FTH1 (ferritin heavy chain 1)

Gene

• Entrez ID: 2495
• Gene name: Ferritin heavy chain 1
• Gene symbol: FTH1
• Synonyms: FHC, FTH, FTHL6, HFE5, NBIA9, PIG15, PLIF
• Chromosome: 11
• Chromosome location: 11q12.3
• Summary: This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rat

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT030032	hsa-miR-26b-5p	Microarray	19088304
MIRT031951	hsa-miR-16-5p	Proteomics	18668040
MIRT050899	hsa-miR-17-5p	CLASH	23622248
MIRT036560	hsa-miR-941	CLASH	23622248
MIRT574177	hsa-miR-6771-3p	PAR-CLIP	20371350
MIRT574175	hsa-miR-548m	PAR-CLIP	20371350
MIRT574176	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT574174	hsa-miR-548ag	PAR-CLIP	20371350
MIRT574173	hsa-miR-548ai	PAR-CLIP	20371350
MIRT574172	hsa-miR-548ba	PAR-CLIP	20371350
MIRT574171	hsa-miR-570-5p	PAR-CLIP	20371350
MIRT574170	hsa-miR-4496	PAR-CLIP	20371350
MIRT518720	hsa-miR-3133	PAR-CLIP	23446348
MIRT518719	hsa-miR-551b-5p	PAR-CLIP	23446348
MIRT518718	hsa-miR-3606-3p	PAR-CLIP	23446348
MIRT518717	hsa-miR-513a-3p	PAR-CLIP	23446348
MIRT518716	hsa-miR-513c-3p	PAR-CLIP	23446348
MIRT518715	hsa-miR-4511	PAR-CLIP	23446348
MIRT518714	hsa-miR-5579-5p	PAR-CLIP	23446348
MIRT518713	hsa-miR-1252-5p	PAR-CLIP	23446348
MIRT518712	hsa-miR-4790-3p	PAR-CLIP	23446348
MIRT518711	hsa-miR-6126	PAR-CLIP	23446348
MIRT518710	hsa-miR-6864-5p	PAR-CLIP	23446348
MIRT574177	hsa-miR-6771-3p	PAR-CLIP	20371350
MIRT574175	hsa-miR-548m	PAR-CLIP	20371350
MIRT574176	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT574174	hsa-miR-548ag	PAR-CLIP	20371350
MIRT574173	hsa-miR-548ai	PAR-CLIP	20371350
MIRT574172	hsa-miR-548ba	PAR-CLIP	20371350
MIRT574171	hsa-miR-570-5p	PAR-CLIP	20371350
MIRT574170	hsa-miR-4496	PAR-CLIP	20371350
MIRT518720	hsa-miR-3133	PAR-CLIP	23446348
MIRT518719	hsa-miR-551b-5p	PAR-CLIP	23446348
MIRT518718	hsa-miR-3606-3p	PAR-CLIP	23446348
MIRT518717	hsa-miR-513a-3p	PAR-CLIP	23446348
MIRT518716	hsa-miR-513c-3p	PAR-CLIP	23446348
MIRT518715	hsa-miR-4511	PAR-CLIP	23446348
MIRT518714	hsa-miR-5579-5p	PAR-CLIP	23446348
MIRT518713	hsa-miR-1252-5p	PAR-CLIP	23446348
MIRT518712	hsa-miR-4790-3p	PAR-CLIP	23446348
MIRT518711	hsa-miR-6126	PAR-CLIP	23446348
MIRT518710	hsa-miR-6864-5p	PAR-CLIP	23446348
MIRT1005644	hsa-miR-1225-5p	CLIP-seq
MIRT1005645	hsa-miR-1252	CLIP-seq
MIRT1005646	hsa-miR-1263	CLIP-seq
MIRT1005647	hsa-miR-2052	CLIP-seq
MIRT1005648	hsa-miR-2110	CLIP-seq
MIRT1005649	hsa-miR-224	CLIP-seq
MIRT1005650	hsa-miR-3675-5p	CLIP-seq
MIRT1005651	hsa-miR-3681	CLIP-seq
MIRT1005652	hsa-miR-3691-5p	CLIP-seq
MIRT1005653	hsa-miR-4271	CLIP-seq
MIRT1005654	hsa-miR-4307	CLIP-seq
MIRT1005655	hsa-miR-4312	CLIP-seq
MIRT1005656	hsa-miR-4636	CLIP-seq
MIRT1005657	hsa-miR-4725-3p	CLIP-seq
MIRT1005658	hsa-miR-4764-5p	CLIP-seq
MIRT1005646	hsa-miR-1263	CLIP-seq
MIRT1005647	hsa-miR-2052	CLIP-seq
MIRT1005649	hsa-miR-224	CLIP-seq
MIRT1005651	hsa-miR-3681	CLIP-seq
MIRT1005652	hsa-miR-3691-5p	CLIP-seq
MIRT1005654	hsa-miR-4307	CLIP-seq
MIRT1005655	hsa-miR-4312	CLIP-seq
MIRT1005658	hsa-miR-4764-5p	CLIP-seq
