BACE2 (beta-secretase 2)

Gene

• Entrez ID: 25825
• Gene name: Beta-secretase 2
• Gene symbol: BACE2
• Synonyms: AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP
• Chromosome: 21
• Chromosome location: 21q22.2-q22.3
• Summary: This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer`s disease and Down syndrome.

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT042142	hsa-miR-484	CLASH	23622248
MIRT720351	hsa-miR-6504-5p	HITS-CLIP	19536157
MIRT720350	hsa-miR-3064-5p	HITS-CLIP	19536157
MIRT720349	hsa-miR-6800-3p	HITS-CLIP	19536157
MIRT720348	hsa-miR-3183	HITS-CLIP	19536157
MIRT720346	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT720347	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT720345	hsa-miR-1237-3p	HITS-CLIP	19536157
MIRT720344	hsa-miR-1248	HITS-CLIP	19536157
MIRT720343	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT720342	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT720340	hsa-miR-4794	HITS-CLIP	19536157
MIRT720341	hsa-miR-664a-5p	HITS-CLIP	19536157
MIRT720339	hsa-miR-149-5p	HITS-CLIP	19536157
MIRT720338	hsa-miR-3182	HITS-CLIP	19536157
MIRT720337	hsa-miR-6821-3p	HITS-CLIP	19536157
MIRT720335	hsa-miR-4448	HITS-CLIP	19536157
MIRT720336	hsa-miR-6861-3p	HITS-CLIP	19536157
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT720334	hsa-miR-3157-3p	HITS-CLIP	19536157
MIRT720333	hsa-miR-874-3p	HITS-CLIP	19536157
MIRT675051	hsa-miR-483-5p	HITS-CLIP	23313552
MIRT675050	hsa-miR-4645-5p	HITS-CLIP	23313552
MIRT675049	hsa-miR-4673	HITS-CLIP	23313552
MIRT675048	hsa-miR-4716-5p	HITS-CLIP	23313552
MIRT693828	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT693827	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT693826	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT693825	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT693824	hsa-miR-372-5p	HITS-CLIP	23313552
MIRT669397	hsa-miR-3653-5p	HITS-CLIP	23313552
MIRT693823	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT693822	hsa-miR-6131	HITS-CLIP	23313552
MIRT675047	hsa-miR-193b-5p	HITS-CLIP	23313552
MIRT675045	hsa-miR-198	HITS-CLIP	23313552
MIRT675044	hsa-miR-6755-3p	HITS-CLIP	23313552
MIRT675042	hsa-miR-197-3p	HITS-CLIP	23313552
MIRT693821	hsa-miR-378a-5p	HITS-CLIP	23313552
MIRT693820	hsa-miR-6843-3p	HITS-CLIP	23313552
MIRT693819	hsa-miR-6848-3p	HITS-CLIP	23313552
MIRT675041	hsa-miR-3912-5p	HITS-CLIP	23313552
MIRT675039	hsa-miR-5096	HITS-CLIP	23313552
MIRT675038	hsa-miR-1303	HITS-CLIP	23313552
MIRT675051	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT675043	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT675050	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT675049	hsa-miR-4673	HITS-CLIP	23824327
MIRT675048	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT675047	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT675046	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT675045	hsa-miR-198	HITS-CLIP	23824327
MIRT675044	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT675043	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT675042	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT675041	hsa-miR-3912-5p	HITS-CLIP	23824327
MIRT675040	hsa-miR-3149	HITS-CLIP	23824327
MIRT675039	hsa-miR-5096	HITS-CLIP	23824327
MIRT675038	hsa-miR-1303	HITS-CLIP	23824327
MIRT669400	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT669399	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT669398	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT669397	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT669396	hsa-miR-1976	HITS-CLIP	23824327
MIRT669395	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT669394	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT669393	hsa-miR-4279	HITS-CLIP	23824327
MIRT669392	hsa-miR-498	HITS-CLIP	23824327
MIRT613302	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT613300	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT613296	hsa-miR-4319	HITS-CLIP	23824327
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT615721	hsa-miR-3660	HITS-CLIP	23824327
MIRT615720	hsa-miR-4526	HITS-CLIP	23824327
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT613302	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT613300	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT613296	hsa-miR-4319	HITS-CLIP	23824327
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT615721	hsa-miR-3660	HITS-CLIP	23824327
MIRT615720	hsa-miR-4526	HITS-CLIP	23824327
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT613292	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT613302	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT613300	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT613296	hsa-miR-4319	HITS-CLIP	23824327
