FSHB (follicle stimulating hormone subunit beta)

Gene

• Entrez ID: 2488
• Gene name: Follicle stimulating hormone subunit beta
• Gene symbol: FSHB
• Synonyms: HH24
• Chromosome: 11
• Chromosome location: 11p14.1
• Summary: The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta sub

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT643776	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT643775	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT643774	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT643773	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT643772	hsa-miR-616-3p	HITS-CLIP	23824327
MIRT643771	hsa-miR-3671	HITS-CLIP	23824327
MIRT643770	hsa-miR-607	HITS-CLIP	23824327
MIRT643776	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT643775	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT643774	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT643773	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT643772	hsa-miR-616-3p	HITS-CLIP	23824327
MIRT643771	hsa-miR-3671	HITS-CLIP	23824327
MIRT643770	hsa-miR-607	HITS-CLIP	23824327
MIRT643776	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT643775	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT643774	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT643773	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT643772	hsa-miR-616-3p	HITS-CLIP	23824327
MIRT643771	hsa-miR-3671	HITS-CLIP	23824327
MIRT643770	hsa-miR-607	HITS-CLIP	23824327
MIRT643776	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT643775	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT643774	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT643773	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT643772	hsa-miR-616-3p	HITS-CLIP	23824327
MIRT643771	hsa-miR-3671	HITS-CLIP	23824327
MIRT643770	hsa-miR-607	HITS-CLIP	23824327
MIRT1005478	hsa-miR-25	CLIP-seq
MIRT1005479	hsa-miR-32	CLIP-seq
MIRT1005480	hsa-miR-363	CLIP-seq
MIRT1005481	hsa-miR-367	CLIP-seq
MIRT1005482	hsa-miR-411	CLIP-seq
MIRT1005483	hsa-miR-4727-5p	CLIP-seq
MIRT1005484	hsa-miR-4769-3p	CLIP-seq
MIRT1005485	hsa-miR-499a-5p	CLIP-seq
MIRT1005486	hsa-miR-92a	CLIP-seq
MIRT1005487	hsa-miR-92b	CLIP-seq
MIRT1005488	hsa-miR-936	CLIP-seq
MIRT1997994	hsa-miR-186	CLIP-seq
MIRT1997995	hsa-miR-3133	CLIP-seq
MIRT1997996	hsa-miR-4263	CLIP-seq
MIRT1997997	hsa-miR-4436a	CLIP-seq
MIRT1997998	hsa-miR-576-5p	CLIP-seq
MIRT1005482	hsa-miR-411	CLIP-seq
MIRT1005483	hsa-miR-4727-5p	CLIP-seq
MIRT1005484	hsa-miR-4769-3p	CLIP-seq
MIRT2231549	hsa-miR-499-3p	CLIP-seq
MIRT2231550	hsa-miR-499a-3p	CLIP-seq
MIRT1005488	hsa-miR-936	CLIP-seq
MIRT2231549	hsa-miR-499-3p	CLIP-seq
MIRT2231550	hsa-miR-499a-3p	CLIP-seq
MIRT1005478	hsa-miR-25	CLIP-seq
MIRT1005479	hsa-miR-32	CLIP-seq
MIRT1005480	hsa-miR-363	CLIP-seq
MIRT1005481	hsa-miR-367	CLIP-seq
MIRT1005485	hsa-miR-499a-5p	CLIP-seq
MIRT1005486	hsa-miR-92a	CLIP-seq
MIRT1005487	hsa-miR-92b	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
FOXO1	Repression	24065703
LHX3	Activation	23766128
LHX3	Unknown	15271874
PITX1	Unknown	18339718
PITX2	Unknown	18339718

