rs1553785338, rs1020764190, rs782581701, rs1560408865, rs761460379, rs773022324, rs782740998, rs1560327427, rs80356528, rs1734162973, rs1716524583, rs1057368575
Seizure	Tonic - clonic seizures	rs587784365, rs28939683, rs74315390, rs28939684, rs74315391, rs267607198, rs74315392, rs118192244, rs118192250, rs121917749, rs121917750, rs121917751, rs121917752, rs267606670, rs267607061, rs121912707, rs118192249, rs118192251, rs118192217, rs118192218, rs118192219, rs118192222, rs118192226, rs118192228, rs118192234, rs118192236, rs118192235, rs118192241, rs118192242, rs118192185, rs118192188, rs118192245, rs118192246, rs118192186, rs118192194, rs118192197, rs118192199, rs118192201, rs118192202, rs118192203, rs118192204, rs118192205, rs118192206, rs118192208, rs118192211, rs118192216, rs118192239, rs387906684, rs387906686, rs387906687, rs1596893185, rs387907126, rs387907281, rs397515405, rs587778771, rs730882067, rs730882073, rs397514579, rs397514582, rs587776976, rs398122394, rs121918784, rs121918751, rs121918735, rs398123588, rs587780450, rs61749751, rs587777620, rs727503974, rs730882124, rs794726710, rs794726697, rs794726799, rs794727444, rs794727740, rs796053166, rs794726825, rs796052676, rs796053219, rs796053220, rs796053228, rs796052653, rs759584387, rs796052650, rs796052641, rs796052626, rs796052623, rs796052663, rs796052615, rs796052802, rs797044999, rs797045047, rs797045942, rs797045941, rs118192212, rs797044938, rs777257591, rs864321712, rs879255652, rs886039268, rs886039517, rs886039529, rs199497486, rs886039496, rs886039903, rs886041300, rs769827124, rs886041339, rs886041591, rs587783092, rs1555850151, rs1057516123, rs1057516121, rs1057516115, rs1057516111, rs1057516106, rs1057516105, rs756921902, rs1057516089, rs1057516087, rs1057516080, rs1057516076, rs1060499544, rs1555850512, rs1057517919, rs118192231, rs1057520413, rs1060503101, rs1064796294, rs1064794981, rs1064794632, rs1064797245, rs1131691830, rs1131692231, rs1131691936, rs1554626549, rs1553579225, rs1553531385, rs121918736, rs1554898088, rs1553579282, rs763353895, rs1553463119, rs1554093891, rs77838305, rs1555408401, rs1554627439, rs1554097873, rs1555850403, rs1064794719, rs1315483224, rs1567134495, rs770187706, rs1057518555, rs1576983339, rs1574192005, rs1459374430, rs1586800133, rs1574641522, rs1572096837, rs1572630269, rs1574554892, rs1574556643, rs1574571769, rs1574641605, rs1574697769, rs1574716524, rs1574746733, rs1574746935, rs1574752700, rs1574754680, rs863225030, rs1601545088, rs1600714727, rs1371059392, rs1600767259, rs1339542565, rs1600785769, rs2065899210, rs1600732174, rs1162306056, rs879255709, rs1900111672, rs2066910297, rs1554122080, rs796052941, rs1600789325, rs2082695884, rs1737677036, rs1737495759, rs868389022, rs1737685202, rs1737672350, rs762737130

Unknown
Disease name	Disease term	dbSNP ID	References
Cerebellar atrophy	Cerebellar atrophy
Congenital microcephaly	Congenital microcephaly
Nervous system diseases	Peripheral Nervous System Diseases
Rachischisis	Rachischisis		19165900
Retinal diseases	Retinal Diseases
Spina bifida	Spina Bifida		19165900
Status dysraphicus	Status Dysraphicus		19165900