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT615721	hsa-miR-3660	HITS-CLIP	23824327
MIRT615720	hsa-miR-4526	HITS-CLIP	23824327
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT613292	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT613302	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT613300	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT613296	hsa-miR-4319	HITS-CLIP	23824327
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT615721	hsa-miR-3660	HITS-CLIP	23824327
MIRT615720	hsa-miR-4526	HITS-CLIP	23824327
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT613292	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT613302	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT613300	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT613296	hsa-miR-4319	HITS-CLIP	23824327
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT613292	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT613302	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT613300	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT613296	hsa-miR-4319	HITS-CLIP	23824327
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT615721	hsa-miR-3660	HITS-CLIP	23824327
MIRT615720	hsa-miR-4526	HITS-CLIP	23824327
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT613302	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT613300	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT613296	hsa-miR-4319	HITS-CLIP	23824327
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT615721	hsa-miR-3660	HITS-CLIP	23824327
MIRT615720	hsa-miR-4526	HITS-CLIP	23824327
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT613292	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT613302	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT613300	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT613296	hsa-miR-4319	HITS-CLIP	23824327
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT615721	hsa-miR-3660	HITS-CLIP	23824327
MIRT615720	hsa-miR-4526	HITS-CLIP	23824327
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT613292	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT613302	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT613300	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT613296	hsa-miR-4319	HITS-CLIP	23824327
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT613292	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT613302	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT613300	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT613296	hsa-miR-4319	HITS-CLIP	23824327
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT613292	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT457409	hsa-miR-583	PAR-CLIP	23592263
MIRT457408	hsa-miR-3125	PAR-CLIP	23592263
MIRT457407	hsa-miR-3916	PAR-CLIP	23592263
MIRT457406	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT457405	hsa-miR-5584-5p	PAR-CLIP	23592263
MIRT457404	hsa-miR-7845-5p	PAR-CLIP	23592263
MIRT457403	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT457401	hsa-miR-3153	PAR-CLIP	23592263
MIRT457402	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT457400	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT457399	hsa-miR-302c-5p	PAR-CLIP	23592263
MIRT441968	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT441967	hsa-miR-3651	PAR-CLIP	22100165
MIRT441966	hsa-miR-4778-5p	PAR-CLIP	22100165
MIRT441965	hsa-miR-3607-3p	PAR-CLIP	22100165
MIRT441964	hsa-miR-5189-3p	PAR-CLIP	22100165
MIRT441963	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT441962	hsa-miR-3686	PAR-CLIP	22100165
MIRT441960	hsa-miR-2054	PAR-CLIP	22100165
MIRT441961	hsa-miR-1299	PAR-CLIP	22100165
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	28735896
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	28735896
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	28735896
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	28735896
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	28735896
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	28735896
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	28735896
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	28735896
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	28735896
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	28735896
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	28735896
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	28735896
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	28735896