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005179	Function	Hormone activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	11222739, 15662415, 22802634
GO:0005576	Component	Extracellular region	NAS	14718574
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005615	Component	Extracellular space	IDA	2494176, 24692546
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	14602737
GO:0006701	Process	Progesterone biosynthetic process	TAS	14557487
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IEP	14557487
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	24692546
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007292	Process	Female gamete generation	TAS	8220432
GO:0007565	Process	Female pregnancy	TAS	8220432
GO:0008284	Process	Positive regulation of cell population proliferation	NAS	20613903
GO:0009755	Process	Hormone-mediated signaling pathway	IBA	21873635
GO:0010469	Process	Regulation of signaling receptor activity	IDA	24692546
GO:0010893	Process	Positive regulation of steroid biosynthetic process	IDA	2494176
GO:0016486	Process	Peptide hormone processing	TAS
GO:0016913	Function	Follicle-stimulating hormone activity	IBA	21873635
GO:0016913	Function	Follicle-stimulating hormone activity	IDA	2494176, 24692546
GO:0016913	Function	Follicle-stimulating hormone activity	IMP	11514332
GO:0016914	Component	Follicle-stimulating hormone complex	IDA	2494176, 24692546
GO:0030335	Process	Positive regulation of cell migration	NAS	20613903
GO:0042699	Process	Follicle-stimulating hormone signaling pathway	IBA	21873635
GO:0045670	Process	Regulation of osteoclast differentiation	IEA
GO:0045780	Process	Positive regulation of bone resorption	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	NAS	20613903
GO:0060011	Process	Sertoli cell proliferation	IEA

Other IDs

• MIM: 136530
• HGNC: 3964
• e!Ensembl: ENSG00000131808

Protein

• UniProt ID: P01225
• Protein name: Follitropin subunit beta (Follicle-stimulating hormone beta subunit) (FSH-B) (FSH-beta) (Follitropin beta chain)
• Protein function: Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream sig
• PDB: 1FL7, 1XWD, 4AY9, 4MQW, 8I2G
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00007	Cys_knot	18 → 122	Cystine-knot domain	Domain

• Sequence:

  MKTLQFFFLFCCWKAICCNSCELTNITIAIEKEECRFCISINTTWCAGYCYTRDLVYKDP
  ARPKIQKTCTFKELVYETVRVPGCAHHADSLYTYPVATQCHCGKCDSDSTDCTVRGLGPS
  YCSFGEMKE

• Sequence length: 129

Pathways

KEGG:

cAMP signaling pathway
Neuroactive ligand-receptor interaction
Hormone signaling
GnRH signaling pathway
Ovarian steroidogenesis

Reactome:

Glycoprotein hormones
Hormone ligand-binding receptors
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Azoospermia	Azoospermia	rs200969445, rs144567652, rs765353898
Hypogonadotropic hypogonadism	Hypogonadotropic hypogonadism	rs104894702, rs104893836, rs104893837, rs104893842, rs121909628, rs138249161, rs1601946139	8263139, 18449926, 24739304
Oligospermia	Oligospermia	rs1602125411, rs2047796277, rs377712900	4607150

Unknown
Disease name	Disease term	dbSNP ID	References
Delayed menarche	Delayed menarche
Female hypogonadism syndrome	Female hypogonadism syndrome
Follicle stimulating hormone deficiency	Follicle stimulating hormone deficiency, Follicle-stimulating hormone deficiency, isolated		15705395, 9280841, 8220432, 28392474, 12161499, 9271483, 9624193, 15705395
Gonadotropin deficiency	Gonadotropin deficiency
Hypogonadism	Hypogonadism, Primary hypogonadism, Hypogonadism, Isolated Hypogonadotropic		8263139, 24739304, 18449926, 8263139, 18449926, 24739304, 24739304, 8263139, 18449926
Isolated follicle stimulating hormone deficiency	Isolated follicle stimulating hormone deficiency
Lateral medullary syndrome	Lateral Medullary Syndrome		17344003
Physiologic amenorrhea	Primary physiologic amenorrhea
Subfertility	Subfertility, Female		8220432
Teratozoospermia	Teratozoospermia
Testicular atrophy	Atrophy of testis
Testicular hypogonadism	Testicular hypogonadism