MIRT1005645	hsa-miR-1252	CLIP-seq
MIRT1005646	hsa-miR-1263	CLIP-seq
MIRT1005647	hsa-miR-2052	CLIP-seq
MIRT1005648	hsa-miR-2110	CLIP-seq
MIRT1005649	hsa-miR-224	CLIP-seq
MIRT1005650	hsa-miR-3675-5p	CLIP-seq
MIRT1005651	hsa-miR-3681	CLIP-seq
MIRT1005652	hsa-miR-3691-5p	CLIP-seq
MIRT1005653	hsa-miR-4271	CLIP-seq
MIRT1005654	hsa-miR-4307	CLIP-seq
MIRT1005655	hsa-miR-4312	CLIP-seq
MIRT1998038	hsa-miR-4427	CLIP-seq
MIRT1998039	hsa-miR-4680-3p	CLIP-seq
MIRT1998040	hsa-miR-4691-3p	CLIP-seq
MIRT1005657	hsa-miR-4725-3p	CLIP-seq
MIRT1005658	hsa-miR-4764-5p	CLIP-seq
MIRT2231647	hsa-miR-1228	CLIP-seq
MIRT1005645	hsa-miR-1252	CLIP-seq
MIRT1005646	hsa-miR-1263	CLIP-seq
MIRT1005647	hsa-miR-2052	CLIP-seq
MIRT1005648	hsa-miR-2110	CLIP-seq
MIRT1005649	hsa-miR-224	CLIP-seq
MIRT2231648	hsa-miR-3129-3p	CLIP-seq
MIRT1005650	hsa-miR-3675-5p	CLIP-seq
MIRT1005651	hsa-miR-3681	CLIP-seq
MIRT1005652	hsa-miR-3691-5p	CLIP-seq
MIRT2231649	hsa-miR-3920	CLIP-seq
MIRT2231650	hsa-miR-3940-3p	CLIP-seq
MIRT1005653	hsa-miR-4271	CLIP-seq
MIRT1005654	hsa-miR-4307	CLIP-seq
MIRT1005655	hsa-miR-4312	CLIP-seq
MIRT1005657	hsa-miR-4725-3p	CLIP-seq
MIRT2231651	hsa-miR-4733-5p	CLIP-seq
MIRT2231652	hsa-miR-4762-3p	CLIP-seq
MIRT1005658	hsa-miR-4764-5p	CLIP-seq
MIRT1005646	hsa-miR-1263	CLIP-seq
MIRT1005647	hsa-miR-2052	CLIP-seq
MIRT1005648	hsa-miR-2110	CLIP-seq
MIRT1005649	hsa-miR-224	CLIP-seq
MIRT1005650	hsa-miR-3675-5p	CLIP-seq
MIRT1005651	hsa-miR-3681	CLIP-seq
MIRT1005652	hsa-miR-3691-5p	CLIP-seq
MIRT1005653	hsa-miR-4271	CLIP-seq
MIRT1005654	hsa-miR-4307	CLIP-seq
MIRT1005655	hsa-miR-4312	CLIP-seq
MIRT1005657	hsa-miR-4725-3p	CLIP-seq
MIRT1005658	hsa-miR-4764-5p	CLIP-seq
MIRT1005644	hsa-miR-1225-5p	CLIP-seq
MIRT1005645	hsa-miR-1252	CLIP-seq
MIRT1005646	hsa-miR-1263	CLIP-seq
MIRT1005647	hsa-miR-2052	CLIP-seq
MIRT1005651	hsa-miR-3681	CLIP-seq
MIRT1005652	hsa-miR-3691-5p	CLIP-seq
MIRT1005654	hsa-miR-4307	CLIP-seq
MIRT1005655	hsa-miR-4312	CLIP-seq
MIRT1005658	hsa-miR-4764-5p	CLIP-seq
MIRT2231647	hsa-miR-1228	CLIP-seq
MIRT1998040	hsa-miR-4691-3p	CLIP-seq
MIRT2231647	hsa-miR-1228	CLIP-seq
MIRT1005648	hsa-miR-2110	CLIP-seq
MIRT1005649	hsa-miR-224	CLIP-seq
MIRT2231648	hsa-miR-3129-3p	CLIP-seq
MIRT2535543	hsa-miR-3591-5p	CLIP-seq
MIRT1005650	hsa-miR-3675-5p	CLIP-seq
MIRT2231650	hsa-miR-3940-3p	CLIP-seq
MIRT2535544	hsa-miR-3978	CLIP-seq
MIRT2535545	hsa-miR-4261	CLIP-seq
MIRT1005653	hsa-miR-4271	CLIP-seq
MIRT1005655	hsa-miR-4312	CLIP-seq
MIRT2535546	hsa-miR-4320	CLIP-seq
MIRT2535547	hsa-miR-4494	CLIP-seq
MIRT2535548	hsa-miR-4522	CLIP-seq
MIRT1005656	hsa-miR-4636	CLIP-seq
MIRT2535549	hsa-miR-4724-5p	CLIP-seq
MIRT1005657	hsa-miR-4725-3p	CLIP-seq
MIRT2535550	hsa-miR-4764-3p	CLIP-seq
MIRT2535551	hsa-miR-4782-5p	CLIP-seq
MIRT2535552	hsa-miR-494	CLIP-seq
MIRT2535553	hsa-miR-499a-5p	CLIP-seq
MIRT2535554	hsa-miR-648	CLIP-seq
MIRT2231647	hsa-miR-1228	CLIP-seq
MIRT2231648	hsa-miR-3129-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ATF1	Activation	17565989
ATF1	Repression	17565989

