PRDX5 (peroxiredoxin 5)

Gene

• Entrez ID: 25824
• Gene name: Peroxiredoxin 5
• Gene symbol: PRDX5
• Synonyms: ACR1, AOEB166, B166, HEL-S-55, PLP, PMP20, PRDX6, PRXV, SBBI10, prx-V
• Chromosome: 11
• Chromosome location: 11q13.1
• Summary: This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT037717	hsa-miR-744-5p	CLASH	23622248
MIRT470292	hsa-miR-302f	PAR-CLIP	23592263
MIRT470291	hsa-miR-1265	PAR-CLIP	23592263
MIRT470290	hsa-miR-3688-3p	PAR-CLIP	23592263
MIRT470289	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT470288	hsa-miR-1205	PAR-CLIP	23592263
MIRT470287	hsa-miR-570-3p	PAR-CLIP	23592263
MIRT470286	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT470285	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT470284	hsa-miR-1286	PAR-CLIP	23592263
MIRT470282	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT470283	hsa-miR-4764-5p	PAR-CLIP	23592263
MIRT737179	hsa-miR-6855-3p	Luciferase reporter assay, Immunoprecipitaion (IP), Immunofluorescence, qRT-PCR	31987042
MIRT738987	hsa-miR-1909	HITS-CLIP	33718276
MIRT738988	hsa-miR-543	HITS-CLIP	33718276
MIRT470292	hsa-miR-302f	PAR-CLIP	23592263
MIRT470291	hsa-miR-1265	PAR-CLIP	23592263
MIRT470290	hsa-miR-3688-3p	PAR-CLIP	23592263
MIRT470289	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT470288	hsa-miR-1205	PAR-CLIP	23592263
MIRT470287	hsa-miR-570-3p	PAR-CLIP	23592263
MIRT470286	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT470285	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT470284	hsa-miR-1286	PAR-CLIP	23592263
MIRT470282	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT470283	hsa-miR-4764-5p	PAR-CLIP	23592263
MIRT1260545	hsa-miR-125a-3p	CLIP-seq
MIRT1260546	hsa-miR-1285	CLIP-seq
MIRT1260547	hsa-miR-1321	CLIP-seq
MIRT738985	hsa-miR-296-5p	CLIP-seq
MIRT1260548	hsa-miR-3126-3p	CLIP-seq
MIRT1260549	hsa-miR-3162-5p	CLIP-seq
MIRT1260550	hsa-miR-3176	CLIP-seq
MIRT1260551	hsa-miR-3187-5p	CLIP-seq
MIRT1260552	hsa-miR-3665	CLIP-seq
MIRT738986	hsa-miR-3918	CLIP-seq
MIRT1260553	hsa-miR-3922-3p	CLIP-seq
MIRT1260554	hsa-miR-3926	CLIP-seq
MIRT1260555	hsa-miR-4446-3p	CLIP-seq
MIRT1260556	hsa-miR-4492	CLIP-seq
MIRT1260557	hsa-miR-4498	CLIP-seq
MIRT1260558	hsa-miR-4505	CLIP-seq
MIRT1260559	hsa-miR-4736	CLIP-seq
MIRT1260560	hsa-miR-4739	CLIP-seq
MIRT1260561	hsa-miR-4756-5p	CLIP-seq
MIRT1260562	hsa-miR-548s	CLIP-seq
MIRT1260563	hsa-miR-612	CLIP-seq
MIRT1260564	hsa-miR-762	CLIP-seq
MIRT1260565	hsa-miR-137	CLIP-seq
MIRT1260566	hsa-miR-25	CLIP-seq
MIRT738985	hsa-miR-296-5p	CLIP-seq
MIRT1260567	hsa-miR-298	CLIP-seq
MIRT1260548	hsa-miR-3126-3p	CLIP-seq
MIRT1260568	hsa-miR-32	CLIP-seq
MIRT1260569	hsa-miR-363	CLIP-seq
MIRT1260570	hsa-miR-367	CLIP-seq
MIRT1260571	hsa-miR-3678-3p	CLIP-seq
MIRT738986	hsa-miR-3918	CLIP-seq
MIRT1260572	hsa-miR-92a	CLIP-seq
MIRT1260573	hsa-miR-92b	CLIP-seq
MIRT1260545	hsa-miR-125a-3p	CLIP-seq
MIRT1260546	hsa-miR-1285	CLIP-seq
MIRT1260547	hsa-miR-1321	CLIP-seq
MIRT738985	hsa-miR-296-5p	CLIP-seq
MIRT1260549	hsa-miR-3162-5p	CLIP-seq
