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TNFAIP8 (TNF alpha induced protein 8)

Gene

25816

TNF alpha induced protein 8

TNFAIP8

GG2-1, MDC-3.13, NDED, SCC-S2, SCCS2

5q23.1

Show/Hide all(180)

miRTarBase ID	miRNA	Experiments	Reference
MIRT053458	hsa-miR-452-5p	Microarray	23807165
MIRT720775	hsa-miR-3614-3p	HITS-CLIP	19536157
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	19536157
MIRT720774	hsa-miR-6884-3p	HITS-CLIP	19536157
MIRT720773	hsa-miR-6787-3p	HITS-CLIP	19536157
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	19536157
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	19536157
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	19536157
MIRT625207	hsa-miR-23c	HITS-CLIP	19536157
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT652329	hsa-miR-541-3p	HITS-CLIP	23824327
MIRT652328	hsa-miR-654-5p	HITS-CLIP	23824327
MIRT652327	hsa-miR-92a-2-5p	HITS-CLIP	23824327
MIRT652326	hsa-miR-6769a-5p	HITS-CLIP	23824327
MIRT652325	hsa-miR-6769b-5p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT634982	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT634981	hsa-miR-147a	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT652329	hsa-miR-541-3p	HITS-CLIP	23824327
MIRT652328	hsa-miR-654-5p	HITS-CLIP	23824327
MIRT652327	hsa-miR-92a-2-5p	HITS-CLIP	23824327
MIRT652326	hsa-miR-6769a-5p	HITS-CLIP	23824327
MIRT652325	hsa-miR-6769b-5p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT634982	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT634981	hsa-miR-147a	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT634982	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT634981	hsa-miR-147a	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT720775	hsa-miR-3614-3p	HITS-CLIP	19536157
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	19536157
MIRT720774	hsa-miR-6884-3p	HITS-CLIP	19536157
MIRT720773	hsa-miR-6787-3p	HITS-CLIP	19536157
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	19536157
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	19536157
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	19536157
MIRT625207	hsa-miR-23c	HITS-CLIP	19536157
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT652329	hsa-miR-541-3p	HITS-CLIP	23824327
MIRT652328	hsa-miR-654-5p	HITS-CLIP	23824327
MIRT652327	hsa-miR-92a-2-5p	HITS-CLIP	23824327
MIRT652326	hsa-miR-6769a-5p	HITS-CLIP	23824327
MIRT652325	hsa-miR-6769b-5p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT634982	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT634981	hsa-miR-147a	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT652329	hsa-miR-541-3p	HITS-CLIP	23824327
MIRT652328	hsa-miR-654-5p	HITS-CLIP	23824327
MIRT652327	hsa-miR-92a-2-5p	HITS-CLIP	23824327
MIRT652326	hsa-miR-6769a-5p	HITS-CLIP	23824327
MIRT652325	hsa-miR-6769b-5p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT634982	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT634981	hsa-miR-147a	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT634982	hsa-miR-6818-5p	HITS-CLIP	23824327
MIRT634981	hsa-miR-147a	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT625214	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT625213	hsa-miR-630	HITS-CLIP	23824327
MIRT625212	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT625211	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT625210	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT625209	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT625208	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT625207	hsa-miR-23c	HITS-CLIP	23824327
MIRT625206	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT1442280	hsa-miR-1271	CLIP-seq
MIRT1442281	hsa-miR-182	CLIP-seq
MIRT1442282	hsa-miR-2116	CLIP-seq
MIRT1442283	hsa-miR-3140-3p	CLIP-seq
MIRT1442284	hsa-miR-3609	CLIP-seq
MIRT1442285	hsa-miR-3671	CLIP-seq
MIRT1442286	hsa-miR-4274	CLIP-seq
MIRT1442287	hsa-miR-4519	CLIP-seq
MIRT1442288	hsa-miR-4524	CLIP-seq
MIRT1442289	hsa-miR-4659a-3p	CLIP-seq
MIRT1442290	hsa-miR-4659b-3p	CLIP-seq
MIRT1442291	hsa-miR-4677-5p	CLIP-seq
MIRT1442292	hsa-miR-548ah	CLIP-seq
MIRT1442293	hsa-miR-548t	CLIP-seq
MIRT1442294	hsa-miR-607	CLIP-seq
MIRT1442295	hsa-miR-96	CLIP-seq
MIRT1442296	hsa-miR-1227	CLIP-seq
MIRT1442297	hsa-miR-455-5p	CLIP-seq
MIRT1442298	hsa-miR-4715-3p	CLIP-seq
MIRT2132420	hsa-miR-3658	CLIP-seq
MIRT2132421	hsa-miR-376c	CLIP-seq
MIRT2132422	hsa-miR-451b	CLIP-seq
MIRT1442296	hsa-miR-1227	CLIP-seq
MIRT1442297	hsa-miR-455-5p	CLIP-seq
MIRT1442298	hsa-miR-4715-3p	CLIP-seq
MIRT1442296	hsa-miR-1227	CLIP-seq
MIRT1442297	hsa-miR-455-5p	CLIP-seq
MIRT1442298	hsa-miR-4715-3p	CLIP-seq
MIRT1442296	hsa-miR-1227	CLIP-seq
MIRT2647488	hsa-miR-1263	CLIP-seq
MIRT2647489	hsa-miR-146a	CLIP-seq
MIRT2647490	hsa-miR-146b-5p	CLIP-seq
MIRT1442282	hsa-miR-2116	CLIP-seq
MIRT2647491	hsa-miR-3127-3p	CLIP-seq
MIRT2647492	hsa-miR-3137	CLIP-seq
MIRT2647493	hsa-miR-3180-5p	CLIP-seq
MIRT2647494	hsa-miR-329	CLIP-seq
MIRT2647495	hsa-miR-362-3p	CLIP-seq
MIRT2647496	hsa-miR-4251	CLIP-seq
MIRT1442286	hsa-miR-4274	CLIP-seq
MIRT2647497	hsa-miR-4303	CLIP-seq
MIRT2647498	hsa-miR-4329	CLIP-seq
MIRT2647499	hsa-miR-4428	CLIP-seq
MIRT1442287	hsa-miR-4519	CLIP-seq
MIRT1442288	hsa-miR-4524	CLIP-seq
MIRT1442297	hsa-miR-455-5p	CLIP-seq
MIRT1442291	hsa-miR-4677-5p	CLIP-seq
MIRT2647500	hsa-miR-4699-5p	CLIP-seq
MIRT2647501	hsa-miR-4713-5p	CLIP-seq
MIRT1442298	hsa-miR-4715-3p	CLIP-seq
MIRT2647502	hsa-miR-4749-3p	CLIP-seq
MIRT2647503	hsa-miR-4762-3p	CLIP-seq
MIRT2647504	hsa-miR-491-3p	CLIP-seq
MIRT2647505	hsa-miR-520a-5p	CLIP-seq
MIRT2647506	hsa-miR-525-5p	CLIP-seq
MIRT2647507	hsa-miR-539	CLIP-seq
MIRT2647508	hsa-miR-642b	CLIP-seq
MIRT2647509	hsa-miR-885-5p	CLIP-seq
MIRT2647503	hsa-miR-4762-3p	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 21516116, 25416956, 32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	14724590
GO:0006915	Process	Apoptotic process	IEA
GO:0043027	Function	Cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IBA	21873635
GO:0043027	Function	Cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP	10644768
GO:0043065	Process	Positive regulation of apoptotic process	IMP	10644768
GO:0043066	Process	Negative regulation of apoptotic process	TAS	10644768
GO:0043154	Process	Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA