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004322	Function	Ferroxidase activity	IBA	21873635
GO:0005506	Function	Iron ion binding	TAS	3020541
GO:0005515	Function	Protein binding	IPI	15607035, 16169070, 16189514, 20133674, 20195357, 21516116, 21573799, 21988832, 22458338, 25277244, 25416956, 25910212, 28514442, 31515488, 32296183
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0006826	Process	Iron ion transport	IBA	21873635
GO:0006879	Process	Cellular iron ion homeostasis	TAS
GO:0006880	Process	Intracellular sequestering of iron ion	IBA	21873635
GO:0006880	Process	Intracellular sequestering of iron ion	IDA	9924025
GO:0006955	Process	Immune response	ISS
GO:0008043	Component	Intracellular ferritin complex	TAS	6589621
GO:0008198	Function	Ferrous iron binding	IBA	21873635
GO:0008199	Function	Ferric iron binding	IBA	21873635
GO:0008285	Process	Negative regulation of cell population proliferation	ISS
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0044754	Component	Autolysosome	IDA	25327288
GO:0048147	Process	Negative regulation of fibroblast proliferation	IDA	9924025
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:1904724	Component	Tertiary granule lumen	TAS
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

Other IDs

• MIM: 134770
• HGNC: 3976
• e!Ensembl: ENSG00000167996

Protein

• UniProt ID: P02794
• Protein name: Ferritin heavy chain (Ferritin H subunit) (EC 1.16.3.1) (Cell proliferation-inducing gene 15 protein) [Cleaved into: Ferritin heavy chain, N-terminally processed]
• Protein function: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity (PubMed:9003196). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (PubMed:9003196). Als
• PDB: 1FHA, 2CEI, 2CHI, 2CIH, 2CLU, 2CN6, 2CN7, 2FHA, 2IU2, 2Z6M, 3AJO, 3AJP, 3AJQ, 3ERZ, 3ES3, 4DYX, 4DYY, 4DYZ, 4DZ0, 4OYN, 4Y08, 4YKH, 4ZJK, 5CMQ, 5CMR, 5GN8, 5GOU, 5JKK, 5JKL, 5JKM, 5N26, 5N27, 5UP7, 5UP8, 5UP9, 5VTD, 5XB1, 5YI5, 5ZND, 6B8F, 6B8G, 6FTV, 6GSR, 6H5I, 6H6T, 6H6U, 6IPC, 6IPO, 6IPP, 6IPQ, 6J4A
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00210	Ferritin	18 → 159	Ferritin-like domain	Domain