MIRT1260551	hsa-miR-3187-5p	CLIP-seq
MIRT1260552	hsa-miR-3665	CLIP-seq
MIRT738986	hsa-miR-3918	CLIP-seq
MIRT1260555	hsa-miR-4446-3p	CLIP-seq
MIRT1260556	hsa-miR-4492	CLIP-seq
MIRT1260557	hsa-miR-4498	CLIP-seq
MIRT1260558	hsa-miR-4505	CLIP-seq
MIRT1552551	hsa-miR-4651	CLIP-seq
MIRT1552552	hsa-miR-4728-5p	CLIP-seq
MIRT1260559	hsa-miR-4736	CLIP-seq
MIRT1260560	hsa-miR-4739	CLIP-seq
MIRT1260561	hsa-miR-4756-5p	CLIP-seq
MIRT1552553	hsa-miR-608	CLIP-seq
MIRT1260563	hsa-miR-612	CLIP-seq
MIRT1260564	hsa-miR-762	CLIP-seq
MIRT1552554	hsa-miR-765	CLIP-seq
MIRT738985	hsa-miR-296-5p	CLIP-seq
MIRT738986	hsa-miR-3918	CLIP-seq
MIRT1260545	hsa-miR-125a-3p	CLIP-seq
MIRT1260546	hsa-miR-1285	CLIP-seq
MIRT1260547	hsa-miR-1321	CLIP-seq
MIRT738985	hsa-miR-296-5p	CLIP-seq
MIRT1260548	hsa-miR-3126-3p	CLIP-seq
MIRT1260549	hsa-miR-3162-5p	CLIP-seq
MIRT1260551	hsa-miR-3187-5p	CLIP-seq
MIRT1260552	hsa-miR-3665	CLIP-seq
MIRT738986	hsa-miR-3918	CLIP-seq
MIRT1260555	hsa-miR-4446-3p	CLIP-seq
MIRT1260556	hsa-miR-4492	CLIP-seq
MIRT1260557	hsa-miR-4498	CLIP-seq
MIRT1260558	hsa-miR-4505	CLIP-seq
MIRT1552551	hsa-miR-4651	CLIP-seq
MIRT1552552	hsa-miR-4728-5p	CLIP-seq
MIRT1260559	hsa-miR-4736	CLIP-seq
MIRT1260560	hsa-miR-4739	CLIP-seq
MIRT1260561	hsa-miR-4756-5p	CLIP-seq
MIRT1552553	hsa-miR-608	CLIP-seq
MIRT1260563	hsa-miR-612	CLIP-seq
MIRT1260564	hsa-miR-762	CLIP-seq
MIRT1552554	hsa-miR-765	CLIP-seq
MIRT1260545	hsa-miR-125a-3p	CLIP-seq
MIRT1260546	hsa-miR-1285	CLIP-seq
MIRT1260547	hsa-miR-1321	CLIP-seq
MIRT1260565	hsa-miR-137	CLIP-seq
MIRT1260566	hsa-miR-25	CLIP-seq
MIRT738985	hsa-miR-296-5p	CLIP-seq
MIRT1260567	hsa-miR-298	CLIP-seq
MIRT1260548	hsa-miR-3126-3p	CLIP-seq
MIRT1260549	hsa-miR-3162-5p	CLIP-seq
MIRT1260550	hsa-miR-3176	CLIP-seq
MIRT1260551	hsa-miR-3187-5p	CLIP-seq
MIRT1260568	hsa-miR-32	CLIP-seq
MIRT1260569	hsa-miR-363	CLIP-seq
MIRT1260552	hsa-miR-3665	CLIP-seq
MIRT1260570	hsa-miR-367	CLIP-seq
MIRT1260571	hsa-miR-3678-3p	CLIP-seq
MIRT738986	hsa-miR-3918	CLIP-seq
MIRT1260553	hsa-miR-3922-3p	CLIP-seq
MIRT1260554	hsa-miR-3926	CLIP-seq
MIRT1260555	hsa-miR-4446-3p	CLIP-seq
MIRT1260556	hsa-miR-4492	CLIP-seq
MIRT1260557	hsa-miR-4498	CLIP-seq
MIRT1260558	hsa-miR-4505	CLIP-seq
MIRT1552551	hsa-miR-4651	CLIP-seq
MIRT1552552	hsa-miR-4728-5p	CLIP-seq
MIRT1260559	hsa-miR-4736	CLIP-seq
MIRT1260560	hsa-miR-4739	CLIP-seq
MIRT1260561	hsa-miR-4756-5p	CLIP-seq
MIRT1260562	hsa-miR-548s	CLIP-seq
MIRT1552553	hsa-miR-608	CLIP-seq
MIRT1260563	hsa-miR-612	CLIP-seq
MIRT1260564	hsa-miR-762	CLIP-seq
MIRT1552554	hsa-miR-765	CLIP-seq
MIRT1260572	hsa-miR-92a	CLIP-seq
MIRT1260573	hsa-miR-92b	CLIP-seq
MIRT738985	hsa-miR-296-5p	CLIP-seq
MIRT1260548	hsa-miR-3126-3p	CLIP-seq
MIRT1260550	hsa-miR-3176	CLIP-seq
MIRT738986	hsa-miR-3918	CLIP-seq
MIRT1260553	hsa-miR-3922-3p	CLIP-seq
MIRT1260554	hsa-miR-3926	CLIP-seq
MIRT1260555	hsa-miR-4446-3p	CLIP-seq
MIRT1260562	hsa-miR-548s	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
DEK	Repression	19229864
NRF1	Activation	21051700

