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KLK5 (kallikrein related peptidase 5)
Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
25818
Gene nameGene Name - the full gene name approved by the HGNC.
Kallikrein related peptidase 5
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
KLK5
SynonymsGene synonyms aliases
KLK-L2, KLKL2, SCTE
ChromosomeChromosome number
19
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.41
SummarySummary of gene provided in NCBI Entrez Gene.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0002803 Process Positive regulation of antibacterial peptide production IBA 21873635
GO:0002803 Process Positive regulation of antibacterial peptide production IMP 17012259
GO:0004252 Function Serine-type endopeptidase activity EXP 16885167
GO:0004252 Function Serine-type endopeptidase activity IDA 16885167
GO:0004252 Function Serine-type endopeptidase activity NAS 11054574
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9Y337
Protein name Kallikrein-5 (EC 3.4.21.-) (Kallikrein-like protein 2) (KLK-L2) (Stratum corneum tryptic enzyme)
Protein function May be involved in desquamation.
PDB 2PSX , 2PSY , 6QFE , 7U5B
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00089 Trypsin
67 → 285
Trypsin
 Domain
Sequence
Sequence length 293
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
 
Reactome
    Formation of the cornified envelope
Associated diseases
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 16517595
Unknown
Disease name Disease term dbSNP ID References
Prostatic neoplasms Prostatic Neoplasms 16517595

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