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ST6GALNAC3 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3)

Gene

256435

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

ST6GALNAC3

PRO7177, SIAT7C, ST6GALNACIII, STY

1p31.1

ST6GALNAC3 belongs to a family of sialyltransferases that transfer sialic acids from CMP-sialic acid to terminal positions of carbohydrate groups in glycoproteins and glycolipids (Lee et al., 1999 [PubMed 10207017]).[supplied by OMIM, Mar 2008]

Show/Hide all(144)

miRTarBase ID	miRNA	Experiments	Reference
MIRT620038	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT620037	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT620036	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT620035	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT620034	hsa-miR-3123	HITS-CLIP	23824327
MIRT620033	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT620032	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT620038	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT620037	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT620036	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT620035	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT620034	hsa-miR-3123	HITS-CLIP	23824327
MIRT620033	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT620032	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT620031	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT653077	hsa-miR-491-3p	HITS-CLIP	23824327
MIRT620038	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT620037	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT620036	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT620035	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT620034	hsa-miR-3123	HITS-CLIP	23824327
MIRT620033	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT620032	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT620031	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT534062	hsa-miR-3121-3p	PAR-CLIP	22012620
MIRT534061	hsa-miR-1224-3p	PAR-CLIP	22012620
MIRT534060	hsa-miR-4286	PAR-CLIP	22012620
MIRT534059	hsa-miR-5009-3p	PAR-CLIP	22012620
MIRT534058	hsa-miR-2355-5p	PAR-CLIP	22012620
MIRT534057	hsa-miR-3679-3p	PAR-CLIP	22012620
MIRT534061	hsa-miR-1224-3p	PAR-CLIP	26701625
MIRT534062	hsa-miR-3121-3p	PAR-CLIP	26701625
MIRT534062	hsa-miR-3121-3p	PAR-CLIP	26701625
MIRT534062	hsa-miR-3121-3p	PAR-CLIP	26701625
MIRT534062	hsa-miR-3121-3p	PAR-CLIP	26701625
MIRT534059	hsa-miR-5009-3p	PAR-CLIP	26701625
MIRT534059	hsa-miR-5009-3p	PAR-CLIP	26701625
MIRT534059	hsa-miR-5009-3p	PAR-CLIP	26701625
MIRT534059	hsa-miR-5009-3p	PAR-CLIP	26701625
MIRT620038	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT620037	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT620036	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT620035	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT620034	hsa-miR-3123	HITS-CLIP	23824327
MIRT620033	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT620032	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT620038	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT620037	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT620036	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT620035	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT620034	hsa-miR-3123	HITS-CLIP	23824327
MIRT620033	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT620032	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT620031	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT653077	hsa-miR-491-3p	HITS-CLIP	23824327
MIRT620038	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT620037	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT620036	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT620035	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT620034	hsa-miR-3123	HITS-CLIP	23824327
MIRT620033	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT620032	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT620031	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT534062	hsa-miR-3121-3p	PAR-CLIP	22012620
MIRT534061	hsa-miR-1224-3p	PAR-CLIP	22012620
MIRT534060	hsa-miR-4286	PAR-CLIP	22012620
MIRT534059	hsa-miR-5009-3p	PAR-CLIP	22012620
MIRT534058	hsa-miR-2355-5p	PAR-CLIP	22012620
MIRT534057	hsa-miR-3679-3p	PAR-CLIP	22012620
MIRT1393733	hsa-miR-1273g	CLIP-seq
MIRT1393734	hsa-miR-297	CLIP-seq
MIRT1393735	hsa-miR-299-3p	CLIP-seq
MIRT1393736	hsa-miR-323-5p	CLIP-seq
MIRT1393737	hsa-miR-4491	CLIP-seq
MIRT1393738	hsa-miR-4657	CLIP-seq
MIRT1393739	hsa-miR-567	CLIP-seq
MIRT1393740	hsa-miR-876-3p	CLIP-seq
MIRT1393741	hsa-miR-1	CLIP-seq
MIRT1393742	hsa-miR-1208	CLIP-seq
MIRT1393743	hsa-miR-1267	CLIP-seq
MIRT1393744	hsa-miR-128	CLIP-seq
MIRT1393745	hsa-miR-1299	CLIP-seq
MIRT1393746	hsa-miR-144	CLIP-seq
MIRT1393747	hsa-miR-203	CLIP-seq
MIRT1393748	hsa-miR-206	CLIP-seq
MIRT1393749	hsa-miR-27a	CLIP-seq
MIRT1393750	hsa-miR-27b	CLIP-seq
MIRT1393751	hsa-miR-3616-5p	CLIP-seq
MIRT1393752	hsa-miR-3647-5p	CLIP-seq
MIRT1393753	hsa-miR-3680	CLIP-seq
MIRT1393754	hsa-miR-4307	CLIP-seq
MIRT1393755	hsa-miR-4670-3p	CLIP-seq
MIRT1393756	hsa-miR-4717-3p	CLIP-seq
MIRT1393757	hsa-miR-4761-3p	CLIP-seq
MIRT1393758	hsa-miR-4782-5p	CLIP-seq
MIRT1393759	hsa-miR-4795-5p	CLIP-seq
MIRT1393760	hsa-miR-4798-3p	CLIP-seq
MIRT1393761	hsa-miR-5096	CLIP-seq
MIRT1393762	hsa-miR-513a-5p	CLIP-seq
MIRT1393763	hsa-miR-516b	CLIP-seq
MIRT1393764	hsa-miR-573	CLIP-seq
MIRT1393765	hsa-miR-613	CLIP-seq
MIRT1393766	hsa-miR-653	CLIP-seq
MIRT1393767	hsa-miR-875-3p	CLIP-seq
MIRT1393742	hsa-miR-1208	CLIP-seq
MIRT1393743	hsa-miR-1267	CLIP-seq
MIRT1393745	hsa-miR-1299	CLIP-seq
MIRT1393753	hsa-miR-3680	CLIP-seq
MIRT1393755	hsa-miR-4670-3p	CLIP-seq
MIRT1393758	hsa-miR-4782-5p	CLIP-seq
MIRT1393760	hsa-miR-4798-3p	CLIP-seq
MIRT1393763	hsa-miR-516b	CLIP-seq
MIRT1393767	hsa-miR-875-3p	CLIP-seq
MIRT1393745	hsa-miR-1299	CLIP-seq
MIRT2118183	hsa-miR-183	CLIP-seq
MIRT2118184	hsa-miR-3121-5p	CLIP-seq
MIRT2118185	hsa-miR-3689a-5p	CLIP-seq
MIRT2118186	hsa-miR-3689b	CLIP-seq
MIRT2118187	hsa-miR-3689e	CLIP-seq
MIRT2118188	hsa-miR-3689f	CLIP-seq
MIRT2118189	hsa-miR-3926	CLIP-seq
MIRT2118190	hsa-miR-4496	CLIP-seq
MIRT2118191	hsa-miR-4742-3p	CLIP-seq
MIRT1393758	hsa-miR-4782-5p	CLIP-seq
MIRT1393763	hsa-miR-516b	CLIP-seq
MIRT2118192	hsa-miR-548s	CLIP-seq
MIRT2118193	hsa-miR-579	CLIP-seq
MIRT2118194	hsa-miR-622	CLIP-seq
MIRT2118195	hsa-miR-758	CLIP-seq
MIRT1393767	hsa-miR-875-3p	CLIP-seq
MIRT1393744	hsa-miR-128	CLIP-seq
MIRT2340197	hsa-miR-182	CLIP-seq
MIRT1393749	hsa-miR-27a	CLIP-seq
MIRT1393750	hsa-miR-27b	CLIP-seq
MIRT2118184	hsa-miR-3121-5p	CLIP-seq
MIRT2340198	hsa-miR-3614-5p	CLIP-seq
MIRT2118185	hsa-miR-3689a-5p	CLIP-seq
MIRT2118186	hsa-miR-3689b	CLIP-seq
MIRT2118187	hsa-miR-3689e	CLIP-seq
MIRT2118188	hsa-miR-3689f	CLIP-seq
MIRT2118189	hsa-miR-3926	CLIP-seq
MIRT2118192	hsa-miR-548s	CLIP-seq
MIRT2340199	hsa-miR-580	CLIP-seq
MIRT2118195	hsa-miR-758	CLIP-seq

