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ALOX15 (arachidonate 15-lipoxygenase)

Gene

246

Arachidonate 15-lipoxygenase

ALOX15

12-LOX, 15-LOX, 15-LOX-1, LOG15

17p13.2

This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The e

Show/Hide all(195)

miRTarBase ID	miRNA	Experiments	Reference
MIRT437575	hsa-miR-203a-3p	Microarray, qRT-PCR	22815788
MIRT541602	hsa-miR-4432	PAR-CLIP	21572407
MIRT541601	hsa-miR-451b	PAR-CLIP	21572407
MIRT541599	hsa-miR-6501-3p	PAR-CLIP	21572407
MIRT541600	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT541598	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT541597	hsa-miR-6776-5p	PAR-CLIP	21572407
MIRT541596	hsa-miR-4696	PAR-CLIP	21572407
MIRT541595	hsa-miR-363-5p	PAR-CLIP	21572407
MIRT541594	hsa-miR-6745	PAR-CLIP	21572407
MIRT541593	hsa-miR-6756-5p	PAR-CLIP	21572407
MIRT541592	hsa-miR-6766-5p	PAR-CLIP	21572407
MIRT541591	hsa-miR-1293	PAR-CLIP	21572407
MIRT541590	hsa-miR-4483	PAR-CLIP	21572407
MIRT541589	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT541588	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT451512	hsa-miR-302f	PAR-CLIP	23592263
MIRT451511	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT451510	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT451509	hsa-miR-940	PAR-CLIP	23592263
MIRT451508	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT451507	hsa-miR-665	PAR-CLIP	23592263
MIRT451506	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT451505	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT451504	hsa-miR-1827	PAR-CLIP	23592263
MIRT451503	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT451502	hsa-miR-139-3p	PAR-CLIP	23592263
MIRT451501	hsa-miR-1273e	PAR-CLIP	23592263
MIRT541602	hsa-miR-4432	PAR-CLIP	21572407
MIRT541601	hsa-miR-451b	PAR-CLIP	21572407
MIRT541599	hsa-miR-6501-3p	PAR-CLIP	21572407
MIRT541600	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT541598	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT541597	hsa-miR-6776-5p	PAR-CLIP	21572407
MIRT541596	hsa-miR-4696	PAR-CLIP	21572407
MIRT541595	hsa-miR-363-5p	PAR-CLIP	21572407
MIRT541594	hsa-miR-6745	PAR-CLIP	21572407
MIRT541593	hsa-miR-6756-5p	PAR-CLIP	21572407
MIRT541592	hsa-miR-6766-5p	PAR-CLIP	21572407
MIRT541591	hsa-miR-1293	PAR-CLIP	21572407
MIRT541590	hsa-miR-4483	PAR-CLIP	21572407
MIRT541589	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT541588	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT451512	hsa-miR-302f	PAR-CLIP	23592263
MIRT451511	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT451510	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT451509	hsa-miR-940	PAR-CLIP	23592263