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001016	Function	RNA polymerase III transcription regulatory region sequence-specific DNA binding	IDA	10095767
GO:0004601	Function	Peroxidase activity	IDA	10521424
GO:0005515	Function	Protein binding	IPI	10514471, 29128334, 32296183
GO:0005615	Component	Extracellular space	HDA	23580065
GO:0005634	Component	Nucleus	IDA	10095767, 15785239
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	15785239
GO:0005739	Component	Mitochondrion	IBA	21873635
GO:0005739	Component	Mitochondrion	IDA	10521424, 10751410, 18262354, 31740833
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005777	Component	Peroxisome	IBA	21873635
GO:0005777	Component	Peroxisome	IDA	10521424
GO:0005782	Component	Peroxisomal matrix	IEA
GO:0005829	Component	Cytosol	IDA	18262354
GO:0005829	Component	Cytosol	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0006954	Process	Inflammatory response	TAS	10521424
GO:0006979	Process	Response to oxidative stress	IDA	10521424
GO:0008379	Function	Thioredoxin peroxidase activity	EXP	15280035
GO:0008379	Function	Thioredoxin peroxidase activity	IBA	21873635
GO:0016480	Process	Negative regulation of transcription by RNA polymerase III	IDA	10095767
GO:0031410	Component	Cytoplasmic vesicle	IDA	10095767
GO:0034599	Process	Cellular response to oxidative stress	IBA	21873635
GO:0034599	Process	Cellular response to oxidative stress	TAS
GO:0034614	Process	Cellular response to reactive oxygen species	IMP	18262354
GO:0042744	Process	Hydrogen peroxide catabolic process	IBA	21873635
GO:0043027	Function	Cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP	18262354
GO:0043066	Process	Negative regulation of apoptotic process	IMP	18262354
GO:0043154	Process	Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA	15785239
GO:0045454	Process	Cell redox homeostasis	IBA	21873635
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	10095767
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 23533145
GO:0098869	Process	Cellular oxidant detoxification	IEA

Other IDs

• MIM: 606583
• HGNC: 9355
• e!Ensembl: ENSG00000126432

Protein

• UniProt ID: P30044
• Protein name: Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxi
• Protein function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrog
• PDB: 1H4O, 1HD2, 1OC3, 1URM, 2VL2, 2VL3, 2VL9, 3MNG, 4K7I, 4K7N, 4K7O, 4MMM
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08534	Redoxin	57 → 211	Redoxin	Domain

• Sequence:

  MGLAGVCALRRSAGYILVGGAGGQSAAAAARRYSEGEWASGGVRSFSRAAAAMAPIKVGD
  AIPAVEVFEGEPGNKVNLAELFKGKKGVLFGVPGAFTPGCSKTHLPGFVEQAEALKAKGV
  QVVACLSVNDAFVTGEWGRAHKAEGKVRLLADPTGAFGKETDLLLDDSLVSIFGNRRLKR
  FSMVVQDGIVKALNVEPDGTGLTCSLAPNIISQL

• Sequence length: 214

Pathways

KEGG:

Peroxisome

Reactome:

Detoxification of Reactive Oxygen Species
TP53 Regulates Metabolic Genes

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	19424620

Unknown
Disease name	Disease term	dbSNP ID	References
Alopecia areata	Alopecia Areata		20596022
Stomach neoplasms	Malignant neoplasm of stomach, Stomach Neoplasms		19424620