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	28735896
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	28735896
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	28735896
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	28735896
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	28735896
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	28735896
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	28735896
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	28735896
MIRT613302	hsa-miR-141-5p	HITS-CLIP	28735896
MIRT613302	hsa-miR-141-5p	HITS-CLIP	28735896
MIRT613302	hsa-miR-141-5p	HITS-CLIP	28735896
MIRT613302	hsa-miR-141-5p	HITS-CLIP	28735896
MIRT613302	hsa-miR-141-5p	HITS-CLIP	28735896
MIRT613302	hsa-miR-141-5p	HITS-CLIP	28735896
MIRT613302	hsa-miR-141-5p	HITS-CLIP	28735896
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	28735896
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	28735896
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	28735896
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	28735896
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	28735896
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	28735896
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	28735896
MIRT613300	hsa-miR-345-3p	HITS-CLIP	28735896
MIRT613300	hsa-miR-345-3p	HITS-CLIP	28735896
MIRT613300	hsa-miR-345-3p	HITS-CLIP	28735896
MIRT613300	hsa-miR-345-3p	HITS-CLIP	28735896
MIRT613300	hsa-miR-345-3p	HITS-CLIP	28735896
MIRT613300	hsa-miR-345-3p	HITS-CLIP	28735896
MIRT613300	hsa-miR-345-3p	HITS-CLIP	28735896
MIRT615721	hsa-miR-3660	HITS-CLIP	28735896
MIRT615721	hsa-miR-3660	HITS-CLIP	28735896
MIRT615721	hsa-miR-3660	HITS-CLIP	28735896
MIRT615721	hsa-miR-3660	HITS-CLIP	28735896
MIRT615721	hsa-miR-3660	HITS-CLIP	28735896
MIRT615721	hsa-miR-3660	HITS-CLIP	28735896
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	28735896
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	28735896
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	28735896
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	28735896
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	28735896
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	28735896
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	28735896
MIRT613296	hsa-miR-4319	HITS-CLIP	28735896
MIRT613296	hsa-miR-4319	HITS-CLIP	28735896
MIRT613296	hsa-miR-4319	HITS-CLIP	28735896
MIRT613296	hsa-miR-4319	HITS-CLIP	28735896
MIRT613296	hsa-miR-4319	HITS-CLIP	28735896
MIRT613296	hsa-miR-4319	HITS-CLIP	28735896
MIRT613296	hsa-miR-4319	HITS-CLIP	28735896
MIRT615720	hsa-miR-4526	HITS-CLIP	28735896
MIRT615720	hsa-miR-4526	HITS-CLIP	28735896
MIRT615720	hsa-miR-4526	HITS-CLIP	28735896
MIRT615720	hsa-miR-4526	HITS-CLIP	28735896
MIRT615720	hsa-miR-4526	HITS-CLIP	28735896
MIRT615720	hsa-miR-4526	HITS-CLIP	28735896
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	28735896
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	28735896
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	28735896
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	28735896
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	28735896
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	28735896
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	28735896
MIRT613292	hsa-miR-670-5p	HITS-CLIP	28735896
MIRT613292	hsa-miR-670-5p	HITS-CLIP	28735896
MIRT613292	hsa-miR-670-5p	HITS-CLIP	28735896
MIRT613292	hsa-miR-670-5p	HITS-CLIP	28735896
MIRT613292	hsa-miR-670-5p	HITS-CLIP	28735896
MIRT613292	hsa-miR-670-5p	HITS-CLIP	28735896
MIRT613292	hsa-miR-670-5p	HITS-CLIP	28735896
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	28735896
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	28735896
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	28735896
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	28735896
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	28735896
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	28735896
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	28735896
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	28735896
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	28735896
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	28735896
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	28735896
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	28735896
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	28735896
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	28735896
MIRT738071	hsa-miR-4308	HITS-CLIP	33718276