MIRT451508	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT451507	hsa-miR-665	PAR-CLIP	23592263
MIRT451506	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT451505	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT451504	hsa-miR-1827	PAR-CLIP	23592263
MIRT451503	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT451502	hsa-miR-139-3p	PAR-CLIP	23592263
MIRT451501	hsa-miR-1273e	PAR-CLIP	23592263
MIRT755579	hsa-miR-660-5p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunofluorescence	37425043
MIRT778866	hsa-miR-1225-3p	CLIP-seq
MIRT778867	hsa-miR-1233	CLIP-seq
MIRT778868	hsa-miR-203	CLIP-seq
MIRT778869	hsa-miR-2114	CLIP-seq
MIRT778870	hsa-miR-3065-5p	CLIP-seq
MIRT778871	hsa-miR-3120-5p	CLIP-seq
MIRT778872	hsa-miR-3135	CLIP-seq
MIRT778873	hsa-miR-3174	CLIP-seq
MIRT778874	hsa-miR-3180-5p	CLIP-seq
MIRT778875	hsa-miR-3609	CLIP-seq
MIRT778876	hsa-miR-3613-3p	CLIP-seq
MIRT778877	hsa-miR-3622b-5p	CLIP-seq
MIRT778878	hsa-miR-3664-3p	CLIP-seq
MIRT778879	hsa-miR-3664-5p	CLIP-seq
MIRT778880	hsa-miR-3672	CLIP-seq
MIRT778881	hsa-miR-3689a-3p	CLIP-seq
MIRT778882	hsa-miR-3689c	CLIP-seq
MIRT778883	hsa-miR-3924	CLIP-seq
MIRT778884	hsa-miR-3929	CLIP-seq
MIRT778885	hsa-miR-3973	CLIP-seq
MIRT778886	hsa-miR-410	CLIP-seq
MIRT778887	hsa-miR-4419b	CLIP-seq
MIRT778888	hsa-miR-4433	CLIP-seq
MIRT778889	hsa-miR-4455	CLIP-seq
MIRT778890	hsa-miR-4459	CLIP-seq
MIRT778891	hsa-miR-4474-3p	CLIP-seq
MIRT778892	hsa-miR-4478	CLIP-seq
MIRT778893	hsa-miR-4517	CLIP-seq
MIRT778894	hsa-miR-4522	CLIP-seq
MIRT778895	hsa-miR-4635	CLIP-seq
MIRT778896	hsa-miR-4695-5p	CLIP-seq
MIRT778897	hsa-miR-4728-5p	CLIP-seq
MIRT778898	hsa-miR-4793-3p	CLIP-seq
MIRT778899	hsa-miR-485-5p	CLIP-seq
MIRT778900	hsa-miR-508-5p	CLIP-seq
MIRT778901	hsa-miR-510	CLIP-seq
MIRT778902	hsa-miR-512-5p	CLIP-seq
MIRT778903	hsa-miR-520g	CLIP-seq
MIRT778904	hsa-miR-520h	CLIP-seq
MIRT778905	hsa-miR-548ah	CLIP-seq
MIRT778906	hsa-miR-554	CLIP-seq
MIRT778907	hsa-miR-579	CLIP-seq
MIRT778908	hsa-miR-609	CLIP-seq
MIRT778909	hsa-miR-661	CLIP-seq
MIRT778910	hsa-miR-766	CLIP-seq
MIRT778911	hsa-miR-921	CLIP-seq
MIRT1920243	hsa-miR-3168	CLIP-seq
MIRT1920244	hsa-miR-587	CLIP-seq
MIRT1920243	hsa-miR-3168	CLIP-seq
MIRT1920244	hsa-miR-587	CLIP-seq
MIRT1920243	hsa-miR-3168	CLIP-seq
MIRT1920244	hsa-miR-587	CLIP-seq
MIRT1929924	hsa-miR-183	CLIP-seq
MIRT778869	hsa-miR-2114	CLIP-seq
MIRT778873	hsa-miR-3174	CLIP-seq
MIRT778877	hsa-miR-3622b-5p	CLIP-seq
MIRT778878	hsa-miR-3664-3p	CLIP-seq
MIRT778881	hsa-miR-3689a-3p	CLIP-seq
MIRT778882	hsa-miR-3689c	CLIP-seq
MIRT778884	hsa-miR-3929	CLIP-seq
MIRT778887	hsa-miR-4419b	CLIP-seq
MIRT778888	hsa-miR-4433	CLIP-seq