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0001574	Process	Ganglioside biosynthetic process	IBA	21873635
GO:0001665	Function	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0006486	Process	Protein glycosylation	IEA
GO:0006677	Process	Glycosylceramide metabolic process	IDA	17123352
GO:0006687	Process	Glycosphingolipid metabolic process	IDA	17123352
GO:0008373	Function	Sialyltransferase activity	IDA	17123352
GO:0009100	Process	Glycoprotein metabolic process	IDA	17123352
GO:0009311	Process	Oligosaccharide metabolic process	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0047290	Function	(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity	IEA
GO:0097503	Process	Sialylation	IEA

MIM	HGNC	e!Ensembl
610133	19343	ENSG00000184005

Protein

UniProt ID

Q8NDV1

Protein name

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (EC 2.4.3.7) (GalNAc alpha-2,6-sialyltransferase III) (ST6GalNAc III) (ST6GalNAcIII) (STY) (Sialyltransferase 7C) (SIAT7-C)

Protein function

Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disial

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00777	Glyco_transf_29	55 → 299	Glycosyltransferase family 29 (sialyltransferase)	Family

Sequence

MACILKRKSVIAVSFIAAFLFLLVVRLVNEVNFPLLLNCFGQPGTKWIPFSYTYRRPLRT
HYGYINVKTQEPLQLDCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVG
RMTMIRVVSHTSVPLLLKNPDYFFKEANTTIYVIWGPFRNMRKDGNGIVYNMLKKTVGIY
PNAQIYVTTEKRMSYCDGVFKKETGKDRVQSGSYLSTGWFTFLLAMDACYGIHVYGMIND
TYCKTEGYRKVPYHYYEQGRDECDEYFLHEHAPYGGHRFITEKKVFAKWAKKHRIIFTHP
NWTLS

Sequence length

305

Interactions

View interactions

	KEGG		Reactome
	Mucin type O-glycan biosynthesis Glycosphingolipid biosynthesis - ganglio series Metabolic pathways		Sialic acid metabolism Termination of O-glycan biosynthesis

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	28736931

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