MIRT738073	hsa-miR-146b-3p	HITS-CLIP	33718276
MIRT720351	hsa-miR-6504-5p	HITS-CLIP	19536157
MIRT720350	hsa-miR-3064-5p	HITS-CLIP	19536157
MIRT720349	hsa-miR-6800-3p	HITS-CLIP	19536157
MIRT720348	hsa-miR-3183	HITS-CLIP	19536157
MIRT720346	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT720347	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT720345	hsa-miR-1237-3p	HITS-CLIP	19536157
MIRT720344	hsa-miR-1248	HITS-CLIP	19536157
MIRT720343	hsa-miR-6515-3p	HITS-CLIP	19536157
MIRT720342	hsa-miR-1236-3p	HITS-CLIP	19536157
MIRT720340	hsa-miR-4794	HITS-CLIP	19536157
MIRT720341	hsa-miR-664a-5p	HITS-CLIP	19536157
MIRT720339	hsa-miR-149-5p	HITS-CLIP	19536157
MIRT720338	hsa-miR-3182	HITS-CLIP	19536157
MIRT720337	hsa-miR-6821-3p	HITS-CLIP	19536157
MIRT720335	hsa-miR-4448	HITS-CLIP	19536157
MIRT720336	hsa-miR-6861-3p	HITS-CLIP	19536157
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT720334	hsa-miR-3157-3p	HITS-CLIP	19536157
MIRT720333	hsa-miR-874-3p	HITS-CLIP	19536157
MIRT675051	hsa-miR-483-5p	HITS-CLIP	23313552
MIRT675050	hsa-miR-4645-5p	HITS-CLIP	23313552
MIRT675049	hsa-miR-4673	HITS-CLIP	23313552
MIRT675048	hsa-miR-4716-5p	HITS-CLIP	23313552
MIRT693828	hsa-miR-371b-5p	HITS-CLIP	23313552
MIRT693827	hsa-miR-373-5p	HITS-CLIP	23313552
MIRT693826	hsa-miR-616-5p	HITS-CLIP	23313552
MIRT693825	hsa-miR-371a-5p	HITS-CLIP	23313552
MIRT693824	hsa-miR-372-5p	HITS-CLIP	23313552
MIRT669397	hsa-miR-3653-5p	HITS-CLIP	23313552
MIRT693823	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT693822	hsa-miR-6131	HITS-CLIP	23313552
MIRT675047	hsa-miR-193b-5p	HITS-CLIP	23313552
MIRT675045	hsa-miR-198	HITS-CLIP	23313552
MIRT675044	hsa-miR-6755-3p	HITS-CLIP	23313552
MIRT675042	hsa-miR-197-3p	HITS-CLIP	23313552
MIRT693821	hsa-miR-378a-5p	HITS-CLIP	23313552
MIRT693820	hsa-miR-6843-3p	HITS-CLIP	23313552
MIRT693819	hsa-miR-6848-3p	HITS-CLIP	23313552
MIRT675041	hsa-miR-3912-5p	HITS-CLIP	23313552
MIRT675039	hsa-miR-5096	HITS-CLIP	23313552
MIRT675038	hsa-miR-1303	HITS-CLIP	23313552
MIRT675051	hsa-miR-483-5p	HITS-CLIP	23824327
MIRT675043	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT675050	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT675049	hsa-miR-4673	HITS-CLIP	23824327
MIRT675048	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT675047	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT675046	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT675045	hsa-miR-198	HITS-CLIP	23824327
MIRT675044	hsa-miR-6755-3p	HITS-CLIP	23824327
MIRT675043	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT675042	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT675041	hsa-miR-3912-5p	HITS-CLIP	23824327
MIRT675040	hsa-miR-3149	HITS-CLIP	23824327
MIRT675039	hsa-miR-5096	HITS-CLIP	23824327
MIRT675038	hsa-miR-1303	HITS-CLIP	23824327
MIRT669400	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT669399	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT669398	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT669397	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT669396	hsa-miR-1976	HITS-CLIP	23824327
MIRT669395	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT669394	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT669393	hsa-miR-4279	HITS-CLIP	23824327
MIRT669392	hsa-miR-498	HITS-CLIP	23824327
MIRT613302	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT613300	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT613296	hsa-miR-4319	HITS-CLIP	23824327
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT615721	hsa-miR-3660	HITS-CLIP	23824327
MIRT615720	hsa-miR-4526	HITS-CLIP	23824327
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT613302	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT613300	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT613296	hsa-miR-4319	HITS-CLIP	23824327
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT615721	hsa-miR-3660	HITS-CLIP	23824327
MIRT615720	hsa-miR-4526	HITS-CLIP	23824327
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT613292	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT613302	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT613300	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT613296	hsa-miR-4319	HITS-CLIP	23824327
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT615721	hsa-miR-3660	HITS-CLIP	23824327
MIRT615720	hsa-miR-4526	HITS-CLIP	23824327
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT613292	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT613302	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT613300	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT613296	hsa-miR-4319	HITS-CLIP	23824327
