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NEGR1 (neuronal growth regulator 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
257194
Gene nameGene Name - the full gene name approved by the HGNC.
Neuronal growth regulator 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
NEGR1
SynonymsGene synonyms aliases
DMML2433, IGLON4, KILON, Ntra
ChromosomeChromosome number
1
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p31.1
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT722855 hsa-miR-6819-3p HITS-CLIP 19536157
MIRT722854 hsa-miR-6877-3p HITS-CLIP 19536157
MIRT722853 hsa-miR-4528 HITS-CLIP 19536157
MIRT722852 hsa-miR-4742-3p HITS-CLIP 19536157
MIRT722851 hsa-miR-2114-3p HITS-CLIP 19536157
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 21982860, 27940359
GO:0005576 Component Extracellular region TAS
GO:0005886 Component Plasma membrane TAS
GO:0007626 Process Locomotory behavior IEA
GO:0007631 Process Feeding behavior IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q7Z3B1
Protein name Neuronal growth regulator 1 (IgLON family member 4)
Protein function May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).
PDB 6DLD , 6U6T
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07679 I-set
43 135
Immunoglobulin I-set domain
Domain
PF13927 Ig_3
138 207
Domain
PF13927 Ig_3
224 301
Domain
Sequence
Sequence length 354
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Cell adhesion molecules   Post-translational modification: synthesis of GPI-anchored proteins
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Obesity Obesity rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840 19079261
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 31374203
Unknown
Disease name Disease term dbSNP ID References
Development disorder Child Development Disorders, Pervasive 30804558
Mental depression Major Depressive Disorder rs587778876, rs587778877 30804558, 29942085
Mood disorder Mood Disorders 29942085

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