• Sequence:

  MTTASTSQVRQNYHQDSEAAINRQINLELYASYVYLSMSYYFDRDDVALKNFAKYFLHQS
  HEEREHAEKLMKLQNQRGGRIFLQDIKKPDCDDWESGLNAMECALHLEKNVNQSLLELHK
  LATDKNDPHLCDFIETHYLNEQVKAIKELGDHVTNLRKMGAPESGLAEYLFDKHTLGDSD
  NES

• Sequence length: 183

Pathways

KEGG:

Porphyrin metabolism
Ferroptosis
Necroptosis
Mineral absorption

Reactome:

Golgi Associated Vesicle Biogenesis
Neutrophil degranulation
Iron uptake and transport

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Bestrophinopathy	BESTROPHINOPATHY, AUTOSOMAL RECESSIVE	rs281865528, rs121918284, rs121918286, rs121918287, rs121918288, rs61755781, rs200277476, rs199529046, rs281865215, rs372989281, rs765998048, rs62637337, rs886041142, rs775283269, rs753614067, rs1555096248, rs752521456, rs281865225, rs1431752515, rs1554963305, rs1554964287, rs1565392261, rs1591284563	19375515
Dermatitis	Contact Dermatitis	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	25724174
Glioma	Glioma, mixed gliomas, Malignant Glioma	rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499, rs1060500122, rs781647403, rs1060500126, rs1554897889, rs1114167629, rs1114167656, rs587782603, rs1554893824, rs1554900615, rs1564568660, rs786204900, rs762518389, rs1339631701	21385903
Vitelliform macular dystrophy	Vitelliform Macular Dystrophy	rs28940273, rs28940274, rs28941468, rs121918285, rs28941469, rs28940275, rs121918283, rs28940276, rs1800995, rs28940570, rs28940278, rs281865528, rs121918284, rs267606677, rs61755793, rs121918564, rs61755792, rs61755798, rs121918565, rs121918566, rs61755769, rs61755797, rs61755801, rs61755817, rs281865373, rs61748430, rs281865221, rs281865207, rs200277476, rs199529046, rs281865212, rs281865238, rs281865239, rs281865241, rs281865214, rs281865215, rs281865255, rs1805143, rs281865218, rs199867882, rs672601356, rs713993045, rs713993046, rs367576664, rs713993049, rs786205564, rs763295314, rs766305807, rs886039311, rs886041141, rs281865205, rs1555100476, rs1554963095, rs1555098634, rs1554963058, rs1559642470, rs1565036465, rs1565382549, rs752125512, rs1591266379, rs1225032182, rs1591283811, rs281865262, rs281865263, rs748351421, rs1591280478, rs1591280714, rs1591283793, rs1159966472, rs1591301548, rs867271343, rs1800118693, rs727503824, rs1942169028, rs1591284563, rs1799986608, rs1799988458	24560797, 21467170

Unknown
Disease name	Disease term	dbSNP ID	References
Degenerative diseases, central nervous system	Degenerative Diseases, Central Nervous System, Degenerative Diseases, Spinal Cord		15964507
Iron overload	Iron Overload, Iron Overload, Autosomal Dominant, FTH1-related iron overload	rs1801390, rs1800008, rs1800009, rs147192139, rs148060787, rs149698, rs111326315, rs368356148, rs17854138, rs112199774, rs1801621, rs886048434, rs17156609, rs201120647, rs186448909, rs141071579, rs886048429, rs763318260, rs142482048	11389486
Malignant mesothelioma	Malignant mesothelioma		26818092
Melancholia	Melancholia		17063146
Mental depression	Endogenous depression, Depressive disorder, Unipolar Depression, Depressive Syndrome, Depression, Neurotic	rs587778876, rs587778877	17063146
Neurodegenerative disorders	Neurodegenerative Disorders		15964507