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT615721	hsa-miR-3660	HITS-CLIP	23824327
MIRT615720	hsa-miR-4526	HITS-CLIP	23824327
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT613292	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT613302	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT613300	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT613296	hsa-miR-4319	HITS-CLIP	23824327
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT613292	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT613302	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT613300	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT613296	hsa-miR-4319	HITS-CLIP	23824327
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT615721	hsa-miR-3660	HITS-CLIP	23824327
MIRT615720	hsa-miR-4526	HITS-CLIP	23824327
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT613302	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT613300	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT613296	hsa-miR-4319	HITS-CLIP	23824327
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT615721	hsa-miR-3660	HITS-CLIP	23824327
MIRT615720	hsa-miR-4526	HITS-CLIP	23824327
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT613292	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT613302	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT613300	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT613296	hsa-miR-4319	HITS-CLIP	23824327
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT615721	hsa-miR-3660	HITS-CLIP	23824327
MIRT615720	hsa-miR-4526	HITS-CLIP	23824327
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT613292	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT613302	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT613300	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT613296	hsa-miR-4319	HITS-CLIP	23824327
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT613292	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT613302	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT613301	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT613300	hsa-miR-345-3p	HITS-CLIP	23824327
MIRT613299	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT613298	hsa-miR-125a-5p	HITS-CLIP	23824327
MIRT613297	hsa-miR-125b-5p	HITS-CLIP	23824327
MIRT613296	hsa-miR-4319	HITS-CLIP	23824327
MIRT613295	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT613294	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT613293	hsa-miR-2277-3p	HITS-CLIP	23824327
MIRT613292	hsa-miR-670-5p	HITS-CLIP	23824327
MIRT613291	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT457409	hsa-miR-583	PAR-CLIP	23592263
MIRT457408	hsa-miR-3125	PAR-CLIP	23592263
MIRT457407	hsa-miR-3916	PAR-CLIP	23592263
MIRT457406	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT457405	hsa-miR-5584-5p	PAR-CLIP	23592263
MIRT457404	hsa-miR-7845-5p	PAR-CLIP	23592263
MIRT457403	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT457401	hsa-miR-3153	PAR-CLIP	23592263
MIRT457402	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT457400	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT457399	hsa-miR-302c-5p	PAR-CLIP	23592263
MIRT441968	hsa-miR-1277-5p	PAR-CLIP	22100165
MIRT441967	hsa-miR-3651	PAR-CLIP	22100165
MIRT441966	hsa-miR-4778-5p	PAR-CLIP	22100165
MIRT441965	hsa-miR-3607-3p	PAR-CLIP	22100165
MIRT441964	hsa-miR-5189-3p	PAR-CLIP	22100165
MIRT441963	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT441962	hsa-miR-3686	PAR-CLIP	22100165
MIRT441960	hsa-miR-2054	PAR-CLIP	22100165
MIRT441961	hsa-miR-1299	PAR-CLIP	22100165
MIRT814224	hsa-miR-1206	CLIP-seq
MIRT814225	hsa-miR-1273e	CLIP-seq
MIRT814226	hsa-miR-3150a-5p	CLIP-seq
MIRT814227	hsa-miR-3150b-5p	CLIP-seq
MIRT738072	hsa-miR-3173-5p	CLIP-seq
MIRT814228	hsa-miR-374c	CLIP-seq
MIRT814229	hsa-miR-4682	CLIP-seq
MIRT814230	hsa-miR-548an	CLIP-seq
MIRT814231	hsa-miR-633	CLIP-seq
MIRT814232	hsa-miR-655	CLIP-seq
MIRT738074	hsa-miR-874	CLIP-seq
MIRT738070	hsa-miR-875-3p	CLIP-seq
MIRT738072	hsa-miR-3173-5p	CLIP-seq
MIRT814229	hsa-miR-4682	CLIP-seq
MIRT814231	hsa-miR-633	CLIP-seq
MIRT738074	hsa-miR-874	CLIP-seq
MIRT738070	hsa-miR-875-3p	CLIP-seq
MIRT738072	hsa-miR-3173-5p	CLIP-seq
MIRT738074	hsa-miR-874	CLIP-seq
MIRT738070	hsa-miR-875-3p	CLIP-seq
MIRT738072	hsa-miR-3173-5p	CLIP-seq
MIRT738074	hsa-miR-874	CLIP-seq
MIRT738070	hsa-miR-875-3p	CLIP-seq
MIRT738072	hsa-miR-3173-5p	CLIP-seq
MIRT738074	hsa-miR-874	CLIP-seq
MIRT738070	hsa-miR-875-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SP1	Unknown	15857888