MIRT778890	hsa-miR-4459	CLIP-seq
MIRT778892	hsa-miR-4478	CLIP-seq
MIRT1929925	hsa-miR-4537	CLIP-seq
MIRT778896	hsa-miR-4695-5p	CLIP-seq
MIRT778897	hsa-miR-4728-5p	CLIP-seq
MIRT778898	hsa-miR-4793-3p	CLIP-seq
MIRT778899	hsa-miR-485-5p	CLIP-seq
MIRT778900	hsa-miR-508-5p	CLIP-seq
MIRT778901	hsa-miR-510	CLIP-seq
MIRT778902	hsa-miR-512-5p	CLIP-seq
MIRT778907	hsa-miR-579	CLIP-seq
MIRT778910	hsa-miR-766	CLIP-seq
MIRT778911	hsa-miR-921	CLIP-seq
MIRT1929924	hsa-miR-183	CLIP-seq
MIRT778869	hsa-miR-2114	CLIP-seq
MIRT778878	hsa-miR-3664-3p	CLIP-seq
MIRT778881	hsa-miR-3689a-3p	CLIP-seq
MIRT778882	hsa-miR-3689c	CLIP-seq
MIRT778884	hsa-miR-3929	CLIP-seq
MIRT778887	hsa-miR-4419b	CLIP-seq
MIRT778888	hsa-miR-4433	CLIP-seq
MIRT778889	hsa-miR-4455	CLIP-seq
MIRT778890	hsa-miR-4459	CLIP-seq
MIRT778892	hsa-miR-4478	CLIP-seq
MIRT778896	hsa-miR-4695-5p	CLIP-seq
MIRT778897	hsa-miR-4728-5p	CLIP-seq
MIRT778898	hsa-miR-4793-3p	CLIP-seq
MIRT778899	hsa-miR-485-5p	CLIP-seq
MIRT778900	hsa-miR-508-5p	CLIP-seq
MIRT778901	hsa-miR-510	CLIP-seq
MIRT778902	hsa-miR-512-5p	CLIP-seq
MIRT778907	hsa-miR-579	CLIP-seq
MIRT778908	hsa-miR-609	CLIP-seq
MIRT778909	hsa-miR-661	CLIP-seq
MIRT778910	hsa-miR-766	CLIP-seq
MIRT778869	hsa-miR-2114	CLIP-seq
MIRT778878	hsa-miR-3664-3p	CLIP-seq
MIRT778881	hsa-miR-3689a-3p	CLIP-seq
MIRT778882	hsa-miR-3689c	CLIP-seq
MIRT778884	hsa-miR-3929	CLIP-seq
MIRT778887	hsa-miR-4419b	CLIP-seq
MIRT778888	hsa-miR-4433	CLIP-seq
MIRT778890	hsa-miR-4459	CLIP-seq
MIRT778892	hsa-miR-4478	CLIP-seq
MIRT778896	hsa-miR-4695-5p	CLIP-seq
MIRT778897	hsa-miR-4728-5p	CLIP-seq
MIRT778899	hsa-miR-485-5p	CLIP-seq
MIRT778901	hsa-miR-510	CLIP-seq
MIRT778902	hsa-miR-512-5p	CLIP-seq
MIRT778907	hsa-miR-579	CLIP-seq
MIRT778878	hsa-miR-3664-3p	CLIP-seq
MIRT778881	hsa-miR-3689a-3p	CLIP-seq
MIRT778882	hsa-miR-3689c	CLIP-seq
MIRT778884	hsa-miR-3929	CLIP-seq
MIRT778887	hsa-miR-4419b	CLIP-seq
MIRT778888	hsa-miR-4433	CLIP-seq
MIRT778890	hsa-miR-4459	CLIP-seq
MIRT778892	hsa-miR-4478	CLIP-seq
MIRT778896	hsa-miR-4695-5p	CLIP-seq
MIRT778897	hsa-miR-4728-5p	CLIP-seq
MIRT778899	hsa-miR-485-5p	CLIP-seq
MIRT778901	hsa-miR-510	CLIP-seq
MIRT778902	hsa-miR-512-5p	CLIP-seq
MIRT778873	hsa-miR-3174	CLIP-seq
MIRT2473398	hsa-miR-4316	CLIP-seq
MIRT778911	hsa-miR-921	CLIP-seq
MIRT778869	hsa-miR-2114	CLIP-seq
MIRT778878	hsa-miR-3664-3p	CLIP-seq
MIRT778884	hsa-miR-3929	CLIP-seq
MIRT778887	hsa-miR-4419b	CLIP-seq
MIRT778888	hsa-miR-4433	CLIP-seq
MIRT778890	hsa-miR-4459	CLIP-seq
MIRT778892	hsa-miR-4478	CLIP-seq
MIRT778896	hsa-miR-4695-5p	CLIP-seq
MIRT778899	hsa-miR-485-5p	CLIP-seq
MIRT778901	hsa-miR-510	CLIP-seq
MIRT778902	hsa-miR-512-5p	CLIP-seq