MIM	HGNC	e!Ensembl
612111	17260	ENSG00000145779

Protein

UniProt ID

O95379

Protein name

Tumor necrosis factor alpha-induced protein 8 (TNF alpha-induced protein 8) (Head and neck tumor and metastasis-related protein) (MDC-3.13) (NF-kappa-B-inducible DED-containing protein) (NDED) (SCC-S2) (TNF-induced protein GG2-1)

Protein function

Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavag

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05527	DUF758	16 → 196	Domain of unknown function (DUF758)	Family

Sequence

MHSEAEESKEVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTRE
YTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVD
YTFDRNVLSRLLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGNFKP
HLQKLCDGINKMLDEENI

Sequence length

198

Interactions

View interactions

	Reactome
			PI Metabolism

Associated diseases

Show/Hide Causal Diseases (3)

Causal
Disease name	Disease term	dbSNP ID	References
Arthritis	Juvenile arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	19565504
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	31619474
Esophagus neoplasm	Squamous cell carcinoma of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	21969086

Show/Hide Unknown Diseases (6)

Unknown
Disease name	Disease term	dbSNP ID	References
Eczema	Eczema		30595370
Juvenile arthritis	Juvenile psoriatic arthritis		19565504
Seronegative polyarthritis	Polyarthritis, Juvenile, Rheumatoid Factor Negative		19565504
Polyarthritis, rheumatoid factor positive	Polyarthritis, Juvenile, Rheumatoid Factor Positive		19565504
Respiratory tract diseases	Respiratory Tract Diseases		30595370
Still disease	Juvenile-Onset Still Disease		19565504

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