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004190	Function	Aspartic-type endopeptidase activity	IDA	10591213
GO:0005515	Function	Protein binding	IPI	26840340, 32814053
GO:0005768	Component	Endosome	IBA	21873635
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005794	Component	Golgi apparatus	IDA	11423558
GO:0005802	Component	Trans-Golgi network	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	21907142
GO:0006508	Process	Proteolysis	NAS	10749877
GO:0006509	Process	Membrane protein ectodomain proteolysis	IBA	21873635
GO:0006509	Process	Membrane protein ectodomain proteolysis	IDA	10591213
GO:0006509	Process	Membrane protein ectodomain proteolysis	IMP	21907142
GO:0016020	Component	Membrane	IBA	21873635
GO:0016021	Component	Integral component of membrane	NAS	10749877
GO:0016486	Process	Peptide hormone processing	NAS	10749877
GO:0031045	Component	Dense core granule	IEA
GO:0042593	Process	Glucose homeostasis	IMP	21907142
GO:0042985	Process	Negative regulation of amyloid precursor protein biosynthetic process	IMP	12801932
GO:0048143	Process	Astrocyte activation	IEA
GO:0050435	Process	Amyloid-beta metabolic process	IBA	21873635

Other IDs

• MIM: 605668
• HGNC: 934
• e!Ensembl: ENSG00000182240

Protein

• UniProt ID: Q9Y5Z0
• Protein name: Beta-secretase 2 (EC 3.4.23.45) (Aspartic-like protease 56 kDa) (Aspartyl protease 1) (ASP1) (Asp 1) (Beta-site amyloid precursor protein cleaving enzyme 2) (Beta-site APP cleaving enzyme 2) (Down region aspartic protease) (DRAP) (Memapsin-1) (Membrane-as
• Protein function: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-
• PDB: 2EWY, 3ZKG, 3ZKI, 3ZKM, 3ZKN, 3ZKQ, 3ZKS, 3ZKX, 3ZL7, 3ZLQ, 4BEL, 4BFB, 6JSZ, 6UJ0, 6UJ1, 7D5B, 7D5U, 7F1G, 7N4N
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00026	Asp	91 → 431	Eukaryotic aspartyl protease	Family

• Sequence:

  MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL
  ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG
  TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI
  FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA
  GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA
  IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI
  YLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFD
  RAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCG
  AILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK

• Sequence length: 518

Pathways

KEGG:

Alzheimer disease

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	31374203