Transcription factors

Show/Hide all(7)

Transcription factor	Regulation	Reference
CREBBP	Activation	12517954
EP300	Activation	12517954
HDAC1	Unknown	19198625
MTA1	Unknown	19198625
SPI1	Activation	16320347
STAT6	Activation	12517954
STAT6	Unknown	10657944

Show/Hide all(56)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001503	Process	Ossification	ISS
GO:0002820	Process	Negative regulation of adaptive immune response	ISS
GO:0004052	Function	Arachidonate 12(S)-lipoxygenase activity	IBA	21873635
GO:0004052	Function	Arachidonate 12(S)-lipoxygenase activity	IDA	1944593
GO:0005506	Function	Iron ion binding	ISS
GO:0005515	Function	Protein binding	IPI	21831839
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IDA	17052953
GO:0005811	Component	Lipid droplet	IDA	19528634
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA	17052953, 21831839
GO:0005829	Component	Cytosol	ISS
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	ISS
GO:0006629	Process	Lipid metabolic process	IDA	23242647, 25293588
GO:0006646	Process	Phosphatidylethanolamine biosynthetic process	ISS
GO:0006691	Process	Leukotriene metabolic process	TAS
GO:0006954	Process	Inflammatory response	TAS	10200270
GO:0010811	Process	Positive regulation of cell-substrate adhesion	IDA	11278875
GO:0016020	Component	Membrane	IDA	21831839
GO:0016165	Function	Linoleate 13S-lipoxygenase activity	IDA	8334154
GO:0016702	Function	Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IBA	21873635
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0019369	Process	Arachidonic acid metabolic process	IBA	21873635
GO:0019369	Process	Arachidonic acid metabolic process	IDA	1944593, 8334154, 17052953, 24282679
GO:0019369	Process	Arachidonic acid metabolic process	NAS	3202857
GO:0019372	Process	Lipoxygenase pathway	IBA	21873635
GO:0019372	Process	Lipoxygenase pathway	IDA	1944593, 23242647
GO:0019372	Process	Lipoxygenase pathway	TAS
GO:0019395	Process	Fatty acid oxidation	ISS
GO:0030282	Process	Bone mineralization	ISS
GO:0030838	Process	Positive regulation of actin filament polymerization	ISS
GO:0031234	Component	Extrinsic component of cytoplasmic side of plasma membrane	IDA	17052953
GO:0034116	Process	Positive regulation of heterotypic cell-cell adhesion	IEA
GO:0034440	Process	Lipid oxidation	IBA	21873635
GO:0034976	Process	Response to endoplasmic reticulum stress	ISS
GO:0035358	Process	Regulation of peroxisome proliferator activated receptor signaling pathway	ISS
GO:0035963	Process	Cellular response to interleukin-13	IMP	21831839
GO:0042060	Process	Wound healing	ISS
GO:0042759	Process	Long-chain fatty acid biosynthetic process	TAS
GO:0043277	Process	Apoptotic cell clearance	ISS
GO:0043651	Process	Linoleic acid metabolic process	IBA	21873635
GO:0043651	Process	Linoleic acid metabolic process	IDA	8334154
GO:0047977	Function	Hepoxilin-epoxide hydrolase activity	IEA
GO:0050473	Function	Arachidonate 15-lipoxygenase activity	IBA	21873635
GO:0050473	Function	Arachidonate 15-lipoxygenase activity	IDA	1944593, 8334154, 17052953, 24282679
GO:0050473	Function	Arachidonate 15-lipoxygenase activity	NAS	3202857
GO:0050473	Function	Arachidonate 15-lipoxygenase activity	TAS
GO:0050727	Process	Regulation of inflammatory response	IDA	23242647
GO:0051120	Function	Hepoxilin A3 synthase activity	IEA
GO:0051122	Process	Hepoxilin biosynthetic process	IBA	21873635
GO:0051122	Process	Hepoxilin biosynthetic process	ISS
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IMP	21831839
GO:0071277	Process	Cellular response to calcium ion	IDA	17052953
GO:1901074	Process	Regulation of engulfment of apoptotic cell	ISS
GO:2001303	Process	Lipoxin A4 biosynthetic process	ISS

MIM	HGNC	e!Ensembl
152392	433	ENSG00000161905

Protein

UniProt ID

P16050

Protein name

Polyunsaturated fatty acid lipoxygenase ALOX15 (12/15-lipoxygenase) (Arachidonate 12-lipoxygenase, leukocyte-type) (12-LOX) (EC 1.13.11.31) (Arachidonate 15-lipoxygenase) (15-LOX) (15-LOX-1) (EC 1.13.11.33) (Arachidonate omega-6 lipoxygenase) (Hepoxilin A

Protein function

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:17052953, PubMed:1944593, PubMed:24282679, PubMed:

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01477	PLAT	4 → 107	PLAT/LH2 domain	Domain
PF00305	Lipoxygenase	183 → 650	Lipoxygenase	Domain

Sequence

MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL
LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP
QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK
GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV
LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL
VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH
LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST
GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS
LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH
ASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQ
PVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSV
AI

Sequence length

662

Interactions

View interactions

	KEGG		Reactome
	Arachidonic acid metabolism Linoleic acid metabolism Metabolic pathways Efferocytosis Ferroptosis Necroptosis Serotonergic synapse		Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Interleukin-4 and Interleukin-13 signaling Biosynthesis of DHA-derived SPMs Biosynthesis of protectins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of E-series 18(R)-resolvins Biosynthesis of DPAn-6 SPMs Biosynthesis of DPAn-3-derived protectins and resolvins

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Esophagus neoplasm	Esophageal Neoplasms, Malignant neoplasm of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	11406566
Hypertension	Hypertensive disease	rs13306026, rs13333226	22467300

Show/Hide Unknown Diseases (4)

Unknown
Disease name	Disease term	dbSNP ID	References
Atherosclerosis	Atherosclerosis	rs699947, rs59439148	16303615
Heart failure	Heart Failure, Diastolic	rs121918074, rs142027794, rs148791216, rs72648927, rs71578935, rs142416150, rs199830512, rs755445214, rs150102469, rs779568205, rs907992794, rs1202130741	29556499
Nasal polyposis	Nasal Polyps		30643255
Sinusitis	Chronic sinusitis		30643255

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